CA1240321A - Process for preparing 5,6,7,8-tetrahydro-6-(l-erythro- 1',2'-dihydroxypropyl)pterin - Google Patents

Process for preparing 5,6,7,8-tetrahydro-6-(l-erythro- 1',2'-dihydroxypropyl)pterin

Info

Publication number
CA1240321A
CA1240321A CA000474602A CA474602A CA1240321A CA 1240321 A CA1240321 A CA 1240321A CA 000474602 A CA000474602 A CA 000474602A CA 474602 A CA474602 A CA 474602A CA 1240321 A CA1240321 A CA 1240321A
Authority
CA
Canada
Prior art keywords
weight
alkali metal
metal hydroxide
hydroxide
basic medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000474602A
Other languages
English (en)
French (fr)
Inventor
Masaaki Azuma
Takehisa Ohashi
Kiyoshi Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanegafuchi Chemical Industry Co Ltd
Original Assignee
Kanegafuchi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=12397654&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA1240321(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kanegafuchi Chemical Industry Co Ltd filed Critical Kanegafuchi Chemical Industry Co Ltd
Application granted granted Critical
Publication of CA1240321A publication Critical patent/CA1240321A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA000474602A 1984-02-23 1985-02-19 Process for preparing 5,6,7,8-tetrahydro-6-(l-erythro- 1',2'-dihydroxypropyl)pterin Expired CA1240321A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP33839/1984 1984-02-23
JP59033839A JPS60178887A (ja) 1984-02-23 1984-02-23 ５，６，７，８−テトラヒドロ−ｌ−ビオプテリンの製造法

Publications (1)

Publication Number Publication Date
CA1240321A true CA1240321A (en) 1988-08-09

Family

ID=12397654

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000474602A Expired CA1240321A (en) 1984-02-23 1985-02-19 Process for preparing 5,6,7,8-tetrahydro-6-(l-erythro- 1',2'-dihydroxypropyl)pterin

Country Status (7)

Country Link
US (1) US4595752A (enExample)
EP (1) EP0153696B1 (enExample)
JP (1) JPS60178887A (enExample)
AT (1) ATE46906T1 (enExample)
CA (1) CA1240321A (enExample)
DE (1) DE3573426D1 (enExample)
ES (1) ES8601993A1 (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60178887A (ja) * 1984-02-23 1985-09-12 Kanegafuchi Chem Ind Co Ltd ５，６，７，８−テトラヒドロ−ｌ−ビオプテリンの製造法
JPS60199889A (ja) * 1984-03-24 1985-10-09 Kanegafuchi Chem Ind Co Ltd ５，６，７，８−テトラヒドロ−ｌ−エリスロ−ビオプテリンの硫酸塩およびその製法
JPS60204786A (ja) * 1984-03-29 1985-10-16 Univ Nagoya （６ｒ）―テトラヒドロビオプテリンの合成法
US4665176A (en) * 1984-10-23 1987-05-12 Mitsui Toatsu Chemicals, Incorporated Process for the preparation of 5,6,7,8-tetrahydrofolic acid
US4713454A (en) * 1985-01-28 1987-12-15 Shiratori Pharmaceutical Co., Ltd. Preparation process of (6R)-tetrahydro-L-biopterin
CA1334654C (en) * 1987-11-30 1995-03-07 Masayasu Kurono Intermediates for synthesizing bh _and its derivatives
US6162914A (en) * 1998-04-24 2000-12-19 Cerbios-Pharma S.A. Process for the reduction of pterins
CH694251A5 (de) * 1999-07-14 2004-10-15 Eprova Ag Herstellung von Tetrahydropterin und Derivaten.
BR0113411A (pt) * 2000-08-31 2004-01-06 Daiichi Suntory Pharma Co Ltd Processo para a produção do composto de biopterina
US7442372B2 (en) 2003-08-29 2008-10-28 Biomarin Pharmaceutical Inc. Delivery of therapeutic compounds to the brain and other tissues
HUE058126T2 (hu) 2003-11-17 2022-07-28 Biomarin Pharm Inc Módszerek és készítmények metabolikus rendellenességek kezelésére
EP1687308B1 (en) * 2003-11-17 2019-06-12 Merck & Cie Process for preparating (6R)-L-erythrotetrahydrobiopterin hydrochloride crystalline form B from other crystalline forms
JP2008504295A (ja) * 2004-06-25 2008-02-14 ボード　オブ　リージェンツ，　ザ　ユニバーシティ　オブ　テキサス　システム 注意欠陥多動性障害及び高フェニルアラニン血症の治療のための方法及び組成物
BRPI0517088A (pt) 2004-11-17 2008-09-30 Biomarin Pharm Inc formulação de comprimido estável
JP2008523090A (ja) * 2004-12-08 2008-07-03 バイオマリン ファーマシューティカル インコーポレイテッド 新生児肺高血圧症の治療のための方法および組成物
KR101258430B1 (ko) 2005-04-14 2013-04-26 다이이찌 산쿄 가부시키가이샤 염산 사프롭테린의 알파형 결정의 제조방법
JP2009518415A (ja) * 2005-12-05 2009-05-07 バイオマリン ファーマシューティカル インコーポレイテッド 疾患の処置のための方法および組成物
JP2010515747A (ja) * 2007-01-12 2010-05-13 ビオマリン プハルマセウトイカル インコーポレイテッド テトラヒドロビオプテリンプロドラッグ
US20100009997A1 (en) * 2007-01-12 2010-01-14 Biomarin Pharmaceutical Inc. Method of treating a metabolic or neuropsychiarty disorder with a bh4 derivative prodrug
HRP20220188T3 (hr) 2007-04-11 2022-04-29 Biomarin Pharmaceutical Inc. Načini primjene tetrahidrobiopterina, povezani pripravci i postupci mjerenja
WO2009088530A1 (en) 2008-01-03 2009-07-16 Biomarin Pharmaceutical Inc. Pterin analog for treating bh4 responsive condition
JP2011508781A (ja) * 2008-01-07 2011-03-17 ビオマリン プハルマセウトイカル インコーポレイテッド テトラヒドロビオプテリンの合成方法
CN102443006B (zh) 2010-10-13 2016-02-24 因华生技制药股份有限公司 (6r)-四氢生物喋呤盐酸盐的制备方法
TWI481612B (zh) * 2010-10-15 2015-04-21 Innopharmax Inc （６ｒ）－四氫生物喋呤鹽酸鹽的製備方法
US9216178B2 (en) 2011-11-02 2015-12-22 Biomarin Pharmaceutical Inc. Dry blend formulation of tetrahydrobiopterin
CN102627644B (zh) * 2012-04-10 2014-04-16 凯莱英医药集团（天津）股份有限公司 一种通过直接手性合成方法制备二盐酸沙丙蝶呤的方法
CN102633799B (zh) * 2012-04-10 2014-06-25 凯莱英医药集团（天津）股份有限公司 一种从消旋体中间体拆分路线合成二盐酸沙丙蝶呤的方法
WO2016189542A1 (en) 2015-05-28 2016-12-01 Natco Pharma Ltd Novel process for the preparation of sapropterin dihydrochloride and its key intermediate, l-biopterin
WO2019175332A1 (en) 2018-03-14 2019-09-19 Imba - Institut Für Molekulare Biotechnologie Gmbh Bh4 pathway inhibition and use thereof for treating t-cell mediated autoimmune diseases or hypersensitivity
WO2019175328A1 (en) 2018-03-14 2019-09-19 Imba - Institut Für Molekulare Biotechnologie Gmbh Bh4pathwayactivationandusethereoffortreatingcancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2741608A (en) * 1951-03-08 1956-04-10 Research Corp 5-formyl-5,6,7,8-tetrahydropteroic acid and amides thereof and method of preparing same
JPS5883691A (ja) * 1981-11-13 1983-05-19 Kanegafuchi Chem Ind Co Ltd １′，２′−ジアシル−（６ｒ，ｓ）−５，６，７，８−テトラヒドロ−ｌ−ビオプテリンおよびその製法
JPS60178887A (ja) * 1984-02-23 1985-09-12 Kanegafuchi Chem Ind Co Ltd ５，６，７，８−テトラヒドロ−ｌ−ビオプテリンの製造法
JPS61172876A (ja) * 1985-01-28 1986-08-04 Shiratori Seiyaku Kk （６ｒ）−テトラヒドロ−ｌ−バイオプテリンの製造法
JPS61172877A (ja) * 1985-01-28 1986-08-04 Shiratori Seiyaku Kk （６ｒ）−テトラヒドロ−ｌ−バイオプテリンの製造方法

Also Published As

Publication number Publication date
ES540638A0 (es) 1985-11-16
JPS60178887A (ja) 1985-09-12
ATE46906T1 (de) 1989-10-15
JPH0212475B2 (enExample) 1990-03-20
ES8601993A1 (es) 1985-11-16
US4595752A (en) 1986-06-17
EP0153696A2 (en) 1985-09-04
EP0153696A3 (en) 1987-08-19
DE3573426D1 (en) 1989-11-09
EP0153696B1 (en) 1989-10-04

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Effective date: 20050809