CA1136885A - Method and apparatus for the non-invasive determination of the characteristics of a segmented fluid stream - Google Patents
Method and apparatus for the non-invasive determination of the characteristics of a segmented fluid streamInfo
- Publication number
- CA1136885A CA1136885A CA000344791A CA344791A CA1136885A CA 1136885 A CA1136885 A CA 1136885A CA 000344791 A CA000344791 A CA 000344791A CA 344791 A CA344791 A CA 344791A CA 1136885 A CA1136885 A CA 1136885A
- Authority
- CA
- Canada
- Prior art keywords
- conduit
- segments
- liquid
- radiation energy
- segment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims abstract description 33
- 239000012530 fluid Substances 0.000 title claims abstract description 31
- 230000005855 radiation Effects 0.000 claims abstract description 41
- 238000001514 detection method Methods 0.000 claims abstract description 18
- 238000012545 processing Methods 0.000 claims abstract description 17
- 238000002835 absorbance Methods 0.000 claims abstract description 12
- 230000003595 spectral effect Effects 0.000 claims abstract description 8
- 239000007788 liquid Substances 0.000 claims description 132
- 239000003550 marker Substances 0.000 claims description 19
- 238000004458 analytical method Methods 0.000 claims description 8
- 239000003153 chemical reaction reagent Substances 0.000 claims description 7
- 210000002966 serum Anatomy 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000000470 constituent Substances 0.000 claims description 5
- 230000003287 optical effect Effects 0.000 claims description 4
- 230000001678 irradiating effect Effects 0.000 claims 4
- 230000007274 generation of a signal involved in cell-cell signaling Effects 0.000 description 20
- 238000005259 measurement Methods 0.000 description 12
- 239000007789 gas Substances 0.000 description 9
- 230000000694 effects Effects 0.000 description 3
- 239000004809 Teflon Substances 0.000 description 2
- 229920006362 Teflon® Polymers 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001052 transient effect Effects 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 238000004159 blood analysis Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004737 colorimetric analysis Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- -1 serum Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F1/00—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow
- G01F1/704—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow using marked regions or existing inhomogeneities within the fluid stream, e.g. statistically occurring variations in a fluid parameter
- G01F1/708—Measuring the time taken to traverse a fixed distance
- G01F1/7086—Measuring the time taken to traverse a fixed distance using optical detecting arrangements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F1/00—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow
- G01F1/74—Devices for measuring flow of a fluid or flow of a fluent solid material in suspension in another fluid
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Measuring Volume Flow (AREA)
- Investigating Materials By The Use Of Optical Means Adapted For Particular Applications (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Geophysics And Detection Of Objects (AREA)
- Measurement Of Levels Of Liquids Or Fluent Solid Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21,034 | 1979-03-16 | ||
| US06/021,034 US4210809A (en) | 1979-03-16 | 1979-03-16 | Method and apparatus for the non-invasive determination of the characteristics of a segmented fluid stream |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1136885A true CA1136885A (en) | 1982-12-07 |
Family
ID=21801939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000344791A Expired CA1136885A (en) | 1979-03-16 | 1980-01-31 | Method and apparatus for the non-invasive determination of the characteristics of a segmented fluid stream |
