CA1030972A - Pharmacologically active benzo (b) thiophene compounds and process for their preparation - Google Patents

Pharmacologically active benzo (b) thiophene compounds and process for their preparation

Info

Publication number
CA1030972A
CA1030972A CA228,687A CA228687A CA1030972A CA 1030972 A CA1030972 A CA 1030972A CA 228687 A CA228687 A CA 228687A CA 1030972 A CA1030972 A CA 1030972A
Authority
CA
Canada
Prior art keywords
preparation
pharmacologically active
thiophene compounds
active benzo
benzo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA228,687A
Other languages
English (en)
French (fr)
Inventor
Jean Gubin
Marcel Descamps
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Labaz SA
Original Assignee
Labaz SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labaz SA filed Critical Labaz SA
Application granted granted Critical
Publication of CA1030972A publication Critical patent/CA1030972A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA228,687A 1974-06-06 1975-06-06 Pharmacologically active benzo (b) thiophene compounds and process for their preparation Expired CA1030972A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2525674A GB1456323A (en) 1974-06-06 1974-06-06 Benzothiophenes process for preparing them and pharmaceutical compositions containing the same

Publications (1)

Publication Number Publication Date
CA1030972A true CA1030972A (en) 1978-05-09

Family

ID=10224753

Family Applications (1)

Application Number Title Priority Date Filing Date
CA228,687A Expired CA1030972A (en) 1974-06-06 1975-06-06 Pharmacologically active benzo (b) thiophene compounds and process for their preparation

Country Status (20)

Country Link
US (1) US4007204A (en:Method)
JP (1) JPS516958A (en:Method)
AR (2) AR207152A1 (en:Method)
AT (1) AT341517B (en:Method)
BE (1) BE829837A (en:Method)
CA (1) CA1030972A (en:Method)
CH (1) CH605910A5 (en:Method)
DE (1) DE2522655A1 (en:Method)
DK (1) DK135808B (en:Method)
ES (1) ES438303A1 (en:Method)
FI (1) FI751602A7 (en:Method)
GB (1) GB1456323A (en:Method)
HU (1) HU172820B (en:Method)
IT (1) IT1038094B (en:Method)
NL (1) NL7504921A (en:Method)
NO (1) NO751989L (en:Method)
OA (1) OA05022A (en:Method)
SE (1) SE7505482L (en:Method)
SU (1) SU578002A3 (en:Method)
ZA (1) ZA752871B (en:Method)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU509682B2 (en) * 1975-10-28 1980-05-22 Eli Lilly And Company 2-Aroyl-3-Phenylbenzothiophene Derivatives
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US5175184A (en) * 1982-10-19 1992-12-29 Kotobuki Seiyaku Company Limited Benzothiophene derivatives and antihyperuricemia thereof
NZ213986A (en) * 1984-10-30 1989-07-27 Usv Pharma Corp Heterocyclic or aromatic compounds, and pharmaceutical compositions containing such
US4851554A (en) * 1987-04-06 1989-07-25 University Of Tennessee Research Corporation Certain 3-substituted 2-alkyl benzofuran derivatives
US4806663A (en) * 1987-04-06 1989-02-21 The University Of Tennessee Research Corporation Certain 3-substituted 2-alkyl benzofuran derivatives
US4912642A (en) * 1987-09-03 1990-03-27 The Boeing Company Coordinated engine autothrottle
US4831156A (en) * 1987-09-30 1989-05-16 The University Of Tennessee Research Corp. 3-substituted 2-alkyl indole derivatives
WO1989002893A1 (en) * 1987-09-30 1989-04-06 The University Of Tennessee Research Corporation Certain 3-substituted 2-alkyl benzothiophene derivatives
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
ATE214059T1 (de) * 1994-04-11 2002-03-15 Chugai Pharmaceutical Co Ltd 4,6-di-t-butyl-2,3-dihydrobenzothiophene, die ldl oxidation hemmen
CO4410190A1 (es) * 1994-09-19 1997-01-09 Lilly Co Eli 3-[4-(2-AMINOETOXI)-BENZOIL]-2-ARIL-6-HIDROXIBENZO [b] TIOFENO CRISTALINO
US6653328B1 (en) * 1995-03-10 2003-11-25 Eli Lilly And Company 3-benzyl-benzothiophenes
US6417199B1 (en) * 1995-03-10 2002-07-09 Eli Lilly And Company 3-benzyl-benzothiophenes
DE69634045T2 (de) 1995-10-31 2005-05-19 Eli Lilly And Co., Indianapolis Antithrombotische diamine
EP0888331A4 (en) * 1996-03-19 2001-05-23 Lilly Co Eli SYNTHESIS OF 3- [4- (2-AMINOETHOXY) BENZOYL] -2-ARYL-6-HYDROXY-BENZO [b] THIOPHENES
AU7170898A (en) 1997-04-30 1998-11-24 Eli Lilly And Company Antithrombotic agents
US6391901B1 (en) 1997-04-30 2002-05-21 Eli Lilly And Company Thrombin inhibitors
AU7165398A (en) * 1997-04-30 1998-11-24 Eli Lilly And Company A regioselective alkylation process for preparing substituted benzo{b}thiophenes
DE69824410T2 (de) 1997-04-30 2005-06-02 Eli Lilly And Co., Indianapolis Antithrombosemittel
US6350774B1 (en) 1997-04-30 2002-02-26 Eli Lilly And Company Antithrombotic agents
US6284756B1 (en) 1998-04-30 2001-09-04 Eli Lilly And Company Antithrombotic agents
PT997460E (pt) * 1998-10-28 2003-03-31 Lilly Co Eli Compostos benzotiofenos como agentes antitromboticos e seus intermediarios
FR2864536B1 (fr) * 2003-12-24 2006-03-17 Clariant France Sa Procede de preparation de n-alkyl-2 (hydroxy-4-benzoyl)-3 benzofurannes et intermediaires pour sa mise en oeuvre
JP6030556B2 (ja) * 2010-08-06 2016-11-24 タスリー・ファーマシューティカル・グループ・カンパニー・リミテッドＴａｓｌｙ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｇｒｏｕｐ Ｃｏ．， Ｌｔｄ． 冠動脈心疾患の二次予防薬の調製におけるタンジン組成物の使用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3514465A (en) * 1966-12-30 1970-05-26 Degussa Certain thiazolyl- and pyridinylaminoketones
US3706747A (en) * 1970-06-05 1972-12-19 Pfizer Benzothieno(3,2-d)- and benzofuro(3,2-d)pyrimidines

Also Published As

Publication number Publication date
HU172820B (hu) 1978-12-28
DE2522655A1 (de) 1975-12-18
DK135808C (en:Method) 1977-11-28
NL7504921A (nl) 1975-12-09
CH605910A5 (en:Method) 1978-10-13
DK251975A (en:Method) 1975-12-07
DK135808B (da) 1977-06-27
AT341517B (de) 1978-02-10
JPS516958A (en) 1976-01-20
US4007204A (en) 1977-02-08
ATA431175A (de) 1977-06-15
SU578002A3 (ru) 1977-10-25
AU8102275A (en) 1976-11-11
IT1038094B (it) 1979-11-20
ES438303A1 (es) 1977-01-16
ZA752871B (en) 1976-04-28
SE7505482L (sv) 1975-12-08
GB1456323A (en) 1976-11-24
FI751602A7 (en:Method) 1975-12-07
BE829837A (fr) 1975-12-04
AR210265A1 (es) 1977-07-15
AR207152A1 (es) 1976-09-15
OA05022A (fr) 1980-12-31
NO751989L (en:Method) 1975-12-09

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