BRPI0710858A2 - uso de uma proteìna anti-secretora, um derivado, homólogo e/ou fragmento da mesma, tendo atividade anti-secretora, e/ou um sal farmaceuticamente ativo da mesma - Google Patents

uso de uma proteìna anti-secretora, um derivado, homólogo e/ou fragmento da mesma, tendo atividade anti-secretora, e/ou um sal farmaceuticamente ativo da mesma Download PDF

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Publication number
BRPI0710858A2
BRPI0710858A2 BRPI0710858-3A BRPI0710858A BRPI0710858A2 BR PI0710858 A2 BRPI0710858 A2 BR PI0710858A2 BR PI0710858 A BRPI0710858 A BR PI0710858A BR PI0710858 A2 BRPI0710858 A2 BR PI0710858A2
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BR
Brazil
Prior art keywords
use according
seq
syndrome
secretory
protein
Prior art date
Application number
BRPI0710858-3A
Other languages
English (en)
Portuguese (pt)
Inventor
Eva Jennische
Hans-Arne Hansson
Bergstroem Thomas
Stefan Lange
Original Assignee
Lantmonnen As Faktor Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lantmonnen As Faktor Ab filed Critical Lantmonnen As Faktor Ab
Publication of BRPI0710858A2 publication Critical patent/BRPI0710858A2/pt

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Dispersion Chemistry (AREA)
  • Pregnancy & Childbirth (AREA)
BRPI0710858-3A 2006-04-27 2007-04-27 uso de uma proteìna anti-secretora, um derivado, homólogo e/ou fragmento da mesma, tendo atividade anti-secretora, e/ou um sal farmaceuticamente ativo da mesma BRPI0710858A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0600933 2006-04-27
SE0600933-6 2006-04-27
PCT/SE2007/000413 WO2007126363A2 (en) 2006-04-27 2007-04-27 Antisecretory protein for use in the treatment of compartment syndrome

Publications (1)

Publication Number Publication Date
BRPI0710858A2 true BRPI0710858A2 (pt) 2011-05-17

Family

ID=38655929

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0710858-3A BRPI0710858A2 (pt) 2006-04-27 2007-04-27 uso de uma proteìna anti-secretora, um derivado, homólogo e/ou fragmento da mesma, tendo atividade anti-secretora, e/ou um sal farmaceuticamente ativo da mesma
BRPI0710794-3A BRPI0710794A2 (pt) 2006-04-27 2007-04-27 proteìna anti-secretória, um derivado homólogo e/ou fragmento da mesma tendo atividade equivalente e uso dos mesmos

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0710794-3A BRPI0710794A2 (pt) 2006-04-27 2007-04-27 proteìna anti-secretória, um derivado homólogo e/ou fragmento da mesma tendo atividade equivalente e uso dos mesmos

Country Status (19)

Country Link
US (2) US8309513B2 (enExample)
EP (2) EP2363140B1 (enExample)
JP (2) JP5323682B2 (enExample)
KR (3) KR101757523B1 (enExample)
CN (3) CN104689299B (enExample)
AT (1) ATE526031T1 (enExample)
AU (1) AU2007244003B2 (enExample)
BR (2) BRPI0710858A2 (enExample)
CA (1) CA2650589C (enExample)
DK (3) DK2040734T3 (enExample)
ES (3) ES2615515T3 (enExample)
IL (1) IL194774A (enExample)
MX (1) MX2008013774A (enExample)
NZ (2) NZ572257A (enExample)
PL (2) PL2040734T3 (enExample)
RU (2) RU2457853C2 (enExample)
SG (1) SG171601A1 (enExample)
WO (1) WO2007126363A2 (enExample)
ZA (2) ZA200809116B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2457853C2 (ru) 2006-04-27 2012-08-10 Лантменнен Ас-Фактор Модуляция липидных рафтов
AU2007244005B2 (en) * 2006-04-27 2012-08-02 Lantmannen As-Faktor Ab Further medical uses of antisecretory protein
AU2007244004B2 (en) 2006-04-27 2012-02-09 Lantmannen As-Faktor Ab Use of antisecretory factors for treating intraocular hypertension
US9962424B2 (en) 2007-04-27 2018-05-08 Lantmännen As-Faktor Ab Use of antisecretory factors (AF) for optimizing cellular uptake
US8901083B2 (en) 2008-11-25 2014-12-02 Temple University Administration of angiocidin for the treatment of leukemia
EP3769778A1 (en) 2009-02-11 2021-01-27 Lantmännen Medical AB Use of antisecretory factors (af) for optimizing cellular uptake
CN107949392B (zh) 2015-07-10 2022-10-11 兰特门内阿斯-法克托尔公司 用于生产含高含量af-16的蛋黄的方法
CN109563142B (zh) * 2016-07-18 2024-09-10 兰特门内阿斯-法克托尔公司 抗分泌因子17
US20250177480A1 (en) 2018-06-28 2025-06-05 Lantmännen Medical Ab Antisecretory Factor for Use in Treatment and/or Prevention of Acute Respiratory Failure
EP3855934A2 (en) 2018-09-28 2021-08-04 Lantmännen Functional Foods AB A consumable product comprising malted dehulled oat
CN112770644A (zh) 2018-09-28 2021-05-07 兰特门内保健食品公司 包含麦芽化小麦的可消耗产品
CN115605214A (zh) 2020-03-26 2023-01-13 兰特门内保健食品公司(Se) 用于促进身体活动恢复的包含麦芽化谷物的可消耗产品

