CA1215369A - Imidazolines and related compounds, their preparation and use - Google Patents

Imidazolines and related compounds, their preparation and use

Info

Publication number
CA1215369A
CA1215369A CA000449452A CA449452A CA1215369A CA 1215369 A CA1215369 A CA 1215369A CA 000449452 A CA000449452 A CA 000449452A CA 449452 A CA449452 A CA 449452A CA 1215369 A CA1215369 A CA 1215369A
Authority
CA
Canada
Prior art keywords
methyl
dihydro
imidazole
naphthalenyl
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000449452A
Other languages
English (en)
French (fr)
Inventor
Denis M. Bailey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Application granted granted Critical
Publication of CA1215369A publication Critical patent/CA1215369A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/18—Monohydroxylic alcohols containing only six-membered aromatic rings as cyclic part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/34—Monohydroxylic alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA000449452A 1983-03-14 1984-03-13 Imidazolines and related compounds, their preparation and use Expired CA1215369A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US475,193 1983-03-14
US06/475,193 US4540705A (en) 1983-03-14 1983-03-14 Antidepressant imidazolines and related compounds

Publications (1)

Publication Number Publication Date
CA1215369A true CA1215369A (en) 1986-12-16

Family

ID=23886585

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000449452A Expired CA1215369A (en) 1983-03-14 1984-03-13 Imidazolines and related compounds, their preparation and use

Country Status (16)

Country Link
US (1) US4540705A (enExample)
EP (1) EP0125410A3 (enExample)
JP (1) JPS59193875A (enExample)
KR (1) KR900001216B1 (enExample)
AU (1) AU568839B2 (enExample)
CA (1) CA1215369A (enExample)
DK (1) DK112984A (enExample)
ES (1) ES8601907A1 (enExample)
FI (1) FI840839A7 (enExample)
GR (1) GR81813B (enExample)
IL (1) IL70966A (enExample)
NO (1) NO840893L (enExample)
NZ (1) NZ207184A (enExample)
PH (1) PH19715A (enExample)
PT (1) PT78195B (enExample)
ZA (1) ZA841323B (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9016800D0 (en) * 1990-07-31 1990-09-12 Shell Int Research Tetrahydropyrimidine derivatives
DK1028110T3 (da) * 1997-10-02 2004-07-19 Daiichi Seiyaku Co Hidtil ukendte dihydronaphthalenforbindelser og fremgangsmåde til fremstilling deraf
US6559157B2 (en) 1997-10-02 2003-05-06 Daiichi Pharmaceutical Co., Ltd. Dihydronaphthalene compounds
US6329369B1 (en) 1997-12-04 2001-12-11 Allergan Sales, Inc. Methods of treating pain and other conditions
US6841684B2 (en) 1997-12-04 2005-01-11 Allergan, Inc. Imidiazoles having reduced side effects
EP0924209B1 (en) * 1997-12-19 2003-05-02 Eli Lilly And Company Hypoglycemic imidazoline compounds
EP1266897A3 (en) * 1997-12-19 2003-12-03 Eli Lilly And Company Hypoglycemic imidazoline compounds
US6410562B1 (en) 1998-12-18 2002-06-25 Eli Lilly And Company Hypoglycemic imidazoline compounds
FR2787451B1 (fr) * 1998-12-18 2001-01-26 Adir Nouveaux composes imidazoliniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA2637312A1 (en) * 2006-01-27 2007-08-02 F. Hoffmann-La Roche Ag Use of substituted 2-imidazole of imidazoline derivatives
MX2009003801A (es) 2006-10-19 2009-04-22 Hoffmann La Roche Aminometil-4-imidazoles.
BRPI0718054A2 (pt) 2006-11-02 2013-11-05 Hoffmann La Roche 2-imidazóis substituídos como moduladores de receptores associados à traços de aminas
AU2007321376A1 (en) 2006-11-16 2008-05-22 F. Hoffmann-La Roche Ag Substituted 4-imidazoles
WO2008071574A1 (en) 2006-12-13 2008-06-19 F. Hoffmann-La Roche Ag Novel 2 -imidazoles as ligands for trace amine associated receptors (taar)
US20080146523A1 (en) 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
US7582691B2 (en) * 2007-01-17 2009-09-01 Sabic Innovative Plastics Ip B.V. Poly(arylene ether) compositions and articles
CA2675221C (en) 2007-02-02 2016-02-23 F. Hoffmann-La Roche Ag Novel 2-aminooxazolines as taar1 ligands
MX2009008465A (es) 2007-02-15 2009-08-20 Hoffmann La Roche Nuevas 2-aminooxazolinas como ligandos de taar1.
CA2691082A1 (en) 2007-07-02 2009-01-08 F. Hoffmann-La Roche Ag 2 -imidazolines having a good affinity to the trace amine associated receptors (taars)
BRPI0812833A2 (pt) 2007-07-03 2014-12-09 Hoffmann La Roche 4-imidazolinas e seu uso como antidepressivos
KR101133862B1 (ko) 2007-07-27 2012-04-06 에프. 호프만-라 로슈 아게 Ｔａａｒ 리간드로서의 2-아제티딘메테인아민 및 2-피롤리딘메테인아민
CA2695331A1 (en) 2007-08-03 2009-02-12 F. Hoffmann-La Roche Ag Pyridinecarboxamide and benzamide derivatives as taar1 ligands
US8242153B2 (en) 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
US8354441B2 (en) 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
RS60825B1 (sr) 2016-03-17 2020-10-30 Hoffmann La Roche Aktivnost derivata 5-etiol-4-metil-pirazol-3-karboksamida kao agonista taar-a

