SE418686B - WATER-BASED SALVATION FOR SKIN INFECTION CONTAINING ALCOHOL AS DISINFECTANT - Google Patents

WATER-BASED SALVATION FOR SKIN INFECTION CONTAINING ALCOHOL AS DISINFECTANT

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Publication number
SE418686B
SE418686B SE7803646A SE7803646A SE418686B SE 418686 B SE418686 B SE 418686B SE 7803646 A SE7803646 A SE 7803646A SE 7803646 A SE7803646 A SE 7803646A SE 418686 B SE418686 B SE 418686B
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SE
Sweden
Prior art keywords
weight
ointment
alcohol
ethanol
vinyl polymer
Prior art date
Application number
SE7803646A
Other languages
Swedish (sv)
Other versions
SE7803646L (en
Inventor
A Svanberg
H Widestrom
Original Assignee
Landstingens Inkopscentral
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Landstingens Inkopscentral filed Critical Landstingens Inkopscentral
Priority to SE7803646A priority Critical patent/SE418686B/en
Priority to DK362978A priority patent/DK362978A/en
Priority to FI782524A priority patent/FI782524A/en
Priority to GB7834382A priority patent/GB2017491B/en
Priority to NO782936A priority patent/NO782936L/en
Priority to CA310,567A priority patent/CA1106762A/en
Priority to NL7809664A priority patent/NL7809664A/en
Priority to BE78191128A priority patent/BE871267A/en
Priority to FR7829404A priority patent/FR2420971A1/en
Priority to JP12994578A priority patent/JPS54132225A/en
Priority to IT29130/78A priority patent/IT1099818B/en
Priority to DE19782854221 priority patent/DE2854221A1/en
Publication of SE7803646L publication Critical patent/SE7803646L/en
Publication of SE418686B publication Critical patent/SE418686B/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Description

7803646'4 2 monoestrar av glycerin och olika fettsyror. 7803646'4 2 monoesters of glycerin and various fatty acids.

För att ge “mjuk känsel i händerna" när salvan fördelas kan isopropylmyristat an- vändas.To give a "soft feeling in the hands" when the ointment is distributed, isopropyl myristate can be used.

Som alkohol användes såsom angivits företrädesvis metyl-, etyl- eller propylalkohol eller blandningar därav. För att uppnå optimal bakteriedödande effekt användes alkoho- len företrädesvis i 50 - 100 %-ig utspädning med vatten.As alcohol, methyl, ethyl or propyl alcohol or mixtures thereof are preferably used as indicated. To achieve optimal bactericidal effect, the alcohol is preferably used in 50 - 100% dilution with water.

För att förlänga verkningstiden kan baktericider tillsättas. Som exempel på dylika kan klorhexidin, Irgasan DP 300, hexaklorofen, n-dodecylguanidin och cetylpyridinium- klorid nämnas. 4 För att belysa hur en salva enligt uppfinningen kan vara sammansatt återgesïFöljan~ de exempel: I Exempel l. 4 Cetylalkohol (0,4 vikt-%), isopropylmyristat (0,4 vikt-%), glycerin (0,6 vikt-%) och trietanolamin (0,5 vikt-%) blandas i 95 %-ig etanol (38,3 vikt-%) tills dess att klar lösning erhålles (lösning A).To prolong the duration of action, bactericides can be added. Examples of such are chlorhexidine, Irgasan DP 300, hexachlorophene, n-dodecylguanidine and cetylpyridinium chloride. To illustrate how an ointment according to the invention may be composed, the following examples are given: In Example 1. 4 Cetyl alcohol (0.4% by weight), isopropyl myristate (0.4% by weight), glycerin (0.6% by weight ) and triethanolamine (0.5% by weight) are mixed in 95% ethanol (38.3% by weight) until a clear solution is obtained (solution A).

Vatten (32,95 vikt-%), etanol (26,5 vikt-%) och karboxylerad vinylpolymer blandas tills dess att homogen lösning erhålles (lösning B).Water (32.95% by weight), ethanol (26.5% by weight) and carboxylated vinyl polymer are mixed until a homogeneous solution is obtained (solution B).

Lösning A tillsättes lösning B under omrörning tills en klar gel bildats.Solution A is added to solution B with stirring until a clear gel is formed.

