CA1233749A - Method for the therapeutic occlusion of blood vessels - Google Patents
Method for the therapeutic occlusion of blood vesselsInfo
- Publication number
- CA1233749A CA1233749A CA000450019A CA450019A CA1233749A CA 1233749 A CA1233749 A CA 1233749A CA 000450019 A CA000450019 A CA 000450019A CA 450019 A CA450019 A CA 450019A CA 1233749 A CA1233749 A CA 1233749A
- Authority
- CA
- Canada
- Prior art keywords
- chitosan
- chitin
- solution
- blood vessels
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 210000004204 blood vessel Anatomy 0.000 title claims abstract description 10
- 230000001225 therapeutic effect Effects 0.000 title claims description 4
- 238000000034 method Methods 0.000 title abstract description 16
- 229920001661 Chitosan Polymers 0.000 claims abstract description 45
- 229920002101 Chitin Polymers 0.000 claims abstract description 15
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000012153 distilled water Substances 0.000 claims abstract description 4
- 239000000243 solution Substances 0.000 claims description 15
- 238000002347 injection Methods 0.000 claims description 5
- 239000007924 injection Substances 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000008280 blood Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 241000282472 Canis lupus familiaris Species 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 208000032843 Hemorrhage Diseases 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 241000238557 Decapoda Species 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 3
- 229960000583 acetic acid Drugs 0.000 description 3
- 238000006640 acetylation reaction Methods 0.000 description 3
- 125000003277 amino group Chemical group 0.000 description 3
- 210000001367 artery Anatomy 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 230000002439 hemostatic effect Effects 0.000 description 3
- 239000011343 solid material Substances 0.000 description 3
- 206010061216 Infarction Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 2
- 230000001054 cortical effect Effects 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 230000007574 infarction Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
- 241000238421 Arthropoda Species 0.000 description 1
- 241000282465 Canis Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000238424 Crustacea Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 159000000021 acetate salts Chemical class 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 229960002442 glucosamine Drugs 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000011344 liquid material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229950006780 n-acetylglucosamine Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US522,492 | 1983-08-12 | ||
| US06/522,492 US4452785A (en) | 1982-11-08 | 1983-08-12 | Method for the therapeutic occlusion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1233749A true CA1233749A (en) | 1988-03-08 |
Family
ID=24081086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000450019A Expired CA1233749A (en) | 1983-08-12 | 1984-03-20 | Method for the therapeutic occlusion of blood vessels |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US4452785A (esLanguage) |
| JP (1) | JPS6042326A (esLanguage) |
| CA (1) | CA1233749A (esLanguage) |
| GB (1) | GB2144630B (esLanguage) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0684309B2 (ja) * | 1986-03-24 | 1994-10-26 | ライオン株式会社 | 人工唾液組成物 |
| EP0606929B1 (en) * | 1987-11-12 | 2001-05-30 | Canon Kabushiki Kaisha | Liquid crystal apparatus |
| US5180426A (en) * | 1987-12-28 | 1993-01-19 | Asahi Kogaku Kogyo K.K. | Composition for forming calcium phosphate type setting material and process for producing setting material |
| JP2798287B2 (ja) * | 1989-02-08 | 1998-09-17 | ユニチカ株式会社 | 抗炎症剤 |
| US6150581A (en) * | 1995-06-07 | 2000-11-21 | United States Surgical Corporation | Chitosan/alginate anti-adhesion barrier |
| CN1216929A (zh) * | 1996-02-02 | 1999-05-19 | 血管转换公司 | 用于阻塞通过血管的流动的方法与装置 |
| US7897832B2 (en) * | 2001-06-14 | 2011-03-01 | Hemcon Medical Technologies, Inc. | Compositions, assemblies, and methods applied during or after a dental procedure to ameliorate fluid loss and/or promote healing, using a hydrophilic polymer sponge structure such as chitosan |
| US20060004314A1 (en) * | 2001-06-14 | 2006-01-05 | Hemcon, Inc. | Antimicrobial barriers, systems, and methods formed from hydrophilic polymer structures such as chistosan |
| US7371403B2 (en) | 2002-06-14 | 2008-05-13 | Providence Health System-Oregon | Wound dressing and method for controlling severe, life-threatening bleeding |
| US8741335B2 (en) | 2002-06-14 | 2014-06-03 | Hemcon Medical Technologies, Inc. | Hemostatic compositions, assemblies, systems, and methods employing particulate hemostatic agents formed from hydrophilic polymer foam such as Chitosan |
| US20050147656A1 (en) * | 2001-06-14 | 2005-07-07 | Hemcon, Inc. | Tissue dressing assemblies, systems, and methods formed from hydrophilic polymer sponge structures such as chitosan |
| CA2450668C (en) * | 2001-06-14 | 2010-05-04 | Providence Health System-Oregon | Wound dressing and method for controlling severe, life-threatening bleeding |
| US20050137512A1 (en) * | 2003-12-23 | 2005-06-23 | Campbell Todd D. | Wound dressing and method for controlling severe, life-threatening bleeding |
| US8269058B2 (en) * | 2002-06-14 | 2012-09-18 | Hemcon Medical Technologies, Inc. | Absorbable tissue dressing assemblies, systems, and methods formed from hydrophilic polymer sponge structures such as chitosan |
| CN1938036B (zh) | 2004-02-23 | 2011-05-11 | 洛马林达大学医学中心 | 局部和内部使用的止血剂 |
| WO2006089167A1 (en) * | 2005-02-18 | 2006-08-24 | Cartilix, Inc. | Glucosamine materials |
| US9204957B2 (en) * | 2005-03-17 | 2015-12-08 | Hemcon Medical Technologies, Inc. | Systems and methods for hemorrhage control and or tissue repair |
| WO2007139845A2 (en) | 2006-05-23 | 2007-12-06 | Providence Health System-Oregon D/B/A Providence St. Vincent Medical Center | Systems and methods for introducing and applying a bandage structure within a body lumen or hollow body organ |
| KR101548766B1 (ko) * | 2008-05-02 | 2015-08-31 | 프로비던스 헬스 앤드 서비시즈, 오레곤 | 상처 드레싱 기구 및 방법 |
| US20110274726A1 (en) | 2008-10-06 | 2011-11-10 | Providence Health System - Oregon | Chitosan foam medical devices and methods |
| WO2011066471A1 (en) | 2009-11-25 | 2011-06-03 | Loma Linda University Medical Center | Chitosan-based hemostatic textile |
| CA2838793C (en) * | 2011-07-19 | 2019-08-06 | Baxter International Inc. | Resorption enhancers as additives to improve the oral formulation of non-anticoagulant sulfated polysaccharides |
| US9192574B2 (en) | 2013-10-24 | 2015-11-24 | Medtronic Xomed, Inc. | Chitosan paste wound dressing |
| US9192692B2 (en) | 2013-10-24 | 2015-11-24 | Medtronic Xomed, Inc. | Chitosan stenting paste |
| US9259357B2 (en) | 2014-04-16 | 2016-02-16 | Loma Linda University | Composition, preparation, and use of chitosan shards for biomedical applications |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3911116A (en) * | 1970-04-13 | 1975-10-07 | Leslie L Balassa | Process for promoting wound healing with chitin derivatives |
| US3989535A (en) * | 1974-02-11 | 1976-11-02 | American Cyanamid Company | Solution of poly(N-acetyl-D-glucosamine) |
| JPS5626049A (en) * | 1979-08-06 | 1981-03-13 | Mitsubishi Rayon Co | Chitine or chitine derivative nonwoven fabric and method |
| JPS56106901A (en) * | 1980-01-30 | 1981-08-25 | Mitsubishi Rayon Co Ltd | Production of formed product of chitosan |
| US4532134A (en) * | 1981-04-06 | 1985-07-30 | Malette William Graham | Method of achieving hemostasis, inhibiting fibroplasia, and promoting tissue regeneration in a tissue wound |
| US4394373A (en) * | 1981-04-06 | 1983-07-19 | Malette William Graham | Method of achieving hemostasis |
-
1983
- 1983-08-12 US US06/522,492 patent/US4452785A/en not_active Expired - Fee Related
-
1984
- 1984-03-20 CA CA000450019A patent/CA1233749A/en not_active Expired
- 1984-03-28 GB GB08408036A patent/GB2144630B/en not_active Expired
- 1984-04-24 JP JP59081261A patent/JPS6042326A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| GB2144630B (en) | 1988-03-30 |
| JPH054370B2 (esLanguage) | 1993-01-19 |
| GB8408036D0 (en) | 1984-05-10 |
| GB2144630A (en) | 1985-03-13 |
| US4452785A (en) | 1984-06-05 |
| JPS6042326A (ja) | 1985-03-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |