CA1197242A - Derives de l'acide pyrimido¬1,2-a|pyrrolo ¬2,1-c|¬1,4|benzodiazepine-3-carboxylique - Google Patents
Derives de l'acide pyrimido¬1,2-a|pyrrolo ¬2,1-c|¬1,4|benzodiazepine-3-carboxyliqueInfo
- Publication number
- CA1197242A CA1197242A CA000422672A CA422672A CA1197242A CA 1197242 A CA1197242 A CA 1197242A CA 000422672 A CA000422672 A CA 000422672A CA 422672 A CA422672 A CA 422672A CA 1197242 A CA1197242 A CA 1197242A
- Authority
- CA
- Canada
- Prior art keywords
- compound
- pyrrolo
- pyrimido
- carboxylic acid
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA000422672A CA1197242A (fr) | 1983-03-02 | 1983-03-02 | Derives de l'acide pyrimido¬1,2-a|pyrrolo ¬2,1-c|¬1,4|benzodiazepine-3-carboxylique |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA000422672A CA1197242A (fr) | 1983-03-02 | 1983-03-02 | Derives de l'acide pyrimido¬1,2-a|pyrrolo ¬2,1-c|¬1,4|benzodiazepine-3-carboxylique |
Publications (1)
Publication Number | Publication Date |
---|---|
CA1197242A true CA1197242A (fr) | 1985-11-26 |
Family
ID=4124689
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA000422672A Expired CA1197242A (fr) | 1983-03-02 | 1983-03-02 | Derives de l'acide pyrimido¬1,2-a|pyrrolo ¬2,1-c|¬1,4|benzodiazepine-3-carboxylique |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA1197242A (fr) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105793263A (zh) * | 2013-12-05 | 2016-07-20 | 豪夫迈·罗氏有限公司 | 反式-8-氯-5-甲基-1-[4-(吡啶-2-基氧基)-环己基]-5,6-二氢-4h-2,3,5,10b-四氮杂-苯并[e]薁及其晶型的合成 |
WO2018195163A1 (fr) * | 2017-04-18 | 2018-10-25 | Gemphire Therapeutics Inc. | Gemcabène, sels pharmaceutiquement acceptables de celui-ci, compositions de celui-ci et procédés d'utilisation de celui-ci |
US10227285B2 (en) | 2014-11-14 | 2019-03-12 | Gemphire Therapeutics Inc. | Processes and intermediates for preparing alpha,omega-dicarboxylic acid-terminated dialkane ethers |
-
1983
- 1983-03-02 CA CA000422672A patent/CA1197242A/fr not_active Expired
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105793263A (zh) * | 2013-12-05 | 2016-07-20 | 豪夫迈·罗氏有限公司 | 反式-8-氯-5-甲基-1-[4-(吡啶-2-基氧基)-环己基]-5,6-二氢-4h-2,3,5,10b-四氮杂-苯并[e]薁及其晶型的合成 |
US10246460B2 (en) | 2013-12-05 | 2019-04-02 | Hoffmann-La Roche Inc. | Synthesis of trans-8-chloro-5-methyl-1-[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10B-tetraaza-benzo[E]azulene and crytalline forms thereof |
CN105793263B (zh) * | 2013-12-05 | 2019-08-23 | 豪夫迈·罗氏有限公司 | 一种苯并[e]薁化合物及其晶型的合成 |
AU2019201183B2 (en) * | 2013-12-05 | 2021-03-04 | F. Hoffmann-La Roche Ag | Synthesis of trans-8-chloro-5-methyl-1 -[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulene and crytalline forms thereof |
US10227285B2 (en) | 2014-11-14 | 2019-03-12 | Gemphire Therapeutics Inc. | Processes and intermediates for preparing alpha,omega-dicarboxylic acid-terminated dialkane ethers |
WO2018195163A1 (fr) * | 2017-04-18 | 2018-10-25 | Gemphire Therapeutics Inc. | Gemcabène, sels pharmaceutiquement acceptables de celui-ci, compositions de celui-ci et procédés d'utilisation de celui-ci |
CN110996928A (zh) * | 2017-04-18 | 2020-04-10 | 燿石治疗公司 | 吉卡宾、其药学上可接受的盐、其组合物和其使用方法 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MKEC | Expiry (correction) | ||
MKEX | Expiry |