CA1179272A - Mouthwash compositions - Google Patents
Mouthwash compositionsInfo
- Publication number
- CA1179272A CA1179272A CA000396419A CA396419A CA1179272A CA 1179272 A CA1179272 A CA 1179272A CA 000396419 A CA000396419 A CA 000396419A CA 396419 A CA396419 A CA 396419A CA 1179272 A CA1179272 A CA 1179272A
- Authority
- CA
- Canada
- Prior art keywords
- composition according
- mouthwash composition
- mouthwash
- pyrophosphate
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 45
- 239000002324 mouth wash Substances 0.000 title claims abstract description 24
- 229940051866 mouthwash Drugs 0.000 title claims abstract description 20
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical class [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims abstract description 11
- 150000003856 quaternary ammonium compounds Chemical class 0.000 claims abstract description 10
- 239000002253 acid Substances 0.000 claims abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000000796 flavoring agent Substances 0.000 claims description 8
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims description 7
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims description 7
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 6
- 239000003995 emulsifying agent Substances 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 claims description 5
- 235000013355 food flavoring agent Nutrition 0.000 claims description 4
- 235000003599 food sweetener Nutrition 0.000 claims description 4
- 239000003906 humectant Substances 0.000 claims description 4
- 239000003765 sweetening agent Substances 0.000 claims description 4
- 229910052783 alkali metal Inorganic materials 0.000 claims description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 2
- 239000011707 mineral Substances 0.000 claims description 2
- 150000007524 organic acids Chemical class 0.000 claims description 2
- 150000007522 mineralic acids Chemical class 0.000 claims 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims 1
- 238000010186 staining Methods 0.000 abstract description 6
- 230000001747 exhibiting effect Effects 0.000 abstract description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 10
- 239000000463 material Substances 0.000 description 9
- 239000000306 component Substances 0.000 description 7
- 230000002882 anti-plaque Effects 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 5
- 125000002091 cationic group Chemical group 0.000 description 5
- 235000011187 glycerol Nutrition 0.000 description 5
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 4
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 239000012153 distilled water Substances 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- 229910052698 phosphorus Inorganic materials 0.000 description 4
- 239000011574 phosphorus Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- NCHJGQKLPRTMAO-XWVZOOPGSA-N [(2R)-2-[(2R,3R,4S)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NCHJGQKLPRTMAO-XWVZOOPGSA-N 0.000 description 3
- -1 alkylene glycol Chemical compound 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 3
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 210000000214 mouth Anatomy 0.000 description 3
- 235000019204 saccharin Nutrition 0.000 description 3
- 229940081974 saccharin Drugs 0.000 description 3
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 3
- 235000002639 sodium chloride Nutrition 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- RWAXQWRDVUOOGG-UHFFFAOYSA-N N,2,3-Trimethyl-2-(1-methylethyl)butanamide Chemical compound CNC(=O)C(C)(C(C)C)C(C)C RWAXQWRDVUOOGG-UHFFFAOYSA-N 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- 235000011037 adipic acid Nutrition 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 125000002947 alkylene group Chemical group 0.000 description 2
- 229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 125000001453 quaternary ammonium group Chemical group 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 125000001424 substituent group Chemical group 0.000 description 2
- DTOUUUZOYKYHEP-UHFFFAOYSA-N 1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine Chemical compound CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 DTOUUUZOYKYHEP-UHFFFAOYSA-N 0.000 description 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical class CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 description 1
- 108010077805 Bacterial Proteins Proteins 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- HZZDXVXOETXUEY-UHFFFAOYSA-N CC.[Na].[Na] Chemical compound CC.[Na].[Na] HZZDXVXOETXUEY-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 208000002064 Dental Plaque Diseases 0.000 description 1
- OJIYIVCMRYCWSE-UHFFFAOYSA-M Domiphen bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CCOC1=CC=CC=C1 OJIYIVCMRYCWSE-UHFFFAOYSA-M 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 244000024873 Mentha crispa Species 0.000 description 1
- 235000014749 Mentha crispa Nutrition 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 244000227633 Ocotea pretiosa Species 0.000 description 1
- 235000004263 Ocotea pretiosa Nutrition 0.000 description 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
- YSMRWXYRXBRSND-UHFFFAOYSA-N TOTP Chemical compound CC1=CC=CC=C1OP(=O)(OC=1C(=CC=CC=1)C)OC1=CC=CC=C1C YSMRWXYRXBRSND-UHFFFAOYSA-N 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 150000001279 adipic acids Chemical class 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 229960001950 benzethonium chloride Drugs 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- DNSISZSEWVHGLH-UHFFFAOYSA-N butanamide Chemical compound CCCC(N)=O DNSISZSEWVHGLH-UHFFFAOYSA-N 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 229940109275 cyclamate Drugs 0.000 description 1
- HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- VICYBMUVWHJEFT-UHFFFAOYSA-N dodecyltrimethylammonium ion Chemical compound CCCCCCCCCCCC[N+](C)(C)C VICYBMUVWHJEFT-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 229960002737 fructose Drugs 0.000 description 1
- 229960001031 glucose Drugs 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 239000013588 oral product Substances 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 230000007505 plaque formation Effects 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- SFVFIFLLYFPGHH-UHFFFAOYSA-M stearalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SFVFIFLLYFPGHH-UHFFFAOYSA-M 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- VKFFEYLSKIYTSJ-UHFFFAOYSA-N tetraazanium;phosphonato phosphate Chemical class [NH4+].[NH4+].[NH4+].[NH4+].[O-]P([O-])(=O)OP([O-])([O-])=O VKFFEYLSKIYTSJ-UHFFFAOYSA-N 0.000 description 1
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/235,873 US4323551A (en) | 1981-02-19 | 1981-02-19 | Mouthwash compositions |
| US235,873 | 1981-02-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1179272A true CA1179272A (en) | 1984-12-11 |
Family
ID=22887242
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000396419A Expired CA1179272A (en) | 1981-02-19 | 1982-02-17 | Mouthwash compositions |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4323551A (forum.php) |
| EP (1) | EP0059012B1 (forum.php) |
| JP (1) | JPS57188510A (forum.php) |
| CA (1) | CA1179272A (forum.php) |
| DE (1) | DE3273503D1 (forum.php) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4405600A (en) * | 1979-06-07 | 1983-09-20 | University Patents, Inc. | Methods and materials for prevention of carious degradation of teeth |