Exempel 2.' Karboxylerad vinylpolymer (0,4 vikt-%) omröres till homogen lösning i etanol (63 vikt-%) och vatten (34,6 vikt-%). Slutligen tillsättes en blandning av vatten (1,5 vikt- -%) och trietanolamin (0,5 vikt-%) varvid en klar gel bildas.Example 2. ' Carboxylated vinyl polymer (0.4% by weight) is stirred to homogeneous solution in ethanol (63% by weight) and water (34.6% by weight). Finally, a mixture of water (1.5% by weight) and triethanolamine (0.5% by weight) is added to form a clear gel.

Exempei 3. 4 e Carboxymetylcellulosa (4 vikt-%) fuktas med etanol (37 vikt-%), varefter vatten (59 vikt-%) tillsättes. Blandningen omröres till en homogen gel. 4 Vid användning av denna salva erhålles "korvar" i händerna.Example 3. 4 e Carboxymethylcellulose (4% by weight) is moistened with ethanol (37% by weight), after which water (59% by weight) is added. The mixture is stirred into a homogeneous gel. 4 When using this ointment, "sausages" are obtained in the hands.

Exempel 4.Example 4.

Vatten (49 vikt-%), etanol (44,3 vikt-%) och kolloidal kiselsyra (6,7 vikt-%) blan- das tills en homogen gel erhålles.Water (49% by weight), ethanol (44.3% by weight) and colloidal silicic acid (6.7% by weight) are mixed until a homogeneous gel is obtained.

Vid användning av denna gel såsom salva erhålles en kärv känsel.When using this gel as an ointment, a harsh feeling is obtained.

Exempel 5. n I stället för trietanolamin kan andra baser såsom t.ex. trietylamin användas, vil- ket framgår av nedanstående: Cetylalkohol (0,3 vikt-%), isopropylmyristat (0,3 vikt-%), glycerin (0,4 vikt-%) och trietylamin (0,l2 vikt-%) blandas i 95 %-ig etanol (26,4 vikt-%) tills dess att klar lösning erhålles (lösning A).Example 5. n Instead of triethanolamine, other bases such as e.g. triethylamine is used, as shown in the following: Cetyl alcohol (0.3% by weight), isopropyl myristate (0.3% by weight), glycerin (0.4% by weight) and triethylamine (0.2% by weight) are mixed in 95% ethanol (26.4% by weight) until a clear solution is obtained (solution A).

Vatten (26,7 vikt-%), etanol (45,4 vikt-%) och karboxylerad vinylpolymer (0,38 vikt-%) blandas tills dess att homogen lösning erhålles (lösning B).Water (26.7% by weight), ethanol (45.4% by weight) and carboxylated vinyl polymer (0.38% by weight) are mixed until a homogeneous solution is obtained (solution B).

Lösning A tillsättes lösning B under omrörning tills en klar gel bildats.Solution A is added to solution B with stirring until a clear gel is formed.

Salvorna enligt exempel 1, 2 och 5 lämpar sig mycket väl för utstrykning på huden a 7803646-4 och ger en behaglig känsla av smidighet sedan etanolen avdunstat.The ointments according to Examples 1, 2 and 5 are very well suited for smearing on the skin a 7803646-4 and give a pleasant feeling of suppleness after the ethanol has evaporated.

En förutsättning för användandet av salvor av denna typ är att alkoholens desinfi- cerande effekt ej minskas eller elimineras. För att undersöka detta har följande bakte- riologiska utvärdering gjorts: I Vid blandningen av ingredienserna kan ett basiskt ämne således tillsättas som av- slutande blandningsmoment. Till följd därav blir blandningen lättflytande fram till si- sta skedet medan i blandningen ingående syra av karboxylerad vinylpolymer i sista ske- det omvandlas av det basiska ämnet, till exempel trietanolamin, di(z-etyl-hexyl)amin, trietylamin eller diisopropanolamin till ett salt av karboxylerad vinylpolymer med ty åtföljande mycket kraftig förtjockning av blandningen. I ~ Detta blandningsförfarande är således fördelaktigt, dock kan man "lösa" syran av karboxylerad vinylpolymer i exempelvis 70 %-ig alkohol för sig och exempelvis trietano- lamin och övriga ingredienser i t.ex. 95 %-ig alkohol för sig, varefter de separata blandningarna sammanföres såsom sista blandningsmoment, varvid den kraftiga förtjocknin- gen erhålles.A prerequisite for the use of ointments of this type is that the disinfectant effect of alcohol is not reduced or eliminated. To investigate this, the following bacteriological evaluation has been made: I When mixing the ingredients, a basic substance can thus be added as the final mixing element. As a result, the mixture becomes readily liquid until the last stage, while the acid of carboxylated vinyl polymer contained in the mixture is finally converted by the basic substance, for example triethanolamine, di (z-ethyl-hexyl) amine, triethylamine or diisopropanolamine to a salt of carboxylated vinyl polymer with consequent very strong thickening of the mixture. This mixing process is thus advantageous, however, one can "dissolve" the acid of carboxylated vinyl polymer in, for example, 70% alcohol alone and for example triethanolamine and other ingredients in e.g. 95% alcohol separately, after which the separate mixtures are combined as the last mixing step, whereby the strong thickening is obtained.

En annan möjlighet är att använda en karboxylerad vinylpolymer som direkt vid in- blandningen ger förtjockning.Another possibility is to use a carboxylated vinyl polymer which directly thickens upon mixing.

Det erhållna kompositionen uppvisade smidig, gelartad konsistens.The resulting composition showed a smooth, gelatinous consistency.

Metod för testning av spritkräm.Method for testing spirit cream.

Bakterier uppodlas på samma sätt som vid utförande av desinf.försök enligt Kjellan- der, där sista steget innebär centrifugering av uppodlade bakterier och sedan uppslam- ning i inaktiverat hästblod. Inokulatet skall bli ca 107 - 108 och eventuell korrigering vid uppslamningen för eventuell avdödning vid applicering av grambakterier. ' 1. Tvätta händerna ordentligt innan försöket börjar och behandla dem med sprit. Låt torka. 2. Applicera 0,2 ml i handflatan, gnugga in 5 sek med vänster pekfinger. Lät torka i ca-5-10 min. ' a 3. 2 ml sprit eller spritkräm appliceras. 30 sekunders gnuggning så att hela handen täcks. Låt lufttorka i ca 2 min. ~ 4. Tvätta handen 5 min. i en liten plåtskål innehållande 250 ml Leetheenbuljong. 5. Tag 0,1 ml från tvättfat, och 0,1 ml från spädning 10-1 och sprid med rackla på leetheenagarplatta. Odla 48 tim vid 35°C.Bacteria are cultured in the same way as when performing disinfection experiments according to Kjellander, where the last step involves centrifugation of cultured bacteria and then slurry in inactivated horse blood. The inoculum should be about 107 - 108 and any correction in the slurry for possible killing when applying gram bacteria. 1. Wash your hands thoroughly before starting the experiment and treat them with alcohol. Let dry. 2. Apply 0.2 ml in the palm of your hand, rub in for 5 seconds with your left index finger. Let dry for about 5-10 min. 'a 3. 2 ml of spirit or cream is applied. 30 seconds rubbing so that the whole hand is covered. Let air dry for about 2 min. ~ 4. Wash your hand 5 min. in a small metal bowl containing 250 ml of Leetheen broth. 5. Take 0.1 ml from washbasin, and 0.1 ml from dilution 10-1 and spread with a spatula on a leetheen agar plate. Cultivate for 48 hours at 35 ° C.

För 0 prov uteslut punkt 3. _ Försöken utföres på 5 försökspersoner 3 ggr minst 1 dygn mellan varje applicering.For 0 tests, exclude point 3. _ The tests are performed on 5 subjects 3 times at least 1 day between each application.

För 0 prov dvs. obehandlat prov 1 serie om 5 personer.For 0 samples ie. untreated sample 1 series of 5 people.

Sammandrag av resultatet i form av inaktiveringsfaktorer.Summary of the result in the form of deactivation factors.

