CA1204442A - Procede de preparation de nouveaux derives de la nitrosouree - Google Patents

Procede de preparation de nouveaux derives de la nitrosouree

Info

Publication number
CA1204442A
CA1204442A CA000441305A CA441305A CA1204442A CA 1204442 A CA1204442 A CA 1204442A CA 000441305 A CA000441305 A CA 000441305A CA 441305 A CA441305 A CA 441305A CA 1204442 A CA1204442 A CA 1204442A
Authority
CA
Canada
Prior art keywords
radical
acid
nitrosouréïdo
chloro
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000441305A
Other languages
English (en)
French (fr)
Inventor
Gilbert Lavielle
Claude Cudennec
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Servier de Medecine Translationnelle SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of CA1204442A publication Critical patent/CA1204442A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CA000441305A 1982-11-17 1983-11-16 Procede de preparation de nouveaux derives de la nitrosouree Expired CA1204442A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR82.19199 1982-11-17
FR8219199A FR2536075B1 (fr) 1982-11-17 1982-11-17 Nouveaux derives de la nitrosouree, leur procede de preparation et les compositions pharmaceutiques les renfermant

Publications (1)

Publication Number Publication Date
CA1204442A true CA1204442A (fr) 1986-05-13

Family

ID=9279241

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000441305A Expired CA1204442A (fr) 1982-11-17 1983-11-16 Procede de preparation de nouveaux derives de la nitrosouree

Country Status (19)

Country Link
US (1) US4567169A (enExample)
EP (1) EP0117959B1 (enExample)
JP (1) JPS59106497A (enExample)
AT (1) ATE21905T1 (enExample)
AU (1) AU557139B2 (enExample)
CA (1) CA1204442A (enExample)
DE (1) DE3365900D1 (enExample)
DK (1) DK169340B1 (enExample)
ES (1) ES527353A0 (enExample)
FR (1) FR2536075B1 (enExample)
IE (1) IE56259B1 (enExample)
IL (1) IL70253A (enExample)
MA (1) MA19952A1 (enExample)
NO (1) NO163409C (enExample)
NZ (1) NZ206293A (enExample)
OA (1) OA07589A (enExample)
PT (1) PT77666B (enExample)
SU (1) SU1303024A3 (enExample)
ZA (1) ZA838558B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2567129B1 (fr) * 1984-07-06 1986-12-05 Adir Nouveaux derives de l'oxaazaphosphorine, leur procede de preparation et les compositions pharmaceutiques les renfermant
IT1246778B (it) * 1991-04-12 1994-11-26 Boehringer Mannheim Italia Nitrosocarbamoil derivati di acidi gem-difosfonici, un processo per la loro preparazione e composizioni farmaceutiche che li contengono
US5298499A (en) * 1991-07-05 1994-03-29 Research Triangle Institute S-2-(substituted ethylamino)ethyl phosphorothioates
WO1997018819A1 (en) * 1995-11-20 1997-05-29 Sepracor, Inc. Antineoplastic methods and compositions employing optically pure (-)-fotemustine
EP0868189A4 (en) * 1995-11-20 1998-12-23 Sepracor Inc Antineoplastic methods and compositions employing (+)-fotemustine
US20040072889A1 (en) * 1997-04-21 2004-04-15 Pharmacia Corporation Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia
CN100365002C (zh) * 2004-06-02 2008-01-30 上海医药科技发展有限公司 注射用福莫司汀制备工艺
AT501496B1 (de) * 2005-02-21 2007-03-15 Iep Gmbh Verfahren zur enantioselektiven enzymatischen reduktion von ketoverbindungen
CN102311456A (zh) * 2011-07-08 2012-01-11 山东睿鹰先锋制药有限公司 一种福莫司汀原料药的合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3920733A (en) * 1973-08-06 1975-11-18 Monsanto Co Ureidoalkylphosphonic acids

Also Published As

Publication number Publication date
ZA838558B (en) 1984-07-25
DK169340B1 (da) 1994-10-10
OA07589A (fr) 1985-03-31
FR2536075B1 (fr) 1985-07-05
PT77666B (fr) 1986-05-12
ES8501772A1 (es) 1984-12-01
JPS59106497A (ja) 1984-06-20
DK524283A (da) 1984-05-18
EP0117959B1 (fr) 1986-09-03
IE56259B1 (en) 1991-06-05
MA19952A1 (fr) 1984-07-01
NO163409B (no) 1990-02-12
FR2536075A1 (fr) 1984-05-18
IE832680L (en) 1984-05-17
NO834214L (no) 1984-05-18
DK524283D0 (da) 1983-11-16
US4567169A (en) 1986-01-28
ATE21905T1 (de) 1986-09-15
ES527353A0 (es) 1984-12-01
IL70253A0 (en) 1984-02-29
IL70253A (en) 1986-10-31
AU557139B2 (en) 1986-12-04
NZ206293A (en) 1987-02-20
AU2143683A (en) 1984-05-24
EP0117959A2 (fr) 1984-09-12
DE3365900D1 (en) 1986-10-09
EP0117959A3 (en) 1984-11-14
JPS6411637B2 (enExample) 1989-02-27
SU1303024A3 (ru) 1987-04-07
PT77666A (fr) 1983-12-01
NO163409C (no) 1990-05-23

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Legal Events

Date Code Title Description
MKEX Expiry