Country Status (7)
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4314241A (en) * | 1980-01-28 | 1982-02-02 | Merrick Scale Mfg. Company | Coal pipe monitor |
| GB2097692B (en) * | 1981-01-10 | 1985-05-22 | Shaw Stewart P D | Combining chemical reagents |
| EP0074365A1 (en) * | 1981-03-16 | 1983-03-23 | Mount Isa Mines Limited | Measurement of bulk density of particulate materials |
| US4419903A (en) * | 1982-02-22 | 1983-12-13 | Beckman Instruments, Inc. | Method and apparatus for detecting insufficient liquid levels |
| JPS58167921A (ja) * | 1982-03-29 | 1983-10-04 | Borukano Kk | 廃油タンクの油水分自動検出法 |
| US4654535A (en) * | 1982-09-30 | 1987-03-31 | Wolske James P | Meniscus position detector with detector at the focal plane of the lens formed by tube and liquid |
| US4517302A (en) * | 1982-11-15 | 1985-05-14 | Technicon Instruments Corporation | Continuous flow metering apparatus |
| DE3346198A1 (de) * | 1983-12-21 | 1985-07-04 | ABC-Analytische Biochemie GmbH, 8039 Puchheim | Sensor fuer die beruehrungsfreie erkennung von fluessigkeiten in leitungen |
| SE450791B (sv) * | 1985-11-19 | 1987-07-27 | Salen & Wicander Ab | Sett och anordning for detektering av fororeningshalten i en vetska |
| US4752690A (en) * | 1986-08-11 | 1988-06-21 | Coulter Electronics, Inc. | Method and apparatus for detecting incongruities, such as air bubbles, in fluid material |
| JPS63167222U (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1987-04-22 | 1988-10-31 | ||
| JPH01105823U (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1988-01-07 | 1989-07-17 | ||
| JP3213307B2 (ja) * | 1989-09-18 | 2001-10-02 | ミネソタ マイニング アンド マニユフアクチユアリング カンパニー | 近赤外スペクトル解析による生物学的材料の特性予知法 |
| CA2025330C (en) * | 1989-09-18 | 2002-01-22 | David W. Osten | Characterizing biological matter in a dynamic condition using near infrared spectroscopy |
| DE4013402C2 (de) * | 1990-04-26 | 1994-03-24 | Infurex Ag Cham | Verfahren und Vorrichtung zur Erkennung von Gasblasen in einer mit Flüssigkeit gefüllten Leitung, insbesondere einer flexiblen, schlauchförmigen Leitung oder einem Container |
| DE4028881A1 (de) * | 1990-09-12 | 1992-03-19 | Rheinhuette Gmbh & Co | Verfahren und einrichtung zum schutz einer foerdereinrichtung von trockenlauf |
| US5094961A (en) * | 1990-12-13 | 1992-03-10 | Coulter Corporation | Aspiration method for hematology analyzing apparatus |
| NL9320032A (nl) * | 1992-05-22 | 1995-05-01 | Commw Scient Ind Res Org | Werkwijze en inrichting voor het meten van de massa-stroomsnelheden van vloeistofcomponenten in een multifase proppenstroom. |
| DE4219270A1 (de) * | 1992-06-14 | 1993-12-16 | Gerhard Woerner | Vorrichtung zum Umschalten eines Mehrwegeventils |
| US5448919A (en) * | 1992-12-07 | 1995-09-12 | Ametek, Inc. | Gas flow meter |
| US5355735A (en) * | 1993-02-23 | 1994-10-18 | Datrend Systems Inc. | Apparatus for metering liquid flow |
| BR9301171A (pt) * | 1993-03-15 | 1994-10-18 | Petroleo Brasileiro Sa | Processo termo-químico de desparafinação de dutos condutores de hidrocarbonetos |
| DE4333624C2 (de) * | 1993-10-04 | 1995-12-21 | Martin Dipl Ing Simon | Anordnung zum Bestimmen der Strömungsform einer Zweiphasenströmung |
| GB2282880B (en) * | 1993-10-18 | 1997-07-23 | Welsh Water Enterprises Ltd | Apparatus for measuring characteristics of a liquid |
| US5581086A (en) * | 1995-08-02 | 1996-12-03 | S.C.R. Engineers Ltd. | Infrared light chamber for fluid measurement |
| US5724142A (en) * | 1996-03-29 | 1998-03-03 | Dade International Inc. | Method and apparatus for measuring and controlling the volume of a liquid segment in a tube |
| US6131471A (en) * | 1997-09-05 | 2000-10-17 | American Standard Inc. | Liquid level sensor |
| US5960129A (en) * | 1997-12-22 | 1999-09-28 | Bayer Corporation | Method and apparatus for detecting liquid and gas segment flow through a tube |
