BRPI0910232A2 - formas de sais inibidores do mtor - Google Patents
formas de sais inibidores do mtorInfo
- Publication number
- BRPI0910232A2 BRPI0910232A2 BRPI0910232A BRPI0910232A BRPI0910232A2 BR PI0910232 A2 BRPI0910232 A2 BR PI0910232A2 BR PI0910232 A BRPI0910232 A BR PI0910232A BR PI0910232 A BRPI0910232 A BR PI0910232A BR PI0910232 A2 BRPI0910232 A2 BR PI0910232A2
- Authority
- BR
- Brazil
- Prior art keywords
- salt forms
- inhibitor salt
- inhibitor
- forms
- salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7006208P | 2008-03-19 | 2008-03-19 | |
| PCT/US2009/037505 WO2009117482A1 (en) | 2008-03-19 | 2009-03-18 | Mtor inhibitor salt forms |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0910232A2 true BRPI0910232A2 (pt) | 2015-09-29 |
Family
ID=40597405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0910232A BRPI0910232A2 (pt) | 2008-03-19 | 2009-03-18 | formas de sais inibidores do mtor |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8557814B2 (pt) |
| EP (1) | EP2276763A1 (pt) |
| JP (1) | JP2011515410A (pt) |
| KR (1) | KR20110017845A (pt) |
| CN (1) | CN101977912A (pt) |
| AU (1) | AU2009225614A1 (pt) |
| BR (1) | BRPI0910232A2 (pt) |
| CA (1) | CA2716924A1 (pt) |
| EA (1) | EA018144B1 (pt) |
| MX (1) | MX2010010300A (pt) |
| WO (1) | WO2009117482A1 (pt) |
| ZA (1) | ZA201006641B (pt) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7700594B2 (en) * | 2005-11-17 | 2010-04-20 | Osi Pharmaceuticals, Inc. | Fused bicyclic mTOR inhibitors |
| WO2009008992A2 (en) * | 2007-07-06 | 2009-01-15 | Osi Pharmaceuticals Inc. | Combination anti-cancer therapy comprising an inhibitor of both mtorc1 and mt0rc2 |
| WO2009117482A1 (en) | 2008-03-19 | 2009-09-24 | Osi Pharmaceuticals, Inc | Mtor inhibitor salt forms |
| WO2011049625A1 (en) | 2009-10-20 | 2011-04-28 | Mansour Samadpour | Method for aflatoxin screening of products |
| AU2010316780B2 (en) | 2009-11-05 | 2015-07-16 | Rhizen Pharmaceuticals Sa | Novel benzopyran kinase modulators |
| US20130005733A1 (en) | 2010-03-09 | 2013-01-03 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
| EP2681218A1 (en) | 2011-02-23 | 2014-01-08 | Pfizer Inc | IMIDAZO[5,1-f][1,2,4]TRIAZINES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS |
| ES2710874T3 (es) | 2011-05-04 | 2019-04-29 | Rhizen Pharmaceuticals S A | Compuestos novedosos como moduladores de proteína cinasas |
| WO2013152342A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Anti-cancer mtor inhibitor and anti-androgen combination |
| CN104470923B (zh) | 2012-07-04 | 2019-03-29 | 理森制药股份公司 | 选择性PI3K δ抑制剂 |
| US9688682B2 (en) * | 2013-07-16 | 2017-06-27 | Dr. Reddy's Laboratories Limited | Crystalline forms of pemetrexed tromethamine salts |
| TWI695717B (zh) * | 2014-03-06 | 2020-06-11 | 美商 Ptc 治療公司 | １,２,４-二唑苯甲酸之鹽及醫藥組合物 |
| US9987241B2 (en) | 2014-09-25 | 2018-06-05 | The Board Of Regents Of The University Of Oklahoma | Enzyme conjugate and prodrug cancer therapy |
| WO2016064958A1 (en) | 2014-10-22 | 2016-04-28 | Bristol-Myers Squibb Company | Heteroaryl substituted pyrrolotriazine amine compounds as pi3k inhibitors |
| ES2807785T3 (es) | 2014-10-22 | 2021-02-24 | Bristol Myers Squibb Co | Compuestos de heteroarilamina bicíclicos como inhibidores de pi3k |
| US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
| JP7034084B2 (ja) | 2016-03-28 | 2022-03-11 | インサイト・コーポレイション | Ｔａｍ阻害剤としてのピロロトリアジン化合物 |
| WO2020032951A1 (en) | 2018-08-09 | 2020-02-13 | The Board Of Regents Of The University Of Oklahoma | Antimalarial enzyme conjugates, kits containing same, and methods of producing and using same |
| FR3075795A1 (fr) | 2017-12-21 | 2019-06-28 | Galderma Research & Development | Nouveaux composes inhibiteurs de mtor |
| FR3075794A1 (fr) | 2017-12-21 | 2019-06-28 | Galderma Research & Development | Nouveaux composes inhibiteurs de mtor |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2200210A1 (en) | 1994-09-29 | 1996-04-04 | Novartis Ag | Pyrrolo[2,3-d]pyrimidines and their use |
| US7863444B2 (en) | 1997-03-19 | 2011-01-04 | Abbott Laboratories | 4-aminopyrrolopyrimidines as kinase inhibitors |
| AU748884B2 (en) | 1997-03-19 | 2002-06-13 | Abbott Gmbh & Co. Kg | Pyrrolo(2,3d)pyrimidines and their use as tyrosine kinase inhibitors |
| EP1140938B1 (en) | 1999-01-11 | 2003-08-27 | Princeton University | High affinity inhibitors for target validation and uses thereof |
| US6921763B2 (en) | 1999-09-17 | 2005-07-26 | Abbott Laboratories | Pyrazolopyrimidines as therapeutic agents |
| JP2005508904A (ja) | 2001-09-11 | 2005-04-07 | スミスクライン ビーチャム コーポレーション | 血管新生阻害剤としてのフロ−及びチエノピリミジン誘導体 |
| TW200530238A (en) | 2003-10-15 | 2005-09-16 | Osi Pharm Inc | Imidazopyrazine tyrosine kinase inhibitors |
| JP2007509943A (ja) | 2003-10-27 | 2007-04-19 | ジェネラブス テクノロジーズ インコーポレーティッド | ウイルス感染症治療のためのヌクレオシド化合物 |
| EP1687309A1 (en) | 2003-11-17 | 2006-08-09 | Pfizer Products Inc. | Pyrrolopyrimidine compounds useful in treatment of cancer |
| UA89493C2 (uk) | 2004-04-02 | 2010-02-10 | Оси Фармасьютикалз, Инк. | 6,6-біциклічні кільцеві заміщені гетеробіциклічні інгібітори протеїнкіназ |
| TW200613306A (en) | 2004-07-20 | 2006-05-01 | Osi Pharm Inc | Imidazotriazines as protein kinase inhibitors |
| US9512125B2 (en) | 2004-11-19 | 2016-12-06 | The Regents Of The University Of California | Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents |
| US7700594B2 (en) | 2005-11-17 | 2010-04-20 | Osi Pharmaceuticals, Inc. | Fused bicyclic mTOR inhibitors |
| AR057960A1 (es) | 2005-12-02 | 2007-12-26 | Osi Pharm Inc | Inhibidores de proteina quinasa biciclicos |
| JP5512975B2 (ja) | 2005-12-29 | 2014-06-04 | アッヴィ・インコーポレイテッド | タンパク質キナーゼ阻害薬 |
| JP5156644B2 (ja) | 2006-01-25 | 2013-03-06 | オーエスアイ・フアーマシユーテイカルズ・エル・エル・シー | 不飽和ｍＴＯＲ阻害剤 |
| EP1996193A2 (en) * | 2006-03-13 | 2008-12-03 | OSI Pharmaceuticals, Inc. | Combined treatment with an egfr kinase inhibitor and an agent that sensitizes tumor cells to the effects of egfr kinase inhibitors |
| CA2647543A1 (en) | 2006-03-29 | 2007-11-08 | Foldrx Pharmaceuticals, Inc. | Inhibition of alpha-synuclein toxicity |
| EA019961B1 (ru) | 2006-04-04 | 2014-07-30 | Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния | Антагонисты киназы |
| DE102006016426A1 (de) | 2006-04-07 | 2007-10-11 | Merck Patent Gmbh | Neuartige Cyclobutyl-Verbindungen als Kinase-Inhibitoren |
| WO2009008992A2 (en) | 2007-07-06 | 2009-01-15 | Osi Pharmaceuticals Inc. | Combination anti-cancer therapy comprising an inhibitor of both mtorc1 and mt0rc2 |
| EP2173338A1 (en) | 2007-07-06 | 2010-04-14 | OSI Pharmaceuticals, Inc. | Combination anti-cancer therapy |
| WO2009050506A2 (en) | 2007-10-15 | 2009-04-23 | Astrazeneca Ab | Combination 059 |
| WO2009117482A1 (en) | 2008-03-19 | 2009-09-24 | Osi Pharmaceuticals, Inc | Mtor inhibitor salt forms |
| EP2451792A4 (en) | 2009-07-09 | 2013-03-06 | Osi Pharmaceuticals Llc | PROCESS FOR THE PRODUCTION OF SUBSTITUTED 3-AMINO-5-OXO-4,5-DIHYDRO- [1,2,4] TRIAZINES |
| WO2011014726A1 (en) | 2009-07-31 | 2011-02-03 | Osi Pharmaceuticals, Inc. | Mtor inhibitor and angiogenesis inhibitor combination therapy |
-
2009
- 2009-03-18 WO PCT/US2009/037505 patent/WO2009117482A1/en active Application Filing
- 2009-03-18 AU AU2009225614A patent/AU2009225614A1/en not_active Abandoned
- 2009-03-18 MX MX2010010300A patent/MX2010010300A/es not_active Application Discontinuation
- 2009-03-18 JP JP2011500920A patent/JP2011515410A/ja active Pending
- 2009-03-18 BR BRPI0910232A patent/BRPI0910232A2/pt not_active IP Right Cessation
- 2009-03-18 CN CN2009801096507A patent/CN101977912A/zh active Pending
- 2009-03-18 KR KR1020107021794A patent/KR20110017845A/ko not_active Application Discontinuation
- 2009-03-18 EA EA201071099A patent/EA018144B1/ru not_active IP Right Cessation
- 2009-03-18 CA CA2716924A patent/CA2716924A1/en not_active Abandoned
- 2009-03-18 EP EP09722933A patent/EP2276763A1/en not_active Withdrawn
- 2009-03-18 US US12/922,928 patent/US8557814B2/en not_active Expired - Fee Related
-
2010
- 2010-09-16 ZA ZA2010/06641A patent/ZA201006641B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101977912A (zh) | 2011-02-16 |
| WO2009117482A8 (en) | 2010-04-08 |
| KR20110017845A (ko) | 2011-02-22 |
| ZA201006641B (en) | 2011-05-25 |
| CA2716924A1 (en) | 2009-09-24 |
| AU2009225614A1 (en) | 2009-09-24 |
| EP2276763A1 (en) | 2011-01-26 |
| JP2011515410A (ja) | 2011-05-19 |
| MX2010010300A (es) | 2010-10-26 |
| WO2009117482A1 (en) | 2009-09-24 |
| US8557814B2 (en) | 2013-10-15 |
| EA018144B1 (ru) | 2013-05-30 |
| US20110015197A1 (en) | 2011-01-20 |
| EA201071099A1 (ru) | 2011-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2344 DE 08-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |