CA1082215A - Process for the preparation of ketoalkynoic acids and use of the process in an improved synthesis of 2- (substituted)-cyclopentane-1,3,4-triones - Google Patents

Process for the preparation of ketoalkynoic acids and use of the process in an improved synthesis of 2- (substituted)-cyclopentane-1,3,4-triones

Info

Publication number
CA1082215A
CA1082215A CA271,321A CA271321A CA1082215A CA 1082215 A CA1082215 A CA 1082215A CA 271321 A CA271321 A CA 271321A CA 1082215 A CA1082215 A CA 1082215A
Authority
CA
Canada
Prior art keywords
methyl
dioxolane
chloro
acid
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA271,321A
Other languages
English (en)
French (fr)
Inventor
Lawrence F. Reverman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Laboratories Inc filed Critical Miles Laboratories Inc
Application granted granted Critical
Publication of CA1082215A publication Critical patent/CA1082215A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/16—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA271,321A 1976-02-23 1977-02-08 Process for the preparation of ketoalkynoic acids and use of the process in an improved synthesis of 2- (substituted)-cyclopentane-1,3,4-triones Expired CA1082215A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/660,270 US4026911A (en) 1976-02-23 1976-02-23 Process for the preparation of ketoalkynoic acids and use of the process in an improved synthesis of 2-(substituted)-cyclo-pentane-1,3,4-triones
US660,270 1976-02-23

Publications (1)

Publication Number Publication Date
CA1082215A true CA1082215A (en) 1980-07-22

Family

ID=24648805

Family Applications (1)

Application Number Title Priority Date Filing Date
CA271,321A Expired CA1082215A (en) 1976-02-23 1977-02-08 Process for the preparation of ketoalkynoic acids and use of the process in an improved synthesis of 2- (substituted)-cyclopentane-1,3,4-triones

Country Status (6)

Country Link
US (1) US4026911A (enExample)
JP (1) JPS52122319A (enExample)
CA (1) CA1082215A (enExample)
DE (1) DE2707128A1 (enExample)
FR (2) FR2357521A1 (enExample)
GB (1) GB1530535A (enExample)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB859897A (en) * 1958-07-05 1961-01-25 Roche Products Ltd Novel unsaturated acids and esters thereof and a process for the manufacture and conversion of same
GB1370022A (en) * 1971-03-25 1974-10-09 Unilever Ltd Process for preparing ethylenic carboxylic acids

Also Published As

Publication number Publication date
DE2707128A1 (de) 1977-08-25
FR2361334B1 (enExample) 1980-02-01
FR2357521A1 (fr) 1978-02-03
FR2361334A1 (fr) 1978-03-10
GB1530535A (en) 1978-11-01
US4026911A (en) 1977-05-31
JPS52122319A (en) 1977-10-14
FR2357521B1 (enExample) 1980-02-22

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Legal Events

Date Code Title Description
MKEX Expiry
MKEX Expiry

Effective date: 19970722