CA1050966A - STEROIDAL (16.alpha.,17-B) 1,4-DIOXANES - Google Patents

STEROIDAL (16.alpha.,17-B) 1,4-DIOXANES

Info

Publication number
CA1050966A
CA1050966A CA217,981A CA217981A CA1050966A CA 1050966 A CA1050966 A CA 1050966A CA 217981 A CA217981 A CA 217981A CA 1050966 A CA1050966 A CA 1050966A
Authority
CA
Canada
Prior art keywords
hydrogen
fluoro
accordance
steroid
dione
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA217,981A
Other languages
English (en)
French (fr)
Other versions
CA217981S (en
Inventor
Christopher M. Cimarusti
Seymour D. Levine
Frank L. Weisenborn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Application granted granted Critical
Publication of CA1050966A publication Critical patent/CA1050966A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10Oxygen atoms
    • C07D309/12Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D319/00Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/101,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/121,4-Dioxanes; Hydrogenated 1,4-dioxanes not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J17/00Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J31/00Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J5/00Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0092Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by an OH group free esterified or etherified
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J51/00Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J7/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005Oxygen-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA217,981A 1974-01-16 1975-01-15 STEROIDAL (16.alpha.,17-B) 1,4-DIOXANES Expired CA1050966A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43397474A 1974-01-16 1974-01-16

Publications (1)

Publication Number Publication Date
CA1050966A true CA1050966A (en) 1979-03-20

Family

ID=23722311

Family Applications (1)

Application Number Title Priority Date Filing Date
CA217,981A Expired CA1050966A (en) 1974-01-16 1975-01-15 STEROIDAL (16.alpha.,17-B) 1,4-DIOXANES

Country Status (20)

Country Link
JP (1) JPS50101358A (fi)
AR (1) AR209758A1 (fi)
BE (1) BE824405A (fi)
CA (1) CA1050966A (fi)
CH (1) CH606116A5 (fi)
CS (1) CS182829B2 (fi)
DD (1) DD117449A5 (fi)
DE (1) DE2501041A1 (fi)
DK (1) DK9075A (fi)
ES (1) ES433814A1 (fi)
FI (1) FI750090A (fi)
FR (2) FR2257299B1 (fi)
GB (1) GB1498132A (fi)
IE (1) IE42427B1 (fi)
IL (1) IL46436A (fi)
NL (1) NL7500458A (fi)
NO (1) NO750119L (fi)
SE (1) SE7500430L (fi)
SU (1) SU581874A3 (fi)
ZA (1) ZA75298B (fi)

Also Published As

Publication number Publication date
ES433814A1 (es) 1977-02-16
FR2257299A1 (fi) 1975-08-08
IL46436A0 (en) 1975-06-25
FR2257299B1 (fi) 1978-08-04
DD117449A5 (fi) 1976-01-12
CS182829B2 (en) 1978-05-31
SU581874A3 (ru) 1977-11-25
NL7500458A (nl) 1975-07-18
NO750119L (fi) 1975-07-17
BE824405A (fr) 1975-07-15
FR2279760A1 (fr) 1976-02-20
DK9075A (fi) 1975-09-15
CH606116A5 (fi) 1978-10-13
FR2279760B1 (fi) 1978-09-22
JPS50101358A (fi) 1975-08-11
IL46436A (en) 1979-05-31
AU7731075A (en) 1976-07-15
AR209758A1 (es) 1977-05-31
GB1498132A (en) 1978-01-18
ZA75298B (en) 1976-01-28
IE42427L (en) 1975-07-16
FI750090A (fi) 1975-07-17
IE42427B1 (en) 1980-08-13
DE2501041A1 (de) 1975-07-17
SE7500430L (fi) 1975-07-17

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