| US4999184A (en) * | 1982-06-22 | 1991-03-12 | The Procter & Gamble Company | Oral compositions |
| US4684518A (en) * | 1982-06-22 | 1987-08-04 | The Procter & Gamble Company | Oral compositions |
| US4515772A (en) * | 1982-06-22 | 1985-05-07 | The Procter & Gamble Company | Oral compositions |
| US4885155A (en) * | 1982-06-22 | 1989-12-05 | The Procter & Gamble Company | Anticalculus compositions using pyrophosphate salt |
| US4590066A (en) * | 1982-06-22 | 1986-05-20 | The Procter & Gamble Company | Oral compositions |
| US4772461A (en) * | 1982-06-22 | 1988-09-20 | The Procter & Gamble Company | Oral compositions |
| PH22221A (en) * | 1982-06-22 | 1988-06-28 | Procter & Gamble | Oral compositions |
| US4806339A (en) * | 1982-06-22 | 1989-02-21 | The Procter & Gamble Company | Oral compositions |
| US4621120A (en) * | 1985-04-01 | 1986-11-04 | Eastman Kodak Company | Polymeric antibacterial compositions |
| US4931273A (en) * | 1985-09-13 | 1990-06-05 | Colgate-Palmolive Company | Anticalculus oral composition |
| WO1987003476A1 (en) * | 1985-12-13 | 1987-06-18 | Micro-Map, Inc. | Composition for the treatment of periodontal disease |
| DE3607480A1 (de) * | 1986-03-07 | 1987-09-10 | Blendax Werke Schneider Co | Zahnpasta |
| AT387715B (de) * | 1987-05-04 | 1989-03-10 | Blendax Werke Schneider Co | Zahnpasta |
| US4847070A (en) * | 1987-10-08 | 1989-07-11 | The Procter & Gamble Company | Anticalculus compositions |
| US4877603A (en) * | 1987-12-18 | 1989-10-31 | The Procter & Gamble Company | Oral compositions |
| US5011679A (en) * | 1989-05-30 | 1991-04-30 | Nabisco Brands, Inc. | Raw hide having a coating containing an inorganic pyrophosphate |
| US5047231A (en) * | 1989-05-30 | 1991-09-10 | Nabisco Brands, Inc. | Raw hide containing an inorganic pyrophosphate |
| US5015485A (en) * | 1989-05-30 | 1991-05-14 | Nabisco Brands, Inc. | Dog biscuits having a coating containing an inorganic pyrophosphate |
| US5000973A (en) * | 1989-05-30 | 1991-03-19 | Nabisco Brands, Inc. | Nutritionally-balanced canine biscuits containing an inorganic pyrophosphate |
| US5000940A (en) * | 1989-05-30 | 1991-03-19 | Nabisco Brands, Inc. | Devices, compositions and the like having or containing an inorganic pyrophosphate |
| US5000943A (en) * | 1989-05-30 | 1991-03-19 | Nabisco Brands, Inc. | Canine biscuits containing an inorganic pyrophosphate |
| US5114704A (en) * | 1989-05-30 | 1992-05-19 | Nabisco Brands, Inc. | Raw hide having a coating containing an inorganic pyrophosphate |
| US5094870A (en) * | 1989-05-30 | 1992-03-10 | Nabisco Brands, Inc. | Canine biscuits containing an inorganic pyrophosphate |
| US5154917A (en) * | 1990-09-11 | 1992-10-13 | Beecham Inc. | Color change mouthrinse |
| US5223245A (en) * | 1990-09-11 | 1993-06-29 | Beecham Inc. | Color change mouthrinse |
| US5096701A (en) * | 1990-12-18 | 1992-03-17 | The Procter & Gamble Company | Oral compositions |
| US5176900A (en) * | 1990-12-18 | 1993-01-05 | The Procter & Gamble Company | Compositions for reducing calculus |
| US5338538A (en) * | 1991-07-29 | 1994-08-16 | Pfizer Inc | Prebrushing pyrophosphate-containing liquid oral compositions |
| US5213790A (en) * | 1991-10-23 | 1993-05-25 | The Procter & Gamble Co. | Methods of reducing plaque and gingivitis with reduced staining |
| US5145666A (en) * | 1991-10-23 | 1992-09-08 | The Proctor & Gamble Co. | Methods of reducing plaque and gingivitis with reduced staining |
| US5281410A (en) * | 1991-10-23 | 1994-01-25 | The Proctor & Gamble Company | Methods of reducing plaque and gingivitis with reduced staining |
| US5281411A (en) * | 1992-07-31 | 1994-01-25 | The Procter & Gamble Company | Oral compositions |
| GB9221593D0 (en) * | 1992-10-14 | 1992-11-25 | Boots Co Plc | Oral hygiene composition |
