CA1094563A - Clavulanic acid derivatives - Google Patents

Clavulanic acid derivatives

Info

Publication number
CA1094563A
CA1094563A CA263,103A CA263103A CA1094563A CA 1094563 A CA1094563 A CA 1094563A CA 263103 A CA263103 A CA 263103A CA 1094563 A CA1094563 A CA 1094563A
Authority
CA
Canada
Prior art keywords
group
benzyl
formula
carbon atoms
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA263,103A
Other languages
English (en)
French (fr)
Inventor
Roger J. Ponsford
Thomas T. Howarth
Irene Stirling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Priority to CA353,771A priority Critical patent/CA1100406A/en
Application granted granted Critical
Publication of CA1094563A publication Critical patent/CA1094563A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
CA263,103A 1975-10-13 1976-10-12 Clavulanic acid derivatives Expired CA1094563A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA353,771A CA1100406A (en) 1975-10-13 1980-06-11 Synergistic pharmaceutical compositions comprising clavulanic acid derivatives with a penicillin or a cephalosporin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB41887/75A GB1566706A (en) 1975-10-13 1975-10-13 Clavulanic acid derivatives
GB41887/75 1975-10-13

Publications (1)

Publication Number Publication Date
CA1094563A true CA1094563A (en) 1981-01-27

Family

ID=10421810

Family Applications (1)

Application Number Title Priority Date Filing Date
CA263,103A Expired CA1094563A (en) 1975-10-13 1976-10-12 Clavulanic acid derivatives

Country Status (28)

Country Link
US (3) US4256638A (de)
JP (1) JPS5248686A (de)
AR (1) AR213294A1 (de)
AT (1) AT352874B (de)
AU (1) AU503489B2 (de)
BE (1) BE847044A (de)
CA (1) CA1094563A (de)
CH (2) CH634323A5 (de)
DD (1) DD126929A5 (de)
DE (1) DE2646003A1 (de)
DK (1) DK457676A (de)
ES (2) ES452361A1 (de)
FI (1) FI762895A (de)
FR (1) FR2327775A1 (de)
GB (1) GB1566706A (de)
GR (1) GR61674B (de)
HU (1) HU175046B (de)
IE (1) IE43840B1 (de)
IL (1) IL50618A (de)
MX (1) MX4688E (de)
NL (1) NL7611206A (de)
NO (3) NO763472L (de)
NZ (1) NZ182190A (de)
PT (1) PT65707B (de)
SE (3) SE7611047L (de)
SU (1) SU639454A3 (de)
ZA (1) ZA765901B (de)
ZM (1) ZM12276A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT363181B (de) * 1976-10-25 1981-07-10 Glaxo Lab Ltd Verfahren zur herstellung von neuen clavulansaeurederivaten
GB1604822A (en) 1977-04-22 1981-12-16 Beecham Group Ltd N-monosubstituted-9-amino-9-deoxyclavulanic acid derivative
US4359473A (en) 1977-04-22 1982-11-16 Beecham Group Limited α-Amino deoxy clavulanic acid antibacterial agents
GB1582884A (en) * 1977-05-19 1981-01-14 Beecham Group Ltd Clavulanic acid derivatives their preparation and use
EP0005014A1 (de) * 1978-04-22 1979-10-31 Beecham Group Plc Clavulansäure-Derivate, Herstellung und Zusammensetzungen
DE2963534D1 (en) * 1978-07-29 1982-10-07 Beecham Group Plc Clavulanic acid derivatives, a process for their preparation, their use, and pharmaceutical compositions containing them
DE2966065D1 (en) * 1978-09-09 1983-09-22 Beecham Group Plc Derivatives of clavulanic acid, a process for their preparation and their compositions
DE2966349D1 (en) * 1978-09-09 1983-12-01 Beecham Group Plc Derivatives of clavulanic acid, a process for their preparation and their use
ATE5143T1 (de) * 1978-09-09 1983-11-15 Beecham Group Plc Clavulansaeure-derivate und verfahren zu ihrer herstellung.
EP0010369B1 (de) 1978-10-25 1983-07-20 Beecham Group Plc Clavulansäure-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
IL60343A0 (en) * 1979-07-02 1980-09-16 Beecham Group Ltd Clavulanic acid derivatives,their preparation and pharmaceutical compositions containing them
ZA804670B (en) * 1979-08-03 1981-07-29 Beecham Group Ltd Derivatives of clavulanic acid, a process for their preparation and their use
DE3066511D1 (en) * 1979-10-26 1984-03-15 Beecham Group Plc Derivatives of clavulanic acid, a process for their preparation and pharmaceutical compositions containing them
EP0053893B1 (de) * 1980-12-09 1985-03-20 Beecham Group Plc Clavulansäure-Derivate, ihre Herstellung und ihre Verwendung
NZ199200A (en) * 1980-12-23 1984-07-31 Beecham Group Ltd Clavulanic acid derivatives and pharmaceutical compositions
JPS57143194A (en) * 1981-02-27 1982-09-04 Matsushita Electric Ind Co Ltd Blower
EP0062407A1 (de) * 1981-03-10 1982-10-13 Beecham Group Plc Beta-Lactame enthaltende therapeutische Verbindungen
JPH0495698U (de) * 1991-01-21 1992-08-19
GB9518917D0 (en) * 1995-09-15 1995-11-15 Smithkline Beecham Plc Compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1424186A (en) * 1971-10-08 1976-02-11 Beecham Group Ltd Penicillins
US3925363A (en) * 1974-01-17 1975-12-09 Merck & Co Inc Process for epimerizing penicillin compounds, and related products
US4051132A (en) * 1974-01-23 1977-09-27 Merck & Co., Inc. Process for epimerizing beta-lactam antibiotic compounds by means of an acid quench
GB1585165A (en) * 1976-06-29 1981-02-25 Leo Pharm Prod Ltd Derivatives of 6-amidino penicillanic acid
IL54859A (en) * 1977-06-21 1982-01-31 Rech Applications Therap Derivatives of amidinopenicillanic acid,their production and pharmaceutical compositions containing them
EP0005348B1 (de) * 1978-05-06 1982-09-22 Beecham Group Plc Carbapenemderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
US4244965A (en) * 1978-06-15 1981-01-13 Beecham Group Limited Azetidinoyl ethers
US4252722A (en) * 1979-08-08 1981-02-24 Merck & Co., Inc. Process for the preparation of 6-hydroxymethyl-2-(β-aminoethylthio)-1-carbadethiapen-2-em-3-carboxylic acid
US4237051A (en) * 1979-04-19 1980-12-02 Schering Corporation Stereospecific production of 6- or 7-carbon-substituted-β-lactams
US4231928A (en) * 1979-04-24 1980-11-04 Bristol-Myers Company Antibacterial agents

Also Published As

Publication number Publication date
US4382084A (en) 1983-05-03
NO763472L (de) 1977-04-14
DE2646003A1 (de) 1977-04-21
IL50618A (en) 1979-09-30
US4256638A (en) 1981-03-17
FR2327775B1 (de) 1978-11-17
GR61674B (en) 1978-12-05
CH639665A5 (de) 1983-11-30
MX4688E (es) 1982-08-02
NO802661L (no) 1977-04-14
AU503489B2 (en) 1979-09-06
NO802662L (no) 1977-04-14
ATA753476A (de) 1979-03-15
ES452361A1 (es) 1978-01-01
BE847044A (fr) 1977-04-07
SU639454A3 (ru) 1978-12-25
AU1858276A (en) 1978-04-20
SE8004329L (sv) 1980-06-10
US4438101A (en) 1984-03-20
HU175046B (hu) 1980-05-28
FI762895A (de) 1977-04-14
DD126929A5 (de) 1977-08-24
JPS612670B2 (de) 1986-01-27
SE7611047L (sv) 1977-04-14
IL50618A0 (en) 1976-12-31
IE43840L (en) 1977-04-13
GB1566706A (en) 1980-05-08
FR2327775A1 (fr) 1977-05-13
AR213294A1 (es) 1979-01-15
JPS5248686A (en) 1977-04-18
PT65707A (en) 1976-11-01
ES463974A1 (es) 1978-12-16
NZ182190A (en) 1979-03-16
DK457676A (da) 1977-04-14
NL7611206A (nl) 1977-04-15
IE43840B1 (en) 1981-06-03
CH634323A5 (de) 1983-01-31
ZA765901B (en) 1977-09-28
ZM12276A1 (en) 1977-07-21
AT352874B (de) 1979-10-10
PT65707B (en) 1978-04-17
SE8004330L (sv) 1980-06-10

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Legal Events

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