CA1176449A - Blood separating composition - Google Patents
Blood separating compositionInfo
- Publication number
- CA1176449A CA1176449A CA000410971A CA410971A CA1176449A CA 1176449 A CA1176449 A CA 1176449A CA 000410971 A CA000410971 A CA 000410971A CA 410971 A CA410971 A CA 410971A CA 1176449 A CA1176449 A CA 1176449A
- Authority
- CA
- Canada
- Prior art keywords
- gel
- fluid
- viscosity
- silicone fluid
- stock
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 25
- 210000004369 blood Anatomy 0.000 title claims abstract description 22
- 239000008280 blood Substances 0.000 title claims abstract description 22
- 239000012530 fluid Substances 0.000 claims abstract description 76
- 229920001296 polysiloxane Polymers 0.000 claims abstract description 54
- 239000000945 filler Substances 0.000 claims abstract description 29
- 239000000463 material Substances 0.000 claims abstract description 29
- 238000006243 chemical reaction Methods 0.000 claims abstract description 17
- 230000005855 radiation Effects 0.000 claims abstract description 15
- 230000001954 sterilising effect Effects 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims description 21
- 230000009974 thixotropic effect Effects 0.000 claims description 18
- 238000002156 mixing Methods 0.000 claims description 15
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical class O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 14
- 230000004888 barrier function Effects 0.000 claims description 13
- 238000000638 solvent extraction Methods 0.000 claims description 10
- 210000002966 serum Anatomy 0.000 claims description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 230000005484 gravity Effects 0.000 claims description 6
- 239000000543 intermediate Substances 0.000 claims description 4
- 239000003921 oil Substances 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 150000001412 amines Chemical class 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims description 2
- 230000005264 electron capture Effects 0.000 claims description 2
- 239000011541 reaction mixture Substances 0.000 claims 3
- 230000000712 assembly Effects 0.000 claims 1
- 238000000429 assembly Methods 0.000 claims 1
- 239000007795 chemical reaction product Substances 0.000 claims 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims 1
- 150000002334 glycols Chemical class 0.000 claims 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims 1
- 239000000499 gel Substances 0.000 description 58
- 239000000306 component Substances 0.000 description 10
- 239000000377 silicon dioxide Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 229920002545 silicone oil Polymers 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 206010073306 Exposure to radiation Diseases 0.000 description 2
- 239000005062 Polybutadiene Substances 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 238000007872 degassing Methods 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 229920002857 polybutadiene Polymers 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- PPDBOQMNKNNODG-NTEUORMPSA-N (5E)-5-(4-chlorobenzylidene)-2,2-dimethyl-1-(1,2,4-triazol-1-ylmethyl)cyclopentanol Chemical compound C1=NC=NN1CC1(O)C(C)(C)CC\C1=C/C1=CC=C(Cl)C=C1 PPDBOQMNKNNODG-NTEUORMPSA-N 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- UHZZMRAGKVHANO-UHFFFAOYSA-M chlormequat chloride Chemical compound [Cl-].C[N+](C)(C)CCCl UHZZMRAGKVHANO-UHFFFAOYSA-M 0.000 description 1
- 229940000425 combination drug Drugs 0.000 description 1
- -1 dimethyl siloxane Chemical class 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
- C08L83/04—Polysiloxanes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/42—Block-or graft-polymers containing polysiloxane sequences
- C08G77/44—Block-or graft-polymers containing polysiloxane sequences containing only polysiloxane sequences
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/42—Block-or graft-polymers containing polysiloxane sequences
- C08G77/46—Block-or graft-polymers containing polysiloxane sequences containing polyether sequences
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
- Y10S516/924—Significant dispersive or manipulative operation or step in making or stabilizing colloid system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Food Science & Technology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Ecology (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- External Artificial Organs (AREA)
- Centrifugal Separators (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/303,001 US4386003A (en) | 1981-09-17 | 1981-09-17 | Blood separating composition |
| US303,001 | 1981-09-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1176449A true CA1176449A (en) | 1984-10-23 |
Family
ID=23170145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000410971A Expired CA1176449A (en) | 1981-09-17 | 1982-09-08 | Blood separating composition |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4386003A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0076051B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JPS5862560A (cg-RX-API-DMAC7.html) |
| AU (1) | AU557208B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA1176449A (cg-RX-API-DMAC7.html) |
| DE (1) | DE3277584D1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES8405729A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX7249E (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA826550B (cg-RX-API-DMAC7.html) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3229046A1 (de) * | 1982-08-04 | 1984-02-16 | Hoechst Ag, 6230 Frankfurt | Verfahren zur umkehrung der konfiguration optisch aktiver verbindungen und optisch aktive zwischenprodukte dieses verfahrens |
| US4785041A (en) * | 1987-12-31 | 1988-11-15 | Dow Corning Corporation | Screen printable organosiloxane resin coating compositions |
| US4946601A (en) * | 1988-08-22 | 1990-08-07 | Sherwood Medical Company | Blood serum separator tube |
| JP2909659B2 (ja) * | 1990-11-08 | 1999-06-23 | 日本ペイント 株式会社 | γ線滅菌した血清分離用シーラント |
| US5269927A (en) * | 1991-05-29 | 1993-12-14 | Sherwood Medical Company | Separation device for use in blood collection tubes |
| US5236604A (en) * | 1991-05-29 | 1993-08-17 | Sherwood Medical Company | Serum separation blood collection tube and the method of using thereof |
| JP2582191B2 (ja) * | 1991-06-25 | 1997-02-19 | 株式会社ニッショー | ゲル状材料 |
| JP2550232B2 (ja) * | 1991-06-25 | 1996-11-06 | 株式会社ニッショー | 血液分離剤 |
| US5362543A (en) * | 1993-02-23 | 1994-11-08 | Jay Medical, Ltd. | Pressure-compensating compositions and pads made therefrom |
| WO1995004098A1 (en) * | 1993-07-30 | 1995-02-09 | Henkel Corporation | Polyesters for use in blood partitioning |
| US5489386A (en) * | 1994-01-31 | 1996-02-06 | Applied Imaging | Density gradient medium for the separation of cells |
| US5432054A (en) * | 1994-01-31 | 1995-07-11 | Applied Imaging | Method for separating rare cells from a population of cells |
| WO1997012679A1 (en) * | 1995-10-03 | 1997-04-10 | Beckman Instruments, Inc. | Axial spin blood separation system and method |
| US6238578B1 (en) | 1996-12-09 | 2001-05-29 | Sherwood Services Ag | Method for dispensing separator gel in a blood collection tube |
| JP3309770B2 (ja) * | 1997-06-13 | 2002-07-29 | 信越化学工業株式会社 | 室温硬化性シリコーンゴム組成物の連続的製造方法 |
| US7971730B2 (en) | 2005-08-10 | 2011-07-05 | The Regents Of The University Of California | Collection tubes apparatus, systems and methods |
| US7674388B2 (en) * | 2005-08-10 | 2010-03-09 | The Regents Of The University Of California | Photopolymer serum separator |
| US7673758B2 (en) | 2005-08-10 | 2010-03-09 | The Regents Of The University Of California | Collection tubes apparatus, systems, and methods |
| US9248447B2 (en) * | 2005-08-10 | 2016-02-02 | The Regents Of The University Of California | Polymers for use in centrifugal separation of liquids |
| EP1934032B1 (en) * | 2005-10-14 | 2009-12-02 | Applied Medical Resources Corporation | Method of making a hand access laparoscopic device |
| EP2357471A1 (en) * | 2008-11-07 | 2011-08-17 | Hitachi Chemical Company, Ltd. | Blood serum or blood plasma separation method |
| TW201026307A (en) * | 2008-11-07 | 2010-07-16 | Hitachi Chemical Co Ltd | Serum or plasma separation material and blood collection tube the same |
| US9669405B2 (en) | 2012-10-22 | 2017-06-06 | The Regents Of The University Of California | Sterilizable photopolymer serum separator |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3780935A (en) * | 1972-07-10 | 1973-12-25 | Lukacs & Jacoby Ass | Serum separating method |
| US3852194A (en) * | 1972-12-11 | 1974-12-03 | Corning Glass Works | Apparatus and method for fluid collection and partitioning |
| US3920549A (en) * | 1974-03-18 | 1975-11-18 | Corning Glass Works | Method and apparatus for multiphase fluid collection and separation |
| US4049692A (en) * | 1974-12-16 | 1977-09-20 | Corning Glass Works | Stabilized blood separating composition |
| US3977982A (en) * | 1975-01-20 | 1976-08-31 | Corning Glass Works | Controlling viscosity of silica-silicone oil gels |
| US4018564A (en) * | 1975-11-24 | 1977-04-19 | General Electric Company | Silicone composition for analyzing blood samples |
| US4180465A (en) * | 1975-12-19 | 1979-12-25 | Sherwood Medical Industries Inc. | Fluid collection device with phase separation means |
| US4172803A (en) * | 1976-10-21 | 1979-10-30 | Terumo Corporation | Liquid separating composition and apparatus for applying said composition |
| US4101422A (en) * | 1977-05-11 | 1978-07-18 | Emery Industries, Inc. | Copolyesters useful in blood separation assemblies |
| US4235725A (en) * | 1978-08-16 | 1980-11-25 | Owens-Illinois, Inc. | Sterile blood-collecting and separating device |
| US4310430A (en) * | 1979-09-11 | 1982-01-12 | Terumo Corporation | α-Olefin-dialkylmaleate-based liquid separating agent |
-
1981
- 1981-09-17 US US06/303,001 patent/US4386003A/en not_active Expired - Lifetime
-
1982
- 1982-09-07 ZA ZA826550A patent/ZA826550B/xx unknown
- 1982-09-08 CA CA000410971A patent/CA1176449A/en not_active Expired
- 1982-09-09 EP EP82304747A patent/EP0076051B1/en not_active Expired
- 1982-09-09 DE DE8282304747T patent/DE3277584D1/de not_active Expired
- 1982-09-10 AU AU88197/82A patent/AU557208B2/en not_active Expired
- 1982-09-15 MX MX8210286U patent/MX7249E/es unknown
- 1982-09-17 ES ES516658A patent/ES8405729A1/es not_active Expired
- 1982-09-17 JP JP57163046A patent/JPS5862560A/ja active Granted
-
1990
- 1990-05-19 JP JP2130096A patent/JPH0315756A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DE3277584D1 (en) | 1987-12-10 |
| ZA826550B (en) | 1984-04-25 |
| AU557208B2 (en) | 1986-12-11 |
| EP0076051B1 (en) | 1987-11-04 |
| JPH0315756A (ja) | 1991-01-24 |
| ES516658A0 (es) | 1984-07-01 |
| US4386003A (en) | 1983-05-31 |
| JPH0363023B2 (cg-RX-API-DMAC7.html) | 1991-09-27 |
| ES8405729A1 (es) | 1984-07-01 |
| MX7249E (es) | 1988-02-16 |
| EP0076051A3 (en) | 1983-08-31 |
| EP0076051A2 (en) | 1983-04-06 |
| AU8819782A (en) | 1983-03-24 |
| JPH035550B2 (cg-RX-API-DMAC7.html) | 1991-01-25 |
| JPS5862560A (ja) | 1983-04-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEC | Expiry (correction) | ||
| MKEX | Expiry |