NO782936L - OINTMENT FOR SKIN INFECTION AND METHOD OF PREPARING THE OINTMENT - Google Patents
OINTMENT FOR SKIN INFECTION AND METHOD OF PREPARING THE OINTMENTInfo
- Publication number
- NO782936L NO782936L NO782936A NO782936A NO782936L NO 782936 L NO782936 L NO 782936L NO 782936 A NO782936 A NO 782936A NO 782936 A NO782936 A NO 782936A NO 782936 L NO782936 L NO 782936L
- Authority
- NO
- Norway
- Prior art keywords
- ointment
- vinyl polymer
- alcohol
- modified vinyl
- ethanol
- Prior art date
Links
- 239000002674 ointment Substances 0.000 title claims description 31
- 238000000034 method Methods 0.000 title claims description 4
- 206010040872 skin infection Diseases 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 61
- 229920002554 vinyl polymer Polymers 0.000 claims description 22
- 238000004659 sterilization and disinfection Methods 0.000 claims description 18
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 16
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 235000011187 glycerol Nutrition 0.000 claims description 8
- 239000004615 ingredient Substances 0.000 claims description 8
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 6
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 3
- 229960000541 cetyl alcohol Drugs 0.000 claims description 3
- 239000000645 desinfectant Substances 0.000 claims description 3
- 238000010790 dilution Methods 0.000 claims description 2
- 239000012895 dilution Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 239000000243 solution Substances 0.000 description 10
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 9
- 239000006071 cream Substances 0.000 description 9
- 241000894006 Bacteria Species 0.000 description 7
- 230000000694 effects Effects 0.000 description 5
- 235000015110 jellies Nutrition 0.000 description 5
- 239000008274 jelly Substances 0.000 description 5
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 241000589516 Pseudomonas Species 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000012456 homogeneous solution Substances 0.000 description 3
- 230000008719 thickening Effects 0.000 description 3
- 241000295644 Staphylococcaceae Species 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- HILAYQUKKYWPJW-UHFFFAOYSA-N 1-dodecylguanidine Chemical compound CCCCCCCCCCCCN=C(N)N HILAYQUKKYWPJW-UHFFFAOYSA-N 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- 206010016322 Feeling abnormal Diseases 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000000721 bacterilogical effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- LVTYICIALWPMFW-UHFFFAOYSA-N diisopropanolamine Chemical compound CC(O)CNCC(C)O LVTYICIALWPMFW-UHFFFAOYSA-N 0.000 description 1
- 229940043276 diisopropanolamine Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- ACGUYXCXAPNIKK-UHFFFAOYSA-N hexachlorophene Chemical compound OC1=C(Cl)C=C(Cl)C(Cl)=C1CC1=C(O)C(Cl)=CC(Cl)=C1Cl ACGUYXCXAPNIKK-UHFFFAOYSA-N 0.000 description 1
- 229960004068 hexachlorophene Drugs 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Natural products OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- 235000013580 sausages Nutrition 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Birds (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Description
Salve for huddesinfeksjon og måteOintment for skin disinfection and manner
til fremstilling av salven.for making the salve.
Denne oppfinnelse vedrører en salve for huddesinfeksjon med alkohol som des infeksjonsmidde1. Oppfinnelsen vedrører dessuten en måte til fremstilling av salven. This invention relates to an ointment for skin disinfection with alcohol as its agent of infection1. The invention also relates to a method for producing the ointment.
Ved de hittil kjente salver av ovennevnte type, er det vanskelig å oppnå høy desinfeksjonseffekt og samtidig opprett-holde nødvendig kremformet konsistens. Salven kan nemlig inne-holde høy desinfeksjonseffekt ved at den tilføres et høyt alko-holinnhold, men salven mister mer av sin kremformede konsistens dess mer alkoholinnholdet og dermed desinfeksjonseffekten økes. With the previously known ointments of the above type, it is difficult to achieve a high disinfection effect and at the same time maintain the necessary creamy consistency. Namely, the ointment can contain a high disinfection effect by adding a high alcohol content, but the ointment loses more of its creamy consistency the higher the alcohol content and thus the disinfection effect is increased.
Formålet med den foreliggende oppfinnelse er å frembringe en salve som har høy desinfeksjonseffekt, samtidig som den har en kremformet konsistens slik at den blir lett å påføre. Salven blir dessuten lett tilgjengelig ved at den kan oppbevares for eksempel i en tube i lommen, og kan derfor'erstatte håndvask i de tilfelle håndvasken utelukkende skulle ha blitt utført i des-inf eksjonshensikt, hvorved tendensen til uttørking av hendene minsker. Dette oppnås ifølge oppfinnelsen hovedsakelig ved at salven inneholder en modifisert vinylpolymer. The purpose of the present invention is to produce an ointment which has a high disinfection effect, while at the same time having a creamy consistency so that it is easy to apply. The ointment is also easily accessible as it can be stored, for example, in a tube in the pocket, and can therefore replace hand washing in cases where the hand washing should have been carried out solely for the purpose of disinfection, whereby the tendency to dry out the hands decreases. According to the invention, this is mainly achieved by the ointment containing a modified vinyl polymer.
Den modifiserte vinylpolymeren tillater at man gir salven en geléartet konsistens. Foruten dette stoffet;.kan andre ingredienser for forskjellige øyemed inngå. Således kan man for å motvirke uttørking av huden tilsette et hudbehandlingsmiddel i form av for eksempel cety1la 1koho1, glyserin eller andre stoff såsom polyglykoler, lanolin, stearinsyre og monoestrer av glyserin og ulikr fettsyrer. The modified vinyl polymer allows the ointment to have a jelly-like consistency. Besides this substance, other ingredients for different purposes may be included. Thus, to counteract drying of the skin, a skin treatment agent can be added in the form of, for example, cetylla 1coho1, glycerin or other substances such as polyglycols, lanolin, stearic acid and monoesters of glycerin and various fatty acids.
For å gi en "myk følelse i hendene" når salven fordeles, kan man benytte isopropylmyristat. To give a "soft feeling in the hands" when the ointment is distributed, isopropyl myristate can be used.
Som alkohol benyttes fortrinnsvis metyll-, etyll- eller propy1la 1koho1 eller blandinger derav. For å oppnå optimal bakteriedrepende effekt benyttes alkoholen fortrinnsvis i 50 - Methyl, ethyl or propyl alcohol or mixtures thereof are preferably used as alcohol. To achieve optimal bactericidal effect, the alcohol is preferably used in 50 -
100 % utspeiding-' med vann.100% reconstitution with water.
For å forlenge virkningstiden kan baktericider tilsettes. Som eksempel på slike kan klorhexidin, Irgasan DP 300, hexa-klorofen, n-dodecylguanidin og cetylpyridiniumklorid nevnes. To extend the duration of action, bactericides can be added. As examples of such, chlorhexidine, Irgasan DP 300, hexa-chlorophene, n-dodecylguanidine and cetylpyridinium chloride can be mentioned.
For å belyse hvordan en salve i henhold til oppfinnelsen kan være sammensatt gjengis følgende eksempel: To illustrate how an ointment according to the invention can be composed, the following example is reproduced:
. Eksempel 1.. Example 1.
Cetylalkohol (0,4%], isopropylmyristat (0,4%], glyserin (0,6%] og trietanolamin (0,5%] blandes i 95% etanol (38,3%] til en klar oppløsningroppnås" (-oppløsning A] . Cetyl alcohol (0.4%], isopropyl myristate (0.4%], glycerin (0.6%] and triethanolamine (0.5%)] are mixed in 95% ethanol (38.3%)) until a clear solution is obtained" (-solution A] .
