CA1202239A - Gel-like calcium salt of 1-hydroxy-3-aminopropane-1,1- diphosphonic acid - Google Patents

Gel-like calcium salt of 1-hydroxy-3-aminopropane-1,1- diphosphonic acid

Info

Publication number
CA1202239A
CA1202239A CA000428203A CA428203A CA1202239A CA 1202239 A CA1202239 A CA 1202239A CA 000428203 A CA000428203 A CA 000428203A CA 428203 A CA428203 A CA 428203A CA 1202239 A CA1202239 A CA 1202239A
Authority
CA
Canada
Prior art keywords
gel
apd
hydroxy
aminopropane
calcium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000428203A
Other languages
English (en)
French (fr)
Inventor
Richard J. Sunberg
James J. Benedict
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Application granted granted Critical
Publication of CA1202239A publication Critical patent/CA1202239A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/06—Chelate

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CA000428203A 1982-05-17 1983-05-16 Gel-like calcium salt of 1-hydroxy-3-aminopropane-1,1- diphosphonic acid Expired CA1202239A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/379,234 US4446052A (en) 1982-05-17 1982-05-17 Aqueous gel containing tricalcium di(1-hydroxy-3-aminopropane-1,1-diphosphonate
US379,234 1982-05-17

Publications (1)

Publication Number Publication Date
CA1202239A true CA1202239A (en) 1986-03-25

Family

ID=23496387

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000428203A Expired CA1202239A (en) 1982-05-17 1983-05-16 Gel-like calcium salt of 1-hydroxy-3-aminopropane-1,1- diphosphonic acid

Country Status (4)

Country Link
US (1) US4446052A (enExample)
EP (1) EP0094714A3 (enExample)
JP (1) JPS5931789A (enExample)
CA (1) CA1202239A (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4639338A (en) * 1984-08-06 1987-01-27 Ciba-Geigy Corporation Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
IT1187828B (it) * 1985-05-24 1987-12-23 Gentili Ist Spa Composizione farmaceutica a base di difosfonati per il trattamento dell aretrosi
US4877603A (en) * 1987-12-18 1989-10-31 The Procter & Gamble Company Oral compositions
MX21453A (es) * 1989-07-07 1994-01-31 Ciba Geigy Ag Preparaciones farmaceuticas que se administran en forma topica.
US5356887A (en) * 1990-01-31 1994-10-18 Merck & Co., Inc. Pharmaceutical compositions containing insoluble calcium salts of amino-hydroxybutylidene bisphoshonic acids
CA2035179C (en) * 1990-01-31 2001-08-14 Gerald S. Brenner Pharmaceutical compositions containing insoluble salts of bisphosphonic acids
US5270365A (en) * 1991-12-17 1993-12-14 Merck & Co., Inc. Prevention and treatment of periodontal disease with alendronate
US5646134A (en) * 1994-04-21 1997-07-08 Merck & Co., Inc. Alendronate therapy to prevent loosening of, or pain associated with, orthopedic implant devices
KR100343232B1 (ko) * 1999-12-10 2002-07-10 김재윤 결정성 파미드론산 이나트륨염 수화물과 그의 제조방법
ATE314862T1 (de) * 2000-05-05 2006-02-15 Hoffmann La Roche Gelartige pharmazeutische zusammensetzung zur subcutanen anwendung enthaltend bisphosphonsäuren oder deren salze
CA2431515C (en) * 2001-01-23 2008-01-22 Gador S.A. Composition comprising bisphosphonates for prevention and/or treatment of metabolic diseases of bones, process for preparing such composition, and use thereof
US8882740B2 (en) 2009-12-23 2014-11-11 Stryker Trauma Gmbh Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3101301A (en) * 1962-05-11 1963-08-20 Bristol Myers Co Transparent water and mineral oil gels as hair conditioners
US3608067A (en) * 1968-03-08 1971-09-21 Monsanto Co Dentifrice compositions containing insoluble salts of alkylene phosphonic acids
US3683080A (en) * 1970-08-28 1972-08-08 Procter & Gamble Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue
DE2405254C2 (de) * 1974-02-04 1982-05-27 Henkel KGaA, 4000 Düsseldorf Verwendung von 3-Amino-1-Hydroxypropan-1, 1-diphosphonsäure oder ihrer wasserlöslichen Salze bei der Beeinflußung von Calciumstoffwechselstörungen im menschlichen oder tierischen Körper
DE2534391C2 (de) * 1975-08-01 1983-01-13 Henkel KGaA, 4000 Düsseldorf 1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren
US4200539A (en) * 1978-04-20 1980-04-29 Halliburton Company Fracturing compositions and method of preparing and using the same
DE2943498C2 (de) * 1979-10-27 1983-01-27 Henkel KGaA, 4000 Düsseldorf Verfahren zur Herstellung von 3-Amino-1-hydroxypropan-1,1-diphosphonsäure

Also Published As

Publication number Publication date
EP0094714A2 (en) 1983-11-23
JPH0415235B2 (enExample) 1992-03-17
US4446052A (en) 1984-05-01
EP0094714A3 (en) 1984-02-29
JPS5931789A (ja) 1984-02-20

Similar Documents

Publication Publication Date Title
CA1202239A (en) Gel-like calcium salt of 1-hydroxy-3-aminopropane-1,1- diphosphonic acid
US3683080A (en) Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue
US3962432A (en) Method of treatment of calcium disorders using aminoalkane-diophosphonic acids
DE689443T1 (de) Verwendung von bisphosphonaten in der knochenchirurgie
US5059412A (en) Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors
CA1174602A (en) Pharmaceutical composition for the treatment of osteopathias
US4134969A (en) Method of treatment of calcium disorders using aminoalkane-diphosphonic acids
JPH08501546A (ja) 骨粗鬆症治療用のプロスタグランジン類似体
US4086334A (en) Composition and method for the treatment of disorders of calcium metabolism
US3962433A (en) Method of treatment of calcium disorders using phosphonoalkane-polycarboxylic acids
US5064633A (en) Macrocyclic aminophosphonic acid complexes, their formulations and use
US4216212A (en) Pyrazolidine anti-inflammatory composition and methods of use
BRPI0707008A2 (pt) associação em doses fixas de fitato e zinco
CA1213519A (en) Bone-seeking complexes of technetium-99m
SE441494B (sv) Antiinflammatorisk komposition innefattande en indolbaserad, antiinflammatorisk forening och ett organofosfonat
NL8004904A (nl) Geneesmiddel tegen resorptie van botmineraal.
US4282214A (en) Phenylacetate anti-inflammatory composition
Rosenblum et al. The effects of various diphosphonates on a rat model of cardiac calciphylaxis
Fouda et al. Developmental disturbances of the rat molar induced by two diphosphonates
US4264582A (en) Isobutylphenylacetate anti-inflammatory composition
CA1100874A (en) Topical pharmaceutical compositions for treating anomalous mobilization and deposition of bone mineral in humans and other animals
KR100385697B1 (ko) 올파드로네이트를포함하는골체량동화성조성물
Meyer et al. The inhibition of calcium oxalate crystal growth by multidentate organic phosphonates: Effect of pH
Miller et al. Effects of N, N, N′, N′-ethylenediaminetetramethylene phosphonic acid and 1-hydroxyethylidene-1, 1-bisphosphonic acid on calcium absorption, plasma calcium, longitudinal bone growth, and bone histology in the growing rat
Van Gelder et al. In vitro and in vivo effects of tetrakisphosphonates on bone resorption, tumor osteolysis, ectopic calcification, and macrophages

Legal Events

Date Code Title Description
MKEX Expiry