Pseudomonas. sz vikt-z spricka-am: - 4,5 x m2 ro vikt-x spritkram: _ 9,7 x m2 ævma%mmmsmn= 4¿x1ß 70 vikt-“ spritkräm: 3,2 x 102 (kontroll av ny sändning färskt blod) 7803611641 4 Staphy1ococcer 52 vikt-z spritxräm: 4,4 x 104 70 vikt-z spritkräm ' 5,1 x 104 62 vikt-% vanlig sprit 6,0 x 104 Enterococcer 5 7 02 vikt-z sprnakräm; 7,5 x 101 70 vikt-% spritkräm: 7,8 x 104 62 vikt-% van1ig sprit: 1,5 X 102 Enterococcer tagna direkt från bu1jong 62 vikt-% spritkräm; > 4,3 x 102 52 vikt-z 0511119 sprit: 4,9 x 108 Resu1tat: Tota1a antaïet bakterier som fanns på handen efter tvätt.Pseudomonas. sz weight-z crack-am: - 4,5 x m2 row weight-x alcohol hug: _ 9.7 x m2 ævma% mmmsmn = 4¿x1ß 70 weight- “alcohol cream: 3.2 x 102 (check of new shipment fresh blood) 7803611641 4 Staphylococcus 52 wt-z alcohol cream: 4.4 x 104 70 wt-z alcohol cream '5.1 x 104 62 wt% regular alcohol 6.0 x 104 Enterococcer 5 7 02 wt-z alcohol cream; 7.5 x 101 70% by weight of spirit cream: 7.8 x 104 62% by weight of ordinary spirit: 1.5 X 102 Enterococcus taken directly from broth 62% by weight of spirit cream; > 4.3 x 102 52 wt-z alcohol: 4.9 x 108 Result: Tota1a antaïet bacteria that were on hand after washing.

Kontro11tvätt för Pseudomonas 1,9 x 108 5,0 x 108 1,0 x 108 4 5,0 x 108 1,0 x 108 5,0 x 108 1,4 x 108 3,5 x 108 1,7 x 108 Genomsnitt: 3,0 x 108 Handdesinfektion med 62 vikt-% spritkräm. 3 oïika ti11fä11en med 5 personer. 7,0 x 105 2,5 x 104 2,5 0,0 x 105 2,0 x 105 1,2 1,7 x 105 1,5 x 105 7,5 2,0 x 105 1,3 x 105 2,3 7,4 x 105 3,0 x 105 1,5 Genomsnitt: 6,7 X 105.Control wash for Pseudomonas 1.9 x 108 5.0 x 108 1.0 x 108 4 5.0 x 108 1.0 x 108 5.0 x 108 1.4 x 108 3.5 x 108 1.7 x 108 Average : 3.0 x 108 Hand disinfection with 62% by weight of alcohol cream. 3 oïika ti11fä11en with 5 people. 7.0 x 105 2.5 x 104 2.5 0.0 x 105 2.0 x 105 1.2 1.7 x 105 1.5 x 105 7.5 2.0 x 105 1.3 x 105 2 .3 7.4 x 105 3.0 x 105 1.5 Average: 6.7 X 105.

Handdesinfektion med 70 vikt-% spritkräm. 3 01ika ti11fä11en. 5 _ 2,5 x 10 , 3,2 x 105 3,0 5 s 1,8 x 10 1,0 x 10 1,3 7,5 x 104 5,0 x 104 5,0 2,3 x 105 2,5 x 104 - 1,5 1,3 x 105 2,5 x 104 5,3 Genomsnitt: 3,1 x 105.Hand disinfection with 70% by weight of alcohol cream. 3 01ika ti11fä11en. 5 _ 2.5 x 10, 3.2 x 105 3.0 5 s 1.8 x 10 1.0 x 10 1.3 7.5 x 104 5.0 x 104 5.0 2.3 x 105 2 .5 x 104 - 1.5 1.3 x 105 2.5 x 104 5.3 Average: 3.1 x 105.

Handdesinfektion med 62 vikt-% vanlig sprit. 3 o1ika ti11fä11en 3,0 x 105 5,3 x 105 1,0 2.5 11105 2.5 x 104 e 1.3 1,3 x 105 5,0 x 105 1,5 5 7803646-4 3,0 X 105 5 1,3 X 106 5,0 X 106 3,0 X 106 1,0 X 106 5,3 X 106 0555555151: 7,2 X 106 6 K0ntro11tvätt för Staphyïococcer. 5,0 X 107 4,3 X 107 5,3 X 107 2,7 X 107 3,4 X 107 2,5 X 107 Genomsnitt: 4,1 x 107.Hand disinfection with 62% by weight of ordinary alcohol. 3 o1ika ti11fä11en 3.0 x 105 5.3 x 105 1.0 2.5 11105 2.5 x 104 e 1.3 1.3 x 105 5.0 x 105 1.5 5 7803646-4 3.0 X 105 5 1.3 X 106 5.0 X 106 3.0 X 106 1.0 X 106 5.3 X 106 0555555151: 7.2 X 106 6 K0ntro11tvätt för Staphyïococcer. 5.0 X 107 4.3 X 107 5.3 X 107 2.7 X 107 3.4 X 107 2.5 X 107 Average: 4.1 x 107.

Handdesinfektion med 62 vikt-% spritkräm. 3 oïika ti11fä11en. 1,3 X 106 1,5 X 106 1,4 X 106 5,0 X 106 4,0 X 106 3,3 X 105 1,5 X 105 1,4 X 106 1,3 X 106 7,5 X 106 3,3 X 106 3,3 X 106 1,5 X 106 2,0 X 106 Genomsnitt: 9,3 x 105 Handdesinfektion med 70 vikt-% spritkräm. 3 oïika tiïïfäiïen. 1,0 X 10: 5,5 X 10: 3,5 X 10: 6,5 x 10 8,5 x 10 3,8 x 10 1,3 X 106 1,3 X 106 7,5 X 104 2,0 X 106 1,0 X 106 5,0 X 104 2,0 X 106 1,0 X 106 3,0 X 106 Genomsnitt: 6,7 x 105 Handdesinfektion med 62 vikt-% vanlig sprit. 3 oiika ti11fä11en; 7,5 X 106 3,3 X 106 1,3 X 106 5,5 X 106 3,3 X 106 ~ 3,0 X 106 2,5 X 106 7,5 X 106 5,0 X 106 5,5 X 106 3,5 X 106 3,3 X 106 1,3 X 106 7,3 X 106 5,3 X 106 Genomsnitt: 6,8 x 105 Kontroïitvätt för Enterococcer. 5,5 X 107 7,3 X 107 7,0 X 107 5,3 X 107 7,3 X 107 7503515-4 , Genomsnitt: 6,9 x 107 Handdesinfektion med 62 vikt-% spritkräm. 3 olika tiïifäiïen. 7,5 X 105 2,0 X 105 5,3 X 105 7,3 X 105 _7,s X 105 1,3 X 105 1,5 X 105 3,0 X 105 3,5 X 105 3,3 X 105 5,0 X 105 2,9 X 105 7,0 X 105 5 2,5 X 104 5,0 X 104 Genomsnitt; 9,2 X 105 Handdesinfektion med 70 vikt-% spritkräm. 3 olika tiïifälien. 1,3 X 105 9,5 X 105 3,0 X 105 5,0 X 104 7,5 X 104 2,5 X 104 1,5 X 105 5,3 X 105 2,0 X 105 1,0 X 105 3,5 X 105 5,3 X 105 ' 2,0 X 105 2,5 X 104 3,5 X 105 Genomsnitt: 8,9 x 105 Handdesinfektion med 62 vikt-% vaniig sprit. 3 oïika tiïifäilen. I 1,0 X 105 1,0 X 105 1,7 X 105 5,3 X 105 2,3 X 105 5,0 X 105 3,0 X 105 1,0 X 105 3,7 X 105 4,5 X 105 5,0 X 104 s,s X 105 4,5 X 105 3,0 X 105 1,3 X 105 Genomsnitt: 4,5 x 105 Omprov på Pseudomonas. (UppkoT1ning av om en ny sändning färskt blod hade någon inverk- 1,0 X 105 2,5 X 104 4,0 X 104 3,0 X 105 3,5 X 104 1,3 X 105 1,0 X 105 7,5 X 105 2,0 X 105 Genomsnitt: 9,4 x 105 Handdesinfektion med 62 vikt#% spritkräm. Enterococcer.Hand disinfection with 62% by weight of alcohol cream. 3 oïika ti11fä11en. 1.3 X 106 1.5 X 106 1.4 X 106 5.0 X 106 4.0 X 106 3.3 X 105 1.5 X 105 1.4 X 106 1.3 X 106 7.5 X 106 3.3 X 106 3.3 X 106 1.5 X 106 2.0 X 106 Average: 9.3 x 105 Hand disinfection with 70% by weight alcohol cream. 3 oïika tiïïfäiïen. 1.0 X 10: 5.5 X 10: 3.5 X 10: 6.5 x 10 8.5 x 10 3.8 x 10 1.3 X 106 1.3 X 106 7.5 X 104 2, 0 X 106 1.0 X 106 5.0 X 104 2.0 X 106 1.0 X 106 3.0 X 106 Average: 6.7 x 105 Hand disinfection with 62% by weight of ordinary alcohol. 3 oiika ti11fä11en; 7.5 X 106 3.3 X 106 1.3 X 106 5.5 X 106 3.3 X 106 ~ 3.0 X 106 2.5 X 106 7.5 X 106 5.0 X 106 5.5 X 106 3.5 X 106 3.3 X 106 1.3 X 106 7.3 X 106 5.3 X 106 Average: 6.8 x 105 Controy wash for Enterococcer. 5.5 X 107 7.3 X 107 7.0 X 107 5.3 X 107 7.3 X 107 7503515-4, Average: 6.9 x 107 Hand disinfection with 62% by weight alcohol cream. 3 different tiïifäiïen. 7.5 X 105 2.0 X 105 5.3 X 105 7.3 X 105 _7, s X 105 1.3 X 105 1.5 X 105 3.0 X 105 3.5 X 105 3.3 X 105 5.0 X 105 2.9 X 105 7.0 X 105 5 2.5 X 104 5.0 X 104 Average; 9.2 X 105 Hand disinfection with 70% by weight of alcohol cream. 3 different tiïifälien. 1.3 X 105 9.5 X 105 3.0 X 105 5.0 X 104 7.5 X 104 2.5 X 104 1.5 X 105 5.3 X 105 2.0 X 105 1.0 X 105 3.5 X 105 5.3 X 105 '2.0 X 105 2.5 X 104 3.5 X 105 Average: 8.9 x 105 Hand disinfection with 62% by weight of ordinary alcohol. 3 oïika tiïifäilen. I 1.0 X 105 1.0 X 105 1.7 X 105 5.3 X 105 2.3 X 105 5.0 X 105 3.0 X 105 1.0 X 105 3.7 X 105 4.5 X 105 5.0 X 104 s, s X 105 4.5 X 105 3.0 X 105 1.3 X 105 Average: 4.5 x 105 Retest of Pseudomonas. Increasing whether a new shipment of fresh blood had any effect 1.0 X 105 2.5 X 104 4.0 X 104 3.0 X 105 3.5 X 104 1.3 X 105 1.0 X 105 7, 5 X 105 2.0 X 105 Average: 9.4 x 105 Hand disinfection with 62% by weight #% alcohol cream.

Bakterierna är tagna från buïjong, ej uppsïammade i biod. < 2,5 X 103 5,0 X 105 < 2,5 X 103 < 2,5 X 105 5,0 X 103 1,0 X 105 1,3 X 104 1,0 X 105 < 2,5 X 105 < 2,5 X 105 , Handdesinfektion med 62 vikt-% vanïig sprit. Enterococcer.The bacteria are taken from buïjong, not soaked in biode. <2.5 X 103 5.0 X 105 <2.5 X 103 <2.5 X 105 5.0 X 103 1.0 X 105 1.3 X 104 1.0 X 105 <2.5 X 105 < 2.5 X 105, Hand disinfection with 62% by weight of ordinary alcohol. Enterococcer.

Claims (3)

7 78036h6~ß Bakterierna tagna från buljong, ej uppslammade i blod. 1,0 X 105 1,5 X 104 8,5 X 105 2,5 X 104 2,5 X 105 2,5 X 104 7,5 X 104 5,0 X 103 2,5 X 104 2,5 X 103 Genomsnitt: 1,4 x 105. Salvan enligt uppfinningen är inte begränsad till de i exempel 1, 2 och 5 beskriv- na varianterna utan dess sammansättning kan variera vad gäller såväl typen på, som stor leken av, ingredienserna. Sålunda kan salvan vara sammansatt enligt följande. Exempel 6 Trietanolamin (0,2 vikt-%), glycerin (5 vikt-%), etanol (45 vikt-%), karboxylerad vinylpolymer (0,2 vikt-%) och vatten (49,6 vikt-%). Exempel 7 Trietanolamin (2 vikt-%), glycerin (0,2 vikt-%), etanol (95 vikt-%), karboxylerad vinylpolymer (2 vikt-%) och vatten (0,8 vikt-%). Av exempel 6 och 7 framgår de väsentligaste ingredienserna i salvan enligt uppfin- ningen. Dessutom framgår att procenthalten av de ingående ingredienserna kan variera i viss utsträckning under bibehållande av salvans huvudsakliga egenskaper. Procenttalen på de huvudsakliga ingredienserna kan variera på följande sätt: Trietanolamin 0,2 - 2,0 vikt-% Glycerin 0,2 - 5,0 vikt-% Etanoi ' 45 - 95 vikt-% Karboxylerad vinylpolymer 0,2 x 2,0 vikt-% Vatten resten Patentkrav7 78036h6 ~ ß The bacteria taken from broth, not suspended in blood. 1.0 X 105 1.5 X 104 8.5 X 105 2.5 X 104 2.5 X 105 2.5 X 104 7.5 X 104 5.0 X 103 2.5 X 104 2.5 X 103 Average: 1.4 x 105. The ointment according to the invention is not limited to the variants described in examples 1, 2 and 5, but its composition may vary in terms of both the type and size of the ingredients. Thus, the ointment may be formulated as follows. Example 6 Triethanolamine (0.2% by weight), glycerin (5% by weight), ethanol (45% by weight), carboxylated vinyl polymer (0.2% by weight) and water (49.6% by weight). Example 7 Triethanolamine (2% by weight), glycerin (0.2% by weight), ethanol (95% by weight), carboxylated vinyl polymer (2% by weight) and water (0.8% by weight). Examples 6 and 7 show the most important ingredients in the ointment according to the invention. In addition, it is seen that the percentage of ingredients included may vary to some extent while maintaining the main properties of the ointment. The percentages of the main ingredients may vary as follows: Triethanolamine 0.2 - 2.0% by weight Glycerin 0.2 - 5.0% by weight Ethanol 45 - 95% by weight Carboxylated vinyl polymer 0.2 x 2.0 weight% Water residue Patent claim 1. Vattenbaserad salva för huddesinfektion innehållande alkohol som desinfek- tionsmedel jämte konventionella tillsatser, k ä n n e t e c k n a d a v att som huvudsakliga beståndsdelar i salvan ingår 45-95 vikt-% alkohol omfattande metanol, eta- nol eller propanol samt 0,2-2,0 vikt-% karboxylerad vinylpolymer varvid angivna halter är baserade på salvans totala vikt. 0Aqueous ointment for skin disinfection containing alcohol as a disinfectant together with conventional additives, characterized in that 45-95% by weight of alcohol comprising methanol, ethanol or propanol and 0.2-2.0 wt. % carboxylated vinyl polymer, the levels indicated being based on the total weight of the ointment. 0 2. Salva för huddesinfektion uppvisande alkohol som desinfektionsmedel, k ä n - n e t e c k n a d a v att den innehåller 0,2-2,0 vikt-% trietanolamin, 0,2-5,0 vikt- -% glycerin, 45-95 vikt-% etanol, 0,2-2,0 vikt-% karboxylerad vinylpolymer.2. Ointment for skin disinfection having alcohol as a disinfectant, characterized in that it contains 0.2-2.0% by weight of triethanolamine, 0.2-5.0% by weight of - glycerin, 45-95% by weight of ethanol , 0.2-2.0% by weight of carboxylated vinyl polymer. 3. Salva enligt patentkrav 2, k ä n n e t e c k n a d a v att den innehålle~ cetylalkohol och isopropylmyristat. ANFÖRDA PUBLIKATIONER: Norge 125 872 (Aólk 9/06 Tyskland 2 207 294 (Aalk 9/06)An ointment according to claim 2, characterized in that it contains cetyl alcohol and isopropyl myristate. PROMISED PUBLICATIONS: Norway 125 872 (Aólk 9/06 Germany 2,207,294 (Aalk 9/06)
SE7803646A 1978-03-31 1978-03-31 WATER-BASED SALVATION FOR SKIN INFECTION CONTAINING ALCOHOL AS DISINFECTANT SE418686B (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
SE7803646A SE418686B (en) 1978-03-31 1978-03-31 WATER-BASED SALVATION FOR SKIN INFECTION CONTAINING ALCOHOL AS DISINFECTANT
DK362978A DK362978A (en) 1978-03-31 1978-08-17 OINTMENT FOR SKIN INFECTION AND PROCEDURE FOR THE PREPARATION OF SUCH ANOINT
FI782524A FI782524A (en) 1978-03-31 1978-08-18 SALVA FOER HUDDESINFEKTION OCH SAETT ATT FRAMSTAELLA DENSAMMA
GB7834382A GB2017491B (en) 1978-03-31 1978-08-23 Ointments containing alcohols
NO782936A NO782936L (en) 1978-03-31 1978-08-29 OINTMENT FOR SKIN INFECTION AND METHOD OF PREPARING THE OINTMENT
CA310,567A CA1106762A (en) 1978-03-31 1978-09-01 Skin disinfection ointment
NL7809664A NL7809664A (en) 1978-03-31 1978-09-22 PROCESS FOR THE PREPARATION OF A SKIN DISINFECTING Ointment.
BE78191128A BE871267A (en) 1978-03-31 1978-10-13 OINTMENT FOR DISINFECTING THE SKIN AND METHOD OF MANUFACTURING
FR7829404A FR2420971A1 (en) 1978-03-31 1978-10-16 OINTMENT FOR DISINFECTS THE SKIN AND METHOD OF MANUFACTURING
JP12994578A JPS54132225A (en) 1978-03-31 1978-10-20 Skin disinfecting ointment agent and production
IT29130/78A IT1099818B (en) 1978-03-31 1978-10-26 DISINFECTANT POMATA OF THE SKIN AND ITS PRODUCTION PROCESS
DE19782854221 DE2854221A1 (en) 1978-03-31 1978-12-15 SKIN DISINFECTANT Ointment, AND THE METHOD OF MANUFACTURING IT

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7803646A SE418686B (en) 1978-03-31 1978-03-31 WATER-BASED SALVATION FOR SKIN INFECTION CONTAINING ALCOHOL AS DISINFECTANT

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SE7803646L SE7803646L (en) 1979-10-01
SE418686B true SE418686B (en) 1981-06-22

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JP (1) JPS54132225A (en)
BE (1) BE871267A (en)
CA (1) CA1106762A (en)
DE (1) DE2854221A1 (en)
DK (1) DK362978A (en)
FI (1) FI782524A (en)
FR (1) FR2420971A1 (en)
GB (1) GB2017491B (en)
IT (1) IT1099818B (en)
NL (1) NL7809664A (en)
NO (1) NO782936L (en)
SE (1) SE418686B (en)

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US4382919A (en) 1980-09-15 1983-05-10 Bristol-Myers Company Composition for treatment and prevention of malodorous generating skin conditions
CH655656B (en) * 1982-10-07 1986-05-15
JPS59227818A (en) * 1983-06-09 1984-12-21 Mitsubishi Chem Ind Ltd Gel ointment
CH643138A5 (en) * 1983-08-29 1984-05-30 Mepha Ag INDOMETHACIN CONTAINING, gelatinous OINTMENT.
CA1299098C (en) * 1985-10-28 1992-04-21 John H. White Alcohol-based antimicrobial compositions
US5098717A (en) * 1987-12-09 1992-03-24 Thames Pharmacal Co., Inc. Method of treatment for pruritus
US5013545A (en) * 1987-12-09 1991-05-07 Thames Pharmacal Co., Inc. Aqueous gels containing topical medicaments
US5256737A (en) * 1990-03-05 1993-10-26 Sigma Prodotti Chimici S.P.A. Thickening agents, processes for the preparation thereof and use thereof
PT751789E (en) * 1994-03-21 2002-04-29 Aase Brown Thomsen GEL FOR THE TREATMENT OF SKIN DISEASES AND SKIN DISINFECTION
FR2785537B1 (en) * 1999-03-26 2001-01-05 Blue Skin Sa SOFTENING ANTISEPTIC COMPOSITION AND GEL AND THEIR USE IN SKIN DISINFECTION PROCESSES
AUPR028000A0 (en) * 2000-09-21 2000-10-12 Hair Advisory Centre Pty. Ltd. Ectoparasite formulation
JP4876500B2 (en) 2005-09-22 2012-02-15 日油株式会社 Gel hand sanitizer
CN110478293A (en) * 2019-09-16 2019-11-22 捷米科技（上海）有限公司 A kind of disposable disinfection hand cleanser and preparation method thereof
EP3919042A1 (en) * 2020-06-04 2021-12-08 Sil'Innov scrl Composition with silanol, ethanol and water for global disinfection use

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Publication number Publication date
NL7809664A (en) 1979-10-02
IT7829130A0 (en) 1978-10-26
CA1106762A (en) 1981-08-11
FI782524A (en) 1979-10-01
BE871267A (en) 1979-02-01
GB2017491B (en) 1982-11-24
DK362978A (en) 1979-10-01
SE7803646L (en) 1979-10-01
JPS54132225A (en) 1979-10-15
NO782936L (en) 1979-10-02
DE2854221A1 (en) 1979-10-04
IT1099818B (en) 1985-09-28
FR2420971A1 (en) 1979-10-26
GB2017491A (en) 1979-10-10
FR2420971B1 (en) 1983-02-25

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