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2731471A (en) * 1956-01-17 Nxg hi
US2161938A (en) * 1934-07-31 1939-06-13 Soc Of Chemical Ind Imidazolines
FR926661A (fr) * 1941-07-09 1947-10-08 Lovens Kemiske Fabrik V Aug Ko Méthyle-imidazolines substituées et leur procédé de préparation
GB757650A (en) * 1953-06-15 1956-09-19 Pfizer & Co C Improvements in or relating to substituted imidazolines and the preparation thereof
DE1150180B (de) * 1962-04-12 1963-06-12 Merck Ag E Mittel zur Vorbehandlung der Haut fuer die Rasur
GB1317514A (en) * 1970-11-30 1973-05-23 Erba Carlo Spa Imidazoline derivatives
US4085209A (en) * 1975-02-05 1978-04-18 Rohm And Haas Company Preparation and safening effect of 1-substituted imidazole metal salt complexes

Also Published As

Publication number Publication date
KR840008327A (ko) 1984-12-14
PT78195A (en) 1984-04-01
ES530345A0 (es) 1985-11-16
JPS59193875A (ja) 1984-11-02
PT78195B (en) 1986-04-24
IL70966A (en) 1987-08-31
EP0125410A3 (en) 1987-01-14
AU568839B2 (en) 1988-01-14
EP0125410A2 (en) 1984-11-21
NZ207184A (en) 1986-12-05
US4540705A (en) 1985-09-10
FI840839A7 (fi) 1984-09-15
GR81813B (enExample) 1984-12-12
DK112984D0 (da) 1984-02-28
DK112984A (da) 1984-09-15
FI840839A0 (fi) 1984-03-02
PH19715A (en) 1986-06-17
AU2487784A (en) 1984-09-20
IL70966A0 (en) 1984-05-31
KR900001216B1 (ko) 1990-02-28
ES8601907A1 (es) 1985-11-16
ZA841323B (en) 1984-10-31
NO840893L (no) 1984-09-17

Similar Documents

Publication Publication Date Title
US4540705A (en) Antidepressant imidazolines and related compounds
US4639464A (en) Antihypertensive substituted imidazole derivatives
US4119635A (en) Substituted 1,2,4-triazole derivatives
US4684659A (en) Antimypertensive substituted imidazoles
AU2002361986A1 (en) Cis-imidazolines as mdm2 inhibitors
HU195189B (en) Process for producing new imidazole derivatives and pharmaceutical preparations comprising them
US4738979A (en) α2 -blocking derivatives of imidazole
FI83310C (fi) Foerfarande foer framstaellning av terapeutiskt aktiva 4,5-substituerade 2-/3-/4-(halogenfenyl)-1- piperazinyl/propyl/-2,4-dihydro-3h-1,2,4-triazol-3-onderivat.
US4280008A (en) Chirally substituted 2-imidazolin-5-ones
CA1183544A (en) Substituted imidazole and imidazoline derivatives and their preparation and use
US6127396A (en) Imidazoline compounds
EP1261588B1 (en) IMIDAZOLE COMPOUNDS AS Alpha2-ADRENOCEPTORS ANTAGONISTS
US4151169A (en) Process for preparing substituted 1,2,4-triazole derivatives
US6388090B2 (en) Imidazole derivatives
US4315021A (en) 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles
US4859691A (en) Certain 1,2-benzisoxazole derivatives
US4598086A (en) α2 antagonistic 2-(4,5-dihydro-2-1H-imidazolyl)-2,3-dihydro-1H-indoles
US3657229A (en) 1 3-diaza-2 3-cycloalkene derivatives
US4559356A (en) 2-(Inden-2-yl)-imidazoline derivatives, process for their preparation and pharmaceutical compositions containing them
DE1944419A1 (de) Antiphlogistisch wirkende 1-H,1-Benzyl- und 1-Benzoyl-2-methyl-5-alkoxy-skatyl-Derivate von 1,3-Dicarbonyl-Verbindungen und Aminen sowie Verfahren zu ihrer Herstellung
US4341797A (en) Bis-(amidine phenyl)cyclohexanecarboxylic acid ketones, compositions containing same and method of use

Legal Events

Date Code Title Description
MKEX Expiry