CA1138459A - Derivatives of pyrido¬4,3-b| carbazoles (ellipticines), substituted in the 1 position by a polyamine chain, process for preparing them, their pharmaceutical compositons and therapeutic treatments therewith - Google Patents

Derivatives of pyrido¬4,3-b| carbazoles (ellipticines), substituted in the 1 position by a polyamine chain, process for preparing them, their pharmaceutical compositons and therapeutic treatments therewith

Info

Publication number
CA1138459A
CA1138459A CA000336000A CA336000A CA1138459A CA 1138459 A CA1138459 A CA 1138459A CA 000336000 A CA000336000 A CA 000336000A CA 336000 A CA336000 A CA 336000A CA 1138459 A CA1138459 A CA 1138459A
Authority
CA
Canada
Prior art keywords
group
derivatives
radical
formula
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000336000A
Other languages
English (en)
French (fr)
Inventor
Claire Ducrocq
Rosette Lidereau
Pierre Tambourin
Christian Rivalle
Francoise Wendling
Alain Civier
Emile Bisagni
Luc Montagnier
Jean-Claude Chermann
Jacqueline Gruest
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bpifrance Financement SA
Original Assignee
Agence National de Valorisation de la Recherche ANVAR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agence National de Valorisation de la Recherche ANVAR filed Critical Agence National de Valorisation de la Recherche ANVAR
Application granted granted Critical
Publication of CA1138459A publication Critical patent/CA1138459A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
CA000336000A 1978-09-21 1979-09-20 Derivatives of pyrido¬4,3-b| carbazoles (ellipticines), substituted in the 1 position by a polyamine chain, process for preparing them, their pharmaceutical compositons and therapeutic treatments therewith Expired CA1138459A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7827.137 1978-09-21
FR7827137A FR2436786A1 (fr) 1978-09-21 1978-09-21 Nouveaux derives des pyrido (4,3-b) carbazoles (ellipticines), substitues en position 1 par une chaine polyaminee, leur obtention et leur application a titre de medicaments

Publications (1)

Publication Number Publication Date
CA1138459A true CA1138459A (en) 1982-12-28

Family

ID=9212892

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000336000A Expired CA1138459A (en) 1978-09-21 1979-09-20 Derivatives of pyrido¬4,3-b| carbazoles (ellipticines), substituted in the 1 position by a polyamine chain, process for preparing them, their pharmaceutical compositons and therapeutic treatments therewith

Country Status (7)

