CA1083592A - Anticariogenic maloaluminate complexes - Google Patents
Anticariogenic maloaluminate complexesInfo
- Publication number
- CA1083592A CA1083592A CA283,451A CA283451A CA1083592A CA 1083592 A CA1083592 A CA 1083592A CA 283451 A CA283451 A CA 283451A CA 1083592 A CA1083592 A CA 1083592A
- Authority
- CA
- Canada
- Prior art keywords
- aluminum
- fluoride
- maloaluminate
- complexes
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000000170 anti-cariogenic effect Effects 0.000 title abstract description 15
- 239000000203 mixture Substances 0.000 claims abstract description 56
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- 229910052708 sodium Inorganic materials 0.000 claims description 3
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- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
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- GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 description 5
- 239000005995 Aluminium silicate Substances 0.000 description 4
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- BJEPYKJPYRNKOW-UHFFFAOYSA-L malate(2-) Chemical compound [O-]C(=O)C(O)CC([O-])=O BJEPYKJPYRNKOW-UHFFFAOYSA-L 0.000 description 3
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- IRPGOXJVTQTAAN-UHFFFAOYSA-N 2,2,3,3,3-pentafluoropropanal Chemical compound FC(F)(F)C(F)(F)C=O IRPGOXJVTQTAAN-UHFFFAOYSA-N 0.000 description 2
- KLZUFWVZNOTSEM-UHFFFAOYSA-K Aluminum fluoride Inorganic materials F[Al](F)F KLZUFWVZNOTSEM-UHFFFAOYSA-K 0.000 description 2
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- BSFVYMTXZLCFKX-UHFFFAOYSA-N hexadecan-1-ol;sulfuric acid Chemical compound OS(O)(=O)=O.CCCCCCCCCCCCCCCCO BSFVYMTXZLCFKX-UHFFFAOYSA-N 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 229940045996 isethionic acid Drugs 0.000 description 1
- 235000010494 karaya gum Nutrition 0.000 description 1
- NEMFQSKAPLGFIP-UHFFFAOYSA-N magnesiosodium Chemical compound [Na].[Mg] NEMFQSKAPLGFIP-UHFFFAOYSA-N 0.000 description 1
- HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 description 1
- 238000003760 magnetic stirring Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 150000004701 malic acid derivatives Chemical class 0.000 description 1
- 210000004373 mandible Anatomy 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- 235000019960 monoglycerides of fatty acid Nutrition 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 210000003739 neck Anatomy 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000001415 potassium malate Substances 0.000 description 1
- SVICABYXKQIXBM-UHFFFAOYSA-L potassium malate Chemical compound [K+].[K+].[O-]C(=O)C(O)CC([O-])=O SVICABYXKQIXBM-UHFFFAOYSA-L 0.000 description 1
- 235000011033 potassium malate Nutrition 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- OGHBATFHNDZKSO-UHFFFAOYSA-N propan-2-olate Chemical compound CC(C)[O-] OGHBATFHNDZKSO-UHFFFAOYSA-N 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000002390 rotary evaporation Methods 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- GJPYYNMJTJNYTO-UHFFFAOYSA-J sodium aluminium sulfate Chemical compound [Na+].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GJPYYNMJTJNYTO-UHFFFAOYSA-J 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- AQMNWCRSESPIJM-UHFFFAOYSA-M sodium metaphosphate Chemical compound [Na+].[O-]P(=O)=O AQMNWCRSESPIJM-UHFFFAOYSA-M 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- ZZIZZTHXZRDOFM-XFULWGLBSA-N tamsulosin hydrochloride Chemical compound [H+].[Cl-].CCOC1=CC=CC=C1OCCN[C@H](C)CC1=CC=C(OC)C(S(N)(=O)=O)=C1 ZZIZZTHXZRDOFM-XFULWGLBSA-N 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000004357 third molar Anatomy 0.000 description 1
- 229910001432 tin ion Inorganic materials 0.000 description 1
- IUTCEZPPWBHGIX-UHFFFAOYSA-N tin(2+) Chemical compound [Sn+2] IUTCEZPPWBHGIX-UHFFFAOYSA-N 0.000 description 1
- 229940100613 topical solution Drugs 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 150000003628 tricarboxylic acids Chemical class 0.000 description 1
- VXYADVIJALMOEQ-UHFFFAOYSA-K tris(lactato)aluminium Chemical compound CC(O)C(=O)O[Al](OC(=O)C(C)O)OC(=O)C(C)O VXYADVIJALMOEQ-UHFFFAOYSA-K 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/06—Aluminium compounds
- C07F5/069—Aluminium compounds without C-aluminium linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71044376A | 1976-08-02 | 1976-08-02 | |
| US710,443 | 1976-08-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1083592A true CA1083592A (en) | 1980-08-12 |
Family
ID=24854052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA283,451A Expired CA1083592A (en) | 1976-08-02 | 1977-07-25 | Anticariogenic maloaluminate complexes |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4042680A (enExample) |
| JP (1) | JPS5341416A (enExample) |
| AU (1) | AU512765B2 (enExample) |
| CA (1) | CA1083592A (enExample) |
| DE (1) | DE2734648A1 (enExample) |
| FR (1) | FR2360597A1 (enExample) |
| GB (1) | GB1589886A (enExample) |
| IT (1) | IT1079906B (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1081804B (it) * | 1977-06-07 | 1985-05-21 | Scharper Spa | Procedimento di preparazione di tris (idrossimetil)-aminometan-lattato-diidrossialluminato |
| US4267164A (en) * | 1980-01-31 | 1981-05-12 | Block Drug Company Inc. | Effervescent stannous fluoride tablet |
| GB2100126B (en) | 1981-06-11 | 1984-08-01 | Colgate Palmolive Co | A dentifrice |
| US4401648A (en) * | 1982-03-29 | 1983-08-30 | Colgate-Palmolive Company | Dental cream composition |
| US4414199A (en) * | 1982-07-15 | 1983-11-08 | Amway Corporation | Toothpaste |
| JPH0742219B2 (ja) * | 1984-07-26 | 1995-05-10 | ライオン株式会社 | 口腔用組成物 |
| US5064640A (en) * | 1986-12-02 | 1991-11-12 | Purdue Research Foundation | Anticariogenic compositions |
| US4976954A (en) * | 1986-12-02 | 1990-12-11 | Purdue Research Foundation | Anticariogenic compositions |
| NO172275C (no) * | 1987-05-01 | 1993-06-30 | Purdue Research Foundation | Oralt antitannstenpreparat |
| JP2558188B2 (ja) * | 1991-06-10 | 1996-11-27 | 花王株式会社 | 入浴剤組成物 |
| US5188819A (en) * | 1992-02-21 | 1993-02-23 | Purdue Research Foundation | Manufacture of aluminum-based anticariogenic compositions |
| CN101437485A (zh) | 2006-05-09 | 2009-05-20 | 高露洁-棕榄公司 | 口腔护理方案 |
| US20080274065A1 (en) * | 2006-05-09 | 2008-11-06 | Richard Scott Robinson | Oral Care Regimen |
| CN101938955A (zh) * | 2008-02-08 | 2011-01-05 | 高露洁-棕榄公司 | 牙线 |
| BRPI0907109A2 (pt) * | 2008-02-08 | 2016-05-03 | Colgate Palmolive Co | lenço dental e método |
| JP5624477B2 (ja) * | 2008-02-08 | 2014-11-12 | コルゲート・パーモリブ・カンパニーＣｏｌｇａｔｅ−Ｐａｌｍｏｌｉｖｅ Ｃｏｍｐａｎｙ | 口腔ケア製品ならびにその使用および製造の方法 |
| US11612553B2 (en) | 2008-02-08 | 2023-03-28 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
| CA2706516C (en) * | 2008-02-08 | 2014-12-16 | Colgate-Palmolive Company | Cleaning compositions and methods |
| TWI409084B (zh) * | 2008-02-08 | 2013-09-21 | 美國棕欖公司 | 治療口乾症之組成物及方法 |
| TW200950812A (en) * | 2008-02-08 | 2009-12-16 | Colgate Palmolive Co | Effervescent compositions |
| TWI552762B (zh) * | 2008-02-08 | 2016-10-11 | 美國棕欖公司 | 雙組分口腔保健產品 |
| TWI386176B (zh) * | 2008-02-08 | 2013-02-21 | Colgate Palmolive Co | 口腔保健牙刷 |
| EP2249794A4 (en) * | 2008-02-08 | 2014-01-08 | Colgate Palmolive Co | COMPOSITIONS AND METHODS COMPRISING BASIC AMINO ACID PEPTIDES AND PROTEASES |
| CN101938970A (zh) * | 2008-02-08 | 2011-01-05 | 高露洁-棕榄公司 | 牙齿密封剂 |
