GB1399670A - Process for preparing adenosine-5-carboxamides - Google Patents

Process for preparing adenosine-5-carboxamides

Info

Publication number
GB1399670A
GB1399670A GB1521473A GB1521473A GB1399670A GB 1399670 A GB1399670 A GB 1399670A GB 1521473 A GB1521473 A GB 1521473A GB 1521473 A GB1521473 A GB 1521473A GB 1399670 A GB1399670 A GB 1399670A
Authority
GB
United Kingdom
Prior art keywords
alkyl
adenosine
carboxamides
cycloalkyl
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1521473A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ABBOUT LAB
Original Assignee
ABBOUT LAB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ABBOUT LAB filed Critical ABBOUT LAB
Publication of GB1399670A publication Critical patent/GB1399670A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1399670 Adenosine-5<SP>1</SP>-carboxamides ABBOTT LABORATORIES 29 March 1973 [10 April 1972] 15214/73 Heading C2C Compounds I in which R 1 and R 2 are hydrogen, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 hydroxyalkyl, C 3-7 cycloalkyl, C 2-6 alkenyl, C 2-6 haloalkenyl, C 2-6 hydroxyalkenyl, C 2-6 alkynyl, C 2-6 haloalkynyl, benzyl, phenyl C 1-4 alkyl, C 3-7 cycloalkyl, C 1-4 alkoxy C 1-4 alkyl, substituted phenyl, 2-methylfuryl, di-(C 1-4 alkyl)amino-C 1-4 alkyl or adamantyl or NR 1 R 2 form a heterocyclic ring and their acid addition salts are prepared by reacting an ester of adenosine-5<SP>1</SP>-carboxylic acid or a salt-thereof with an amine HNR 1 R 2 by suspending the ester in a C 1-3 alkanol containing the amine and heating the mixture for at least part of the time above 70‹ C. R 1 is hydrogen and R 2 is allyl, propargyl i-propyl, 2-hydroxyethyl or cyclopropyl.
GB1521473A 1972-04-10 1973-03-29 Process for preparing adenosine-5-carboxamides Expired GB1399670A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24277972A 1972-04-10 1972-04-10

Publications (1)

Publication Number Publication Date
GB1399670A true GB1399670A (en) 1975-07-02

Family

ID=22916155

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1521473A Expired GB1399670A (en) 1972-04-10 1973-03-29 Process for preparing adenosine-5-carboxamides

Country Status (7)

Country Link
JP (1) JPS4913200A (en)
CA (1) CA1082695A (en)
CH (1) CH565175A5 (en)
DE (1) DE2317770A1 (en)
FR (1) FR2179886B1 (en)
GB (1) GB1399670A (en)
ZA (1) ZA731380B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495528B1 (en) 1998-06-23 2002-12-17 Smithkline Beecham Corporation 2-(Purin -9-yl)-tetrahydrofuran-3,4-diol derivatives
US6762170B1 (en) 1998-01-31 2004-07-13 Smithklinebeecham Corporation 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
US7985740B2 (en) 2005-07-19 2011-07-26 Glaxo Group Limited Purine derivatives as agonists of the adenosine A2A receptor

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8702926A (en) * 1986-12-15 1988-07-01 Sandoz Ag NEW FURANURONIC ACID DERIVATIVES AND METHODS FOR PREPARING AND USING THESE DERIVATIVES.
TW528755B (en) 1996-12-24 2003-04-21 Glaxo Group Ltd 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
PE20060272A1 (en) 2004-05-24 2006-05-22 Glaxo Group Ltd (2R, 3R, 4S, 5R, 2'R, 3'R, 4'S, 5'S) -2.2 '- {TRANS-1,4-CYCLOHEXANODIYLBIS- [IMINO (2 - {[2- (1-METHYL- 1H-IMIDAZOL-4-IL) ETHYL] AMINO} -9H-PURIN-6,9-DIYL)]} BIS [5- (2-ETHYL-2H-TETRAZOLE-5-IL) TETRAHYDRO-3,4-FURANODIOL] AS AN A2A AGONIST

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2034785A1 (en) * 1970-07-14 1972-01-20 Boehnnger Mannheim GmbH, 6800 Mann heim Waldhof Adenosine 5 carboxylic acid derivatives

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6762170B1 (en) 1998-01-31 2004-07-13 Smithklinebeecham Corporation 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
US6495528B1 (en) 1998-06-23 2002-12-17 Smithkline Beecham Corporation 2-(Purin -9-yl)-tetrahydrofuran-3,4-diol derivatives
US7985740B2 (en) 2005-07-19 2011-07-26 Glaxo Group Limited Purine derivatives as agonists of the adenosine A2A receptor

Also Published As

Publication number Publication date
CH565175A5 (en) 1975-08-15
ZA731380B (en) 1973-11-28
FR2179886A1 (en) 1973-11-23
DE2317770A1 (en) 1973-10-18
FR2179886B1 (en) 1978-04-21
CA1082695A (en) 1980-07-29
AU5286573A (en) 1974-09-05
JPS4913200A (en) 1974-02-05

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee