CA1082695A - Process for preparing adenosine-5'-carboxamides - Google Patents
Process for preparing adenosine-5'-carboxamidesInfo
- Publication number
- CA1082695A CA1082695A CA164,578A CA164578A CA1082695A CA 1082695 A CA1082695 A CA 1082695A CA 164578 A CA164578 A CA 164578A CA 1082695 A CA1082695 A CA 1082695A
- Authority
- CA
- Canada
- Prior art keywords
- adenosine
- ester
- alcohol
- amide
- reaction mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title claims abstract 4
- MWEQTWJABOLLOS-UHFFFAOYSA-L disodium;[[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-oxidophosphoryl] hydrogen phosphate;trihydrate Chemical compound O.O.O.[Na+].[Na+].C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)C(O)C1O MWEQTWJABOLLOS-UHFFFAOYSA-L 0.000 title abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 35
- 150000002148 esters Chemical class 0.000 claims abstract description 16
- 150000001412 amines Chemical class 0.000 claims abstract description 11
- 150000003839 salts Chemical class 0.000 claims abstract description 8
- IBYWUFHJUDTSOC-SOVPELCUSA-N 9-riburonosyladenine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H]1O IBYWUFHJUDTSOC-SOVPELCUSA-N 0.000 claims abstract description 5
- 239000002253 acid Substances 0.000 claims abstract 3
- 238000000034 method Methods 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 238000006243 chemical reaction Methods 0.000 claims description 12
- 150000001408 amides Chemical class 0.000 claims description 9
- -1 ester salt Chemical class 0.000 claims description 9
- 239000011541 reaction mixture Substances 0.000 claims description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 6
- BLMHAOGGJQDPLX-LKCKTBJASA-N (2s,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolane-2-carboxamide Chemical compound O[C@@H]1[C@H](O)[C@@H](C(=O)N)O[C@H]1N1C2=NC=NC(N)=C2N=C1 BLMHAOGGJQDPLX-LKCKTBJASA-N 0.000 claims description 3
- BPASLSSCGMNTIG-ZXCJZDNZSA-N ethyl 2-[(2s,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyacetate Chemical group O[C@@H]1[C@H](O)[C@@H](C(O)C(=O)OCC)O[C@H]1N1C2=NC=NC(N)=C2N=C1 BPASLSSCGMNTIG-ZXCJZDNZSA-N 0.000 claims description 3
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims 2
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 125000005907 alkyl ester group Chemical group 0.000 claims 1
- 239000000047 product Substances 0.000 description 13
- 239000007787 solid Substances 0.000 description 13
- 239000000203 mixture Substances 0.000 description 8
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- OIRDTQYFTABQOQ-KQYNXXCUSA-N Adenosine Natural products C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 5
- 239000002126 C01EB10 - Adenosine Substances 0.000 description 5
- 229960005305 adenosine Drugs 0.000 description 5
- 239000012043 crude product Substances 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
- VQKFNUFAXTZWDK-UHFFFAOYSA-N 2-Methylfuran Chemical compound CC1=CC=CO1 VQKFNUFAXTZWDK-UHFFFAOYSA-N 0.000 description 2
- VVJKKWFAADXIJK-UHFFFAOYSA-N Allylamine Chemical compound NCC=C VVJKKWFAADXIJK-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 239000005457 ice water Substances 0.000 description 2
- JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- UUFQTNFCRMXOAE-UHFFFAOYSA-N 1-methylmethylene Chemical compound C[CH] UUFQTNFCRMXOAE-UHFFFAOYSA-N 0.000 description 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 description 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 description 1
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 230000005792 cardiovascular activity Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229940031098 ethanolamine Drugs 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229960004592 isopropanol Drugs 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- JKANAVGODYYCQF-UHFFFAOYSA-N prop-2-yn-1-amine Chemical compound NCC#C JKANAVGODYYCQF-UHFFFAOYSA-N 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000036647 reaction Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- UBBZKZRMWONRRS-UHFFFAOYSA-N thionyl dichloride hydrochloride Chemical compound Cl.ClS(Cl)=O UBBZKZRMWONRRS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24277972A | 1972-04-10 | 1972-04-10 | |
| US242,779 | 1972-04-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1082695A true CA1082695A (en) | 1980-07-29 |
Family
ID=22916155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA164,578A Expired CA1082695A (en) | 1972-04-10 | 1973-02-26 | Process for preparing adenosine-5'-carboxamides |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS4913200A (enrdf_load_html_response) |
| CA (1) | CA1082695A (enrdf_load_html_response) |
| CH (1) | CH565175A5 (enrdf_load_html_response) |
| DE (1) | DE2317770A1 (enrdf_load_html_response) |
| FR (1) | FR2179886B1 (enrdf_load_html_response) |
| GB (1) | GB1399670A (enrdf_load_html_response) |
| ZA (1) | ZA731380B (enrdf_load_html_response) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7737126B2 (en) | 2004-05-24 | 2010-06-15 | Glaxo Group Limited | Purine derivative |
| US7985740B2 (en) | 2005-07-19 | 2011-07-26 | Glaxo Group Limited | Purine derivatives as agonists of the adenosine A2A receptor |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU198950B (en) * | 1986-12-15 | 1989-12-28 | Sandoz Ag | Process for producing new furanuronic acid derivatives and pharmaceutical compositions comprising such compounds |
| TW528755B (en) | 1996-12-24 | 2003-04-21 | Glaxo Group Ltd | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives |
| YU44900A (sh) | 1998-01-31 | 2003-01-31 | Glaxo Group Limited | Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola |
| NZ509030A (en) | 1998-06-23 | 2003-07-25 | Glaxo Group Ltd | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2034785A1 (de) * | 1970-07-14 | 1972-01-20 | Boehnnger Mannheim GmbH, 6800 Mann heim Waldhof | Adenosin 5 carbonsäurederivate |
-
1973
- 1973-02-26 CA CA164,578A patent/CA1082695A/en not_active Expired
- 1973-02-27 ZA ZA731380A patent/ZA731380B/xx unknown
- 1973-03-29 GB GB1521473A patent/GB1399670A/en not_active Expired
- 1973-04-02 JP JP48036829A patent/JPS4913200A/ja active Pending
- 1973-04-09 DE DE2317770A patent/DE2317770A1/de active Pending
- 1973-04-10 FR FR7312779A patent/FR2179886B1/fr not_active Expired
- 1973-04-10 CH CH514273A patent/CH565175A5/xx not_active IP Right Cessation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7737126B2 (en) | 2004-05-24 | 2010-06-15 | Glaxo Group Limited | Purine derivative |
| US7985740B2 (en) | 2005-07-19 | 2011-07-26 | Glaxo Group Limited | Purine derivatives as agonists of the adenosine A2A receptor |
Also Published As
| Publication number | Publication date |
|---|---|
| GB1399670A (en) | 1975-07-02 |
| FR2179886A1 (enrdf_load_html_response) | 1973-11-23 |
| FR2179886B1 (enrdf_load_html_response) | 1978-04-21 |
| AU5286573A (en) | 1974-09-05 |
| ZA731380B (en) | 1973-11-28 |
| CH565175A5 (enrdf_load_html_response) | 1975-08-15 |
| DE2317770A1 (de) | 1973-10-18 |
| JPS4913200A (enrdf_load_html_response) | 1974-02-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |