CA1106762A - Skin disinfection ointment - Google Patents
Skin disinfection ointmentInfo
- Publication number
- CA1106762A CA1106762A CA310,567A CA310567A CA1106762A CA 1106762 A CA1106762 A CA 1106762A CA 310567 A CA310567 A CA 310567A CA 1106762 A CA1106762 A CA 1106762A
- Authority
- CA
- Canada
- Prior art keywords
- ointment
- vinyl polymer
- carboxy vinyl
- amine
- gel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
ABSTRACT OF THE DISCLOSURE
A skin ointment consists of a stable disinfectant gel having a creamy consistency comprising by weight:
ethanol 45 to 95 %
glycerine 0.2 to 5.0 %
carboxy vinyl polymer 0.2 to 2.0 %
a basic amine 0.2 to 2.0 %
cetyl alcohol 0.3 to 0.4 %
isopropyl myrisate 0.3 to 0.4 %
Water to make 100 %
The carboxy vinyl polymer and the basic amine react to form a salt of the carboxy vinyl polymer sufficient to impart a gel-like consistency to the ointment without interfering with its disinfectant activity.
A skin ointment consists of a stable disinfectant gel having a creamy consistency comprising by weight:
ethanol 45 to 95 %
glycerine 0.2 to 5.0 %
carboxy vinyl polymer 0.2 to 2.0 %
a basic amine 0.2 to 2.0 %
cetyl alcohol 0.3 to 0.4 %
isopropyl myrisate 0.3 to 0.4 %
Water to make 100 %
The carboxy vinyl polymer and the basic amine react to form a salt of the carboxy vinyl polymer sufficient to impart a gel-like consistency to the ointment without interfering with its disinfectant activity.
Description
~6'76;~:
The present invention relates to a skin disinfection ointment containing alcohol as its disinfectan-t.
With prior art ointments of the type mentioned in the opening paragraph, it is difficult to attain a high disinfective power while maintaining the necessary creamy consistency. As a matter of fact, the ointment can obtain a high disinfective power by imparting to it a high alcohol content, but on the other hand the ointment will more and more lose its creamy consistency, the more its alcohol content, and thus its disinfective power is 0 increased.
The present invention has for its object to provide an ointment which has a high disinfective power and, in addition, has a creamy consistency so that it is conveniently applicable.
The ointment, in addition, will be easily available because it may be kept up, for instance, in a collapsible tube to put in a pocket and, thus may substitute a handwash in cases where the handwash would have been undertaken solely for disinfection pur-poses, whereby the tendency of the hands to dry out will be reduced.
According to the present invention, a skin ointment consists of a stable disinfectant gel having a creamy consistency comprising by weight:
ethanol 45 to 95 %
glycerine 0.2 to 5.0 %
carboxy vinyl polymer 0.2 to 2.0 %
a basic amine0 2 to 2.0 %
cetyl alcohol0.3 to 0.4 %
isopropyl myrisate0.3 to 0.4 %
water to make 100 %
- 1- '~
~i6762 The carboxy vinyl polymer and the basic amine react to form a salt of the carboxy vinyl polymer sufficient to impart a gel-like consistency to the ointment without interfering with its dis-infectant activity.
The salt forming amine may be selected from the group consisting of triethanol amine, di(2-ethylhexyl) amine, tri-ethylamine and diisopropanolamine.
The ointment may further comprise cetyl alcohol in an amount effective to reduce drying of the skin and isopropyl myrisate in an amount effective to soften the skin. The ointment may comprise from about 0.3 to about 0.4% cetyl alcohol and from about 0.3 to about 0.4% isopropyl myrisate.
To cause prolongation of the time of activity, bacteri-cidic agents may be added. Examples of such agents are, i.a.
chlorohexidine, Irgasan DP 300, hexa-chlorophen, n-dodecyl guanidine and cetyl-pyridinium chloride.
To illustrate the possible composition of an ointment according to the invention, the following examples are given:
Example 1 Cetyl alcohol (0.4%), isopropyl myrisate (0.4%), glycerine (0.6%) and triethanolamine (0.5%) are admixed into 95 percentage ethanol (38.3%) until a clear solution is obtained (Solution A).
Water (32.95%), ethanol (26.5%) and carboxy vinyl polymer are mixed until a homogeneous solution is obtained (Solution B).
Solution A is added to Solution B while s-tirring, until a clear gel has formed.
* Trade Mark .~
:' ' ' ' ":
~6762 Example 2 Cetyl alcohol (0.3%), isopropyl myristate (0.3%), glycerine (0.4%) and triethylamine (0.12%) are mixed into 95 percentage ethanol (26.4%) until a clear solution will result (Solution A).
Water (26.7%), ethanol (45.4~) and carboxy vinyl polymer (0.38~) are mixed until a hornogeneous solution is obtained (Solution B).
Solution A is added to So]Lution B while stirring, until a clear gel has formed. The ointments according to Examples 1 and
The present invention relates to a skin disinfection ointment containing alcohol as its disinfectan-t.
With prior art ointments of the type mentioned in the opening paragraph, it is difficult to attain a high disinfective power while maintaining the necessary creamy consistency. As a matter of fact, the ointment can obtain a high disinfective power by imparting to it a high alcohol content, but on the other hand the ointment will more and more lose its creamy consistency, the more its alcohol content, and thus its disinfective power is 0 increased.
The present invention has for its object to provide an ointment which has a high disinfective power and, in addition, has a creamy consistency so that it is conveniently applicable.
The ointment, in addition, will be easily available because it may be kept up, for instance, in a collapsible tube to put in a pocket and, thus may substitute a handwash in cases where the handwash would have been undertaken solely for disinfection pur-poses, whereby the tendency of the hands to dry out will be reduced.
According to the present invention, a skin ointment consists of a stable disinfectant gel having a creamy consistency comprising by weight:
ethanol 45 to 95 %
glycerine 0.2 to 5.0 %
carboxy vinyl polymer 0.2 to 2.0 %
a basic amine0 2 to 2.0 %
cetyl alcohol0.3 to 0.4 %
isopropyl myrisate0.3 to 0.4 %
water to make 100 %
- 1- '~
~i6762 The carboxy vinyl polymer and the basic amine react to form a salt of the carboxy vinyl polymer sufficient to impart a gel-like consistency to the ointment without interfering with its dis-infectant activity.
The salt forming amine may be selected from the group consisting of triethanol amine, di(2-ethylhexyl) amine, tri-ethylamine and diisopropanolamine.
The ointment may further comprise cetyl alcohol in an amount effective to reduce drying of the skin and isopropyl myrisate in an amount effective to soften the skin. The ointment may comprise from about 0.3 to about 0.4% cetyl alcohol and from about 0.3 to about 0.4% isopropyl myrisate.
To cause prolongation of the time of activity, bacteri-cidic agents may be added. Examples of such agents are, i.a.
chlorohexidine, Irgasan DP 300, hexa-chlorophen, n-dodecyl guanidine and cetyl-pyridinium chloride.
To illustrate the possible composition of an ointment according to the invention, the following examples are given:
Example 1 Cetyl alcohol (0.4%), isopropyl myrisate (0.4%), glycerine (0.6%) and triethanolamine (0.5%) are admixed into 95 percentage ethanol (38.3%) until a clear solution is obtained (Solution A).
Water (32.95%), ethanol (26.5%) and carboxy vinyl polymer are mixed until a homogeneous solution is obtained (Solution B).
Solution A is added to Solution B while s-tirring, until a clear gel has formed.
* Trade Mark .~
:' ' ' ' ":
~6762 Example 2 Cetyl alcohol (0.3%), isopropyl myristate (0.3%), glycerine (0.4%) and triethylamine (0.12%) are mixed into 95 percentage ethanol (26.4%) until a clear solution will result (Solution A).
Water (26.7%), ethanol (45.4~) and carboxy vinyl polymer (0.38~) are mixed until a hornogeneous solution is obtained (Solution B).
Solution A is added to So]Lution B while stirring, until a clear gel has formed. The ointments according to Examples 1 and
2 are very well adapted to be smeared on the skin and give an agreeable feel of smoothness after evaporation of the ethanol.
One condition for the use of ointments of this type is that the disinfectant power of the alcohol will not diminish or disappear. In order to investigate this, the following bacterio-logical ev~luation was made:
Thus, when mixing the ingredients, a basic material may be added as a final mixing step. Owing to this step, the mixture will rest very fluid as far as the last phase, whereas acid of carboxy vinyl polymer as contained in the mixture will, in the last phase, be converted by the basic compound, for instance tri-ethanolamine, di(2-ethylhexyl)amine, triethylamine or diiso-propanolamine, into a salt of the carboxy vinyl polymer, accompanied by a very substantial thickening of the mixture.
Thus, this mixing method is advantageous, however it is possible to "dissolve" the acid of carboxy vinyl polymer separately, for instance in 70 percentage alcohol, and for example triethanolamine and the remaining ingredients separately, for A
.. . . . . . . . . .
.. . . . . . .. . ~
~ .
7~
instance in 95 percentage alcohol, a~ter which the separate mixtures are combined as a final mixing step, whereby the sub-stantial thickening of the mixture is obtained The resulting compositiOn had a smooth, creamy con-sistency.
A method of testing spirit cream:
Cultivation of bacteria is performed in the same way as in performing disinfection tests according to Kjellander, where the last step comprises a centrifugation of cultivated bacteria, followed by sludging in inactivated horse blood. The inoculate should be about 107 to 108, and possible correction in the sludge for any gram-bacteria-killing on application.
l. Hands to be washed carefully before commencing the test run, and treat with spirit. Let dry.
