BRPI0910702A2 - polipeptídeos de fator ix modificados e usos dos mesmos - Google Patents
polipeptídeos de fator ix modificados e usos dos mesmosInfo
- Publication number
- BRPI0910702A2 BRPI0910702A2 BRPI0910702A BRPI0910702A BRPI0910702A2 BR PI0910702 A2 BRPI0910702 A2 BR PI0910702A2 BR PI0910702 A BRPI0910702 A BR PI0910702A BR PI0910702 A BRPI0910702 A BR PI0910702A BR PI0910702 A2 BRPI0910702 A2 BR PI0910702A2
- Authority
- BR
- Brazil
- Prior art keywords
- polypeptides
- modified factor
- factor
- modified
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/644—Coagulation factor IXa (3.4.21.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12456708P | 2008-04-16 | 2008-04-16 | |
US4596108P | 2008-04-17 | 2008-04-17 | |
PCT/US2009/040813 WO2009137254A2 (en) | 2008-04-16 | 2009-04-16 | Modified factor ix polypeptides and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0910702A2 true BRPI0910702A2 (pt) | 2016-07-05 |
Family
ID=41265284
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0910702A BRPI0910702A2 (pt) | 2008-04-16 | 2009-04-16 | polipeptídeos de fator ix modificados e usos dos mesmos |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP2288622A4 (es) |
JP (1) | JP2011517951A (es) |
KR (1) | KR20110005862A (es) |
CN (1) | CN102083856A (es) |
AU (1) | AU2009244633A1 (es) |
BR (1) | BRPI0910702A2 (es) |
CA (1) | CA2721683A1 (es) |
CO (1) | CO6311000A2 (es) |
CR (1) | CR11737A (es) |
DO (1) | DOP2010000311A (es) |
EC (1) | ECSP10010551A (es) |
IL (1) | IL208718A0 (es) |
MX (1) | MX2010011345A (es) |
RU (1) | RU2010146387A (es) |
SG (1) | SG189790A1 (es) |
SV (1) | SV2010003704A (es) |
WO (1) | WO2009137254A2 (es) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200804416A (en) * | 2006-06-19 | 2008-01-16 | Nautilus Technology Llc | Modified coagulation factor IX polypeptides and use thereof for treatment |
JP5613876B2 (ja) * | 2007-10-15 | 2014-10-29 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | 延長された半減期を備えるヒト第ix因子変異体 |
FI3581650T3 (fi) | 2008-09-15 | 2023-03-23 | Uniqure Biopharma B V | IX-tekijän polypeptidimutantti, sen käyttöjä ja menetelmä sen valmistamiseksi |
NZ605348A (en) | 2010-07-09 | 2015-01-30 | Biogen Idec Hemophilia Inc | Factor ix polypeptides and methods of use thereof |
TWI595004B (zh) | 2010-11-03 | 2017-08-11 | 介控生化科技公司 | 經修飾之第九因子多胜肽及其用途 |
AU2013204511B2 (en) * | 2010-11-03 | 2016-03-17 | Gc Biopharma Corp. | Modified factor ix polypeptides and uses thereof |
US9486507B2 (en) | 2011-06-10 | 2016-11-08 | Biogen Ma Inc. | Pro-coagulant compounds and methods of use thereof |
US10656167B2 (en) | 2011-07-25 | 2020-05-19 | Bioverativ Therapeutics Inc. | Assays to monitor bleeding disorders |
US9738884B2 (en) | 2012-04-27 | 2017-08-22 | Nihon University | Therapeutic agent for epithelial and endothelial injury |
EP2877202A4 (en) | 2012-07-25 | 2016-06-01 | Biogen Ma Inc | BLOOD FACTOR MONITORING TEST AND USES THEREOF |
EP3542861A1 (en) | 2012-09-25 | 2019-09-25 | Bioverativ Therapeutics Inc. | Methods of using fix polypeptides |
EP2908847B1 (en) | 2012-10-18 | 2022-03-30 | Bioverativ Therapeutics Inc. | Methods of using a fixed dose of a clotting factor |
US10717965B2 (en) | 2013-01-10 | 2020-07-21 | Gloriana Therapeutics, Inc. | Mammalian cell culture-produced neublastin antibodies |
FI2956477T4 (fi) | 2013-02-15 | 2024-04-24 | Bioverativ Therapeutics Inc | Optimoitu tekijä viii:n geeni |
SG11201505926VA (en) | 2013-03-15 | 2015-09-29 | Biogen Ma Inc | Factor ix polypeptide formulations |
EP3048899B1 (en) | 2013-09-25 | 2021-09-08 | Bioverativ Therapeutics Inc. | On-column viral inactivation methods |
EP3065769A4 (en) | 2013-11-08 | 2017-05-31 | Biogen MA Inc. | Procoagulant fusion compound |
WO2015085276A1 (en) | 2013-12-06 | 2015-06-11 | Biogen Idec Ma Inc. | Population pharmacokinetics tools and uses thereof |
EP3083933A1 (en) | 2013-12-20 | 2016-10-26 | Biogen MA Inc. | Use of perfusion seed cultures to improve biopharmaceutical fed-batch production capacity and product quality |
TWI700101B (zh) | 2014-03-24 | 2020-08-01 | 美商百歐維拉提夫治療公司 | 凍乾之因子ix調配物 |
EP3160478A4 (en) | 2014-06-30 | 2018-05-16 | Bioverativ Therapeutics Inc. | Optimized factor ix gene |
GB201420139D0 (en) | 2014-11-12 | 2014-12-24 | Ucl Business Plc | Factor IX gene therapy |
EA201890423A1 (ru) | 2015-08-03 | 2018-07-31 | Биовератив Терапьютикс Инк. | Слитые белки фактора ix, способы их получения и применения |
PL3411478T3 (pl) | 2016-02-01 | 2022-10-03 | Bioverativ Therapeutics Inc. | Geny zoptymalizowanego czynnika VIII |
CN105695616A (zh) * | 2016-04-22 | 2016-06-22 | 王冬国 | 诊断甲状腺癌的分析标志物及其应用 |
EP3548066A1 (en) | 2016-12-02 | 2019-10-09 | Bioverativ Therapeutics Inc. | Methods of treating hemophilic arthropathy using chimeric clotting factors |
KR20190112763A (ko) | 2017-01-31 | 2019-10-07 | 바이오버라티브 테라퓨틱스 인크. | 인자 ix 융합 단백질 및 이의 제조 및 사용 방법 |
FR3069540B1 (fr) | 2017-07-28 | 2019-09-13 | Universite Claude Bernard Lyon 1 | Proteine modifiee avec demi-vie amelioree |
SG11202000764RA (en) | 2017-08-09 | 2020-02-27 | Bioverativ Therapeutics Inc | Nucleic acid molecules and uses thereof |
US11491212B1 (en) | 2017-09-27 | 2022-11-08 | Catalyst Biosciences, Inc. | Subcutaneous administration of modified factor IX polypeptides and treatment of hemophilia B |
AU2018338608A1 (en) | 2017-09-27 | 2020-04-09 | Sigilon Therapeutics, Inc. | Methods, compositions, and implantable elements comprising active cells |
IL277713B2 (en) | 2018-04-04 | 2024-09-01 | Sigilon Therapeutics Inc | Implantable particles and related methods |
US20210145889A1 (en) | 2018-04-04 | 2021-05-20 | Sigilon Therapeutics, Inc. | Methods, compositions, and implantable elements comprising stem cells |
SG11202010767SA (en) | 2018-05-18 | 2020-11-27 | Bioverativ Therapeutics Inc | Methods of treating hemophilia a |
BR112021002017A2 (pt) | 2018-08-09 | 2021-05-11 | Bioverativ Therapeutics Inc. | moléculas de ácido nucleico e usos das mesmas para terapia genética não viral |
US10842885B2 (en) | 2018-08-20 | 2020-11-24 | Ucl Business Ltd | Factor IX encoding nucleotides |
UY38389A (es) | 2018-09-27 | 2020-04-30 | Sigilon Therapeutics Inc | Dispositivos implantables para terapia celular y métodos relacionados |
WO2020086408A1 (en) | 2018-10-26 | 2020-04-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | A high-yield perfusion-based transient gene expression bioprocess |
US20220323519A1 (en) | 2019-04-17 | 2022-10-13 | Codiak Biosciences, Inc. | Compositions of exosomes and aav |
WO2021154414A2 (en) | 2020-01-29 | 2021-08-05 | Catalyst Biosciences, Inc. | Gene therapy for hemophilia b with a chimeric aav capsid vector encoding modified factor ix polypeptides |
AU2022226969A1 (en) | 2021-02-24 | 2023-09-14 | Bluehalo Llc | System and method for a digitally beamformed phased array feed |
WO2024081309A1 (en) | 2022-10-11 | 2024-04-18 | Sigilon Therapeutics, Inc. | Engineered cells and implantable elements for treatment of disease |
WO2024081310A1 (en) | 2022-10-11 | 2024-04-18 | Sigilon Therapeutics, Inc. | Engineered cells and implantable elements for treatment of disease |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2638643B1 (fr) * | 1988-11-09 | 1991-04-12 | Transgene Sa | Sequence d'adn codant pour le facteur ix humain ou une proteine analogue, vecteur d'expression, cellules transformees, procede de preparation du facteur ix et produits obtenus correspondants |
WO1999003496A1 (en) * | 1997-07-21 | 1999-01-28 | The University Of North Carolina At Chapel Hill | Factor ix antihemophilic factor with increased clotting activity |
HUP0401534A3 (en) * | 2001-09-04 | 2006-01-30 | Merck Patent Gmbh | Modified factor ix |
US20050008580A1 (en) * | 2003-04-09 | 2005-01-13 | Wyeth | Hemophilia treatment by inhalation of coagulation factors |
US20060040856A1 (en) * | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
BRPI0417341A (pt) * | 2003-12-03 | 2007-04-17 | Neose Technologies Inc | fator ix glicopeguilado |
TW200804416A (en) * | 2006-06-19 | 2008-01-16 | Nautilus Technology Llc | Modified coagulation factor IX polypeptides and use thereof for treatment |
US7700734B2 (en) * | 2007-01-09 | 2010-04-20 | Shu-Wha Lin | Recombinant human factor IX and use thereof |
-
2009
- 2009-04-16 KR KR1020107025567A patent/KR20110005862A/ko not_active Application Discontinuation
- 2009-04-16 SG SG2013028790A patent/SG189790A1/en unknown
- 2009-04-16 CN CN2009801227842A patent/CN102083856A/zh active Pending
- 2009-04-16 EP EP09743241A patent/EP2288622A4/en not_active Withdrawn
- 2009-04-16 CA CA2721683A patent/CA2721683A1/en not_active Abandoned
- 2009-04-16 AU AU2009244633A patent/AU2009244633A1/en not_active Abandoned
- 2009-04-16 RU RU2010146387/10A patent/RU2010146387A/ru not_active Application Discontinuation
- 2009-04-16 WO PCT/US2009/040813 patent/WO2009137254A2/en active Application Filing
- 2009-04-16 MX MX2010011345A patent/MX2010011345A/es not_active Application Discontinuation
- 2009-04-16 BR BRPI0910702A patent/BRPI0910702A2/pt not_active IP Right Cessation
- 2009-04-16 JP JP2011505204A patent/JP2011517951A/ja active Pending
-
2010
- 2010-10-14 IL IL208718A patent/IL208718A0/en unknown
- 2010-10-15 EC EC2010010551A patent/ECSP10010551A/es unknown
- 2010-10-15 CO CO10128682A patent/CO6311000A2/es active IP Right Grant
- 2010-10-15 DO DO2010000311A patent/DOP2010000311A/es unknown
- 2010-10-15 SV SV2010003704A patent/SV2010003704A/es unknown
- 2010-10-15 CR CR11737A patent/CR11737A/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MX2010011345A (es) | 2011-02-23 |
CO6311000A2 (es) | 2011-08-22 |
JP2011517951A (ja) | 2011-06-23 |
CR11737A (es) | 2011-02-07 |
SG189790A1 (en) | 2013-05-31 |
WO2009137254A2 (en) | 2009-11-12 |
AU2009244633A1 (en) | 2009-11-12 |
CN102083856A (zh) | 2011-06-01 |
ECSP10010551A (es) | 2010-11-30 |
EP2288622A2 (en) | 2011-03-02 |
RU2010146387A (ru) | 2012-05-27 |
KR20110005862A (ko) | 2011-01-19 |
IL208718A0 (en) | 2010-12-30 |
WO2009137254A3 (en) | 2010-01-14 |
SV2010003704A (es) | 2011-02-21 |
CA2721683A1 (en) | 2009-11-12 |
EP2288622A4 (en) | 2012-04-18 |
DOP2010000311A (es) | 2011-02-28 |
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Legal Events
Date | Code | Title | Description |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
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B350 | Update of information on the portal [chapter 15.35 patent gazette] |