BRPI0715821A2 - inibiÇço de gremlina mediada por rnai para tratamento de condiÇÕes relacionadas À iop - Google Patents
inibiÇço de gremlina mediada por rnai para tratamento de condiÇÕes relacionadas À iop Download PDFInfo
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- BRPI0715821A2 BRPI0715821A2 BRPI0715821-1A BRPI0715821A BRPI0715821A2 BR PI0715821 A2 BRPI0715821 A2 BR PI0715821A2 BR PI0715821 A BRPI0715821 A BR PI0715821A BR PI0715821 A2 BRPI0715821 A2 BR PI0715821A2
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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| PCT/US2007/076776 WO2008024983A2 (en) | 2006-08-24 | 2007-08-24 | Rnai-mediated inhibition of gremlin for treatment of iop-related conditions |
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| WO2009046059A1 (en) * | 2007-10-01 | 2009-04-09 | Alcon Research, Ltd. | Self complementary aav-mediated delivery of interfering rna molecules to treat or prevent ocular disorders |
| BRPI0802525A2 (pt) | 2008-07-11 | 2010-03-09 | Kiyoshi Hashiba | endoscópio cirúrgico |
| WO2010090762A1 (en) | 2009-02-04 | 2010-08-12 | Rxi Pharmaceuticals Corporation | Rna duplexes with single stranded phosphorothioate nucleotide regions for additional functionality |
| US8778904B2 (en) * | 2009-12-09 | 2014-07-15 | Quark Pharmaceuticals, Inc. | Methods and compositions for treating diseases, disorders or injury of the CNS |
| CN106074591B (zh) * | 2010-03-24 | 2020-01-14 | 菲奥医药公司 | 眼部症候中的rna干扰 |
| KR101722948B1 (ko) | 2012-01-05 | 2017-04-04 | (주)바이오니아 | 리간드가 결합된 이중나선 올리고 ｒｎａ 구조체 및 그 제조방법 |
| JP5952423B2 (ja) | 2011-12-15 | 2016-07-13 | バイオニア コーポレーションＢｉｏｎｅｅｒ Ｃｏｒｐｏｒａｔｉｏｎ | 新規オリゴヌクレオチド接合体およびその用途 |
| CN104114704A (zh) | 2012-01-05 | 2014-10-22 | 株式会社百奥尼 | 高效率的纳米颗粒型双螺旋寡rna结构体及其制备方法 |
| EP2805713B1 (en) | 2012-01-18 | 2018-10-10 | Bioneer Corporation | Magnetic nanoparticle-samirna complex and method for preparing same |
| ES2720617T3 (es) * | 2012-03-15 | 2019-07-23 | Snu R&Db Foundation | Anticuerpo anti-gremlin-1 |
| EP2893018B1 (en) * | 2012-09-05 | 2019-07-24 | Sylentis S.A.U. | Sirna and their use in methods and compositions for the treatment and/or prevention of eye conditions |
| GB201215857D0 (en) * | 2012-09-05 | 2012-10-24 | Sylentis Sau | siRNA and their use in methods and compositions for the treatment and/or prevention of eye conditions |
| KR101862349B1 (ko) | 2013-07-05 | 2018-05-31 | (주)바이오니아 | 개선된 고효율 나노입자형 올리고뉴클레오타이드 구조체 및 그의 제조방법 |
| US10011837B2 (en) | 2014-03-04 | 2018-07-03 | Sylentis Sau | SiRNAs and their use in methods and compositions for the treatment and/or prevention of eye conditions |
| WO2015168108A2 (en) | 2014-04-28 | 2015-11-05 | Rxi Pharmaceuticals Corporation | Methods for treating cancer using nucleic targeting mdm2 or mycn |
| JP2017200928A (ja) * | 2017-05-31 | 2017-11-09 | シレンティス・エセ・ア・ウ | ｓｉＲＮＡならびに眼の状態の処置および／または予防のための方法および組成物におけるその使用 |
| CN106978509B (zh) * | 2017-06-07 | 2018-10-26 | 中南大学湘雅二医院 | 青光眼诊断分子标记物lncRNAs ENST00000607393、试剂盒及应用 |
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| MXPA04003697A (es) * | 2001-10-31 | 2005-04-08 | Alcon Inc | Proteinas morfogenicas de hueso (bmp), receptores de bmp y proteinas de enlace de bmp y su uso en el diagnostico y tratamiento de glaucoma. |
| US20040138163A1 (en) * | 2002-05-29 | 2004-07-15 | Mcswiggen James | RNA interference mediated inhibition of vascular edothelial growth factor and vascular edothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| WO2006006948A2 (en) * | 2002-11-14 | 2006-01-19 | Dharmacon, Inc. | METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY |
| US20060141049A1 (en) * | 2003-11-12 | 2006-06-29 | Allergan, Inc. | Triamcinolone compositions for intravitreal administration to treat ocular conditions |
| TW200639253A (en) * | 2005-02-01 | 2006-11-16 | Alcon Inc | RNAi-mediated inhibition of ocular targets |
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- 2007-08-24 MX MX2009001896A patent/MX2009001896A/es active IP Right Grant
- 2007-08-24 ZA ZA200900553A patent/ZA200900553B/xx unknown
- 2007-08-24 CN CNA2007800308171A patent/CN101517081A/zh active Pending
- 2007-08-24 EP EP07841339A patent/EP2059597A2/en not_active Withdrawn
- 2007-08-24 AU AU2007286545A patent/AU2007286545A1/en not_active Abandoned
- 2007-08-24 CN CN2012102535702A patent/CN102743767A/zh active Pending
- 2007-08-24 KR KR1020097004684A patent/KR20090042297A/ko not_active Ceased
- 2007-08-24 JP JP2009525796A patent/JP2010501188A/ja active Pending
- 2007-08-24 CA CA002659464A patent/CA2659464A1/en not_active Abandoned
- 2007-08-24 US US11/844,869 patent/US20080051361A1/en not_active Abandoned
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| WO2008024983A2 (en) | 2008-02-28 |
| US20120077864A1 (en) | 2012-03-29 |
| US20100305193A1 (en) | 2010-12-02 |
| EP2059597A2 (en) | 2009-05-20 |
| KR20090042297A (ko) | 2009-04-29 |
| CN102743767A (zh) | 2012-10-24 |
| AU2007286545A1 (en) | 2008-02-28 |
| ZA200900553B (en) | 2010-04-28 |
| JP2010501188A (ja) | 2010-01-21 |
| WO2008024983A3 (en) | 2008-10-09 |
| CA2659464A1 (en) | 2008-02-28 |
| MX2009001896A (es) | 2009-04-17 |
| US20080051361A1 (en) | 2008-02-28 |
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