CA1048020A - Pseudotrisaccharides and methods for their production - Google Patents

Pseudotrisaccharides and methods for their production

Info

Publication number
CA1048020A
CA1048020A CA240,567A CA240567A CA1048020A CA 1048020 A CA1048020 A CA 1048020A CA 240567 A CA240567 A CA 240567A CA 1048020 A CA1048020 A CA 1048020A
Authority
CA
Canada
Prior art keywords
epi
antibiotic
amino
formula
gentamicin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA240,567A
Other languages
English (en)
French (fr)
Inventor
Peter J. L. Daniels
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD International Holdings GmbH
Original Assignee
Scherico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/611,290 external-priority patent/US4000262A/en
Priority claimed from US05/611,289 external-priority patent/US4000261A/en
Application filed by Scherico Ltd filed Critical Scherico Ltd
Application granted granted Critical
Publication of CA1048020A publication Critical patent/CA1048020A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
CA240,567A 1974-11-29 1975-11-26 Pseudotrisaccharides and methods for their production Expired CA1048020A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US52859374A 1974-11-29 1974-11-29
US52859274A 1974-11-29 1974-11-29
US05/611,290 US4000262A (en) 1974-11-29 1975-09-08 5-epi-amino and 5-epi-azido-4,6-di-o-(aminoglycosyl)-2,5-dideoxystreptamines 1-n-alkyl-5-epi-amino and 1-n-alkyl-5-epi-azido-4,6-di-o-(aminoglycosyl)-2,5-dideoxystreptamines
US05/611,289 US4000261A (en) 1974-11-29 1975-09-08 5-epi-4,6-di-o-(aminoglycosyl)-2-deoxystreptamines, methods for their manufacture and intermediates useful therein, methods for their use as antibacterial agents and compositions useful therefor

Publications (1)

Publication Number Publication Date
CA1048020A true CA1048020A (en) 1979-02-06

Family

ID=27504618

Family Applications (1)

Application Number Title Priority Date Filing Date
CA240,567A Expired CA1048020A (en) 1974-11-29 1975-11-26 Pseudotrisaccharides and methods for their production

Country Status (17)

Country Link
JP (1) JPS52244A (OSRAM)
AR (1) AR215848A1 (OSRAM)
CA (1) CA1048020A (OSRAM)
CH (1) CH618986A5 (OSRAM)
DE (1) DE2552799A1 (OSRAM)
DK (1) DK531375A (OSRAM)
ES (1) ES442989A1 (OSRAM)
FI (1) FI753318A7 (OSRAM)
FR (1) FR2292482A1 (OSRAM)
GB (1) GB1528930A (OSRAM)
GR (1) GR58472B (OSRAM)
IE (1) IE43126B1 (OSRAM)
IL (1) IL48558A (OSRAM)
LU (1) LU73887A1 (OSRAM)
NL (1) NL7513737A (OSRAM)
NO (2) NO142080C (OSRAM)
SE (1) SE7513330L (OSRAM)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2832268A1 (de) * 1978-07-22 1980-01-31 Bayer Ag Pseudotrisaccharide
DE2924659A1 (de) * 1979-06-19 1981-01-22 Bayer Ag Pseudotrisaccharide, ihre herstellung und verwendung als arzneimittel
WO2005070945A1 (ja) * 2004-01-21 2005-08-04 Meiji Seika Kaisha, Ltd. メチシリン耐性黄色ブドウ球菌（ｍｒｓａ）に有効な新規アミノグリコシド系抗生物質

Also Published As

Publication number Publication date
GR58472B (en) 1977-10-14
NO142080B (no) 1980-03-17
JPS52244A (en) 1977-01-05
IE43126L (en) 1976-05-29
NO790908L (no) 1976-06-01
ES442989A1 (es) 1977-08-16
AU8698875A (en) 1977-06-09
FR2292482A1 (fr) 1976-06-25
AR215848A1 (es) 1979-11-15
GB1528930A (en) 1978-10-18
IL48558A (en) 1980-07-31
CH618986A5 (en) 1980-08-29
LU73887A1 (OSRAM) 1976-09-06
IE43126B1 (en) 1980-12-31
SE7513330L (sv) 1976-05-31
NO753969L (OSRAM) 1976-06-01
DE2552799A1 (de) 1976-08-12
FI753318A7 (OSRAM) 1976-05-30
FR2292482B1 (OSRAM) 1981-12-31
NO142080C (no) 1980-06-25
DK531375A (da) 1976-05-30
IL48558A0 (en) 1976-01-30
NL7513737A (nl) 1976-06-01

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