CA1040078A - Method for constituent analysis with thin-layer reactant mixture - Google Patents
Method for constituent analysis with thin-layer reactant mixtureInfo
- Publication number
- CA1040078A CA1040078A CA168,313A CA168313A CA1040078A CA 1040078 A CA1040078 A CA 1040078A CA 168313 A CA168313 A CA 168313A CA 1040078 A CA1040078 A CA 1040078A
- Authority
- CA
- Canada
- Prior art keywords
- reaction
- site
- constituent
- reaction product
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004458 analytical method Methods 0.000 title claims abstract description 31
- 238000000034 method Methods 0.000 title claims abstract description 30
- 239000000470 constituent Substances 0.000 title claims abstract description 24
- 239000000376 reactant Substances 0.000 title claims description 14
- 239000000203 mixture Substances 0.000 title description 2
- 238000006243 chemical reaction Methods 0.000 claims abstract description 40
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 35
- 238000012360 testing method Methods 0.000 claims abstract description 25
- 239000007795 chemical reaction product Substances 0.000 claims abstract description 20
- 238000009826 distribution Methods 0.000 claims abstract description 16
- 238000005259 measurement Methods 0.000 claims abstract description 13
- 239000000047 product Substances 0.000 claims abstract description 7
- 230000005670 electromagnetic radiation Effects 0.000 claims abstract description 5
- 239000000523 sample Substances 0.000 claims description 24
- 230000005855 radiation Effects 0.000 claims description 12
- 230000035945 sensitivity Effects 0.000 claims description 11
- 239000000835 fiber Substances 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 10
- 230000007480 spreading Effects 0.000 claims description 10
- 238000003892 spreading Methods 0.000 claims description 10
- 230000004044 response Effects 0.000 claims description 8
- 230000008859 change Effects 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 5
- 239000002657 fibrous material Substances 0.000 claims description 3
- 230000006872 improvement Effects 0.000 claims 13
- 239000006193 liquid solution Substances 0.000 claims 3
- 230000006335 response to radiation Effects 0.000 claims 1
- 239000000463 material Substances 0.000 abstract description 18
- 239000012488 sample solution Substances 0.000 abstract description 13
- 210000002966 serum Anatomy 0.000 description 15
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 12
- 210000004369 blood Anatomy 0.000 description 9
- 239000008280 blood Substances 0.000 description 9
- XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 8
- 238000000151 deposition Methods 0.000 description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 6
- 239000011541 reaction mixture Substances 0.000 description 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 230000008021 deposition Effects 0.000 description 5
- 239000008103 glucose Substances 0.000 description 5
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 5
- KCOPMCWPGUZUET-UHFFFAOYSA-N 2-aminoacetate;aminoazanium Chemical compound NN.NCC(O)=O KCOPMCWPGUZUET-UHFFFAOYSA-N 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 102000004882 Lipase Human genes 0.000 description 3
- 108090001060 Lipase Proteins 0.000 description 3
- 239000004367 Lipase Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000011152 fibreglass Substances 0.000 description 3
- 150000002605 large molecules Chemical class 0.000 description 3
- 235000019421 lipase Nutrition 0.000 description 3
- 229920002521 macromolecule Polymers 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 239000012190 activator Substances 0.000 description 2
- 239000013060 biological fluid Substances 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 150000003384 small molecules Chemical class 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 102000057621 Glycerol kinases Human genes 0.000 description 1
- 102000005548 Hexokinase Human genes 0.000 description 1
- 108700040460 Hexokinases Proteins 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 101710163410 Probable glycerol kinase Proteins 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000004159 blood analysis Methods 0.000 description 1
- 239000003990 capacitor Substances 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005672 electromagnetic field Effects 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000012886 linear function Methods 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 238000011022 operating instruction Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- -1 polyoxyethylene Polymers 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/8483—Investigating reagent band
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/521—Single-layer analytical elements
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24306872A | 1972-04-11 | 1972-04-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1040078A true CA1040078A (en) | 1978-10-10 |
Family
ID=22917235
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA168,313A Expired CA1040078A (en) | 1972-04-11 | 1973-04-03 | Method for constituent analysis with thin-layer reactant mixture |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS4917794A (enrdf_load_stackoverflow) |
| CA (1) | CA1040078A (enrdf_load_stackoverflow) |
| DE (1) | DE2318044A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2180358A5 (enrdf_load_stackoverflow) |
| GB (1) | GB1432811A (enrdf_load_stackoverflow) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1522965A (en) * | 1974-08-19 | 1978-08-31 | Damon Corp | Method and apparatus of chemical photometric spot test analysis |
| JPS5328063A (en) * | 1976-08-27 | 1978-03-15 | Ishikawajima Harima Heavy Ind | Inlet side equipment of strip treating line |
| JPS5328064A (en) * | 1976-08-27 | 1978-03-15 | Ishikawajima Harima Heavy Ind | Exit side equipment of strip treating line |
| US4298345A (en) | 1977-11-21 | 1981-11-03 | Damon Corporation | Method and apparatus for chemical spot test analysis |
| JPS62116444A (ja) * | 1985-11-12 | 1987-05-28 | Satsuki Seisakusho:Kk | 長尺物の巻取装置 |
| JP2560326B2 (ja) * | 1987-05-21 | 1996-12-04 | 石川島播磨重工業株式会社 | 巻取設備 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3260413A (en) * | 1964-08-31 | 1966-07-12 | Scientific Industries | Automatic chemical analyzer |
| US3526480A (en) * | 1966-12-15 | 1970-09-01 | Xerox Corp | Automated chemical analyzer |
-
1973
- 1973-04-03 CA CA168,313A patent/CA1040078A/en not_active Expired
- 1973-04-10 GB GB1710973A patent/GB1432811A/en not_active Expired
- 1973-04-10 DE DE2318044A patent/DE2318044A1/de not_active Ceased
- 1973-04-10 FR FR7312943A patent/FR2180358A5/fr not_active Expired
- 1973-04-11 JP JP48040512A patent/JPS4917794A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPS4917794A (enrdf_load_stackoverflow) | 1974-02-16 |
| DE2318044A1 (de) | 1973-10-31 |
| GB1432811A (en) | 1976-04-22 |
| FR2180358A5 (enrdf_load_stackoverflow) | 1973-11-23 |
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