2. Apply 0~2 ml. in the palm of the hand, rub in during 5 secs. with left forefinger. Let dry about 5 to lO min.
One condition for the use of ointments of this type is that the disinfectant power of the alcohol will not diminish or disappear. In order to investigate this, the following bacterio-logical ev~luation was made:
Thus, when mixing the ingredients, a basic material may be added as a final mixing step. Owing to this step, the mixture will rest very fluid as far as the last phase, whereas acid of carboxy vinyl polymer as contained in the mixture will, in the last phase, be converted by the basic compound, for instance tri-ethanolamine, di(2-ethylhexyl)amine, triethylamine or diiso-propanolamine, into a salt of the carboxy vinyl polymer, accompanied by a very substantial thickening of the mixture.
Thus, this mixing method is advantageous, however it is possible to "dissolve" the acid of carboxy vinyl polymer separately, for instance in 70 percentage alcohol, and for example triethanolamine and the remaining ingredients separately, for A
.. . . . . . . . . .
.. . . . . . .. . ~
~ .
7~
instance in 95 percentage alcohol, a~ter which the separate mixtures are combined as a final mixing step, whereby the sub-stantial thickening of the mixture is obtained The resulting compositiOn had a smooth, creamy con-sistency.
A method of testing spirit cream:
Cultivation of bacteria is performed in the same way as in performing disinfection tests according to Kjellander, where the last step comprises a centrifugation of cultivated bacteria, followed by sludging in inactivated horse blood. The inoculate should be about 107 to 108, and possible correction in the sludge for any gram-bacteria-killing on application.
l. Hands to be washed carefully before commencing the test run, and treat with spirit. Let dry.
2. Apply 0~2 ml. in the palm of the hand, rub in during 5 secs. with left forefinger. Let dry about 5 to lO min.
3. Apply 2 ml. spirit or spirit cream. Rub for 30 secs.
to cover the hand completely. Let dry in air for about 2 min.
to cover the hand completely. Let dry in air for about 2 min.
4. Wash hands 5 min, in a small metal bowl containing 250 ml. Leetheen-bouillon.
5. Take 0.1 ml. from the washing bowl and 0.1 ml. from dilution 10 l and spread out with a scraper on a Leetheen-agar slide. Cultivate for 48 hours at 35C.
For O-test exclude Point 3.
The tests are carried out on 5 test persons 3 times, at least 24 hrs. between applications.
For O-test, i.e. non-treated test, 1 series of 5 persons.
1~
~, .
:~' ' ' ' ~ " ' ' ' Other examples of the invention will be clearly apparent to a person skilled in the art, the scope of the invention being defined in the appended claims.
, . ~ .
,
For O-test exclude Point 3.
The tests are carried out on 5 test persons 3 times, at least 24 hrs. between applications.
For O-test, i.e. non-treated test, 1 series of 5 persons.
1~
~, .
:~' ' ' ' ~ " ' ' ' Other examples of the invention will be clearly apparent to a person skilled in the art, the scope of the invention being defined in the appended claims.
, . ~ .
,
Claims (3)
1. A skin ointment consisting of a stable disinfectant gel having a creamy consistency comprising by weight:
ethanol 45 to 95%
glycerine 0.2 to 5.0%
carboxy vinyl polymer 0.2 to 2.0%
a basic amine 0.2 to 2.0%
cetyl alcohol 0.3 to 0.4%
isopropyl myrisate 0.3 to 0.4%
water to make 100%
said carboxy vinyl polymer and said basic amine reacting to form a salt of said carboxy vinyl polymer sufficient to im-part a gel-like consistency to said ointment without inter-fering with the disinfectant activity of the ointment.
ethanol 45 to 95%
glycerine 0.2 to 5.0%
carboxy vinyl polymer 0.2 to 2.0%
a basic amine 0.2 to 2.0%
cetyl alcohol 0.3 to 0.4%
isopropyl myrisate 0.3 to 0.4%
water to make 100%
said carboxy vinyl polymer and said basic amine reacting to form a salt of said carboxy vinyl polymer sufficient to im-part a gel-like consistency to said ointment without inter-fering with the disinfectant activity of the ointment.
2. An ointment according to claim 1, wherein said salt forming amine is selected from the group consisting of triethanol amine, di(2-ethylhexyl) amine, triethylamine and diisopropanolamine.
3. An ointment according to claim 1, wherein said amine is triethanolamine.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE7803646A SE418686B (en) | 1978-03-31 | 1978-03-31 | WATER-BASED SALVATION FOR SKIN INFECTION CONTAINING ALCOHOL AS DISINFECTANT |
| SE7803646-4 | 1978-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1106762A true CA1106762A (en) | 1981-08-11 |
Family
ID=20334453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA310,567A Expired CA1106762A (en) | 1978-03-31 | 1978-09-01 | Skin disinfection ointment |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS54132225A (en) |
| BE (1) | BE871267A (en) |
| CA (1) | CA1106762A (en) |
| DE (1) | DE2854221A1 (en) |
| DK (1) | DK362978A (en) |
| FI (1) | FI782524A (en) |
| FR (1) | FR2420971A1 (en) |
| GB (1) | GB2017491B (en) |
| IT (1) | IT1099818B (en) |
| NL (1) | NL7809664A (en) |
| NO (1) | NO782936L (en) |
| SE (1) | SE418686B (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4382919A (en) | 1980-09-15 | 1983-05-10 | Bristol-Myers Company | Composition for treatment and prevention of malodorous generating skin conditions |
| CH655656B (en) * | 1982-10-07 | 1986-05-15 | ||
| JPS59227818A (en) * | 1983-06-09 | 1984-12-21 | Mitsubishi Chem Ind Ltd | Gel ointment |
| CH643138A5 (en) * | 1983-08-29 | 1984-05-30 | Mepha Ag | INDOMETHACIN CONTAINING, gelatinous OINTMENT. |
| CA1299098C (en) * | 1985-10-28 | 1992-04-21 | John H. White | Alcohol-based antimicrobial compositions |
| US5098717A (en) * | 1987-12-09 | 1992-03-24 | Thames Pharmacal Co., Inc. | Method of treatment for pruritus |
| US5013545A (en) * | 1987-12-09 | 1991-05-07 | Thames Pharmacal Co., Inc. | Aqueous gels containing topical medicaments |
| US5256737A (en) * | 1990-03-05 | 1993-10-26 | Sigma Prodotti Chimici S.P.A. | Thickening agents, processes for the preparation thereof and use thereof |
| PT751789E (en) * | 1994-03-21 | 2002-04-29 | Aase Brown Thomsen | GEL FOR THE TREATMENT OF SKIN DISEASES AND SKIN DISINFECTION |
| FR2785537B1 (en) * | 1999-03-26 | 2001-01-05 | Blue Skin Sa | SOFTENING ANTISEPTIC COMPOSITION AND GEL AND THEIR USE IN SKIN DISINFECTION PROCESSES |
| AUPR028000A0 (en) * | 2000-09-21 | 2000-10-12 | Hair Advisory Centre Pty. Ltd. | Ectoparasite formulation |
| JP4876500B2 (en) | 2005-09-22 | 2012-02-15 | 日油株式会社 | Gel hand sanitizer |
| CN110478293A (en) * | 2019-09-16 | 2019-11-22 | 捷米科技（上海）有限公司 | A kind of disposable disinfection hand cleanser and preparation method thereof |
| EP3919042A1 (en) * | 2020-06-04 | 2021-12-08 | Sil'Innov scrl | Composition with silanol, ethanol and water for global disinfection use |
-
1978
- 1978-03-31 SE SE7803646A patent/SE418686B/en unknown
- 1978-08-17 DK DK362978A patent/DK362978A/en unknown
- 1978-08-18 FI FI782524A patent/FI782524A/en unknown
- 1978-08-23 GB GB7834382A patent/GB2017491B/en not_active Expired
- 1978-08-29 NO NO782936A patent/NO782936L/en unknown
- 1978-09-01 CA CA310,567A patent/CA1106762A/en not_active Expired
- 1978-09-22 NL NL7809664A patent/NL7809664A/en not_active Application Discontinuation
- 1978-10-13 BE BE78191128A patent/BE871267A/en not_active IP Right Cessation
- 1978-10-16 FR FR7829404A patent/FR2420971A1/en active Granted
- 1978-10-20 JP JP12994578A patent/JPS54132225A/en active Pending
- 1978-10-26 IT IT29130/78A patent/IT1099818B/en active
- 1978-12-15 DE DE19782854221 patent/DE2854221A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| NL7809664A (en) | 1979-10-02 |
| IT7829130A0 (en) | 1978-10-26 |
| FI782524A (en) | 1979-10-01 |
| BE871267A (en) | 1979-02-01 |
| SE418686B (en) | 1981-06-22 |
| GB2017491B (en) | 1982-11-24 |
| DK362978A (en) | 1979-10-01 |
| SE7803646L (en) | 1979-10-01 |
| JPS54132225A (en) | 1979-10-15 |
| NO782936L (en) | 1979-10-02 |
| DE2854221A1 (en) | 1979-10-04 |
| IT1099818B (en) | 1985-09-28 |
| FR2420971A1 (en) | 1979-10-26 |
| GB2017491A (en) | 1979-10-10 |
| FR2420971B1 (en) | 1983-02-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |