CA1113086A - 25-alkylcholesterol derivatives - Google Patents

25-alkylcholesterol derivatives

Info

Publication number
CA1113086A
CA1113086A CA310,200A CA310200A CA1113086A CA 1113086 A CA1113086 A CA 1113086A CA 310200 A CA310200 A CA 310200A CA 1113086 A CA1113086 A CA 1113086A
Authority
CA
Canada
Prior art keywords
formula
methylcholest
ene
diol
pyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA310,200A
Other languages
English (en)
French (fr)
Inventor
Robert J. Chorvat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of CA1113086A publication Critical patent/CA1113086A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA310,200A 1977-08-29 1978-08-28 25-alkylcholesterol derivatives Expired CA1113086A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82838577A 1977-08-29 1977-08-29
US828,385 1977-08-29

Publications (1)

Publication Number Publication Date
CA1113086A true CA1113086A (en) 1981-11-24

Family

ID=25251653

Family Applications (1)

Application Number Title Priority Date Filing Date
CA310,200A Expired CA1113086A (en) 1977-08-29 1978-08-28 25-alkylcholesterol derivatives

Country Status (9)

Country Link
JP (1) JPS5448751A (enExample)
AU (1) AU520334B2 (enExample)
CA (1) CA1113086A (enExample)
CH (1) CH643566A5 (enExample)
DE (1) DE2837414A1 (enExample)
ES (1) ES472877A1 (enExample)
FR (1) FR2401935A1 (enExample)
GB (1) GB2009180B (enExample)
IT (1) IT1106121B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4225525A (en) * 1979-02-08 1980-09-30 Hoffmann-La Roche Inc. Vitamin D3 metabolite derivatives
US4230626A (en) * 1979-07-30 1980-10-28 G. D. Searle & Co. 25-Halocholest-5-ene-3β,22-diols and esters thereof
US4329295A (en) * 1981-06-29 1982-05-11 G. D. Searle & Co. 24-Cyclopropylcholene-3β, 22-diols and esters thereof
US4348328A (en) * 1981-11-09 1982-09-07 G.D. Searle & Co. 25-Substituted-5α-cholestane-3β,22S-diol
IL105050A0 (en) * 1992-03-27 1993-07-08 Lilly Co Eli Steroid derivatives
DK1163258T3 (da) * 1999-03-09 2003-03-31 Akzo Nobel Nv Derivater af 22R-hydroxycholesta-8, 14-dien til inhiberingen af meiosis
WO2002062302A2 (en) * 2001-02-08 2002-08-15 The University Of Chicago Steroidal derivatives
US7078396B2 (en) 2001-05-03 2006-07-18 Arch Development Corporation Method of treating disorder related to high cholesterol concentration
JP2013500986A (ja) 2009-07-29 2013-01-10 ザ・ユニバーシティ・オブ・シカゴ 肝臓ｘ受容体アゴニスト

Also Published As

Publication number Publication date
DE2837414C2 (enExample) 1987-09-03
CH643566A5 (de) 1984-06-15
FR2401935B1 (enExample) 1981-07-10
GB2009180B (en) 1982-05-26
GB2009180A (en) 1979-06-13
FR2401935A1 (fr) 1979-03-30
JPS5448751A (en) 1979-04-17
JPS6259720B2 (enExample) 1987-12-12
AU3931878A (en) 1980-03-06
ES472877A1 (es) 1979-02-16
IT7850879A0 (it) 1978-08-28
IT1106121B (it) 1985-11-11
DE2837414A1 (de) 1979-03-08
AU520334B2 (en) 1982-01-28

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Legal Events

Date Code Title Description
MKEX Expiry
MKEX Expiry

Effective date: 19981124