CA1066279A - Process for the manufacture of new 2,3-dihydro-1-benzothiepin-4-carboxamides - Google Patents

Process for the manufacture of new 2,3-dihydro-1-benzothiepin-4-carboxamides

Info

Publication number
CA1066279A
CA1066279A CA236,220A CA236220A CA1066279A CA 1066279 A CA1066279 A CA 1066279A CA 236220 A CA236220 A CA 236220A CA 1066279 A CA1066279 A CA 1066279A
Authority
CA
Canada
Prior art keywords
formula
compound
reaction
mono
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA236,220A
Other languages
English (en)
French (fr)
Inventor
Melvin H. Rosen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of CA1066279A publication Critical patent/CA1066279A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA236,220A 1974-09-26 1975-09-24 Process for the manufacture of new 2,3-dihydro-1-benzothiepin-4-carboxamides Expired CA1066279A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US50952474A 1974-09-26 1974-09-26
US58514775A 1975-06-09 1975-06-09
US74320876A 1976-11-18 1976-11-18
US05/854,176 US4185109A (en) 1974-09-26 1977-11-23 1-Benzothiepin-4-carboxamides

Publications (1)

Publication Number Publication Date
CA1066279A true CA1066279A (en) 1979-11-13

Family

ID=27504481

Family Applications (1)

Application Number Title Priority Date Filing Date
CA236,220A Expired CA1066279A (en) 1974-09-26 1975-09-24 Process for the manufacture of new 2,3-dihydro-1-benzothiepin-4-carboxamides

Country Status (10)

Country Link
US (1) US4185109A (US20100154141A1-20100624-C00001.png)
AT (1) AT346338B (US20100154141A1-20100624-C00001.png)
AU (1) AU496764B2 (US20100154141A1-20100624-C00001.png)
BE (1) BE833787A (US20100154141A1-20100624-C00001.png)
CA (1) CA1066279A (US20100154141A1-20100624-C00001.png)
CH (3) CH617433A5 (US20100154141A1-20100624-C00001.png)
DE (1) DE2542329C2 (US20100154141A1-20100624-C00001.png)
FR (1) FR2285872A1 (US20100154141A1-20100624-C00001.png)
NL (1) NL7511316A (US20100154141A1-20100624-C00001.png)
SE (1) SE420725B (US20100154141A1-20100624-C00001.png)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4242266A (en) * 1974-09-26 1980-12-30 Ciba-Geigy Corporation 1-Benzothiepin-4-carboxylic acid derivatives
US4277484A (en) * 1978-09-20 1981-07-07 Ciba-Geigy Corporation 1-Benzothiepin-4-carboxamides
US4582850A (en) * 1985-02-28 1986-04-15 Ciba-Geigy Corporation Topical and systemic treatment of psoriasis using 7-chloro-N-(3,4-dichlorophenyl)-2,3-dihydro-5-hydroxy-1-benzothiepin-4-carboxamide 1,1-dioxide and pharmaceutically acceptable salts thereof
US4803197A (en) * 1987-01-12 1989-02-07 Ciba-Geigy Corporation 2,1-benzothiazepine-2,2-dioxide-5-carboxylic acid derivatives
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6221897B1 (en) * 1998-06-10 2001-04-24 Aventis Pharma Deutschland Gmbh Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
AU3103800A (en) 1998-12-23 2000-07-31 G.D. Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acidderivatives for cardiovascular indications
HUP0104793A2 (en) 1998-12-23 2002-06-29 Searle Llc Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications
EP1340509A1 (en) 1998-12-23 2003-09-03 G.D. Searle LLC. Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications
ES2200587T3 (es) 1998-12-23 2004-03-01 G.D. Searle Llc Combinaciones de inhibidors del transporte de acidos biliares del ileon e inhibidores de la proteina de transferencia de colesteril ester para indicaciones cardiovasculares.
MXPA01006470A (es) 1998-12-23 2003-06-06 Searle Llc Combinaciones de inhibidores de transporte de acido biliar ileal y agentes de secuentro de acido biliar para indicaciones cardiovasculares.
IL143944A0 (en) * 1998-12-23 2002-04-21 Searle Llc Combinations for cardiovascular indications
WO2000038723A1 (en) 1998-12-23 2000-07-06 G.D. Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications
WO2000038722A1 (en) 1998-12-23 2000-07-06 G.D. Searle & Co. COMBINATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG CoA REDUCTASE INHIBITORS FOR CARDIOVASCULAR INDICATIONS
EP1286984A2 (en) 2000-03-10 2003-03-05 Pharmacia Corporation Method for the preparation of tetrahydrobenzothiepines
WO2001068096A2 (en) * 2000-03-10 2001-09-20 Pharmacia Corporation Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders
US20040077625A1 (en) * 2001-07-25 2004-04-22 Tremont Samuel J. Novel 1,4-benzothiazepine and 1,5-benzothiazepine compounds as inhibitors of apical sodium codependent bile acid transport abd taurocholate uptake
WO2003040127A1 (en) * 2001-11-02 2003-05-15 G.D. Searle Llc Novel mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (asbt) and taurocholate uptake
CA2471639A1 (en) 2002-01-17 2003-07-31 Pharmacia Corporation Novel alkyl/aryl hydroxy or keto thiepines.
EP2771003B1 (en) 2011-10-28 2017-04-19 Lumena Pharmaceuticals LLC Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3389144A (en) * 1965-06-08 1968-06-18 Mcneilab Inc 5-pyridyl-2, 3, 4, 5-tetrahydrobenzothiepin-5-ols
US3287370A (en) * 1965-06-08 1966-11-22 Mcneilab Inc Tetrahydrobenzothiepins
US3287368A (en) * 1965-06-08 1966-11-22 Mcneilab Inc Dihydrobenzothiepin-5(2h)-one oximes
US3444176A (en) * 1967-04-28 1969-05-13 Mcneilab Inc Certain 4-diloweralkylamino-lower alkyl - 5 - pyridyl (or phenyl)-2,3-dihydro - 1 - benzothiepins and derivatives thereof
US3505355A (en) * 1968-08-12 1970-04-07 Mcneilab Inc Certain dihydrobenzo-thiepin-5(2h)-ones
DE2264938A1 (de) * 1971-07-15 1975-06-12 Warner Lambert Co 3-arylaminocarbonyl-4-hydroxy-benzo eckige klammer auf b eckige klammer zu thiacyclohex(3)en-1,1-dioxide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US3769292A (en) * 1972-04-28 1973-10-30 Warner Lambert Co N-(pyridyl)2h 1-benzothiopyran-3-carboxamide-4-hydroxy 1,1-dioxides
US3826791A (en) * 1972-04-28 1974-07-30 Warner Lambert Co Heterocyclic amides of 4-hydroxy-2h-1-benzothiopyran-3-carboxylic acid 1,1-dioxide and process for their production
US3828055A (en) * 1972-04-28 1974-08-06 Warner Lambert Co Heterocyclic amides of 4-hydroxy-2h-1-benzothiopyran-3-carboxylic acid 1,1-dioxide
US3962261A (en) * 1974-02-04 1976-06-08 Warner-Lambert Company 2,3,4,5-tetra hydro-5-oxo-1-benzothiepi n-4-carboxamide 1,1-dioxides

Also Published As

Publication number Publication date
CH623581A5 (US20100154141A1-20100624-C00001.png) 1981-06-15
DE2542329A1 (de) 1976-04-15
US4185109A (en) 1980-01-22
AU496764B2 (en) 1978-10-26
SE7510196L (sv) 1976-03-29
NL7511316A (nl) 1976-03-30
CH617433A5 (US20100154141A1-20100624-C00001.png) 1980-05-30
CH623580A5 (US20100154141A1-20100624-C00001.png) 1981-06-15
ATA734175A (de) 1978-03-15
BE833787A (fr) 1976-03-25
SE420725B (sv) 1981-10-26
FR2285872B1 (US20100154141A1-20100624-C00001.png) 1978-11-10
FR2285872A1 (fr) 1976-04-23
AT346338B (de) 1978-11-10
DE2542329C2 (de) 1984-05-24
AU8514875A (en) 1977-03-31

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