Vann (32,95%], etanol (26,5%] og modifiserte vinylpolymer blandes til en homogen oppløsning oppnås (oppløsning B]. Water (32.95%], ethanol (26.5%] and modified vinyl polymer are mixed until a homogeneous solution is obtained (solution B).
Oppløsning A tilsettes oppløsning B under omrøring til en klar gelé dannes. Solution A is added to solution B while stirring until a clear jelly forms.
Eksempel 2.Example 2.
Modifiserte vinylpolymer (0,4%] omrøres til en homogen oppløsning i etanol (63%] og vann (34,6%]. Til slutt tilsettes en blanding av vann (1,5%] og trietanolamin (0,5%] hvorved en klar gele dannes. Modified vinyl polymer (0.4%] is stirred to a homogeneous solution in ethanol (63%] and water (34.6%). Finally, a mixture of water (1.5%] and triethanolamine (0.5%)] is added whereby a clear gel is formed.
Eksempel 3.Example 3.
Carboxymety1lee 1lu lose (4%] fuktes med etanol (37%], hvoretter vann (59%] tilsettes. Blandingen omrøres til en homogen gelé . Carboxymety1lee 1lu lose (4%] is moistened with ethanol (37%], after which water (59%)] is added. The mixture is stirred into a homogeneous jelly.
Ved bruk av denne salven får man "pølser" i hendene. E ksémpe1 ' 4 . When using this ointment, you get "sausages" in your hands. Example 1 ' 4 .
Vann (49%], etanol (44,3%] og kolloidal kiselsyre (6,7%] blandes til en homogen gelé oppnås. Water (49%], ethanol (44.3%] and colloidal silicic acid (6.7%)) are mixed until a homogeneous jelly is obtained.
Ved bruk av denne gelé som salve oppnås en seig følelse. Eksempel 5. When using this jelly as an ointment, a chewy feeling is achieved. Example 5.
I stedet for trietanolamin kan andre baser såsom for eksempel trietylamin benyttes, hvilket fremgår av nedenstående: Cetyllalkohol (0,3%], isopropylmyristat (0,3%], glyserin (0,4%] og trietylamin (0,12%] blandes i 95% etanol (26,4%] til en klar oppløsning oppnås (oppløsning A]. Instead of triethanolamine, other bases such as triethylamine can be used, as can be seen from the following: Cetyl alcohol (0.3%], isopropyl myristate (0.3%], glycerin (0.4%] and triethylamine (0.12%)] are mixed in 95% ethanol (26.4%] until a clear solution is obtained (solution A].
Vann (26,7%], etanol (45,4%] og modifiserte vinylpolymer (0,38%] blandes til en homogen oppløsning oppnås (oppløsning B]. Water (26.7%], ethanol (45.4%] and modified vinyl polymer [0.38%] are mixed until a homogeneous solution is obtained (solution B).
Oppløsning A tilsettes oppløsning B under omrøring til en klar gelé dannes. Solution A is added to solution B while stirring until a clear jelly forms.
Salvene som angitt i eksempel 1, 2 og 5 egner seg svært godt for utstrykning på huden, og gir en behagelig følelse av smidighet siden etanolen har dunstet bort. The ointments as indicated in examples 1, 2 and 5 are very suitable for spreading on the skin, and give a pleasant feeling of suppleness since the ethanol has evaporated.
En forutsetning for å benytte salver av denne typen er at alkoholens desinfiserende effekt ikke minskes eller elimineres. For å undersøke dette har følgende bakteriologiske utprøvning blitt gjort: Ved blandingen av ingrediensene kan et basisk stoff således tilsettes som avsluttende blandingsmoment. Som følge derav blir blandingen lettflytende frem til siste sluttfase, mens den i blandingen benyttede syre av modifiserte vinylpolymer i siste sluttfase omdannes av det basiske stoffet, for eksempel trietanolamin, di(z-ety11hexy1)amin, trietylamin eller diiso-propanolamin til et salt av modifiserte vinylpolymer med en deravfølgende meget kraftig fortykkning av blandingen. A prerequisite for using ointments of this type is that the disinfecting effect of the alcohol is not reduced or eliminated. To investigate this, the following bacteriological test has been carried out: When mixing the ingredients, a basic substance can thus be added as a final mixing step. As a result, the mixture becomes easy-flowing until the last final phase, while the acid of modified vinyl polymer used in the mixture is converted in the last final phase by the basic substance, for example triethanolamine, di(z-ethyl11hexy1)amine, triethylamine or diiso-propanolamine into a salt of modified vinyl polymer with a consequent very strong thickening of the mixture.
Denne blandingsmetode er således fordelaktig, dog kan man "oppløse" syren av modifiserte vinylpolymer i for eksempel 70% alkohol for seg og for eksempel trietanolamin og øvrige ingredienser i for eksempel 95% alkohol for seg, hvoretter de separate blandingene sammenføres som siste blandingsmoment, hvorved den kraftige fortykkningen oppnås. This mixing method is thus advantageous, however, one can "dissolve" the acid of modified vinyl polymer in, for example, 70% alcohol separately and, for example, triethanolamine and other ingredients in, for example, 95% alcohol separately, after which the separate mixtures are combined as the final mixing step, whereby the strong thickening is achieved.
En annen mulighet er å benytte en modifisert vinylpolymer som direkte ved innblandingen gir fortykkning. Another possibility is to use a modified vinyl polymer which directly when mixed in gives thickening.
Den oppnådde komposisjonen fremviste smidig, kremformet konsistens. The resulting composition exhibited smooth, creamy consistency.
Metode for testing av spritkrem.Method for testing alcohol cream.
Bakterier oppdyrkes på samme måte som ved utførelse av desinfeksjonsforsøk ifølge Kjellander, der siste trinnet inne-bærer sentrifugering av oppdyrkede bakterier og siden oppslam-ning i inaktivert hesteblod. Inokulatet skal bli ca. 10 7 - 108<,>og eventuell korrigering ved oppslamni ngen for eventuelle avdøde bakterier ved påføring av grambakterier. 1. Vask hendene omhyggelig før forsøket begynner og behandl dem med sprit. La tørke. 2. Påfør 0,2 ml i håndflaten, gni inn i 5 sekund med vens-tre pekefinger. La tørke i ca. 5-10 minutt. 3. 2 ml sprit eller spritkrem påføres. 30 sekunders gnid-ing slik at hele hånden dekkes. La lufttørke i ca. 2 minutter. 4. Vask hendene i 5 minutter i en liten plateskål som inneholder 250 ml Leetheenbu1jong. 5. Ta 0,1 ml fra vaskefat, og 0,1 ml fra spedning 10_ 1 og spred med sparkel på leetheenagarplate. Dyrk i 48 timer ved 35°C. Bacteria are cultured in the same way as when carrying out disinfection experiments according to Kjellander, where the last step involves centrifugation of cultured bacteria and then suspension in inactivated horse blood. The inoculum should be approx. 10 7 - 108<,>and possible correction during the suspension for any dead bacteria when applying Gram bacteria. 1. Wash your hands thoroughly before starting the experiment and treat them with alcohol. Let dry. 2. Apply 0.2 ml in the palm of the hand, rub in for 5 seconds with the third index finger. Let dry for approx. 5-10 minutes. 3. 2 ml alcohol or alcohol cream is applied. 30 seconds of rubbing so that the whole hand is covered. Allow to air dry for approx. 2 minutes. 4. Wash your hands for 5 minutes in a small plate bowl containing 250 ml of Leetheenbu1jong. 5. Take 0.1 ml from the wash dish, and 0.1 ml from dilution 10_ 1 and spread with a spatula on a leetheenagar plate. Grow for 48 hours at 35°C.
For kontro1lprøve utelukk punkt 3.For control test exclude item 3.
Forsøkene utføres på 5 forsøkspersoner 3 ganger med minst 1 døgn mellom hver påføring. The experiments are carried out on 5 subjects 3 times with at least 1 day between each application.
For kontrollprøve dvv.s. ubehandlet prøve 1 serie medFor control test dvv.s. untreated sample 1 series with
5 personer.5 people.
Sammendrag av resultatet i form av inaktiveringsfaktorer. Pseudomonas. Summary of the result in the form of inactivation factors. Pseudomonas.
Staphylococcer Enterococcer Enterococcer tatt direkte fra buljong Staphylococci Enterococci Enterococci taken directly from broth
Resultat: Totale antallet bakterier som fantes på hånden etter Result: Total number of bacteria found on the hand after
vask.wash.
Kontrollvask for PseudomonasControl wash for Pseudomonas
Hånddesihfeksjon med 62 % ( vektprosent) Spritkrem. Hand sanitizer with 62% (percent by weight) alcohol cream.
3 forskjellige anledninger med 5 personer. 3 different occasions with 5 people.
Hånddesinfeksjon med 70 % ( vektprosent) Spritkrem. Hand disinfection with 70% (percentage by weight) alcohol cream.
3 forskjellige anledninger.3 different occasions.
Hånddesinf eks jon med 62 % ( vektprosent) vanlig Sprit. Hand sanitizer with 62% (percentage by weight) regular alcohol.
3 forskjellige anledninger.3 different occasions.
Kontrollvask for Staphylococcer. Control wash for Staphylococci.
6,0 x 10<7>6.0 x 10<7>
4,8 x 10<7>4.8 x 10<7>
5.3 x 10<7>5.3 x 10<7>
2,7 x 10<7>' 2.7 x 10<7>'
3.4 x 10<7>3.4 x 10<7>
2.5 x 10<7>2.5 x 10<7>
Gjennomsnitt: 4,1 x 10<7>Average: 4.1 x 10<7>
Hånddesinfeksjon med 62 % ( vektprosent) Spritkrem. Hand disinfection with 62% (percentage by weight) Alcohol cream.
3 forskjellige anledninger.3 different occasions.
Hånddesinfeksjon med 70 % ( vektprosent) Spritkrem. Hand disinfection with 70% (percentage by weight) alcohol cream.
3 forskjellige anledninger.3 different occasions.
Hånddesinfeksjon med 62 % ( vektprosent) vanlig Sprit. Hand disinfection with 62% (percentage by weight) regular alcohol.
3 forskjellige anledninger. 3 different occasions.
Kontrollvask for Enterococcer. Control wash for Enterococci.
6,5 x 10<7>6.5 x 10<7>
7,3 x 10<7>7.3 x 10<7>
7,0 x 10<7>7.0 x 10<7>
6,3 x 10<7>6.3 x 10<7>
7,3 x 10<7>7.3 x 10<7>
Gjennomsnitt: 6,9 x 10<7>Average: 6.9 x 10<7>
Hånddesinfeksjon med 62 % ( vektprosent) Spritkrem. Hand disinfection with 62% (percentage by weight) Alcohol cream.
3 forskjellige anledninger. 3 different occasions.
Hånddesinfeksjon med 70 % ( vektprosent) Spritkrem. Hand disinfection with 70% (percentage by weight) alcohol cream.
3 forskjellige anledninger.3 different occasions.
Hånddesinfeksjon med 62 % ( vektprosent) vanlig Sprit. Hand disinfection with 62% (percentage by weight) regular alcohol.
3 forskjellige anledninger3 different occasions
□ mtest på Pseudomonas. ( oppsjekking av om en ny sending ferskt blod hadde noen innvirkning). □ mtest on Pseudomonas. (checking whether a new batch of fresh blood had any effect).
Hånddesinfeksjori med 62,% ( vektprosent) Spritkrem. Enterococcer. Bakteriene er tatt fra buljong, ikke oppslammet i blod. Hand disinfectant with 62.% (percentage by weight) Alcohol cream. Enterococci. The bacteria are taken from broth, not suspended in blood.
Hånddesinfeksjon med 62 % ( vektprosent) vanlig Sprit. Enterococcer. Hand disinfection with 62% (percentage by weight) regular alcohol. Enterococci.
Bakteriene er tatt fra buljong, ikke oppslammet i blod.The bacteria are taken from broth, not suspended in blood.
Salven i henhold til oppfinnelsen er ikke begrenset til de i eksempel 1, 2 og 3 beskrevne variantene. Salvens sammen-setning kan variere såvel når det gjelder typen på, som størrel-sen av, ingrediensene. Således kan salven være sammensatt i overensstemmelse med følgende (de i parantes angitte prosenttall gjelder vektprosent, hvilket også gjelder i eksempel 1-5): The ointment according to the invention is not limited to the variants described in examples 1, 2 and 3. The composition of the ointment can vary both in terms of the type and size of the ingredients. Thus, the ointment can be composed in accordance with the following (the percentages given in parentheses apply to percentage by weight, which also applies in examples 1-5):
Eksempe1 6.Example 1 6.
Trietanolamin(0,2%), glyserin(5%), etanol(45%), modifisert vinylpolymer(0,2%) og varin(49,6%). Triethanolamine (0.2%), glycerine (5%), ethanol (45%), modified vinyl polymer (0.2%) and varian (49.6%).
E ksempe1 7.Example 1 7.
Trietanolamin(2%), glyserin(0,2%), etanol(95%), modifisert vinylpolymer(2%) og vann(0,8%). Triethanolamine (2%), glycerin (0.2%), ethanol (95%), modified vinyl polymer (2%) and water (0.8%).
Av eksempel 6 og 7 fremgår de vesentligste ingrediensene i salven i henhold til oppfinnelsen. Dessuten fremgår at pro-sentinnholdet av de benyttede ingrediensene kan variere i en viss utstrekning under fastholdelse av salvens hovedsakelige egenskaper. Prosenttallene på de hovedsakelige ingrediensene kan variere på følgende måte: Examples 6 and 7 show the most important ingredients in the ointment according to the invention. It also appears that the percentage content of the ingredients used can vary to a certain extent while maintaining the salve's main properties. The percentages of the main ingredients can vary as follows:
Som modifisert vinylpolymer har man i ovennevnte eksempel benyttet karboxylert vinylpolymer, men. alternative modifiserte vinylpolymer kan komme til anvendelse. As modified vinyl polymer, carboxylated vinyl polymer has been used in the above example, but. alternative modified vinyl polymers may be used.
Claims (6)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE7803646A SE418686B (en) | 1978-03-31 | 1978-03-31 | WATER-BASED SALVATION FOR SKIN INFECTION CONTAINING ALCOHOL AS DISINFECTANT |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO782936L true NO782936L (en) | 1979-10-02 |
Family
ID=20334453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO782936A NO782936L (en) | 1978-03-31 | 1978-08-29 | OINTMENT FOR SKIN INFECTION AND METHOD OF PREPARING THE OINTMENT |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS54132225A (en) |
| BE (1) | BE871267A (en) |
| CA (1) | CA1106762A (en) |
| DE (1) | DE2854221A1 (en) |
