FR2279760A1 - Intermediaire de synthese de steroido(16a, 17-b)1,4-dioxanes et 1,4-dioxines - Google Patents

Intermediaire de synthese de steroido(16a, 17-b)1,4-dioxanes et 1,4-dioxines

Info

Publication number
FR2279760A1
FR2279760A1 FR7528266A FR7528266A FR2279760A1 FR 2279760 A1 FR2279760 A1 FR 2279760A1 FR 7528266 A FR7528266 A FR 7528266A FR 7528266 A FR7528266 A FR 7528266A FR 2279760 A1 FR2279760 A1 FR 2279760A1
Authority
FR
France
Prior art keywords
steroido
dioxanes
dioxins
synthesis intermediate
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7528266A
Other languages
English (en)
Other versions
FR2279760B1 (fr
Inventor
Christopher Michael Cimarusti
Seymour David Levine
Frank Lee Weisenborn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of FR2279760A1 publication Critical patent/FR2279760A1/fr
Application granted granted Critical
Publication of FR2279760B1 publication Critical patent/FR2279760B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/12—1,4-Dioxanes; Hydrogenated 1,4-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0092—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR7528266A 1974-01-16 1975-09-15 Intermediaire de synthese de steroido(16a, 17-b)1,4-dioxanes et 1,4-dioxines Granted FR2279760A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43397474A 1974-01-16 1974-01-16

Publications (2)

Publication Number Publication Date
FR2279760A1 true FR2279760A1 (fr) 1976-02-20
FR2279760B1 FR2279760B1 (fr) 1978-09-22

Family

ID=23722311

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7501118A Expired FR2257299B1 (fr) 1974-01-16 1975-01-15
FR7528266A Granted FR2279760A1 (fr) 1974-01-16 1975-09-15 Intermediaire de synthese de steroido(16a, 17-b)1,4-dioxanes et 1,4-dioxines

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR7501118A Expired FR2257299B1 (fr) 1974-01-16 1975-01-15

Country Status (20)

Country Link
JP (1) JPS50101358A (fr)
AR (1) AR209758A1 (fr)
BE (1) BE824405A (fr)
CA (1) CA1050966A (fr)
CH (1) CH606116A5 (fr)
CS (1) CS182829B2 (fr)
DD (1) DD117449A5 (fr)
DE (1) DE2501041A1 (fr)
DK (1) DK9075A (fr)
ES (1) ES433814A1 (fr)
FI (1) FI750090A (fr)
FR (2) FR2257299B1 (fr)
GB (1) GB1498132A (fr)
IE (1) IE42427B1 (fr)
IL (1) IL46436A (fr)
NL (1) NL7500458A (fr)
NO (1) NO750119L (fr)
SE (1) SE7500430L (fr)
SU (1) SU581874A3 (fr)
ZA (1) ZA75298B (fr)

Also Published As

Publication number Publication date
CS182829B2 (en) 1978-05-31
AU7731075A (en) 1976-07-15
ES433814A1 (es) 1977-02-16
DE2501041A1 (de) 1975-07-17
IL46436A (en) 1979-05-31
JPS50101358A (fr) 1975-08-11
IE42427L (en) 1975-07-16
FI750090A (fr) 1975-07-17
SE7500430L (fr) 1975-07-17
CH606116A5 (fr) 1978-10-13
IL46436A0 (en) 1975-06-25
NO750119L (fr) 1975-07-17
DK9075A (fr) 1975-09-15
FR2257299B1 (fr) 1978-08-04
BE824405A (fr) 1975-07-15
FR2279760B1 (fr) 1978-09-22
IE42427B1 (en) 1980-08-13
CA1050966A (fr) 1979-03-20
NL7500458A (nl) 1975-07-18
GB1498132A (en) 1978-01-18
AR209758A1 (es) 1977-05-31
SU581874A3 (ru) 1977-11-25
FR2257299A1 (fr) 1975-08-08
ZA75298B (en) 1976-01-28
DD117449A5 (fr) 1976-01-12

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Legal Events

Date Code Title Description
ST Notification of lapse