AU452896B2 - Prostaglandins and methods for preparing same - Google Patents

Prostaglandins and methods for preparing same

Info

Publication number
AU452896B2
AU452896B2 AU51081/73A AU5108173A AU452896B2 AU 452896 B2 AU452896 B2 AU 452896B2 AU 51081/73 A AU51081/73 A AU 51081/73A AU 5108173 A AU5108173 A AU 5108173A AU 452896 B2 AU452896 B2 AU 452896B2
Authority
AU
Australia
Prior art keywords
prostaglandins
methods
preparing same
preparing
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU51081/73A
Other versions
AU5108173A (en
Inventor
John Sid Charles
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/221,058 external-priority patent/US4031129A/en
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of AU5108173A publication Critical patent/AU5108173A/en
Application granted granted Critical
Publication of AU452896B2 publication Critical patent/AU452896B2/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/06Aluminium compounds
    • C07F5/061Aluminium compounds with C-aluminium linkage
    • C07F5/066Aluminium compounds with C-aluminium linkage compounds with Al linked to an element other than Al, C, H or halogen (this includes Al-cyanide linkage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • C07C17/013Preparation of halogenated hydrocarbons by addition of halogens
    • C07C17/02Preparation of halogenated hydrocarbons by addition of halogens to unsaturated hydrocarbons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • C07C17/093Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/513Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an etherified hydroxyl group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/58Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in three-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C07C45/66Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups by dehydration
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/12Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/32Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10Oxygen atoms
    • C07D309/12Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00Compounds containing elements of Groups 1 or 11 of the Periodic System
    • C07F1/02Lithium compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00Compounds containing elements of Groups 1 or 11 of the Periodic System
    • C07F1/08Copper compounds
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/582Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Materials Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AU51081/73A 1972-01-26 1973-01-15 Prostaglandins and methods for preparing same Expired AU452896B2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US05/221,058 US4031129A (en) 1972-01-26 1972-01-26 15-Deoxy-PGE1 and method for preparing same
USUS221,058 1972-01-26
US25572872A 1972-05-22 1972-05-22
USUS255,728 1972-05-22
US29344272A 1972-09-29 1972-09-29
USUS293,442 1972-09-29

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
AU73303/74A Division AU468704B2 (en) 1974-09-13 1974-09-13 A process for preparing a 2-(6'alkoxycarbonyl hexyl)-2-cyclopenten-lone
AU73302/74A Division AU473301B2 (en) 1974-09-13 1974-09-13 3-substituted-iodo-alkenyl compounds and preparation thereof

Publications (2)

Publication Number Publication Date
AU5108173A AU5108173A (en) 1974-07-18
AU452896B2 true AU452896B2 (en) 1974-08-30

Family

ID=27396893

Family Applications (1)

Application Number Title Priority Date Filing Date
AU51081/73A Expired AU452896B2 (en) 1972-01-26 1973-01-15 Prostaglandins and methods for preparing same

Country Status (17)

Country Link
JP (3) JPS5333583B2 (en)
AR (2) AR199893A1 (en)
AU (1) AU452896B2 (en)
BE (1) BE794516A (en)
BG (3) BG25207A3 (en)
CA (1) CA1014092A (en)
CH (3) CH580046A5 (en)
DD (3) DD113214A5 (en)
DE (2) DE2365513C3 (en)
ES (3) ES410962A1 (en)
FR (3) FR2181693B1 (en)
GB (3) GB1419183A (en)
IE (2) IE37106B1 (en)
IL (5) IL49285A (en)
NL (2) NL153514B (en)
RO (1) RO71588A (en)
SE (3) SE7600888L (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1018970A (en) * 1972-10-27 1977-10-11 American Home Products Corporation 15-substituted prostanoic acids
JPS5720305B2 (en) * 1973-02-28 1982-04-27
US4029693A (en) * 1975-01-20 1977-06-14 The Upjohn Company 2A,2B-Dihomo-11-deoxy-17(substituted phenyl)-18,19,20-trinor-PGE2 compounds and their corresponding esters
US4032561A (en) * 1975-05-27 1977-06-28 The Upjohn Company 17-Phenyl-18,19,20-trinor-cis-4,5-didehydro-PGF1.sub.α compounds
US4016184A (en) * 1975-09-17 1977-04-05 The Upjohn Company 9-Deoxy-9,10-didehydro-PGD1 compounds
US4365075A (en) * 1975-09-17 1982-12-21 The Upjohn Company ω-Aryl-PGD compounds
US4029814A (en) * 1975-12-29 1977-06-14 The Upjohn Company Phenyl-substituted prostaglandin-e type analogs
US4219662A (en) * 1977-02-28 1980-08-26 The Upjohn Company 11-Deoxy-17-phenyl-PGE1 analogs
AU529883B2 (en) * 1978-09-04 1983-06-23 Australian National University, The Substituted cyclopentenones

Also Published As

Publication number Publication date
GB1419183A (en) 1975-12-24
DE2365513B2 (en) 1978-11-16
NL7301094A (en) 1973-07-30
BG25207A3 (en) 1978-08-10
ES410962A1 (en) 1977-04-01
SE7600889L (en) 1976-01-28
DE2365513A1 (en) 1975-06-26
CH590834A5 (en) 1977-08-31
AR199893A1 (en) 1974-10-08
BG25208A3 (en) 1978-08-10
IE37106L (en) 1973-07-26
IL41305A (en) 1977-10-31
JPS5333583B2 (en) 1978-09-14
CH580046A5 (en) 1976-09-30
BG25206A3 (en) 1978-08-10
IE37106B1 (en) 1977-05-11
DE2365927A1 (en) 1976-12-09
DD108069A5 (en) 1974-09-05
FR2272642A1 (en) 1975-12-26
BE794516A (en) 1973-05-16
DE2365513C3 (en) 1979-07-19
IL49285A (en) 1977-10-31
SE7600890L (en) 1976-01-28
IL49285A0 (en) 1976-05-31
GB1419182A (en) 1975-12-24
AR200537A1 (en) 1974-11-15
JPS4881836A (en) 1973-11-01
FR2257567B1 (en) 1978-02-03
CH578502A5 (en) 1976-08-13
DD113214A5 (en) 1975-05-20
ES438595A1 (en) 1977-06-16
ES438594A1 (en) 1977-10-16
DE2303612A1 (en) 1973-10-25
NL153514B (en) 1977-06-15
SE7600888L (en) 1976-01-28
FR2181693A1 (en) 1973-12-07
RO71588A (en) 1982-02-26
IL49286A (en) 1977-10-31
DE2303612B2 (en) 1977-04-07
FR2181693B1 (en) 1979-01-12
GB1419181A (en) 1975-12-24
JPS5253801A (en) 1977-04-30
NL7708070A (en) 1977-10-31
JPS5253840A (en) 1977-04-30
IL41305A0 (en) 1973-03-30
FR2272642B1 (en) 1981-08-07
DD112750A5 (en) 1975-05-05
IL49286A0 (en) 1976-05-31
FR2257567A1 (en) 1975-08-08
CA1014092A (en) 1977-07-19
IE37108B1 (en) 1977-05-11
AU5108173A (en) 1974-07-18
IE37108L (en) 1973-07-26

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