BRPI0716992A2 - inibidores da histona desacetilase com atividade combinada sobre as histona desacetilases classe i e classe iib em combinaÇço com inibidores da proteossoma - Google Patents

inibidores da histona desacetilase com atividade combinada sobre as histona desacetilases classe i e classe iib em combinaÇço com inibidores da proteossoma

Info

Publication number
BRPI0716992A2
BRPI0716992A2 BRPI0716992-2A2A BRPI0716992A BRPI0716992A2 BR PI0716992 A2 BRPI0716992 A2 BR PI0716992A2 BR PI0716992 A BRPI0716992 A BR PI0716992A BR PI0716992 A2 BRPI0716992 A2 BR PI0716992A2
Authority
BR
Brazil
Prior art keywords
class
histone
inhibitors
combination
combined activity
Prior art date
Application number
BRPI0716992-2A2A
Other languages
English (en)
Inventor
Janine Arts
Peter Willem Jan Hellemans
Michel Marie Francois Janicot
Martin John Page
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Priority claimed from PCT/EP2007/059518 external-priority patent/WO2008031817A2/en
Publication of BRPI0716992A2 publication Critical patent/BRPI0716992A2/pt

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

INIBIDORES DA HISTONA DESACETILASE COM ATIVIDADE COMBINADA SOBRE AS HISTONA DESACETILASES CLASSE I E CLASSE IIB EM COMBINAÇçO COM INIBIDORES DA PROTEOSSOMA. A presente invenção refere-se a combinações de um inibidor da proteossoma e de um inibidor da histona desacetilase pelo inibidor com atividade combinada sobre histona desacetilases classe I e classe IIB, para inibir o crescimento de células tumorais, úteis no tratamento do câncer.
BRPI0716992-2A2A 2006-09-15 2007-09-11 inibidores da histona desacetilase com atividade combinada sobre as histona desacetilases classe i e classe iib em combinaÇço com inibidores da proteossoma BRPI0716992A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06120726 2006-09-15
US91589507P 2007-05-03 2007-05-03
PCT/EP2007/059518 WO2008031817A2 (en) 2006-09-15 2007-09-11 Histone deacetylase inhibitors with combined activity on class-i and class-iib histone deacetylases in combination with proteasome inhibitors

Publications (1)

Publication Number Publication Date
BRPI0716992A2 true BRPI0716992A2 (pt) 2013-09-17

Family

ID=41040414

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0716992-2A2A BRPI0716992A2 (pt) 2006-09-15 2007-09-11 inibidores da histona desacetilase com atividade combinada sobre as histona desacetilases classe i e classe iib em combinaÇço com inibidores da proteossoma

Country Status (12)

Country Link
CN (1) CN101516374B (pt)
BR (1) BRPI0716992A2 (pt)
DK (1) DK2066327T3 (pt)
ES (1) ES2399670T3 (pt)
ME (1) ME01514B (pt)
NZ (1) NZ575030A (pt)
PT (1) PT2066327E (pt)
RS (1) RS52638B (pt)
SG (1) SG177219A1 (pt)
SI (1) SI2066327T1 (pt)
UA (1) UA97249C2 (pt)
ZA (1) ZA200901818B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8957066B2 (en) * 2011-02-28 2015-02-17 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
CN107095871A (zh) * 2016-02-22 2017-08-29 中国科学院上海巴斯德研究所 Quisinostat，一种新型的高效抗疟药物
WO2018017858A1 (en) * 2016-07-20 2018-01-25 The Trustees Of Columbia University In The City Of New York Histone acetyltransferase activators and compositions and uses thereof
CN114409638B (zh) * 2022-02-09 2023-02-14 深圳大学 组蛋白去乙酰化酶8选择性降解剂、制备方法及其在抗肿瘤活性中的应用
CN115028678B (zh) * 2022-07-08 2024-09-06 杭州医学院 基于vhl配体诱导bcr-abl蛋白降解的双功能分子及其制备方法和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1781639B1 (en) * 2004-07-28 2012-01-25 Janssen Pharmaceutica NV Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase

Also Published As

Publication number Publication date
PT2066327E (pt) 2013-02-06
NZ575030A (en) 2012-07-27
CN101516374B (zh) 2013-04-24
ME01514B (me) 2014-04-20
SG177219A1 (en) 2012-01-30
ZA200901818B (en) 2010-05-26
SI2066327T1 (sl) 2013-04-30
DK2066327T3 (da) 2013-02-11
CN101516374A (zh) 2009-08-26
ES2399670T3 (es) 2013-04-02
UA97249C2 (ru) 2012-01-25
RS52638B (en) 2013-06-28

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]