Country Link
US (1) US4434290A (de)
EP (1) EP0010029B1 (de)
JP (3) JPS5545679A (de)
CA (1) CA1138459A (de)
DE (1) DE2964062D1 (de)
ES (1) ES484317A1 (de)
FR (1) FR2436786A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK158666C (da) * 1982-11-04 1990-11-19 Glaxo Group Ltd Analogifremgangsmaade til fremstilling af 5,14-dihydrobenz-oe5,6aa-isoindolooe2,1-baa-isoquinolin-8,13-dion
EP0161102B1 (de) * 1984-05-03 1990-02-21 Glaxo Group Limited Isochinolinderivate
NO872963L (no) * 1986-07-29 1988-02-01 Glaxo Group Ltd Isokinolinderivater.
DK616087A (da) * 1986-11-27 1988-05-28 Glaxo Group Ltd Isoquinolinderivater og farmaceutiske praeparater indeholdende dem
FR2623191B1 (fr) * 1987-11-16 1990-04-06 Centre Nat Rech Scient Procede de preparation de chloro-1 alkyl-5 isoquinoleines condensees avec des groupes aromatiques, les nouveaux produits obtenus, et leur application comme medicaments
GB8800312D0 (en) * 1988-01-07 1988-02-10 Glaxo Group Ltd Process
FR2627493B1 (fr) * 1988-02-23 1991-10-31 Sanofi Sa Procede de preparation de derives d'isoquinoleine
KR950002885B1 (ko) * 1990-06-05 1995-03-28 토레이가부시키가이샤 인돌 유도체
FR2757858B1 (fr) * 1996-12-30 1999-01-29 Adir Nouveaux derives d'ellipticine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2859474B1 (fr) 2003-09-04 2006-01-13 Centre Nat Rech Scient Utilisation de composes derives d'indole pour la preparation d'un medicament utile pour le traitement de maladies genetiques resultant de l'alteration des processus d'epissage
FR2926297B1 (fr) 2008-01-10 2013-03-08 Centre Nat Rech Scient Molecules chimiques inhibitrices du mecanisme d'epissage pour traiter des maladies resultant d'anomalies d'epissage.
FR2942476B1 (fr) 2009-02-20 2013-03-15 Commissariat Energie Atomique Composes de type pyridocarbazole et leurs applications
KR101982461B1 (ko) 2009-06-12 2019-05-24 아비박스 조기 노화, 구체적으로 조로증을 치료하는데 유용한 화합물
EP2266972A1 (de) 2009-06-12 2010-12-29 Splicos Neuartige chemische Moleküle zum Hemmen des Splicing-Mechanismus zur Behandlung von durch Splicing-Anomalien verursachte Krankheiten
US10253020B2 (en) 2009-06-12 2019-04-09 Abivax Compounds for preventing, inhibiting, or treating cancer, AIDS and/or premature aging
EP2465502A1 (de) 2010-12-15 2012-06-20 Société Splicos Nützliche Verbindungen zur Behandlung von AIDS
EP2505198A1 (de) 2011-04-01 2012-10-03 Société Splicos Verbindungen zur Verwendung als Therapiemittel mit Beeinträchtigung der p53-Expression und/oder -Aktivität
EP2757161A1 (de) 2013-01-17 2014-07-23 Splicos miRNA-124 als ein Biomarker für virale Infektion
HRP20211839T1 (hr) 2013-07-05 2022-03-04 Abivax Biciklički spojevi korisni za liječenje bolesti uzrokovanih retrovirusima
EP2975034A1 (de) 2014-07-17 2016-01-20 Abivax Chinolinderivat zur Behandlung von Entzündungskrankheiten und AIDS
EP2974729A1 (de) 2014-07-17 2016-01-20 Abivax Chinolinderivate zur Verwendung bei der Behandlung von Entzündungskrankheiten
EP3059236A1 (de) 2015-02-23 2016-08-24 Abivax Neue Chinolinderivate zur Verwendung bei der Behandlung und Prävention von Virusinfektionen
CN109748917B (zh) * 2017-11-01 2021-07-02 中国医学科学院药物研究所 玫瑰树碱衍生物、其药物组合物及其制备方法和用途
EP3669873A1 (de) 2018-12-20 2020-06-24 Abivax Chinolinderivate zur verwendung bei der behandlung von entzündlichen krankheiten

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2477049A (en) 1949-07-26 Pyridoacridines
US3514462A (en) * 1966-10-21 1970-05-26 Upjohn Co 1 and 2 ethoxy 3,4,5,10 - tetrahydroazepino(3,4-b) and (2,3-b)indoles and corresponding amino derivatives thereof
FR1556174A (de) * 1968-03-15 1969-01-31
US3933827A (en) 1974-10-29 1976-01-20 Hoffmann-La Roche Inc. 9-Acyloxy-5,11-dimethyl-6H-pyrido[4,3-B]carbazoles

Also Published As

Publication number Publication date
DE2964062D1 (en) 1982-12-23
ES484317A1 (es) 1980-05-16
EP0010029A3 (en) 1980-07-23
EP0010029B1 (de) 1982-11-17
JPS62281877A (ja) 1987-12-07
JPS6234037B2 (de) 1987-07-24
FR2436786A1 (fr) 1980-04-18
EP0010029A2 (de) 1980-04-16
JPH0236595B2 (de) 1990-08-17
US4434290A (en) 1984-02-28
JPH0255422B2 (de) 1990-11-27
FR2436786B1 (de) 1981-04-30
JPS5545679A (en) 1980-03-31
JPS6345254A (ja) 1988-02-26

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