CA1101426A - 4-diphenylmethylene-1-hydroxybenzyl-piperidine compounds - Google Patents

4-diphenylmethylene-1-hydroxybenzyl-piperidine compounds

Info

Publication number
CA1101426A
CA1101426A CA294,674A CA294674A CA1101426A CA 1101426 A CA1101426 A CA 1101426A CA 294674 A CA294674 A CA 294674A CA 1101426 A CA1101426 A CA 1101426A
Authority
CA
Canada
Prior art keywords
diphenylmethylene
piperidine
process according
hydroxybenzyl
fluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA294,674A
Other languages
English (en)
French (fr)
Inventor
Dusan Zivkovic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB SA
Original Assignee
UCB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB SA filed Critical UCB SA
Application granted granted Critical
Publication of CA1101426A publication Critical patent/CA1101426A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA294,674A 1977-01-11 1978-01-10 4-diphenylmethylene-1-hydroxybenzyl-piperidine compounds Expired CA1101426A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB931/77 1977-01-11
GB931/77A GB1542823A (en) 1977-01-11 1977-01-11 Piperidine derivatives

Publications (1)

Publication Number Publication Date
CA1101426A true CA1101426A (en) 1981-05-19

Family

ID=9713045

Family Applications (1)

Application Number Title Priority Date Filing Date
CA294,674A Expired CA1101426A (en) 1977-01-11 1978-01-10 4-diphenylmethylene-1-hydroxybenzyl-piperidine compounds

Country Status (22)

Country Link
JP (1) JPS5387367A (sv)
BE (1) BE862769A (sv)
BG (1) BG28574A3 (sv)
CA (1) CA1101426A (sv)
CS (1) CS195652B2 (sv)
DD (1) DD134089A5 (sv)
DE (1) DE2800919A1 (sv)
DK (1) DK5778A (sv)
ES (1) ES465861A1 (sv)
FI (1) FI780028A (sv)
FR (1) FR2376846A1 (sv)
GB (1) GB1542823A (sv)
IL (1) IL53766A0 (sv)
IT (1) IT1103117B (sv)
LU (1) LU78839A1 (sv)
NL (1) NL7800146A (sv)
NO (1) NO780040L (sv)
PL (1) PL203912A1 (sv)
PT (1) PT67511B (sv)
SE (1) SE7800184L (sv)
SU (2) SU772482A3 (sv)
ZA (1) ZA78158B (sv)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650874A (en) * 1984-11-26 1987-03-17 G. D. Searle & Co. N-(aralkoxybenzyl)-4(benzhydryl) piperidines
US4628095A (en) * 1985-06-05 1986-12-09 G. D. Searle & Co. Substituted N-benzyl-4-(benzhydryl) piperidines
EP0228893A3 (en) * 1985-12-20 1990-01-03 A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl group in allergy treatment
GB9000305D0 (en) * 1990-01-06 1990-03-07 Pfizer Ltd Anticholinergic agents
DE19681115D2 (de) * 1995-12-20 1999-11-25 Eckhart Pein Neue 1-Phenylalkyl/Alkylen-4-(.Alpha.-Hydroxydiphenylmethyl)-Piperidin Derivative und ihre Verwendung als Serotonin Antagonisten
ATE292116T1 (de) * 1998-01-16 2005-04-15 Eisai Co Ltd Verfahren zur herstellung von donepezilderivaten
BR0316747A (pt) * 2002-12-18 2005-10-18 Fmc Corp Piperidinas n-(arilmetil substituìdas)-4-(metil dissubstituìdas) e piperazinas
EP1626044A4 (en) * 2003-05-20 2008-08-20 Ajinomoto Kk NEW PIPERIDINE DERIVATIVE

Also Published As

Publication number Publication date
DK5778A (da) 1978-07-12
PT67511A (fr) 1978-02-01
FI780028A (fi) 1978-07-12
SU772482A3 (ru) 1980-10-15
BE862769A (fr) 1978-07-10
NL7800146A (nl) 1978-07-13
JPS6125031B2 (sv) 1986-06-13
CS195652B2 (en) 1980-02-29
DE2800919A1 (de) 1978-07-13
LU78839A1 (fr) 1978-09-18
FR2376846A1 (fr) 1978-08-04
SE7800184L (sv) 1978-07-12
JPS5387367A (en) 1978-08-01
PT67511B (fr) 1979-06-11
ES465861A1 (es) 1978-09-16
BG28574A3 (en) 1980-05-15
IT7847573A0 (it) 1978-01-10
IL53766A0 (en) 1978-04-30
ZA78158B (en) 1978-10-25
SU990761A1 (ru) 1983-01-23
IT1103117B (it) 1985-10-14
FR2376846B1 (sv) 1983-02-04
NO780040L (no) 1978-07-12
GB1542823A (en) 1979-03-28
DD134089A5 (de) 1979-02-07
PL203912A1 (pl) 1979-06-04

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Legal Events

Date Code Title Description
MKEX Expiry