CA1095523A - 4-[[4-(diphenylmethyl)-1-piperidinyl] methyl] benzenamines - Google Patents

4-[[4-(diphenylmethyl)-1-piperidinyl] methyl] benzenamines

Info

Publication number
CA1095523A
CA1095523A CA284,567A CA284567A CA1095523A CA 1095523 A CA1095523 A CA 1095523A CA 284567 A CA284567 A CA 284567A CA 1095523 A CA1095523 A CA 1095523A
Authority
CA
Canada
Prior art keywords
diphenylmethyl
methyl
piperidinyl
benzenamine
acid addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA284,567A
Other languages
English (en)
French (fr)
Inventor
James R. Deason
Robert W. Hamilton
Harman S. Lowrie
Kurt J. Rorig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of CA1095523A publication Critical patent/CA1095523A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA284,567A 1976-08-13 1977-08-12 4-[[4-(diphenylmethyl)-1-piperidinyl] methyl] benzenamines Expired CA1095523A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/714,429 US4035372A (en) 1976-08-13 1976-08-13 4-{[4-(Diphenylmethyl)-1-piperidinyl]methyl}benzenamines
US714,429 1976-08-13

Publications (1)

Publication Number Publication Date
CA1095523A true CA1095523A (en) 1981-02-10

Family

ID=24870002

Family Applications (1)

Application Number Title Priority Date Filing Date
CA284,567A Expired CA1095523A (en) 1976-08-13 1977-08-12 4-[[4-(diphenylmethyl)-1-piperidinyl] methyl] benzenamines

Country Status (18)

Country Link
US (1) US4035372A (enExample)
JP (1) JPS5323982A (enExample)
AT (2) AT366031B (enExample)
AU (1) AU506432B2 (enExample)
BE (1) BE857708A (enExample)
CA (1) CA1095523A (enExample)
DE (1) DE2736201A1 (enExample)
DK (1) DK359177A (enExample)
ES (1) ES461543A1 (enExample)
FR (1) FR2361367A1 (enExample)
GB (1) GB1531949A (enExample)
GR (1) GR71900B (enExample)
IE (1) IE45402B1 (enExample)
IL (1) IL52706A (enExample)
NL (1) NL7708978A (enExample)
NZ (1) NZ184902A (enExample)
SE (1) SE7709135L (enExample)
ZA (1) ZA774910B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4256891A (en) * 1978-05-08 1981-03-17 Mcneil Laboratories, Inc. (2-Amino-2-oxoethoxy)acetic acid compounds
US4650874A (en) * 1984-11-26 1987-03-17 G. D. Searle & Co. N-(aralkoxybenzyl)-4(benzhydryl) piperidines
US4628095A (en) * 1985-06-05 1986-12-09 G. D. Searle & Co. Substituted N-benzyl-4-(benzhydryl) piperidines
EP0228893A3 (en) * 1985-12-20 1990-01-03 A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl group in allergy treatment
IN163948B (enExample) * 1986-01-17 1988-12-10 Robins Co Inc A H
JPH01240821A (ja) * 1988-03-23 1989-09-26 Hamamatsu Photonics Kk ロータリエンコーダ
US5070087A (en) * 1989-05-08 1991-12-03 A. H. Robins Company, Incorporated Aryl(alkyland alkylene)-N-((phenoxy and phenylthio)alkyl) aminoheterocyclics as cardiovascular, anthihistaminic, antisecretory and antiallergy agents
ES2102830T3 (es) * 1993-01-21 1997-08-01 Merrell Pharma Inc Diarilalquil piperidinas utiles como agentes para tumores con resistencia multifarmaco.
US5569664A (en) * 1995-02-16 1996-10-29 Fmc Corporation Insecticidal n-(substituted arylmethyl)-4-[bis(substituted phenyl) methyl]pi
US6017931A (en) * 1994-03-01 2000-01-25 Fmc Corporation Insecticidal compositions containing n-(substituted phenylmethyl)-4-[bis(substituted phenyl)methyl]piperidines
US5670521A (en) * 1994-08-05 1997-09-23 Merrell Pharmaceuticals Inc. Reversal of multi-drug resistance by triphenyl-azacycloalkane derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3068237A (en) * 1961-03-17 1962-12-11 Searle & Co N-[(chloro/nitro/amino)phenylalkyl]-alpha, alpha-diphenylpipidinemethanols
US3081303A (en) * 1961-10-13 1963-03-12 Searle & Co 1-aminoalkyl-alpha, alpha-diphenylpiperidine-methanols
GB1252315A (enExample) * 1969-06-05 1971-11-03
US3946022A (en) * 1974-03-04 1976-03-23 Richardson-Merrell Inc. Piperidine derivatives

Also Published As

Publication number Publication date
ATA418179A (de) 1981-07-15
GR71900B (enExample) 1983-08-11
DE2736201C2 (enExample) 1989-03-16
ZA774910B (en) 1978-09-27
NZ184902A (en) 1980-05-08
AU506432B2 (en) 1980-01-03
NL7708978A (nl) 1978-02-15
AU2784277A (en) 1979-02-15
US4035372A (en) 1977-07-12
AT358581B (de) 1980-09-25
SE7709135L (sv) 1978-02-14
IL52706A0 (en) 1977-10-31
AT366031B (de) 1982-03-10
FR2361367B1 (enExample) 1980-07-18
DE2736201A1 (de) 1978-02-16
IE45402B1 (en) 1982-08-11
ES461543A1 (es) 1978-06-01
FR2361367A1 (fr) 1978-03-10
GB1531949A (en) 1978-11-15
ATA587777A (de) 1980-02-15
JPS6134413B2 (enExample) 1986-08-07
IE45402L (en) 1978-02-13
BE857708A (fr) 1978-02-13
JPS5323982A (en) 1978-03-06
DK359177A (da) 1978-02-14
IL52706A (en) 1980-09-16

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Legal Events

Date Code Title Description
MKEX Expiry
MKEX Expiry

Effective date: 19980210