BRPI0715821A2 - inibiÇço de gremlina mediada por rnai para tratamento de condiÇÕes relacionadas À iop - Google Patents
inibiÇço de gremlina mediada por rnai para tratamento de condiÇÕes relacionadas À iop Download PDFInfo
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- BRPI0715821A2 BRPI0715821A2 BRPI0715821-1A BRPI0715821A BRPI0715821A2 BR PI0715821 A2 BRPI0715821 A2 BR PI0715821A2 BR PI0715821 A BRPI0715821 A BR PI0715821A BR PI0715821 A2 BRPI0715821 A2 BR PI0715821A2
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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| PCT/US2007/076776 WO2008024983A2 (en) | 2006-08-24 | 2007-08-24 | Rnai-mediated inhibition of gremlin for treatment of iop-related conditions |
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| MX (1) | MX2009001896A (enExample) |
| WO (1) | WO2008024983A2 (enExample) |
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| WO2006006948A2 (en) * | 2002-11-14 | 2006-01-19 | Dharmacon, Inc. | METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY |
| GB0708662D0 (en) * | 2007-05-04 | 2007-06-13 | Galapagos Nv | shRNA sequences |
| WO2009046059A1 (en) * | 2007-10-01 | 2009-04-09 | Alcon Research, Ltd. | Self complementary aav-mediated delivery of interfering rna molecules to treat or prevent ocular disorders |
| BRPI0802525A2 (pt) | 2008-07-11 | 2010-03-09 | Kiyoshi Hashiba | endoscópio cirúrgico |
| US9745574B2 (en) | 2009-02-04 | 2017-08-29 | Rxi Pharmaceuticals Corporation | RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality |
| US8778904B2 (en) * | 2009-12-09 | 2014-07-15 | Quark Pharmaceuticals, Inc. | Methods and compositions for treating diseases, disorders or injury of the CNS |
| CN103200945B (zh) | 2010-03-24 | 2016-07-06 | 雷克西制药公司 | 眼部症候中的rna干扰 |
| RU2599449C1 (ru) | 2011-12-15 | 2016-10-10 | Байонир Корпорейшн | Новые конъюгаты олигонуклеотидов и их применение |
| KR101722948B1 (ko) | 2012-01-05 | 2017-04-04 | (주)바이오니아 | 리간드가 결합된 이중나선 올리고 ｒｎａ 구조체 및 그 제조방법 |
| JP6060178B2 (ja) | 2012-01-05 | 2017-01-18 | バイオニア コーポレーションＢｉｏｎｅｅｒ Ｃｏｒｐｏｒａｔｉｏｎ | 高効率のナノ粒子型二本鎖オリゴｒｎａ構造体およびその製造方法 |
| JP5906327B2 (ja) | 2012-01-18 | 2016-04-20 | バイオニア コーポレーションＢｉｏｎｅｅｒ Ｃｏｒｐｏｒａｔｉｏｎ | 磁性ナノ粒子−ＳＡＭｉＲＮＡ複合体およびその製造方法 |
| TR201905395T4 (tr) * | 2012-03-15 | 2019-05-21 | Hyun Kee Kim | Anti-gremlin-1 antikoru. |
| IN2015DN02699A (enExample) * | 2012-09-05 | 2015-09-04 | Sylentis Sau | |
| GB201215857D0 (en) * | 2012-09-05 | 2012-10-24 | Sylentis Sau | siRNA and their use in methods and compositions for the treatment and/or prevention of eye conditions |
| US10030243B2 (en) | 2013-07-05 | 2018-07-24 | Bioneer Corporation | Nanoparticle type oligonucleotide structure having high efficiency and method for preparing same |
| WO2015132303A1 (en) | 2014-03-04 | 2015-09-11 | Sylentis Sau | Sirnas and their use in methods and compositions for the treatment and/or prevention of eye conditions |
| CA2947270A1 (en) | 2014-04-28 | 2015-11-05 | Rxi Pharmaceuticals Corporation | Methods for treating cancer using nucleic acids targeting mdm2 or mycn |
| JP2017200928A (ja) * | 2017-05-31 | 2017-11-09 | シレンティス・エセ・ア・ウ | ｓｉＲＮＡならびに眼の状態の処置および／または予防のための方法および組成物におけるその使用 |
| CN106978509B (zh) * | 2017-06-07 | 2018-10-26 | 中南大学湘雅二医院 | 青光眼诊断分子标记物lncRNAs ENST00000607393、试剂盒及应用 |
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| CN1685055A (zh) * | 2001-10-31 | 2005-10-19 | 爱尔康公司 | 骨形态发生蛋白(bmp)、bmp受体和bmp结合蛋白及它们在诊断和治疗青光眼中的用途 |
| US20040138163A1 (en) * | 2002-05-29 | 2004-07-15 | Mcswiggen James | RNA interference mediated inhibition of vascular edothelial growth factor and vascular edothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| WO2006006948A2 (en) * | 2002-11-14 | 2006-01-19 | Dharmacon, Inc. | METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY |
| US20060141049A1 (en) * | 2003-11-12 | 2006-06-29 | Allergan, Inc. | Triamcinolone compositions for intravitreal administration to treat ocular conditions |
| TW200639253A (en) * | 2005-02-01 | 2006-11-16 | Alcon Inc | RNAi-mediated inhibition of ocular targets |
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- 2007-08-24 CN CN2012102535702A patent/CN102743767A/zh active Pending
- 2007-08-24 WO PCT/US2007/076776 patent/WO2008024983A2/en not_active Ceased
- 2007-08-24 JP JP2009525796A patent/JP2010501188A/ja active Pending
- 2007-08-24 EP EP07841339A patent/EP2059597A2/en not_active Withdrawn
- 2007-08-24 AU AU2007286545A patent/AU2007286545A1/en not_active Abandoned
- 2007-08-24 CA CA002659464A patent/CA2659464A1/en not_active Abandoned
- 2007-08-24 CN CNA2007800308171A patent/CN101517081A/zh active Pending
- 2007-08-24 MX MX2009001896A patent/MX2009001896A/es active IP Right Grant
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| WO2008024983A3 (en) | 2008-10-09 |
| MX2009001896A (es) | 2009-04-17 |
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| CN101517081A (zh) | 2009-08-26 |
| US20120077864A1 (en) | 2012-03-29 |
| EP2059597A2 (en) | 2009-05-20 |
| JP2010501188A (ja) | 2010-01-21 |
| US20080051361A1 (en) | 2008-02-28 |
| WO2008024983A2 (en) | 2008-02-28 |
| ZA200900553B (en) | 2010-04-28 |
| US20100305193A1 (en) | 2010-12-02 |
| KR20090042297A (ko) | 2009-04-29 |
| CN102743767A (zh) | 2012-10-24 |
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