BRPI0800957A2 - vetores biológicos compreendendo o gene max, método de produção dos mesmos, método de expressão do gene max nas células e método de terapia gênica citoprotetora - Google Patents
vetores biológicos compreendendo o gene max, método de produção dos mesmos, método de expressão do gene max nas células e método de terapia gênica citoprotetoraInfo
- Publication number
- BRPI0800957A2 BRPI0800957A2 BRPI0800957-0A BRPI0800957A BRPI0800957A2 BR PI0800957 A2 BRPI0800957 A2 BR PI0800957A2 BR PI0800957 A BRPI0800957 A BR PI0800957A BR PI0800957 A2 BRPI0800957 A2 BR PI0800957A2
- Authority
- BR
- Brazil
- Prior art keywords
- gene
- max
- cells
- max gene
- cytoprotective
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
VETORES BIOLóGICOS COMPREENDENDO O GENE MAX, MéTODO DE PRODUçãO DOS MESMOS, MéTODO DE EXPRESSãO DO GENE MAX NAS CéLULAS E MéTODO DE TERAPIA GêNICA CITOPROTETORA. A presente invenção está relacionada a construções de vetores de clonagem contendo o gene max. Especialmente, a presente invenção trata da introdução dos vetores de clonagem contendo o gene max nas células utilizando vetores de transporte. Adicionalmente, a presença de vetores de clonagem contendo o gene max nas células permite a expressão diferencial do gene max nas mesmas células. Adicionalmente, a presente invenção refere-se a um método de terapia gênica no qual a expressão diferencial do gene max possui atividade citoprotetora, especialmente neuroprotetora, podendo ser aplicada a terapéutica médica e veterinária para condições de neurodegeneração.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BRPI0800957-0A BRPI0800957A2 (pt) | 2008-04-04 | 2008-04-04 | vetores biológicos compreendendo o gene max, método de produção dos mesmos, método de expressão do gene max nas células e método de terapia gênica citoprotetora |
US12/936,352 US20110086090A1 (en) | 2008-04-04 | 2009-04-03 | Vectors Containing the Max Gene |
JP2011502198A JP2011516047A (ja) | 2008-04-04 | 2009-04-03 | Max遺伝子含有ベクター |
PCT/BR2009/000093 WO2009121157A1 (en) | 2008-04-04 | 2009-04-03 | Vectors containing the max gene |
US13/683,632 US20130184332A1 (en) | 2008-04-04 | 2012-11-21 | Vectors Containing the Max Gene |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BRPI0800957-0A BRPI0800957A2 (pt) | 2008-04-04 | 2008-04-04 | vetores biológicos compreendendo o gene max, método de produção dos mesmos, método de expressão do gene max nas células e método de terapia gênica citoprotetora |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0800957A2 true BRPI0800957A2 (pt) | 2009-11-17 |
Family
ID=41134762
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0800957-0A BRPI0800957A2 (pt) | 2008-04-04 | 2008-04-04 | vetores biológicos compreendendo o gene max, método de produção dos mesmos, método de expressão do gene max nas células e método de terapia gênica citoprotetora |
Country Status (4)
Country | Link |
---|---|
US (2) | US20110086090A1 (pt) |
JP (1) | JP2011516047A (pt) |
BR (1) | BRPI0800957A2 (pt) |
WO (1) | WO2009121157A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012158757A1 (en) * | 2011-05-16 | 2012-11-22 | The Trustees Of The University Of Pennsylvania | Proviral plasmids for production of recombinant adeno-associated virus |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5302519A (en) * | 1991-09-09 | 1994-04-12 | Fred Hutchinson Cancer Research Center | Method of producing a Mad polypeptide |
US5512473A (en) * | 1993-01-29 | 1996-04-30 | Brent; Roger | Max-interacting proteins and related molecules and methods |
US5827702A (en) * | 1994-10-31 | 1998-10-27 | Genentech, Inc. | Ocular gene therapy |
US5811298A (en) * | 1996-02-29 | 1998-09-22 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Rep-max protein having anti-oncogenic activity and uses thereof |
WO1998009524A1 (en) * | 1996-09-06 | 1998-03-12 | Chiron Corporation | Methods and compositions for liver specific delivery of therapeutic molecules using recombinant aav vectors |
US6696423B1 (en) * | 1997-08-29 | 2004-02-24 | Biogen, Inc. | Methods and compositions for therapies using genes encoding secreted proteins such as interferon-beta |
AU9319198A (en) * | 1997-09-19 | 1999-04-05 | Trustees Of The University Of Pennsylvania, The | Methods and vector constructs useful for production of recombinant aav |
US6683058B1 (en) * | 1998-04-15 | 2004-01-27 | Regents Of The University Of California | Methods for therapy of neurodegenerative disease of the brain |
US6521255B2 (en) * | 2000-01-13 | 2003-02-18 | Osmotica Corp. | Osmotic device containing ranitidine and a prokinetic agent |
US6998118B2 (en) * | 2001-12-21 | 2006-02-14 | The Salk Institute For Biological Studies | Targeted retrograde gene delivery for neuronal protection |
US7186699B2 (en) * | 2003-06-03 | 2007-03-06 | Cell Genesys, Inc. | Method for treating cancer by vector-mediated delivery of one or more anti-angiogenic or pro-apoptotic genes |
EP1656542A4 (en) * | 2003-07-29 | 2008-09-03 | Bristol Myers Squibb Co | BIOMARKER OF MODULATION CYCLIN-DEPENDENT KINASE |
US20050287565A1 (en) * | 2004-05-12 | 2005-12-29 | Merchiers Pascal G | Methods, compositions and compound assays for inhibiting amyloid-beta protein production |
-
2008
- 2008-04-04 BR BRPI0800957-0A patent/BRPI0800957A2/pt not_active Application Discontinuation
-
2009
- 2009-04-03 US US12/936,352 patent/US20110086090A1/en not_active Abandoned
- 2009-04-03 WO PCT/BR2009/000093 patent/WO2009121157A1/en active Application Filing
- 2009-04-03 JP JP2011502198A patent/JP2011516047A/ja active Pending
-
2012
- 2012-11-21 US US13/683,632 patent/US20130184332A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20110086090A1 (en) | 2011-04-14 |
JP2011516047A (ja) | 2011-05-26 |
WO2009121157A1 (en) | 2009-10-08 |
US20130184332A1 (en) | 2013-07-18 |
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B03A | Publication of a patent application or of a certificate of addition of invention [chapter 3.1 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B03H | Publication of an application: rectification [chapter 3.8 patent gazette] |
Free format text: REFERENTE A RPI 2028 DE 17/11/2009, QUANTO AO ITEM (72). |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
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B08H | Application fees: decision cancelled [chapter 8.8 patent gazette] |
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
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