CA1069502A - D-6-alkyl-8-cyanomethylergolines, their salts and methods of producing them - Google Patents

D-6-alkyl-8-cyanomethylergolines, their salts and methods of producing them

Info

Publication number
CA1069502A
CA1069502A CA267,668A CA267668A CA1069502A CA 1069502 A CA1069502 A CA 1069502A CA 267668 A CA267668 A CA 267668A CA 1069502 A CA1069502 A CA 1069502A
Authority
CA
Canada
Prior art keywords
cyanomethylergoline
alkyl
general formula
ester
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA267,668A
Other languages
English (en)
French (fr)
Inventor
Antonin Cerny
Rudolf Kotva
Miroslav Semonsky
Miroslav Seda
Marie Auskova
Karel Rezabek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SPOFA UNITED PHARMACEUTICAL WORKS
Original Assignee
SPOFA UNITED PHARMACEUTICAL WORKS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SPOFA UNITED PHARMACEUTICAL WORKS filed Critical SPOFA UNITED PHARMACEUTICAL WORKS
Application granted granted Critical
Publication of CA1069502A publication Critical patent/CA1069502A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D457/00Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA267,668A 1975-12-12 1976-12-10 D-6-alkyl-8-cyanomethylergolines, their salts and methods of producing them Expired CA1069502A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS758472A CS188414B1 (en) 1975-12-12 1975-12-12 New d-6-alkyl-8-cyanmethyl ergolines,their salts and method of producing

Publications (1)

Publication Number Publication Date
CA1069502A true CA1069502A (en) 1980-01-08

Family

ID=5435273

Family Applications (1)

Application Number Title Priority Date Filing Date
CA267,668A Expired CA1069502A (en) 1975-12-12 1976-12-10 D-6-alkyl-8-cyanomethylergolines, their salts and methods of producing them

Country Status (15)

Country Link
US (1) US4321380A (US20050192411A1-20050901-C00001.png)
JP (1) JPS5285195A (US20050192411A1-20050901-C00001.png)
AT (1) AT356293B (US20050192411A1-20050901-C00001.png)
AU (1) AU502928B2 (US20050192411A1-20050901-C00001.png)
BE (1) BE849318A (US20050192411A1-20050901-C00001.png)
CA (1) CA1069502A (US20050192411A1-20050901-C00001.png)
CH (1) CH622259A5 (US20050192411A1-20050901-C00001.png)
CS (1) CS188414B1 (US20050192411A1-20050901-C00001.png)
DE (1) DE2656093A1 (US20050192411A1-20050901-C00001.png)
DK (1) DK141874B (US20050192411A1-20050901-C00001.png)
FI (1) FI61189C (US20050192411A1-20050901-C00001.png)
FR (1) FR2334360A1 (US20050192411A1-20050901-C00001.png)
GB (1) GB1505800A (US20050192411A1-20050901-C00001.png)
NL (1) NL7613843A (US20050192411A1-20050901-C00001.png)
SE (1) SE419986B (US20050192411A1-20050901-C00001.png)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3913756A1 (de) * 1989-04-21 1990-10-25 Schering Ag 8(beta)-substituierte ergoline, verfahren zu ihrer herstellung und ihre verwendung

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH507248A (de) * 1967-03-16 1971-05-15 Spofa Vereinigte Pharma Werke Verfahren zur Herstellung von D-6-Methylergolin(I)ylessigsäure
US3920664A (en) * 1972-07-21 1975-11-18 Lilly Co Eli D-2-halo-6-alkyl-8-substituted ergolines and related compounds
US3880856A (en) * 1973-06-29 1975-04-29 Lilly Co Eli Ergoline dimers
CS171480B1 (US20050192411A1-20050901-C00001.png) * 1974-03-19 1976-10-29
US3959288A (en) * 1974-12-13 1976-05-25 Eli Lilly And Company 8-Oxymethylergolines and process therefor
US3992385A (en) * 1975-01-20 1976-11-16 Eli Lilly And Company 2,3-Dihydroergolines

Also Published As

Publication number Publication date
AU2037776A (en) 1978-06-15
FR2334360A1 (fr) 1977-07-08
GB1505800A (en) 1978-03-30
FR2334360B1 (US20050192411A1-20050901-C00001.png) 1980-03-07
DE2656093A1 (de) 1977-06-23
FI61189B (fi) 1982-02-26
FI61189C (fi) 1982-06-10
BE849318A (fr) 1977-04-01
US4321380A (en) 1982-03-23
SE7613673L (sv) 1977-06-13
CH622259A5 (US20050192411A1-20050901-C00001.png) 1981-03-31
CS188414B1 (en) 1979-03-30
FI763442A (US20050192411A1-20050901-C00001.png) 1977-06-13
DK141874B (da) 1980-07-07
DK141874C (US20050192411A1-20050901-C00001.png) 1980-12-15
AU502928B2 (en) 1979-08-16
AT356293B (de) 1980-04-25
ATA881776A (de) 1979-09-15
DK553376A (US20050192411A1-20050901-C00001.png) 1977-06-13
JPS5285195A (en) 1977-07-15
SE419986B (sv) 1981-09-07
NL7613843A (nl) 1977-06-14

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Legal Events

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