BRPI0907487A2 - Sais de triazólio como inibidores de par1, produção dos mesmos e uso como medicamentos - Google Patents
Sais de triazólio como inibidores de par1, produção dos mesmos e uso como medicamentosInfo
- Publication number
- BRPI0907487A2 BRPI0907487A2 BRPI0907487-2A BRPI0907487A BRPI0907487A2 BR PI0907487 A2 BRPI0907487 A2 BR PI0907487A2 BR PI0907487 A BRPI0907487 A BR PI0907487A BR PI0907487 A2 BRPI0907487 A2 BR PI0907487A2
- Authority
- BR
- Brazil
- Prior art keywords
- medicines
- production
- triazole salts
- par1 inhibitors
- par1
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08290114 | 2008-02-05 | ||
PCT/EP2009/000407 WO2009097971A1 (de) | 2008-02-05 | 2009-01-23 | Triazoliumsalze als par1-inhibitoren, ihre herstellung und verwendung als arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0907487A2 true BRPI0907487A2 (pt) | 2015-07-14 |
Family
ID=39816936
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0907487-2A BRPI0907487A2 (pt) | 2008-02-05 | 2009-01-23 | Sais de triazólio como inibidores de par1, produção dos mesmos e uso como medicamentos |
Country Status (20)
Country | Link |
---|---|
US (2) | US8198272B2 (pt) |
EP (1) | EP2240486B1 (pt) |
JP (1) | JP5577259B2 (pt) |
KR (1) | KR20100120139A (pt) |
CN (1) | CN101981035B (pt) |
AU (1) | AU2009211888B2 (pt) |
BR (1) | BRPI0907487A2 (pt) |
CA (1) | CA2713551C (pt) |
CO (1) | CO6311103A2 (pt) |
ES (1) | ES2553588T3 (pt) |
HK (1) | HK1149012A1 (pt) |
IL (1) | IL207203A0 (pt) |
MA (1) | MA32062B1 (pt) |
MX (1) | MX2010007893A (pt) |
MY (1) | MY148732A (pt) |
NZ (1) | NZ587142A (pt) |
PL (1) | PL2240486T3 (pt) |
RU (1) | RU2494100C2 (pt) |
WO (1) | WO2009097971A1 (pt) |
ZA (1) | ZA201004468B (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RS52264B (en) * | 2008-02-05 | 2012-10-31 | Sanofi | TRIAZOLOPYRIDASINES AS PAR1 INHIBITORS, THEIR PRODUCTION AND USE AS MEDICINES |
US8673890B2 (en) | 2009-10-29 | 2014-03-18 | Janssen Pharmaceutica Nv | 2,3-dihydro-1H-isoindol-1-imine derivatives useful as thrombin PAR-1 receptor antagonist |
CN102961382B (zh) * | 2012-11-28 | 2014-07-16 | 玉林师范学院 | 一种骨肉瘤细胞抑制剂及制备方法 |
AR107165A1 (es) | 2015-12-23 | 2018-03-28 | Chiesi Farm Spa | Inhibidores de quinasa |
CN114890955A (zh) * | 2022-06-23 | 2022-08-12 | 江西瑞威尔生物科技有限公司 | 一种n取代吗啉类有机化合物的制备工艺 |
CN115385853B (zh) * | 2022-10-17 | 2024-02-02 | 山东友道化学有限公司 | 一种2-肼基-3-氯吡啶的生产方法 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4578464A (en) | 1983-11-22 | 1986-03-25 | Merrell Dow Pharmaceuticals Inc. | 6-Hydroxyalkylamino-8-methyl-1,2,4-triazolo-[4,3-b]pyridazine and related compounds |
LT3200B (en) * | 1992-03-18 | 1995-03-27 | Takeda Chemical Industries Ltd | Triazolopyridazine methodfor production thereof and use |
ATE201875T1 (de) * | 1994-09-16 | 2001-06-15 | Takeda Chemical Industries Ltd | Triazolopyridazine, verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung als arzneimittel |
US6063847A (en) | 1997-11-25 | 2000-05-16 | Schering Corporation | Thrombin receptor antagonists |
US7304078B2 (en) | 2002-04-16 | 2007-12-04 | Schering Corporation | Thrombin receptor antagonists |
US7488742B2 (en) | 2000-06-15 | 2009-02-10 | Schering Corporation | Thrombin receptor antagonists |
EP1391456B1 (en) * | 2001-04-19 | 2009-07-22 | Eisai R&D Management Co., Ltd. | 2-iminoimidazole derivatives |
JPWO2002096875A1 (ja) | 2001-05-25 | 2004-09-09 | 持田製薬株式会社 | 鎮痛作用を有する4−ヒドロキシピペリジン誘導体 |
US6984653B2 (en) | 2001-10-05 | 2006-01-10 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds, oxazole derivatives, process for preparation of the same and use thereof |
AU2004218187C1 (en) | 2003-02-19 | 2011-04-07 | Eisai R&D Management Co., Ltd. | Methods for producing cyclic benzamidine derivatives |
TW200531688A (en) | 2004-03-05 | 2005-10-01 | Hoffmann La Roche | Novel pentafluorosulfanyl compounds, their manufacture and use as pharmaceutical agents |
WO2006051648A1 (ja) | 2004-11-09 | 2006-05-18 | Eisai R & D Management Co., Ltd. | トロンビン受容体アンタゴニストを有効成分とするくも膜下出血に伴う血管攣縮の治療剤 |
CA2634721C (en) * | 2005-12-21 | 2014-06-17 | Janssen Pharmaceutica N.V. | Triazolopyridazines as tyrosine kinase modulators |
DE102006025318A1 (de) | 2006-05-31 | 2007-12-06 | Bayer Healthcare Ag | Dihydro-pyrrolopyridin-, Dihydro-pyrrolopyridazin- und Dihydro-pyrrolopyrimidin-Derivate und ihre Verwendung |
WO2009097973A2 (de) | 2008-02-05 | 2009-08-13 | Sanofi-Aventis | Imidazopyridazine als parl-inhibitoren, ihre herstellung und verwendung als arzneimittel |
RS52264B (en) | 2008-02-05 | 2012-10-31 | Sanofi | TRIAZOLOPYRIDASINES AS PAR1 INHIBITORS, THEIR PRODUCTION AND USE AS MEDICINES |
WO2009097972A1 (de) | 2008-02-05 | 2009-08-13 | Sanofi-Aventis | Sf5-derivate als par1-inhibitoren, ihre herstellung und verwendung als arzneimittel |
WO2009126861A2 (en) * | 2008-04-11 | 2009-10-15 | Bristol-Myers Squibb Company | Triazolopyridine compounds useful as dgat1 inhibitors |
US8324241B2 (en) * | 2008-04-11 | 2012-12-04 | Bristol-Myers Squibb Company | Triazolo compounds useful as DGAT1 inhibitors |
WO2010009319A2 (en) * | 2008-07-16 | 2010-01-21 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
-
2009
- 2009-01-23 CN CN2009801115090A patent/CN101981035B/zh not_active Expired - Fee Related
- 2009-01-23 PL PL09707892T patent/PL2240486T3/pl unknown
- 2009-01-23 EP EP09707892.7A patent/EP2240486B1/de active Active
- 2009-01-23 CA CA2713551A patent/CA2713551C/en not_active Expired - Fee Related
- 2009-01-23 JP JP2010545379A patent/JP5577259B2/ja not_active Expired - Fee Related
- 2009-01-23 RU RU2010136941/04A patent/RU2494100C2/ru not_active IP Right Cessation
- 2009-01-23 MY MYPI2010003265A patent/MY148732A/en unknown
- 2009-01-23 BR BRPI0907487-2A patent/BRPI0907487A2/pt not_active IP Right Cessation
- 2009-01-23 KR KR1020107017381A patent/KR20100120139A/ko not_active Application Discontinuation
- 2009-01-23 WO PCT/EP2009/000407 patent/WO2009097971A1/de active Application Filing
- 2009-01-23 MX MX2010007893A patent/MX2010007893A/es active IP Right Grant
- 2009-01-23 ES ES09707892.7T patent/ES2553588T3/es active Active
- 2009-01-23 AU AU2009211888A patent/AU2009211888B2/en not_active Ceased
- 2009-01-23 NZ NZ587142A patent/NZ587142A/en not_active IP Right Cessation
-
2010
- 2010-06-24 ZA ZA2010/04468A patent/ZA201004468B/en unknown
- 2010-07-22 CO CO10089143A patent/CO6311103A2/es active IP Right Grant
- 2010-07-25 IL IL207203A patent/IL207203A0/en unknown
- 2010-08-04 MA MA33060A patent/MA32062B1/fr unknown
- 2010-08-05 US US12/851,219 patent/US8198272B2/en not_active Expired - Fee Related
-
2011
- 2011-03-30 HK HK11103241.8A patent/HK1149012A1/xx not_active IP Right Cessation
-
2012
- 2012-04-20 US US13/452,146 patent/US8853206B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CO6311103A2 (es) | 2011-08-22 |
KR20100120139A (ko) | 2010-11-12 |
RU2494100C2 (ru) | 2013-09-27 |
HK1149012A1 (en) | 2011-09-23 |
MA32062B1 (fr) | 2011-02-01 |
CN101981035A (zh) | 2011-02-23 |
CN101981035B (zh) | 2013-08-28 |
JP5577259B2 (ja) | 2014-08-20 |
MY148732A (en) | 2013-05-31 |
AU2009211888B2 (en) | 2013-06-20 |
EP2240486B1 (de) | 2015-09-09 |
US20120208805A1 (en) | 2012-08-16 |
AU2009211888A1 (en) | 2009-08-13 |
CA2713551A1 (en) | 2009-08-13 |
EP2240486A1 (de) | 2010-10-20 |
PL2240486T3 (pl) | 2016-02-29 |
ZA201004468B (en) | 2011-03-30 |
US8198272B2 (en) | 2012-06-12 |
IL207203A0 (en) | 2010-12-30 |
US8853206B2 (en) | 2014-10-07 |
MX2010007893A (es) | 2010-08-09 |
NZ587142A (en) | 2012-04-27 |
JP2011511017A (ja) | 2011-04-07 |
ES2553588T3 (es) | 2015-12-10 |
RU2010136941A (ru) | 2012-03-20 |
WO2009097971A1 (de) | 2009-08-13 |
US20110034452A1 (en) | 2011-02-10 |
CA2713551C (en) | 2016-06-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 10A ANUIDADE. |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2498 DE 21-11-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |