CA1217717A - Pharmaceutical composition containing a fibrinolytic agent and a diffusion factor, useful for the treatment of the myocardium infarction - Google Patents

Pharmaceutical composition containing a fibrinolytic agent and a diffusion factor, useful for the treatment of the myocardium infarction

Info

Publication number
CA1217717A
CA1217717A CA000438588A CA438588A CA1217717A CA 1217717 A CA1217717 A CA 1217717A CA 000438588 A CA000438588 A CA 000438588A CA 438588 A CA438588 A CA 438588A CA 1217717 A CA1217717 A CA 1217717A
Authority
CA
Canada
Prior art keywords
hyaluronidase
treatment
urokinase
useful
infarction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000438588A
Other languages
English (en)
French (fr)
Inventor
Francesco Borrelli
Francesco Antonetti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Serono SpA
Original Assignee
Istituto Farmacologico Serono SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto Farmacologico Serono SpA filed Critical Istituto Farmacologico Serono SpA
Application granted granted Critical
Publication of CA1217717A publication Critical patent/CA1217717A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A61K38/166—Streptokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
CA000438588A 1982-10-08 1983-10-07 Pharmaceutical composition containing a fibrinolytic agent and a diffusion factor, useful for the treatment of the myocardium infarction Expired CA1217717A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT49241/1982 1982-10-08
IT49241/82A IT1189379B (it) 1982-10-08 1982-10-08 Composizione farmaceutica contenente un agente fibrinolitico ed un fattore di diffusione,utile per il trattamento dell'infarto miocardico

Publications (1)

Publication Number Publication Date
CA1217717A true CA1217717A (en) 1987-02-10

Family

ID=11270058

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000438588A Expired CA1217717A (en) 1982-10-08 1983-10-07 Pharmaceutical composition containing a fibrinolytic agent and a diffusion factor, useful for the treatment of the myocardium infarction

Country Status (12)

Country Link
US (1) US4568543A (OSRAM)
EP (1) EP0106812B1 (OSRAM)
JP (1) JPS5989630A (OSRAM)
AT (1) ATE44467T1 (OSRAM)
AU (1) AU559192B2 (OSRAM)
CA (1) CA1217717A (OSRAM)
DE (2) DE106812T1 (OSRAM)
DK (1) DK161564C (OSRAM)
ES (1) ES8704736A1 (OSRAM)
IL (1) IL69938A (OSRAM)
IT (1) IT1189379B (OSRAM)
ZA (1) ZA837484B (OSRAM)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5275812A (en) * 1985-06-07 1994-01-04 The General Hospital Corporation Method of treatment for myocardial infarction
US5279824A (en) * 1988-04-14 1994-01-18 Merck Patent Gmbh Pharmaceutical formulation containing heparin and endo-beta-glucuronidase, useful for the treatment of thrombosis
DK0456724T3 (da) * 1989-01-27 1995-10-02 Immunolytics Inc Præparat og fremgangsmåde til behandling af benign prostatisk hypertrofi
CA2027936C (en) 1989-10-23 2001-07-24 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
US5939412A (en) * 1992-06-26 1999-08-17 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
EP0794779A4 (en) * 1994-12-22 1998-04-29 Smithkline Beecham Corp FIBRINOGENIC RECEPTOR ANTAGONISTS
AU2003220115A1 (en) * 2002-05-20 2003-12-12 Board Of Regents, The University Of Texas System Methods and compositions for delivering enzymes and nucleic acid molecules to brain, bone, and other tissues
US7220407B2 (en) * 2003-10-27 2007-05-22 Amgen Inc. G-CSF therapy as an adjunct to reperfusion therapy in the treatment of acute myocardial infarction

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1179787A (en) * 1967-03-22 1970-01-28 Biorex Laboratories Ltd Stabilised and Potentiated Therapeutic Enzyme Compositions
US3708575A (en) * 1970-05-13 1973-01-02 Biorex Laboratories Ltd Method for the treatment of atherosclerosis employing glucuronoglycos-aminoglycan-hyaluronate-lyase
US4271150A (en) * 1979-03-07 1981-06-02 Zeria-Shinyaku Kogyo Kabushiki Kaisha Urokinase preparation for oral administration

Also Published As

Publication number Publication date
DK464483D0 (da) 1983-10-07
IL69938A0 (en) 1984-01-31
EP0106812A3 (en) 1985-09-11
US4568543A (en) 1986-02-04
ZA837484B (en) 1984-06-27
DE3380166D1 (en) 1989-08-17
EP0106812A2 (en) 1984-04-25
IL69938A (en) 1987-09-16
EP0106812B1 (en) 1989-07-12
AU1988383A (en) 1984-04-12
ATE44467T1 (de) 1989-07-15
IT8249241A1 (it) 1984-04-08
DK464483A (da) 1984-04-09
DK161564C (da) 1992-01-06
DK161564B (da) 1991-07-22
ES8704736A1 (es) 1987-05-01
ES526300A0 (es) 1987-05-01
DE106812T1 (de) 1984-08-30
JPS5989630A (ja) 1984-05-23
IT1189379B (it) 1988-02-04
AU559192B2 (en) 1987-02-26
JPS6150927B2 (OSRAM) 1986-11-06
IT8249241A0 (it) 1982-10-08

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Legal Events

Date Code Title Description
MKEX Expiry