CA1014092A - Prostaglandins and methods for preparing same - Google Patents

Prostaglandins and methods for preparing same

Info

Publication number
CA1014092A
CA1014092A CA161,270A CA161270A CA1014092A CA 1014092 A CA1014092 A CA 1014092A CA 161270 A CA161270 A CA 161270A CA 1014092 A CA1014092 A CA 1014092A
Authority
CA
Canada
Prior art keywords
prostaglandins
methods
preparing same
preparing
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA161,270A
Other languages
English (en)
Other versions
CA161270S (en
Inventor
Charles J. Sih
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/221,058 external-priority patent/US4031129A/en
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Priority to CA233,089A priority Critical patent/CA1021790A/en
Application granted granted Critical
Publication of CA1014092A publication Critical patent/CA1014092A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/06Aluminium compounds
    • C07F5/061Aluminium compounds with C-aluminium linkage
    • C07F5/066Aluminium compounds with C-aluminium linkage compounds with Al linked to an element other than Al, C, H or halogen (this includes Al-cyanide linkage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • C07C17/013Preparation of halogenated hydrocarbons by addition of halogens
    • C07C17/02Preparation of halogenated hydrocarbons by addition of halogens to unsaturated hydrocarbons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • C07C17/093Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/513Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an etherified hydroxyl group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/58Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in three-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C07C45/66Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups by dehydration
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/12Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/32Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10Oxygen atoms
    • C07D309/12Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00Compounds containing elements of Groups 1 or 11 of the Periodic System
    • C07F1/02Lithium compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00Compounds containing elements of Groups 1 or 11 of the Periodic System
    • C07F1/08Copper compounds
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/582Recycling of unreacted starting or intermediate materials
CA161,270A 1972-01-26 1973-01-15 Prostaglandins and methods for preparing same Expired CA1014092A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA233,089A CA1021790A (en) 1972-01-26 1975-08-08 3-substituted-iodo-alkenyl compound

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US05/221,058 US4031129A (en) 1972-01-26 1972-01-26 15-Deoxy-PGE1 and method for preparing same
US25572872A 1972-05-22 1972-05-22
US29344272A 1972-09-29 1972-09-29

Publications (1)

Publication Number Publication Date
CA1014092A true CA1014092A (en) 1977-07-19

Family

ID=27396893

Family Applications (1)

Application Number Title Priority Date Filing Date
CA161,270A Expired CA1014092A (en) 1972-01-26 1973-01-15 Prostaglandins and methods for preparing same

Country Status (17)

Country Link
JP (3) JPS5333583B2 (nl)
AR (2) AR199893A1 (nl)
AU (1) AU452896B2 (nl)
BE (1) BE794516A (nl)
BG (3) BG25206A3 (nl)
CA (1) CA1014092A (nl)
CH (3) CH590834A5 (nl)
DD (3) DD112750A5 (nl)
DE (2) DE2365513C3 (nl)
ES (3) ES410962A1 (nl)
FR (3) FR2181693B1 (nl)
GB (3) GB1419181A (nl)
IE (2) IE37108B1 (nl)
IL (5) IL49285A (nl)
NL (2) NL153514B (nl)
RO (1) RO71588A (nl)
SE (3) SE7600888L (nl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1018970A (en) * 1972-10-27 1977-10-11 American Home Products Corporation 15-substituted prostanoic acids
JPS5720305B2 (nl) * 1973-02-28 1982-04-27
US4029693A (en) * 1975-01-20 1977-06-14 The Upjohn Company 2A,2B-Dihomo-11-deoxy-17(substituted phenyl)-18,19,20-trinor-PGE2 compounds and their corresponding esters
US4032561A (en) * 1975-05-27 1977-06-28 The Upjohn Company 17-Phenyl-18,19,20-trinor-cis-4,5-didehydro-PGF1.sub.α compounds
US4016184A (en) * 1975-09-17 1977-04-05 The Upjohn Company 9-Deoxy-9,10-didehydro-PGD1 compounds
US4365075A (en) * 1975-09-17 1982-12-21 The Upjohn Company ω-Aryl-PGD compounds
US4029814A (en) * 1975-12-29 1977-06-14 The Upjohn Company Phenyl-substituted prostaglandin-e type analogs
US4219662A (en) * 1977-02-28 1980-08-26 The Upjohn Company 11-Deoxy-17-phenyl-PGE1 analogs
AU529883B2 (en) * 1978-09-04 1983-06-23 Australian National University, The Substituted cyclopentenones

Also Published As

Publication number Publication date
FR2181693A1 (nl) 1973-12-07
JPS5253801A (en) 1977-04-30
DE2365927A1 (de) 1976-12-09
ES438595A1 (es) 1977-06-16
DE2365513A1 (de) 1975-06-26
CH590834A5 (nl) 1977-08-31
JPS5253840A (en) 1977-04-30
AR200537A1 (es) 1974-11-15
IE37106B1 (en) 1977-05-11
DD112750A5 (nl) 1975-05-05
GB1419182A (en) 1975-12-24
BG25208A3 (en) 1978-08-10
NL153514B (nl) 1977-06-15
IL41305A0 (en) 1973-03-30
JPS5333583B2 (nl) 1978-09-14
AU5108173A (en) 1974-07-18
AR199893A1 (es) 1974-10-08
DD108069A5 (nl) 1974-09-05
NL7301094A (nl) 1973-07-30
GB1419181A (en) 1975-12-24
SE7600888L (sv) 1976-01-28
DE2365513B2 (de) 1978-11-16
DE2365513C3 (de) 1979-07-19
IL49285A (en) 1977-10-31
FR2272642A1 (nl) 1975-12-26
IL49286A0 (en) 1976-05-31
GB1419183A (en) 1975-12-24
NL7708070A (nl) 1977-10-31
ES438594A1 (es) 1977-10-16
CH580046A5 (nl) 1976-09-30
BG25207A3 (en) 1978-08-10
JPS4881836A (nl) 1973-11-01
IE37108L (en) 1973-07-26
BE794516A (fr) 1973-05-16
IE37106L (en) 1973-07-26
DE2303612A1 (de) 1973-10-25
FR2257567B1 (nl) 1978-02-03
DE2303612B2 (de) 1977-04-07
IL41305A (en) 1977-10-31
SE7600890L (sv) 1976-01-28
DD113214A5 (nl) 1975-05-20
CH578502A5 (nl) 1976-08-13
RO71588A (fr) 1982-02-26
BG25206A3 (en) 1978-08-10
SE7600889L (sv) 1976-01-28
IE37108B1 (en) 1977-05-11
FR2257567A1 (nl) 1975-08-08
ES410962A1 (es) 1977-04-01
FR2181693B1 (nl) 1979-01-12
IL49285A0 (en) 1976-05-31
AU452896B2 (en) 1974-08-30
IL49286A (en) 1977-10-31
FR2272642B1 (nl) 1981-08-07

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