CA1150168A - Cleomycins and process for producing same - Google Patents

Cleomycins and process for producing same

Info

Publication number
CA1150168A
CA1150168A CA000356115A CA356115A CA1150168A CA 1150168 A CA1150168 A CA 1150168A CA 000356115 A CA000356115 A CA 000356115A CA 356115 A CA356115 A CA 356115A CA 1150168 A CA1150168 A CA 1150168A
Authority
CA
Canada
Prior art keywords
cleomycins
formula
cleomycin
produced
process according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000356115A
Other languages
English (en)
French (fr)
Inventor
Hamao Umezawa
Akio Fujii
Tomohisa Takita
Mamoru Kunishima
Yasuhiko Muraoka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Application granted granted Critical
Publication of CA1150168A publication Critical patent/CA1150168A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/003—Peptides being substituted by heterocyclic radicals, e.g. bleomycin, phleomycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/19—Antibiotic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA000356115A 1979-07-19 1980-07-14 Cleomycins and process for producing same Expired CA1150168A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP90951/79 1979-07-19
JP9095179A JPS5625197A (en) 1979-07-19 1979-07-19 Cleomycin and its preparation

Publications (1)

Publication Number Publication Date
CA1150168A true CA1150168A (en) 1983-07-19

Family

ID=14012775

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000356115A Expired CA1150168A (en) 1979-07-19 1980-07-14 Cleomycins and process for producing same

Country Status (7)

Country Link
US (1) US4326054A (en:Method)
JP (1) JPS5625197A (en:Method)
CA (1) CA1150168A (en:Method)
DE (1) DE3027326A1 (en:Method)
FR (1) FR2461716A1 (en:Method)
GB (1) GB2054591B (en:Method)
IT (1) IT1145379B (en:Method)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH634853A5 (de) * 1978-06-08 1983-02-28 Sandoz Ag Schwefelhaltige metabolite, ihre herstellung und verwendung in arznei- und futtermitteln.
BR8108655A (pt) * 1980-06-24 1982-05-11 Commw Scient Ind Res Org Agentes antibioticos e antitumores amplificados
EP0058838A1 (en) * 1981-02-23 1982-09-01 American Cyanamid Company Antibiotic LL BO1208 alpha and LL BO1208 beta
US4650765A (en) * 1981-02-23 1987-03-17 American Cyanamid Company Biologically pure culture of Streptoverticillium stramineum sp. nov.
JPS58116496A (ja) * 1981-12-29 1983-07-11 Nippon Kayaku Co Ltd アミドｎ置換ブレオマイシン類
CH657779A5 (de) * 1982-10-05 1986-09-30 Sandoz Ag Galenische zusammensetzungen enthaltend calcitonin.
CN101628931B (zh) * 2008-07-14 2011-11-16 中国医学科学院医药生物技术研究所 一种抗肿瘤抗生素和其药学上可接受的盐、及其制备方法和用途
CN101781343B (zh) * 2010-01-07 2012-07-04 哈尔滨莱博通药业有限公司 盐酸平阳霉素含铜品的脱铜方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3846400A (en) * 1969-02-15 1974-11-05 Microbial Chem Res Found Novel process for producing antibiotics bleomycin
US3922262A (en) * 1971-04-28 1975-11-25 Nippon Kayaku Kk N-Substituted derivatives of bleomycins
US3960834A (en) * 1971-09-02 1976-06-01 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Method for preparing 3-(methylmercaptol) propylaminobleomycin
JPS5739751B2 (en:Method) * 1972-03-03 1982-08-23
US4195018A (en) * 1977-07-01 1980-03-25 Nippon Kayaku Kabushiki Kaisha 3-[(S)-1'-Phenylethylamino]propylaminobleomycin, non-toxic salt thereof, and method for producing same

Also Published As

Publication number Publication date
JPS5625197A (en) 1981-03-10
GB2054591A (en) 1981-02-18
DE3027326C2 (en:Method) 1988-09-01
IT1145379B (it) 1986-11-05
FR2461716A1 (fr) 1981-02-06
JPS643879B2 (en:Method) 1989-01-23
DE3027326A1 (de) 1981-02-12
FR2461716B1 (en:Method) 1984-03-16
IT8049278A0 (it) 1980-07-18
GB2054591B (en) 1983-07-20
US4326054A (en) 1982-04-20

Similar Documents

Publication Publication Date Title
CA1182447A (en) Derivatives of actaplanin
Kiyoto et al. A NEW ANTITUMOR ANTIBIOTIC, FR-900482 II. PRODUCTION, ISOLATION, CHARACTERIZATION AND BIOLOGICAL ACTIVITY
Itoh et al. Isolation, physicochemical properties and biological activities of amicoumacins produced by Bacillus pumilus
CA1334655C (en) De-mannosyl teicoplanin derivatives
CA1339348C (en) Novel glycopeptide antibiotics
CA1150168A (en) Cleomycins and process for producing same
HK97986A (en) Antibiotic a/16686 factor a2, the process for the preparation thereof, and the co-produced antibiotic a/16686 factors a1 and a3
DD238068A5 (de) Verfahren zur herstellung von derivaten der cyclopeptidantibiotika a-21978 c
EP0300273B1 (en) AB-006 antibiotics and process for their production
US3639582A (en) Antibiotic laspartomycin
CA1207694A (en) Anthracycline compounds, process for production thereof, and uses thereof
CA1158999A (en) Istamycins and production thereof
DE2638766C2 (de) Antibiotika,Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
CA1287589C (en) Process for producing antibiotics from micromonospora
EP0057812B1 (de) Neues Peptid-Antibiotikum Komponente A, Verfahren zu seiner Herstellung sowie seine Verwendung in Arzneimitteln
US4169140A (en) Antibiotics SF-1771 substance and SF-1771-B substance as well as the production of these substances
FI67876B (fi) Foerfarande foer framstaellning av antimikrobiellt och antitumoert verkande derivat av tallysomycin a och tallysomycin b
US5164507A (en) Antibiotic pyridine compound
US4546084A (en) Biologically pure culture of Actinomadura Sp.
US4301248A (en) Fermentation process for making rachelmycin
CA1215337A (en) Antitumor antibiotic
EP0069882B1 (de) Neue antibiotisch wirksame Verbindungen, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
Konishi et al. Bu-2470, A NEW PEPTIDE ANTIBIOTIC COMPLEX I. PRODUCTION, ISOLATION AND PROPERTIES OF Bu-2470 A, B 1 AND B 2
US5171836A (en) Antibiotics plusbacin
US4039660A (en) Antibiotic y-g19z d3 and the production thereof

Legal Events

Date Code Title Description
MKEX Expiry