| US5405604A (en) * | 1992-10-16 | 1995-04-11 | The Procter & Gamble Company | Concentrated mouthrinse for efficient delivery of antimicrobials |
| BR9507742A (pt) * | 1994-05-20 | 1997-10-07 | Novavax Inc | Emulsões em óleo em água antimicrobianas |
| US5547677A (en) * | 1994-05-20 | 1996-08-20 | Novavax, Inc. | Antimicrobial oil-in-water emulsions |
| WO1995034277A1 (en) * | 1994-06-10 | 1995-12-21 | The Procter & Gamble Company | Mouthrinse compositions |
| FR2727860B1 (fr) * | 1994-12-09 | 1997-01-17 | Oreal | Compositions a base d'un pyrophosphate de metal alcalin et d'un tensio-actif |
| JP2001518064A (ja) * | 1996-02-08 | 2001-10-09 | ワーナー―ランバート・カンパニー | 高溶解性ピロリン酸塩を含有する抗歯石性歯磨き剤 |
| US5827503A (en) * | 1996-08-08 | 1998-10-27 | Collagenex Pharmaceuticals, Inc. | Method and composition for treating periodontitis |
| US20070025928A1 (en) * | 1999-11-12 | 2007-02-01 | The Procter & Gamble Company | Stannous oral care compositions |
| ES2350177T3 (es) | 1999-11-12 | 2011-01-19 | THE PROCTER & GAMBLE COMPANY | Composiciones orales que contienen iones estannosos. |
| US8283135B2 (en) * | 2000-06-30 | 2012-10-09 | The Procter & Gamble Company | Oral care compositions containing combinations of anti-bacterial and host-response modulating agents |
| US6361762B1 (en) * | 2001-05-21 | 2002-03-26 | Vi-Jon Laboratories, Inc. | Prebrushing liquid oral composition |
| US9241885B2 (en) * | 2004-01-29 | 2016-01-26 | The Procter & Gamble Company | Oral care compositions comprising increased bioavailable levels of quaternary ammonium antimicrobials |
| EP1806125B1 (en) * | 2004-10-20 | 2011-08-03 | Kao Corporation | Liquid compositions for oral cavity |
| US20070034118A1 (en) * | 2005-08-12 | 2007-02-15 | Jardine Leslie A | Dosage efficient, storage stable compositions for reducing chromium (VI) in cement |
| US20070110788A1 (en) * | 2005-11-14 | 2007-05-17 | Hissong James B | Injectable formulation capable of forming a drug-releasing device |
| US20070264296A1 (en) * | 2006-05-10 | 2007-11-15 | Myntti Matthew F | Biofilm extracellular polysachharide solvating system |
| US7993675B2 (en) | 2006-05-10 | 2011-08-09 | Medtronic Xomed, Inc. | Solvating system and sealant for medical use in the sinuses and nasal passages |
| US8088095B2 (en) * | 2007-02-08 | 2012-01-03 | Medtronic Xomed, Inc. | Polymeric sealant for medical use |
| RU2513142C2 (ru) | 2008-06-12 | 2014-04-20 | Медтроник Ксомед Инк. | Способ лечения хронических ран |
| US20100086576A1 (en) * | 2008-10-06 | 2010-04-08 | Myntti Matthew F | Antimicrobial composition and methods of making and using same |
| CA2835211C (en) | 2011-05-10 | 2019-09-24 | Next Science, Llc | Antimicrobial solid and methods of making and using same |
| US10123953B2 (en) | 2012-06-21 | 2018-11-13 | The Procter & Gamble Company | Reduction of tooth staining derived from cationic antimicrobials |
| WO2015171836A1 (en) | 2014-05-09 | 2015-11-12 | The Procter & Gamble Company | Oral compositions containing stannous |
| EP3017806B1 (en) | 2014-11-04 | 2018-06-06 | The Procter and Gamble Company | Anti-tatar oral care compositions providing crystallisation prevention |
| EP3017807B1 (en) | 2014-11-04 | 2019-01-16 | The Procter and Gamble Company | Anti-tatar oral care compositions providing crystallisation prevention |
| EP3481368A1 (en) | 2016-08-11 | 2019-05-15 | Colgate-Palmolive Company | Oral care compositions |
| JP6618508B2 (ja) * | 2017-05-31 | 2019-12-11 | アース製薬株式会社 | 歯牙又は歯垢への色素付着を防止する方法及び色素付着防止剤 |
| CN113747948B (zh) | 2019-04-26 | 2023-12-15 | 宝洁公司 | 减少来源于阳离子抗微生物剂的牙齿变色 |
| WO2024228945A1 (en) | 2023-05-03 | 2024-11-07 | Nutrition & Biosciences USA 4, Inc. | Controlling bacterial cell adhesion with alpha-glucan comprising alpha-1,6 glycosidic linkages |
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| US2041473A (en) * | 1934-10-11 | 1936-05-19 | Victor Chemical Works | Dentifrice polishing base |
| BE516996A (forum.php) * | 1952-02-19 | |||
| US2921885A (en) * | 1955-11-25 | 1960-01-19 | Colgate Palmolive Co | Antibacterial composition |
| US2956479A (en) * | 1958-02-28 | 1960-10-18 | Musser C Walton | Cascaded gun barrel |
| US3355392A (en) * | 1963-10-18 | 1967-11-28 | West Laboratories Inc | Alkaline germicidal cleaner with color indicator |
| US3330767A (en) * | 1964-11-27 | 1967-07-11 | Armour & Co | Germicidal washing powder and method of making the same |
| US3956479A (en) * | 1966-09-13 | 1976-05-11 | Colgate-Palmolive Company | Pharmaceutical composition containing novel quaternary ammonium compounds |
| US3531564A (en) * | 1966-09-15 | 1970-09-29 | Colgate Palmolive Co | Fluoride dental preparation |
| US3507796A (en) * | 1967-05-11 | 1970-04-21 | Procter & Gamble | Antibacterial compositions |
| US3703583A (en) * | 1971-06-10 | 1972-11-21 | Lever Brothers Ltd | Anticalculus formulations |
| US3953605A (en) * | 1972-04-10 | 1976-04-27 | Colgate-Palmolive Company | Antimicrobial quaternary ammonium compounds compositions |
| US3989813A (en) * | 1973-01-26 | 1976-11-02 | Colgate-Palmolive Company | Stabilized dentifrice |
| CA1023666A (en) * | 1973-01-29 | 1978-01-03 | Eric Baines | Transparent dentifrices |
| US3959458A (en) * | 1973-02-09 | 1976-05-25 | The Procter & Gamble Company | Oral compositions for calculus retardation |
| US3976765A (en) * | 1973-11-01 | 1976-08-24 | Colgate-Palmolive Company | Antibacterial oral preparations |
| IT1004032B (it) * | 1973-11-16 | 1976-07-10 | Colgate Palmolive Co | Procedimento per la produzione di particelle da incorporare in denti frici per dare agli stessi un aspetto screziato particelle otte nute e dentifricio che le contiene |
| US3957964A (en) * | 1974-01-30 | 1976-05-18 | Colgate-Palmolive Company | Dentifrice containing encapsulated flavoring |
| US4062793A (en) * | 1975-01-14 | 1977-12-13 | Blendax-Werke R. Schneider Gmbh & Co. | Cleaning agents for dentures |
| US4241049A (en) * | 1975-10-10 | 1980-12-23 | Colgate Palmolive Company | Stable dentifrice |
| US4042679A (en) * | 1975-11-07 | 1977-08-16 | Colgate-Palmolive Company | Antibacterial oral composition |
| US4130637A (en) * | 1977-01-31 | 1978-12-19 | Colgate-Palmolive Company | Anti-plaque agents |
| US4130636A (en) * | 1977-07-27 | 1978-12-19 | Colgate-Palmolive Company | Dentifrice |
| US4150151A (en) * | 1977-12-12 | 1979-04-17 | Lever Brothers Company | Mouthwash |
| US4213961A (en) * | 1978-03-23 | 1980-07-22 | Beecham, Inc. | Oral compositions |
| US4183916A (en) * | 1978-03-31 | 1980-01-15 | Beecham Inc. | Oral compositions |
| US4264580A (en) * | 1979-04-23 | 1981-04-28 | Barberio Giacinto G | Dental cream composition |
| US4273759A (en) * | 1979-05-18 | 1981-06-16 | Colgate-Palmolive Company | Antibacterial oral composition |
| US4224309A (en) * | 1979-08-24 | 1980-09-23 | Colgate-Palmolive Company | Antibacterial oral composition |
-
1981
- 1981-02-19 US US06/235,873 patent/US4323551A/en not_active Expired - Lifetime
-
1982
- 1982-02-09 DE DE8282200149T patent/DE3273503D1/de not_active Expired
- 1982-02-09 EP EP82200149A patent/EP0059012B1/en not_active Expired
- 1982-02-17 CA CA000396419A patent/CA1179272A/en not_active Expired
- 1982-02-19 JP JP57025858A patent/JPS57188510A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| EP0059012B1 (en) | 1986-10-01 |
| JPS57188510A (en) | 1982-11-19 |
| EP0059012A3 (en) | 1983-06-01 |
| DE3273503D1 (en) | 1986-11-06 |
| US4323551A (en) | 1982-04-06 |
| JPH0247445B2 (forum.php) | 1990-10-19 |
| EP0059012A2 (en) | 1982-09-01 |
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