| DK (1) | DK362978A (en) |
| FI (1) | FI782524A (en) |
| FR (1) | FR2420971A1 (en) |
| GB (1) | GB2017491B (en) |
| IT (1) | IT1099818B (en) |
| NL (1) | NL7809664A (en) |
| NO (1) | NO782936L (en) |
| SE (1) | SE418686B (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4382919A (en) | 1980-09-15 | 1983-05-10 | Bristol-Myers Company | Composition for treatment and prevention of malodorous generating skin conditions |
| CH655656B (en) * | 1982-10-07 | 1986-05-15 | ||
| JPS59227818A (en) * | 1983-06-09 | 1984-12-21 | Mitsubishi Chem Ind Ltd | Gel ointment |
| CH643138A5 (en) * | 1983-08-29 | 1984-05-30 | Mepha Ag | INDOMETHACIN CONTAINING, gelatinous OINTMENT. |
| CA1299098C (en) * | 1985-10-28 | 1992-04-21 | John H. White | Alcohol-based antimicrobial compositions |
| US5013545A (en) * | 1987-12-09 | 1991-05-07 | Thames Pharmacal Co., Inc. | Aqueous gels containing topical medicaments |
| US5098717A (en) * | 1987-12-09 | 1992-03-24 | Thames Pharmacal Co., Inc. | Method of treatment for pruritus |
| US5256737A (en) * | 1990-03-05 | 1993-10-26 | Sigma Prodotti Chimici S.P.A. | Thickening agents, processes for the preparation thereof and use thereof |
| CA2186045A1 (en) | 1994-03-21 | 1995-09-28 | Jens Christian Moller | Gel for treatment of skin diseases and for disinfection of the skin |
| FR2785537B1 (en) * | 1999-03-26 | 2001-01-05 | Blue Skin Sa | SOFTENING ANTISEPTIC COMPOSITION AND GEL AND THEIR USE IN SKIN DISINFECTION PROCESSES |
| AUPR028000A0 (en) * | 2000-09-21 | 2000-10-12 | Hair Advisory Centre Pty. Ltd. | Ectoparasite formulation |
| JP4876500B2 (en) | 2005-09-22 | 2012-02-15 | 日油株式会社 | Gel hand sanitizer |
| CN110478293A (en) * | 2019-09-16 | 2019-11-22 | 捷米科技（上海）有限公司 | A kind of disposable disinfection hand cleanser and preparation method thereof |
| EP3919042A1 (en) * | 2020-06-04 | 2021-12-08 | Sil'Innov scrl | Composition with silanol, ethanol and water for global disinfection use |
-
1978
- 1978-03-31 SE SE7803646A patent/SE418686B/en unknown
- 1978-08-17 DK DK362978A patent/DK362978A/en unknown
- 1978-08-18 FI FI782524A patent/FI782524A/en unknown
- 1978-08-23 GB GB7834382A patent/GB2017491B/en not_active Expired
- 1978-08-29 NO NO782936A patent/NO782936L/en unknown
- 1978-09-01 CA CA310,567A patent/CA1106762A/en not_active Expired
- 1978-09-22 NL NL7809664A patent/NL7809664A/en not_active Application Discontinuation
- 1978-10-13 BE BE78191128A patent/BE871267A/en not_active IP Right Cessation
- 1978-10-16 FR FR7829404A patent/FR2420971A1/en active Granted
- 1978-10-20 JP JP12994578A patent/JPS54132225A/en active Pending
- 1978-10-26 IT IT29130/78A patent/IT1099818B/en active
- 1978-12-15 DE DE19782854221 patent/DE2854221A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| NL7809664A (en) | 1979-10-02 |
| SE7803646L (en) | 1979-10-01 |
| FI782524A (en) | 1979-10-01 |
| BE871267A (en) | 1979-02-01 |
| FR2420971B1 (en) | 1983-02-25 |
| DE2854221A1 (en) | 1979-10-04 |
| IT1099818B (en) | 1985-09-28 |
| IT7829130A0 (en) | 1978-10-26 |
| CA1106762A (en) | 1981-08-11 |
| JPS54132225A (en) | 1979-10-15 |
| GB2017491A (en) | 1979-10-10 |
| FR2420971A1 (en) | 1979-10-26 |
| GB2017491B (en) | 1982-11-24 |
| SE418686B (en) | 1981-06-22 |
| DK362978A (en) | 1979-10-01 |
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