CA1163562A - Lipid amines formulated with fat or lipid emulsions as vaccine adjuvants - Google Patents

Lipid amines formulated with fat or lipid emulsions as vaccine adjuvants

Info

Publication number
CA1163562A
CA1163562A CA000363110A CA363110A CA1163562A CA 1163562 A CA1163562 A CA 1163562A CA 000363110 A CA000363110 A CA 000363110A CA 363110 A CA363110 A CA 363110A CA 1163562 A CA1163562 A CA 1163562A
Authority
CA
Canada
Prior art keywords
lipid
fat
pharmaceutical composition
saline
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000363110A
Other languages
English (en)
French (fr)
Inventor
John S. Wolff, Iii
George R. Hemsworth
Keith E. Jensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Application granted granted Critical
Publication of CA1163562A publication Critical patent/CA1163562A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA000363110A 1979-10-26 1980-10-23 Lipid amines formulated with fat or lipid emulsions as vaccine adjuvants Expired CA1163562A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US088,638 1979-10-26
US06/088,638 US4310550A (en) 1979-10-26 1979-10-26 Lipid amines formulated with fat or lipid emulsions as vaccine adjuvants

Publications (1)

Publication Number Publication Date
CA1163562A true CA1163562A (en) 1984-03-13

Family

ID=22212534

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000363110A Expired CA1163562A (en) 1979-10-26 1980-10-23 Lipid amines formulated with fat or lipid emulsions as vaccine adjuvants

Country Status (7)

Country Link
US (1) US4310550A (enExample)
JP (1) JPS5671024A (enExample)
AU (1) AU522338B2 (enExample)
CA (1) CA1163562A (enExample)
DE (1) DE2945788A1 (enExample)
NZ (1) NZ195354A (enExample)
PT (1) PT71236A (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0058021A3 (en) * 1981-02-06 1982-10-27 Beecham Group Plc Pharmaceutical compositions
IL74289A (en) * 1985-02-10 1989-02-28 Israel State Vaccine system comprising a live-non-virulent vaccine and an adjuvant
NL9000207A (enExample) * 1990-01-29 1991-08-16 Duphar Int Res
US6369201B1 (en) 1998-02-19 2002-04-09 Metamorphix International, Inc. Myostatin multimers
AU2002218927B2 (en) 2001-01-04 2007-08-30 The University Of British Columbia Enterohemorrhagic Escherichia coli vaccine
MXPA06004858A (es) 2003-10-31 2007-04-16 Univ British Columbia Factores de virulencia bacteriana y sus usos.
KR20110132416A (ko) 2004-04-05 2011-12-07 화이자 프로덕츠 인코포레이티드 미세유체화된 수중유 유화액 및 백신 조성물
US20080102067A1 (en) * 2006-10-25 2008-05-01 Cook Mark E Immunogenic composition
US20190030153A1 (en) 2015-07-22 2019-01-31 University Of Saskatchewan Mycoplasma vaccines and uses thereof
EP4138894A4 (en) 2020-04-20 2024-06-26 The University of Saskatchewan COMPOSITIONS AND METHODS FOR THE PREVENTION, CONTROL AND DIAGNOSIS OF MYCOBACTERIAL INFECTIONS

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA725596A (en) * 1960-08-26 1966-01-11 J. Wretlind Arvid Method of preparing intravenously injectable fat emulsions free from side reactions or complications
US3872171A (en) * 1971-05-24 1975-03-18 Pfizer Polyamines as antiviral agents in animals
US4034040A (en) * 1971-05-24 1977-07-05 Pfizer Inc. Xylene-diamines as antiviral agents
US4173641A (en) * 1978-05-15 1979-11-06 Pfizer Inc. Di-O-n-alkyl glycerol derivatives as immune stimulants

Also Published As

Publication number Publication date
US4310550A (en) 1982-01-12
NZ195354A (en) 1982-12-21
AU6366480A (en) 1981-04-30
PT71236A (en) 1980-06-01
DE2945788A1 (de) 1981-05-07
JPS5671024A (en) 1981-06-13
JPS6225646B2 (enExample) 1987-06-04
AU522338B2 (en) 1982-05-27
DE2945788C2 (enExample) 1988-01-28

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Legal Events

Date Code Title Description
MKEX Expiry