FR2357521A1 - Procede de preparation d'acides cetoalcynoiques et son application a la synthese de cyclopentane-1,3,4-triones substituees en position 2 - Google Patents

Procede de preparation d'acides cetoalcynoiques et son application a la synthese de cyclopentane-1,3,4-triones substituees en position 2

Info

Publication number
FR2357521A1
FR2357521A1 FR7705145A FR7705145A FR2357521A1 FR 2357521 A1 FR2357521 A1 FR 2357521A1 FR 7705145 A FR7705145 A FR 7705145A FR 7705145 A FR7705145 A FR 7705145A FR 2357521 A1 FR2357521 A1 FR 2357521A1
Authority
FR
France
Prior art keywords
triones
synthesis
acids
substituted
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7705145A
Other languages
English (en)
Other versions
FR2357521B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Laboratories Inc filed Critical Miles Laboratories Inc
Publication of FR2357521A1 publication Critical patent/FR2357521A1/fr
Application granted granted Critical
Publication of FR2357521B1 publication Critical patent/FR2357521B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/16—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne un procécé de préparation d'acides cétoalcytloïques. La réaction d'un 2-méthyl-2-(alcényl)-1,3-dioxolane avec un alpha, oméga-dihalogénalcane donne un 2-méthyl-2-(oméga-chloralcynyl)-dioxolane qui est ensuite transformé en un nitrile correspondant et l'hydrolyse de ce nitrile forme l'acide cétoalcynoïque désiré. Le procédé de l'invention fait progresser la synthèse de cydopentane-1,,3,4-triones substituées en position 2.
FR7705145A 1976-02-23 1977-02-22 Procede de preparation d'acides cetoalcynoiques et son application a la synthese de cyclopentane-1,3,4-triones substituees en position 2 Granted FR2357521A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/660,270 US4026911A (en) 1976-02-23 1976-02-23 Process for the preparation of ketoalkynoic acids and use of the process in an improved synthesis of 2-(substituted)-cyclo-pentane-1,3,4-triones

Publications (2)

Publication Number Publication Date
FR2357521A1 true FR2357521A1 (fr) 1978-02-03
FR2357521B1 FR2357521B1 (fr) 1980-02-22

Family

ID=24648805

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7705145A Granted FR2357521A1 (fr) 1976-02-23 1977-02-22 Procede de preparation d'acides cetoalcynoiques et son application a la synthese de cyclopentane-1,3,4-triones substituees en position 2
FR7722314A Granted FR2361334A1 (fr) 1976-02-23 1977-07-20 Synthese de cyclopentane-1,3,4-triones substituees en position 2

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR7722314A Granted FR2361334A1 (fr) 1976-02-23 1977-07-20 Synthese de cyclopentane-1,3,4-triones substituees en position 2

Country Status (6)

Country Link
US (1) US4026911A (fr)
JP (1) JPS52122319A (fr)
CA (1) CA1082215A (fr)
DE (1) DE2707128A1 (fr)
FR (2) FR2357521A1 (fr)
GB (1) GB1530535A (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB859897A (en) * 1958-07-05 1961-01-25 Roche Products Ltd Novel unsaturated acids and esters thereof and a process for the manufacture and conversion of same
GB1370022A (en) * 1971-03-25 1974-10-09 Unilever Ltd Process for preparing ethylenic carboxylic acids

Also Published As

Publication number Publication date
DE2707128A1 (de) 1977-08-25
GB1530535A (en) 1978-11-01
US4026911A (en) 1977-05-31
FR2361334A1 (fr) 1978-03-10
JPS52122319A (en) 1977-10-14
CA1082215A (fr) 1980-07-22
FR2357521B1 (fr) 1980-02-22
FR2361334B1 (fr) 1980-02-01

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