CA1144010A - Process for preparing semi-permeable microcapsules by dilution of a hydrophobic continuous phase with a solvent of different polar character - Google Patents

Process for preparing semi-permeable microcapsules by dilution of a hydrophobic continuous phase with a solvent of different polar character

Info

Publication number
CA1144010A
CA1144010A CA000333335A CA333335A CA1144010A CA 1144010 A CA1144010 A CA 1144010A CA 000333335 A CA000333335 A CA 000333335A CA 333335 A CA333335 A CA 333335A CA 1144010 A CA1144010 A CA 1144010A
Authority
CA
Canada
Prior art keywords
monomer
continuous phase
phase
affinity
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000333335A
Other languages
English (en)
French (fr)
Inventor
Franklin Lim
Richard D. Moss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Damon Corp
Original Assignee
Damon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/030,847 external-priority patent/US4251387A/en
Application filed by Damon Corp filed Critical Damon Corp
Application granted granted Critical
Publication of CA1144010A publication Critical patent/CA1144010A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/5375—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by changing the physical or chemical properties of the medium or immunochemicals, e.g. temperature, density, pH, partitioning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/14—Polymerisation; cross-linking
    • B01J13/16—Interfacial polymerisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
CA000333335A 1978-08-04 1979-08-03 Process for preparing semi-permeable microcapsules by dilution of a hydrophobic continuous phase with a solvent of different polar character Expired CA1144010A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US93117778A 1978-08-04 1978-08-04
US931,177 1978-08-04
US06/030,847 US4251387A (en) 1979-04-17 1979-04-17 Process for preparing semipermeable microcapsules
US030,847 1996-11-15

Publications (1)

Publication Number Publication Date
CA1144010A true CA1144010A (en) 1983-04-05

Family

ID=26706527

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000333335A Expired CA1144010A (en) 1978-08-04 1979-08-03 Process for preparing semi-permeable microcapsules by dilution of a hydrophobic continuous phase with a solvent of different polar character

Country Status (8)

Country Link
CA (1) CA1144010A (no)
CH (1) CH648216A5 (no)
DE (1) DE2931651A1 (no)
DK (1) DK151212C (no)
FR (1) FR2432337A2 (no)
IT (1) IT1118818B (no)
NO (1) NO148320C (no)
SE (1) SE434470B (no)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003233276A1 (en) * 2002-05-16 2003-12-02 Mcmaster University Novel composite tecto-membranes formed by interfacial reaction of crosslinked polymer microspheres with coupling agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3429827A (en) * 1962-11-23 1969-02-25 Moore Business Forms Inc Method of encapsulation
CH453305A (fr) * 1963-10-21 1968-06-14 Pilot Pen Co Ltd Procédé pour encapsuler de fines gouttelettes de liquides dispersées
US3577515A (en) * 1963-12-13 1971-05-04 Pennwalt Corp Encapsulation by interfacial polycondensation
NO147883C (no) * 1976-10-01 1983-06-29 Damon Corp Fremgangsmaate for innkapsling av labile biologiske materialer

Also Published As

Publication number Publication date
DK151212C (da) 1988-04-18
SE7906567L (sv) 1980-02-05
CH648216A5 (en) 1985-03-15
NO148320B (no) 1983-06-13
FR2432337B2 (no) 1983-02-11
DK329179A (da) 1980-02-05
SE434470B (sv) 1984-07-30
NO792558L (no) 1980-02-05
IT1118818B (it) 1986-03-03
DE2931651A1 (de) 1980-02-21
FR2432337A2 (fr) 1980-02-29
NO148320C (no) 1983-09-21
DK151212B (da) 1987-11-16
IT7968610A0 (it) 1979-08-03

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Legal Events

Date Code Title Description
MKEX Expiry