IL48558A - 5-epi-derivatives of 4-6-di-3-(aminoglycosyl)-2-deoxystreptamine antibiotics and methods for their preparation - Google Patents

5-epi-derivatives of 4-6-di-3-(aminoglycosyl)-2-deoxystreptamine antibiotics and methods for their preparation

Info

Publication number
IL48558A
IL48558A IL48558A IL4855875A IL48558A IL 48558 A IL48558 A IL 48558A IL 48558 A IL48558 A IL 48558A IL 4855875 A IL4855875 A IL 4855875A IL 48558 A IL48558 A IL 48558A
Authority
IL
Israel
Prior art keywords
aminoglycosyl
epi
derivatives
preparation
methods
Prior art date
Application number
IL48558A
Other languages
English (en)
Other versions
IL48558A0 (en
Original Assignee
Scherico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/611,289 external-priority patent/US4000261A/en
Priority claimed from US05/611,290 external-priority patent/US4000262A/en
Application filed by Scherico Ltd filed Critical Scherico Ltd
Publication of IL48558A0 publication Critical patent/IL48558A0/xx
Publication of IL48558A publication Critical patent/IL48558A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
IL48558A 1974-11-29 1975-11-27 5-epi-derivatives of 4-6-di-3-(aminoglycosyl)-2-deoxystreptamine antibiotics and methods for their preparation IL48558A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US52859374A 1974-11-29 1974-11-29
US52859274A 1974-11-29 1974-11-29
US05/611,289 US4000261A (en) 1974-11-29 1975-09-08 5-epi-4,6-di-o-(aminoglycosyl)-2-deoxystreptamines, methods for their manufacture and intermediates useful therein, methods for their use as antibacterial agents and compositions useful therefor
US05/611,290 US4000262A (en) 1974-11-29 1975-09-08 5-epi-amino and 5-epi-azido-4,6-di-o-(aminoglycosyl)-2,5-dideoxystreptamines 1-n-alkyl-5-epi-amino and 1-n-alkyl-5-epi-azido-4,6-di-o-(aminoglycosyl)-2,5-dideoxystreptamines

Publications (2)

Publication Number Publication Date
IL48558A0 IL48558A0 (en) 1976-01-30
IL48558A true IL48558A (en) 1980-07-31

Family

ID=27504618

Family Applications (1)

Application Number Title Priority Date Filing Date
IL48558A IL48558A (en) 1974-11-29 1975-11-27 5-epi-derivatives of 4-6-di-3-(aminoglycosyl)-2-deoxystreptamine antibiotics and methods for their preparation

Country Status (17)

Country Link
JP (1) JPS52244A (xx)
AR (1) AR215848A1 (xx)
CA (1) CA1048020A (xx)
CH (1) CH618986A5 (xx)
DE (1) DE2552799A1 (xx)
DK (1) DK531375A (xx)
ES (1) ES442989A1 (xx)
FI (1) FI753318A (xx)
FR (1) FR2292482A1 (xx)
GB (1) GB1528930A (xx)
GR (1) GR58472B (xx)
IE (1) IE43126B1 (xx)
IL (1) IL48558A (xx)
LU (1) LU73887A1 (xx)
NL (1) NL7513737A (xx)
NO (2) NO142080C (xx)
SE (1) SE7513330L (xx)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2832268A1 (de) * 1978-07-22 1980-01-31 Bayer Ag Pseudotrisaccharide
DE2924659A1 (de) * 1979-06-19 1981-01-22 Bayer Ag Pseudotrisaccharide, ihre herstellung und verwendung als arzneimittel
US20070161581A1 (en) * 2004-01-21 2007-07-12 Nobuto Minowa Novel aminoglycoside antibiotics effective against methicillin resistant staphylococcus auerus (mrsas)

Also Published As

Publication number Publication date
NO142080C (no) 1980-06-25
CH618986A5 (en) 1980-08-29
IL48558A0 (en) 1976-01-30
ES442989A1 (es) 1977-08-16
DE2552799A1 (de) 1976-08-12
FR2292482B1 (xx) 1981-12-31
FI753318A (xx) 1976-05-30
CA1048020A (en) 1979-02-06
AR215848A1 (es) 1979-11-15
NO753969L (xx) 1976-06-01
NO142080B (no) 1980-03-17
LU73887A1 (xx) 1976-09-06
SE7513330L (sv) 1976-05-31
FR2292482A1 (fr) 1976-06-25
NL7513737A (nl) 1976-06-01
DK531375A (da) 1976-05-30
NO790908L (no) 1976-06-01
AU8698875A (en) 1977-06-09
IE43126B1 (en) 1980-12-31
IE43126L (en) 1976-05-29
GR58472B (en) 1977-10-14
GB1528930A (en) 1978-10-18
JPS52244A (en) 1977-01-05

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