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH682716A5 (de) * 1992-01-13 1993-11-15 Christian Fricker Benzo-Pyrone und/oder Dobesilat-Calcium enthaltende pharmazeutische Zusammensetzung.
US5585401A (en) 1994-12-09 1996-12-17 The Reents Of The University Of California Method for enhancing outflow of aqueous humor in treatment of glaucoma
SE508609C2 (sv) 1995-08-24 1998-10-19 Rural Patent Svenska Ab Antisekretorisk faktor - dess aminosyrasekvens, nubleinsyrasekvens och användning
SE506486C2 (sv) * 1996-11-20 1997-12-22 Svenska Lantmaennen Riksfoerbu Födoämne som vid förtäring inducerar antisekretoriska proteiner
SE513496C2 (sv) * 1998-12-17 2000-09-18 Rural Patent Svenska Ab NASP-berikad äggula samt dess användning
US7662169B2 (en) * 2000-09-05 2010-02-16 Wittmann Dietmar H Prosthesis and method for lowering abdominal pressure
GB0322645D0 (en) * 2003-09-26 2003-10-29 Melacure Therapeutics Ab Use of antisecretory factor peptides
RU2457853C2 (ru) 2006-04-27 2012-08-10 Лантменнен Ас-Фактор Модуляция липидных рафтов
AU2007244005B2 (en) 2006-04-27 2012-08-02 Lantmannen As-Faktor Ab Further medical uses of antisecretory protein
WO2009052478A1 (en) * 2007-10-19 2009-04-23 Trustees Of Boston University Metabolic and cardioprotection by the myokine follistatin-like 1 polypeptide

Also Published As

Publication number Publication date
ZA200809116B (en) 2009-07-29
RU2008146731A (ru) 2010-06-10
PL2040734T3 (pl) 2012-04-30
US20110305773A1 (en) 2011-12-15
EP2040734B1 (en) 2011-09-28
CN101460187A (zh) 2009-06-17
IL194774A0 (en) 2011-08-01
ZA200809114B (en) 2009-06-24
AU2007244003A1 (en) 2007-11-08
US20090185982A1 (en) 2009-07-23
KR20140141729A (ko) 2014-12-10
KR101757523B1 (ko) 2017-07-12
ES2615515T3 (es) 2017-06-07
ATE526031T1 (de) 2011-10-15
HK1131738A1 (en) 2010-02-05
RU2457853C2 (ru) 2012-08-10
WO2007126363A3 (en) 2008-03-13
RU2008146734A (ru) 2010-06-10
NZ572257A (en) 2011-10-28
BRPI0710794A2 (pt) 2011-06-21
CN101460187B (zh) 2014-11-05
ES2472737T3 (es) 2014-07-02
DK2363140T3 (en) 2017-03-06
CN104689299A (zh) 2015-06-10
NZ572256A (en) 2012-02-24
ES2374712T3 (es) 2012-02-21
PL2363140T3 (pl) 2017-05-31
DK2037950T3 (da) 2014-06-30
JP5285043B2 (ja) 2013-09-11
WO2007126363A8 (en) 2008-10-30
CA2650589C (en) 2017-06-13
CA2650589A1 (en) 2007-11-08
AU2007244003B2 (en) 2012-08-02
KR20140123601A (ko) 2014-10-22
CN101437533B (zh) 2016-10-12
JP5323682B2 (ja) 2013-10-23
DK2040734T3 (da) 2012-01-23
EP2040734A2 (en) 2009-04-01
KR20090045148A (ko) 2009-05-07
EP2363140A1 (en) 2011-09-07
CN104689299B (zh) 2020-02-21
MX2008013774A (es) 2009-02-03
US8309513B2 (en) 2012-11-13
CN101437533A (zh) 2009-05-20
WO2007126363A2 (en) 2007-11-08
EP2363140B1 (en) 2016-12-14
SG171601A1 (en) 2011-06-29
JP2011032284A (ja) 2011-02-17
JP2009535328A (ja) 2009-10-01
US8389468B2 (en) 2013-03-05
RU2465914C2 (ru) 2012-11-10
KR101805973B1 (ko) 2017-12-06
IL194774A (en) 2015-07-30

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
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Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B12G Publication of notification of appeal cancelled [chapter 12.7 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 12.2 NA RPI NO 2530 DE 02/07/2019 POR TER SIDO INDEVIDA.