CA1188989A - Nonapeptide for the treatment of drug withdrawal symptoms - Google Patents

Nonapeptide for the treatment of drug withdrawal symptoms

Info

Publication number
CA1188989A
CA1188989A CA000401386A CA401386A CA1188989A CA 1188989 A CA1188989 A CA 1188989A CA 000401386 A CA000401386 A CA 000401386A CA 401386 A CA401386 A CA 401386A CA 1188989 A CA1188989 A CA 1188989A
Authority
CA
Canada
Prior art keywords
nonapeptide
gly
treatment
drug withdrawal
ala
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000401386A
Other languages
English (en)
French (fr)
Inventor
Richard R. Scherschlicht
Rene Tissot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of CA1188989A publication Critical patent/CA1188989A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Addiction (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA000401386A 1981-05-21 1982-04-21 Nonapeptide for the treatment of drug withdrawal symptoms Expired CA1188989A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH330681 1981-05-21
CH3306/81 1981-05-21

Publications (1)

Publication Number Publication Date
CA1188989A true CA1188989A (en) 1985-06-18

Family

ID=4253131

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000401386A Expired CA1188989A (en) 1981-05-21 1982-04-21 Nonapeptide for the treatment of drug withdrawal symptoms

Country Status (11)

Country Link
US (2) US4444758A (enExample)
EP (1) EP0065747B1 (enExample)
JP (1) JPS5823630A (enExample)
AU (1) AU552547B2 (enExample)
CA (1) CA1188989A (enExample)
DE (1) DE3218761A1 (enExample)
IE (1) IE53395B1 (enExample)
IL (1) IL65782A (enExample)
IT (1) IT1152116B (enExample)
PH (1) PH17981A (enExample)
ZA (1) ZA823369B (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486599A (en) * 1989-03-29 1996-01-23 The Board Of Trustees Of The Leland Stanford Junior University Construction and use of synthetic constructs encoding syndecan
US5403595A (en) * 1991-05-07 1995-04-04 Dynagen, Inc. Controlled, sustained release delivery system for smoking cessation
US5486362A (en) * 1991-05-07 1996-01-23 Dynagen, Inc. Controlled, sustained release delivery system for treating drug dependency
US5780051A (en) * 1992-04-02 1998-07-14 Dynagen, Inc. Methods and articles of manufacture for nicotine cessation and monitoring nicotine use
AU754088B2 (en) * 1997-09-04 2002-11-07 Demerx, Inc. Noribogaine in the treatment of pain and drug addiction
US7220737B1 (en) 1997-09-04 2007-05-22 Novoneuron, Inc Noribogaine in the treatment of pain and drug addiction
WO2000045832A2 (en) * 1999-02-05 2000-08-10 The Victoria University Of Manchester Regulation of anaesthesia
DE10014007A1 (de) * 2000-03-22 2001-10-11 Strathmann Ag & Co Neue Darreichungsformen für DSIP
RU2005128993A (ru) * 2005-09-08 2007-03-20 Общество С Ограниченной Ответственностью Исследовательский Центр "Комкон" (Ru) Средство для коррекции стресс-индуцируемых нейромедиаторных, нейроэндокринных и метаболических нарушений, а также способ профилактики и лечения сопутствующих им паталогических состояний
CA2699026A1 (en) * 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent
US8362007B1 (en) 2010-05-11 2013-01-29 Demerx, Inc. Substituted noribogaine
US8765737B1 (en) 2010-05-11 2014-07-01 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US9394294B2 (en) 2010-05-11 2016-07-19 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US8741891B1 (en) 2010-06-22 2014-06-03 Demerx, Inc. N-substituted noribogaine prodrugs
US8637648B1 (en) 2010-06-22 2014-01-28 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
US8802832B2 (en) 2010-06-22 2014-08-12 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
UA111065C2 (uk) 2010-07-23 2016-03-25 Демеркс, Інк. Композиції норибогаїну
EP2481740B1 (en) 2011-01-26 2015-11-04 DemeRx, Inc. Methods and compositions for preparing noribogaine from voacangine
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
CA2855994A1 (en) 2011-12-09 2013-06-13 Demerx, Inc. Phosphate esters of noribogaine
US8877921B2 (en) 2012-01-25 2014-11-04 Demerx, Inc. Synthetic voacangine
US9150584B2 (en) 2012-01-25 2015-10-06 Demerx, Inc. Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
US9045481B2 (en) 2012-12-20 2015-06-02 Demerx, Inc. Substituted noribogaine
US8940728B2 (en) 2012-12-20 2015-01-27 Demerx, Inc. Substituted noribogaine
CA2896133A1 (en) 2012-12-20 2014-06-26 Demerx, Inc. Substituted noribogaine
US9550789B2 (en) 2014-06-18 2017-01-24 Demerx, Inc. Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH634331A5 (de) * 1977-06-30 1983-01-31 Hoffmann La Roche Phosphorylierte nonapeptide und verfahren zu deren herstellung.

Also Published As

Publication number Publication date
JPH0354089B2 (enExample) 1991-08-19
IL65782A (en) 1985-08-30
AU8375682A (en) 1982-11-25
IE53395B1 (en) 1988-11-09
DE3218761C2 (enExample) 1993-05-06
EP0065747B1 (de) 1986-10-15
AU552547B2 (en) 1986-06-05
PH17981A (en) 1985-02-26
IT1152116B (it) 1986-12-31
IL65782A0 (en) 1982-08-31
US4444758A (en) 1984-04-24
US4496545A (en) 1985-01-29
EP0065747A1 (de) 1982-12-01
ZA823369B (en) 1983-03-30
IT8221072A0 (it) 1982-05-04
IE821214L (en) 1982-11-21
JPS5823630A (ja) 1983-02-12
DE3218761A1 (de) 1982-12-16

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Legal Events

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