| BRPI0906452A2 (pt) * | 2008-02-08 | 2015-07-14 | Colgate Palmolive Co | Composição, dispositivo, método para produzir ou inibir a formação de cáries dentais, reduzir, reparar ou inibir as leões pré-cárie do esmalte, reduzir ou inibir a desmineralização e promover a remineralização dos dentes, reduzir a hipersensibilidade dos dentes, reduzir ou inibir a gengivite, promover a cura de feridas ou de cortes na boca, reduzir os níveis de bactérias que produzem ácido, aumentar os níveis relativos de bactérias arginolíticas, inibir a formação de composição, dispositivo, método para reduzir ou inibir a formação de cáries dentais, reduzir, reparar ou inibir as leões pré-cárie dp esmalte, reduzir ou inibir a desmineralização e promover a remineralização dos dentes, reduzir a hipersibilidade dos dentes, reduzir ou inibir a gengivite, promover a cura de feridas ou de cortes na boca, reduzir os níveis de bactérias que produzem ácido, aumentar os níveis relativos de bactérias arginolíticas, inibir a formação de biofilme microbiano na cavidade oral, elevar e/ou manter o ph da placa em níveis de pelos menos um ph de 5,5, reduzir o acúmulo de placa, tratar, aliviar ou reduzir a boca seca, limpar os dentes e a cavidade oral, reduzir a erosão, branquear os dentes, imunizar os dentes contra as bactérias cariogênicas, e/ ou promover a saúde sistêmica, incluindo a saúde cardiovascular, e, uso de um aminoácido básico |
| MX2010005211A (es) | 2008-02-08 | 2010-09-30 | Colgate Palmolive Co | Metodos y sistemas para el cuidado oral. |
| EP2252169A4 (en) * | 2008-02-08 | 2013-08-21 | Colgate Palmolive Co | ARGINE-CONTAINING DRINK |
| JP5520235B2 (ja) | 2008-02-08 | 2014-06-11 | コルゲート・パーモリブ・カンパニー | 塩の製造のための方法 |
| RU2475231C2 (ru) * | 2008-02-08 | 2013-02-20 | Колгейт-Палмолив Компани | Продукт для ухода за полостью рта и способы его применения и производства |
| WO2009100277A2 (en) | 2008-02-08 | 2009-08-13 | Colgate-Palmolive Company | Compositions and devices |
| US20090202452A1 (en) * | 2008-02-08 | 2009-08-13 | Colgate-Palmolive Company | Oral care regimen |
| MX2012005971A (es) | 2009-12-18 | 2012-06-13 | Colgate Palmolive Co | Metodos para la produccion a baja presion de bicarbonato de arginina. |
| BR112012014739A2 (pt) | 2009-12-18 | 2016-04-05 | Colgate Palmolive Co | métodos para a produção de solução de bicarbonato de arginina de alta concentração em alta pressão |
| JP5723001B2 (ja) | 2010-06-23 | 2015-05-27 | コルゲート・パーモリブ・カンパニーＣｏｌｇａｔｅ−Ｐａｌｍｏｌｉｖｅ Ｃｏｍｐａｎｙ | 治療用口腔用組成物 |
| HK1215162A1 (zh) | 2012-12-06 | 2016-08-19 | Colgate-Palmolive Company | 用於敏感性和牙齿疼痛的口用凝胶 |
| BR112022004374A2 (pt) | 2019-09-30 | 2022-06-07 | Procter & Gamble | Composições para tratamento bucal que compreendem beta ácido de lúpulo e íons metálicos |
| WO2021062607A1 (en) | 2019-09-30 | 2021-04-08 | The Procter & Gamble Company | Oral care compositions comprising hops beta acid and amino acid |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3485858A (en) * | 1968-04-03 | 1969-12-23 | Mobil Oil Corp | Metal alkyl,or alkoxy metal alkyl,ester tetrapropenylsuccinates |
| US3584025A (en) * | 1968-08-30 | 1971-06-08 | Allied Chem | Hydrocarbon gels |
-
1975
- 1975-08-02 US US05/710,443 patent/US4042680A/en not_active Expired - Lifetime
-
1977
- 1977-07-25 CA CA283,451A patent/CA1083592A/en not_active Expired
- 1977-07-29 GB GB31936/77A patent/GB1589886A/en not_active Expired
- 1977-08-01 DE DE19772734648 patent/DE2734648A1/de active Granted
- 1977-08-01 IT IT50519/77A patent/IT1079906B/it active
- 1977-08-02 FR FR7723810A patent/FR2360597A1/fr active Granted
- 1977-08-02 JP JP9291277A patent/JPS5341416A/ja active Granted
- 1977-08-02 AU AU27544/77A patent/AU512765B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2360597A1 (fr) | 1978-03-03 |
| JPS5341416A (en) | 1978-04-14 |
| DE2734648C2 (enExample) | 1988-11-17 |
| IT1079906B (it) | 1985-05-13 |
| AU2754477A (en) | 1979-02-08 |
| GB1589886A (en) | 1981-05-20 |
| JPS6156217B2 (enExample) | 1986-12-01 |
| FR2360597B1 (enExample) | 1981-02-06 |
| AU512765B2 (en) | 1980-10-23 |
| DE2734648A1 (de) | 1978-02-09 |
| US4042680A (en) | 1977-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |