BRPI1015369A2 - agentes terapêuticos para o tratamento de doenças associadas à proliferação celular indesejada - Google Patents

agentes terapêuticos para o tratamento de doenças associadas à proliferação celular indesejada Download PDF

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Publication number
BRPI1015369A2
BRPI1015369A2 BRPI1015369-1A BRPI1015369A BRPI1015369A2 BR PI1015369 A2 BRPI1015369 A2 BR PI1015369A2 BR PI1015369 A BRPI1015369 A BR PI1015369A BR PI1015369 A2 BRPI1015369 A2 BR PI1015369A2
Authority
BR
Brazil
Prior art keywords
lif
cancer
gene
expression
cell
Prior art date
Application number
BRPI1015369-1A
Other languages
English (en)
Portuguese (pt)
Inventor
Joan Seoane Suarez
Silvia Penuelas Prieto
José Baselga Torres
Original Assignee
Fundació Privada Institució Catalana De Recerca I Estudis Avançats (Icrea)
Fundació Privada Institut D'investigació Oncológica De Vall Hebron (Vhio)
Fundació Privada Institut de Recerca Hospital Universtiari Vall Hebron (IRHUVH)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fundació Privada Institució Catalana De Recerca I Estudis Avançats (Icrea), Fundació Privada Institut D'investigació Oncológica De Vall Hebron (Vhio), Fundació Privada Institut de Recerca Hospital Universtiari Vall Hebron (IRHUVH) filed Critical Fundació Privada Institució Catalana De Recerca I Estudis Avançats (Icrea)
Publication of BRPI1015369A2 publication Critical patent/BRPI1015369A2/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2093—Leukaemia inhibitory factor [LIF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Cell Biology (AREA)
BRPI1015369-1A 2009-04-03 2010-04-06 agentes terapêuticos para o tratamento de doenças associadas à proliferação celular indesejada BRPI1015369A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES200900928A ES2363358B1 (es) 2009-04-03 2009-04-03 Agentes terapéuticos para el tratamiento de enfermedades asociadas con una proliferación celular indeseable.
ESP200900928 2009-04-03
PCT/EP2010/054499 WO2010115868A2 (en) 2009-04-03 2010-04-06 Therapeutic agents for the treatment of diseases associated with undesired cell proliferation

Publications (1)

Publication Number Publication Date
BRPI1015369A2 true BRPI1015369A2 (pt) 2021-06-29

Family

ID=42342718

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1015369-1A BRPI1015369A2 (pt) 2009-04-03 2010-04-06 agentes terapêuticos para o tratamento de doenças associadas à proliferação celular indesejada

Country Status (24)

Country Link
US (4) US10100112B2 (https=)
EP (2) EP3045474B1 (https=)
JP (5) JP6207836B2 (https=)
KR (6) KR20180079470A (https=)
CN (2) CN102574918A (https=)
AU (1) AU2010233791B2 (https=)
BR (1) BRPI1015369A2 (https=)
CA (1) CA2757680C (https=)
CY (1) CY1124148T1 (https=)
DK (1) DK3045474T3 (https=)
EA (1) EA201101450A1 (https=)
ES (2) ES2363358B1 (https=)
HR (1) HRP20210352T1 (https=)
HU (1) HUE054196T2 (https=)
IL (1) IL215467A (https=)
LT (1) LT3045474T (https=)
MX (1) MX336903B (https=)
PL (1) PL3045474T3 (https=)
PT (1) PT3045474T (https=)
SG (2) SG10202010568RA (https=)
SI (1) SI3045474T1 (https=)
SM (1) SMT202100153T1 (https=)
WO (1) WO2010115868A2 (https=)
ZA (1) ZA201107215B (https=)

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JP2015071566A (ja) * 2013-10-03 2015-04-16 住友ベークライト株式会社 Ｆｇｆ４遺伝子増幅腫瘍の医薬組成物
JP2017507969A (ja) * 2014-03-11 2017-03-23 ゴーダーヴァリ バイオリファイナリーズ リミテッド がん幹細胞標的化合物
CA3151221C (en) * 2014-06-30 2026-01-13 Altor Bioscience Corporation Il-15-based molecules and methods of use thereof
CN106687134A (zh) * 2014-09-10 2017-05-17 加利福尼亚大学董事会 通过抗hLIF抗体靶向K‑RAS介导的信号转导通路和恶性肿瘤
EP3067422B1 (en) * 2015-03-13 2024-07-31 Sabanci Üniversitesi Ct-1 inhibitors
EP3273983B1 (en) 2015-03-23 2021-05-05 Evestra, Inc. Novel cytotoxic agents that preferentially target leukemia inhibitory factor (lif) for the treatment of malignancies and as new contraceptive agents
EP3173483A1 (en) 2015-11-27 2017-05-31 Fundació Privada Institut d'Investigació Oncològica de Vall-Hebron Agents for the treatment of diseases associated with undesired cell proliferation
US10583191B2 (en) 2016-12-19 2020-03-10 Mosaic Biomedicals Slu Antibodies against LIF and uses thereof
EP3555132B1 (en) * 2016-12-19 2023-11-15 Medimmune Limited Antibodies against lif and uses thereof
AU2019269131B2 (en) * 2018-05-14 2024-02-22 Fundació Privada Institució Catalana De Recerca I Estudis Avançats Antibodies against LIF and dosage forms thereof
MA52300A (fr) * 2018-06-18 2021-04-21 Fundacio Privada Inst Dinvestigacio Oncològica De Vall Hebron Combinaison d'inhibiteurs de lif et d'agents anti-néoplasiques à base de platine à utiliser dans le traitement du cancer
AU2019291305B2 (en) * 2018-06-18 2024-03-21 Fundacio Privada Institucio Catalana de Recerca i Estudis Avancats Methods for improving response to anti-LIF antibody treatment in individuals with cancer
WO2020056349A2 (en) * 2018-09-13 2020-03-19 Evestra, Inc. Lif/lifr antagonist oncology and nonmalignant diseases
IL287220B2 (en) * 2019-04-17 2026-03-01 Univ Hiroshima A therapeutic agent for urological cancer characterized by administering an IL-6 inhibitor in combination with a CCR2 inhibitor
CN111020030A (zh) * 2019-12-03 2020-04-17 中山大学 一种骨肉瘤干细胞标志物及其应用、试剂盒
EP3988116A1 (en) * 2020-10-23 2022-04-27 Consejo Superior De Investigaciones Científicas (CSIC) Methods and compositions for the treatment of hematologic malignancies
CN120507517B (zh) * 2025-05-21 2026-04-10 浙江省肿瘤医院 用于评估宫颈癌鳞癌和腺癌特异性的预后分子标记物及其应用

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US10583191B2 (en) * 2016-12-19 2020-03-10 Mosaic Biomedicals Slu Antibodies against LIF and uses thereof

Also Published As

Publication number Publication date
EP2414394A2 (en) 2012-02-08
US20120114671A1 (en) 2012-05-10
KR102373754B1 (ko) 2022-03-15
SG10202010568RA (en) 2020-11-27
EP3045474A2 (en) 2016-07-20
PL3045474T3 (pl) 2021-08-09
US20190211095A1 (en) 2019-07-11
SG175032A1 (en) 2011-11-28
HRP20210352T1 (hr) 2021-05-28
PT3045474T (pt) 2021-03-22
CA2757680A1 (en) 2010-10-14
KR20220035978A (ko) 2022-03-22
ZA201107215B (en) 2012-12-27
DK3045474T3 (da) 2021-03-22
US11999782B2 (en) 2024-06-04
JP2020090522A (ja) 2020-06-11
JP6207836B2 (ja) 2017-10-04
US20200385455A1 (en) 2020-12-10
JP2022031742A (ja) 2022-02-22
JP2012522756A (ja) 2012-09-27
HUE054196T2 (hu) 2021-08-30
ES2363358B1 (es) 2012-06-21
KR20190093691A (ko) 2019-08-09
KR20180079470A (ko) 2018-07-10
AU2010233791B2 (en) 2016-01-21
JP2019006784A (ja) 2019-01-17
EP3045474A3 (en) 2016-09-28
JP2016040255A (ja) 2016-03-24
CN102574918A (zh) 2012-07-11
WO2010115868A3 (en) 2011-02-03
KR20170121319A (ko) 2017-11-01
CA2757680C (en) 2021-11-02
MX336903B (es) 2016-02-04
ES2363358A1 (es) 2011-08-01
EP3045474B1 (en) 2021-01-13
US10100112B2 (en) 2018-10-16
US20240400667A1 (en) 2024-12-05
IL215467A (en) 2016-06-30
KR20120100703A (ko) 2012-09-12
EA201101450A1 (ru) 2012-04-30
SI3045474T1 (sl) 2021-07-30
IL215467A0 (en) 2011-12-29
LT3045474T (lt) 2021-05-10
KR20200078668A (ko) 2020-07-01
CY1124148T1 (el) 2022-05-27
JP7197665B2 (ja) 2022-12-27
CN107964043A (zh) 2018-04-27
AU2010233791A1 (en) 2011-11-03
MX2011010425A (es) 2012-03-06
ES2864639T3 (es) 2021-10-14
WO2010115868A2 (en) 2010-10-14
SMT202100153T1 (it) 2021-05-07

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B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
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Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.