| DE19956958A1 (de) * | 1999-11-16 | 2001-06-13 | Vogel Willi Ag | Verfahren und Vorrichtung zur Überwachung des Ölstroms einer Einrichtung zur Öl+Luft-Schmierung von Bauteilen |
| DE10041014A1 (de) * | 2000-08-22 | 2002-03-07 | Merck Patent Gmbh | Bestimmung von Flußraten |
| GB0028647D0 (en) * | 2000-11-24 | 2001-01-10 | Nextgen Sciences Ltd | Apparatus for chemical assays |
| GB0107184D0 (en) * | 2001-03-22 | 2001-05-09 | Yortech Instr Ltd | Gas velocity measurement |
| US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
| GB0307428D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
| GB0307403D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Selection by compartmentalised screening |
| US20050221339A1 (en) | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
| EP1617202B1 (en) * | 2004-07-13 | 2009-09-23 | Services Petroliers Schlumberger | Detector for distinguishing phases in a multiphase fluid mixture |
| US7482591B2 (en) * | 2004-09-22 | 2009-01-27 | Miox Corporation | Carbonate scale detector |
| US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
| US7834312B2 (en) | 2005-02-24 | 2010-11-16 | Weatherford/Lamb, Inc. | Water detection and 3-phase fraction measurement systems |
| WO2007081385A2 (en) | 2006-01-11 | 2007-07-19 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
| EP2047910B1 (en) | 2006-05-11 | 2012-01-11 | Raindance Technologies, Inc. | Microfluidic device and method |
| US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
| US9012390B2 (en) | 2006-08-07 | 2015-04-21 | Raindance Technologies, Inc. | Fluorocarbon emulsion stabilizing surfactants |
| US8772046B2 (en) | 2007-02-06 | 2014-07-08 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
| WO2008130623A1 (en) | 2007-04-19 | 2008-10-30 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| DE102007018752B4 (de) * | 2007-04-20 | 2011-09-22 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Vorrichtung und Verfahren zum geregelten Transport mikrofluidischer Proben |
| FR2931232B1 (fr) * | 2008-05-16 | 2010-05-28 | Rhodia Operations | Procede et installation de determination d'une valeur de debit d'un fluide |
| WO2010009365A1 (en) | 2008-07-18 | 2010-01-21 | Raindance Technologies, Inc. | Droplet libraries |
| US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| WO2010111231A1 (en) | 2009-03-23 | 2010-09-30 | Raindance Technologies, Inc. | Manipulation of microfluidic droplets |
| US10520500B2 (en) | 2009-10-09 | 2019-12-31 | Abdeslam El Harrak | Labelled silica-based nanomaterial with enhanced properties and uses thereof |
| WO2011079176A2 (en) | 2009-12-23 | 2011-06-30 | Raindance Technologies, Inc. | Microfluidic systems and methods for reducing the exchange of molecules between droplets |
| US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
| US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
| EP4484577A3 (en) | 2010-02-12 | 2025-03-26 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| EP3447155A1 (en) | 2010-09-30 | 2019-02-27 | Raindance Technologies, Inc. | Sandwich assays in droplets |
| EP3859011A1 (en) | 2011-02-11 | 2021-08-04 | Bio-Rad Laboratories, Inc. | Methods for forming mixed droplets |
| EP2675819B1 (en) | 2011-02-18 | 2020-04-08 | Bio-Rad Laboratories, Inc. | Compositions and methods for molecular labeling |
| EP3709018A1 (en) | 2011-06-02 | 2020-09-16 | Bio-Rad Laboratories, Inc. | Microfluidic apparatus for identifying components of a chemical reaction |
| US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
| US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
| FR3003948B1 (fr) * | 2013-03-29 | 2016-02-05 | Centre Nat Rech Scient | Procede de detection d'elements disperses circulant a travers un tube capillaire, et appareil associe |
| GB2518415B (en) * | 2013-09-20 | 2016-10-05 | Spirax-Sarco Ltd | Apparatus and method for determining a non-condensable gas parameter |
| US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
| US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
| US11193176B2 (en) | 2013-12-31 | 2021-12-07 | Bio-Rad Laboratories, Inc. | Method for detecting and quantifying latent retroviral RNA species |
| US10585075B2 (en) | 2014-02-27 | 2020-03-10 | Elemental Scientific, Inc. | System for collecting liquid samples |
| US11054344B2 (en) * | 2014-02-27 | 2021-07-06 | Elemental Scientific, Inc. | System for collecting liquid samples from a distance |
| JP7108260B2 (ja) * | 2015-06-26 | 2022-07-28 | エレメンタル・サイエンティフィック・インコーポレイテッド | 液体サンプルを収集するためのシステム |
| US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
| IT201800004630A1 (it) * | 2018-04-17 | 2019-10-17 | Apparato e procedimento per la determinazione della velocita' di sedimentazione del sangue e di altri parametri ad essa correlati |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2797149A (en) * | 1953-01-08 | 1957-06-25 | Technicon International Ltd | Methods of and apparatus for analyzing liquids containing crystalloid and non-crystalloid constituents |
| NL287532A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1962-01-23 | |||
| US3480369A (en) * | 1966-02-21 | 1969-11-25 | Technion Corp | Method and apparatus for the colorimetric analysis of liquid samples |
| SE351925B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1968-08-12 | 1972-12-11 | Lkb Produkter Ab | |
| US3842670A (en) * | 1969-03-28 | 1974-10-22 | Nat Res Dev | Improvements in measuring the velocity of gases |
| US3600953A (en) * | 1969-07-25 | 1971-08-24 | Technicon Corp | Method and apparatus for the introduction of auxiliary separating fluid in fluid sample analyses means |
| US3634853A (en) * | 1970-06-08 | 1972-01-11 | Charles P Hedges | Liquid displacement encoder |
| US3693436A (en) * | 1970-08-28 | 1972-09-26 | Lab Data Control Inc | Liquid flow meter |
| US3688574A (en) * | 1970-11-02 | 1972-09-05 | Us Army | Fluid flowmeter |
| SE364113B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1971-05-05 | 1974-02-11 | Lkb Produkter Ab | |
| US3881351A (en) * | 1972-06-29 | 1975-05-06 | Gen Motors Corp | Method of measuring the mass flow rate of a constituent of a gaseous stream |
| FR2198194A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1972-08-30 | 1974-03-29 | Toulouse Pierre | |
| US3929413A (en) * | 1974-03-04 | 1975-12-30 | Anatronics Corp | Fluid transport and metering system |
| CH582878A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1974-09-23 | 1976-12-15 | Contraves Ag | |
| JPS5711208Y2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1976-12-21 | 1982-03-05 |
-
1979
- 1979-03-16 US US06/021,034 patent/US4210809A/en not_active Expired - Lifetime
-
1980
- 1980-01-31 CA CA000344791A patent/CA1136885A/en not_active Expired
- 1980-02-15 GB GB8005210A patent/GB2047880B/en not_active Expired
- 1980-03-14 JP JP3171280A patent/JPS55125472A/ja active Granted
- 1980-03-14 IT IT67396/80A patent/IT1129430B/it active
- 1980-03-14 FR FR8005731A patent/FR2451579A1/fr active Granted
- 1980-03-14 DE DE19803009835 patent/DE3009835A1/de active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| IT8067396A0 (it) | 1980-03-14 |
| GB2047880A (en) | 1980-12-03 |
| US4210809A (en) | 1980-07-01 |
| JPS55125472A (en) | 1980-09-27 |
| FR2451579A1 (fr) | 1980-10-10 |
| FR2451579B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1984-10-19 |
| JPH0319932B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1991-03-18 |
| DE3009835A1 (de) | 1980-09-25 |
| GB2047880B (en) | 1983-08-03 |
| DE3009835C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1992-02-20 |
| IT1129430B (it) | 1986-06-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |