BRPI0620291B8 - método e uso de 4,4'-diaminodifenil sulfona para produzir cepas rugosas de bactérias e composição de modulador imune - Google Patents

método e uso de 4,4'-diaminodifenil sulfona para produzir cepas rugosas de bactérias e composição de modulador imune

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Publication number
BRPI0620291B8
BRPI0620291B8 BRPI0620291A BRPI0620291A BRPI0620291B8 BR PI0620291 B8 BRPI0620291 B8 BR PI0620291B8 BR PI0620291 A BRPI0620291 A BR PI0620291A BR PI0620291 A BRPI0620291 A BR PI0620291A BR PI0620291 B8 BRPI0620291 B8 BR PI0620291B8
Authority
BR
Brazil
Prior art keywords
immune modulator
bacterial strains
modulator composition
diaminodiphenyl sulfone
roughened
Prior art date
Application number
BRPI0620291A
Other languages
English (en)
Inventor
Ann Stanford Cynthia
Mcintyre Graham
Lawson Stanford John
Adelmo Bottasso Oscar
Original Assignee
Bioeos Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioeos Ltd filed Critical Bioeos Ltd
Publication of BRPI0620291A2 publication Critical patent/BRPI0620291A2/pt
Publication of BRPI0620291B1 publication Critical patent/BRPI0620291B1/pt
Publication of BRPI0620291B8 publication Critical patent/BRPI0620291B8/pt

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract

método de produzir cepas rugosas de bactérias e usos das mesmas a presente invenção refere-se a um método de produzir cepas rugosas de uma bactéria, como mycobacterium obuense, sendo que referido método compreende expor referida bactéria a uma sulfona e/ou sulfonamida (como 4,4'- diaminodifenil sulfona ou um análogo da mesma). uma cepa rugosa de mycobacterium obuense produzível por meio de referido método, e usos da mesma. em particular, usos de uma cepa rugosa de mycobacterium obuense depositada sob o tratado de budapeste na nctc com o número de acesso nctc 13365.
BRPI0620291A 2005-12-21 2006-12-19 método e uso de 4,4'-diaminodifenil sulfona para produzir cepas rugosas de bactérias e composição de modulador imune BRPI0620291B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0526033.6 2005-12-21
GBGB0526033.6A GB0526033D0 (en) 2005-12-21 2005-12-21 Method
PCT/GB2006/004780 WO2007071978A1 (en) 2005-12-21 2006-12-19 Method of producing rough strains of bacteria and uses thereof

Publications (3)

Publication Number Publication Date
BRPI0620291A2 BRPI0620291A2 (pt) 2011-11-08
BRPI0620291B1 BRPI0620291B1 (pt) 2020-12-15
BRPI0620291B8 true BRPI0620291B8 (pt) 2021-05-25

Family

ID=35840894

Family Applications (1)

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BRPI0620291A BRPI0620291B8 (pt) 2005-12-21 2006-12-19 método e uso de 4,4'-diaminodifenil sulfona para produzir cepas rugosas de bactérias e composição de modulador imune

Country Status (15)

Country Link
US (2) US8071354B2 (pt)
EP (2) EP2298860A3 (pt)
JP (1) JP5202330B2 (pt)
CN (1) CN101384699B (pt)
AT (1) ATE519838T1 (pt)
AU (1) AU2006328209B2 (pt)
BR (1) BRPI0620291B8 (pt)
CA (1) CA2633127C (pt)
DK (1) DK1963484T3 (pt)
ES (1) ES2369569T3 (pt)
GB (1) GB0526033D0 (pt)
NZ (1) NZ568810A (pt)
PL (1) PL1963484T3 (pt)
SI (1) SI1963484T1 (pt)
WO (1) WO2007071978A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0716778D0 (en) * 2007-08-29 2007-10-10 Bioeos Ltd Use
GB201120779D0 (en) 2011-12-02 2012-01-11 Immodulon Therapeutics Ltd Cancer therapy
GB201216800D0 (en) * 2012-09-20 2012-11-07 Immodulon Therapeutics Ltd Novel use
GB201322725D0 (en) 2013-12-20 2014-02-05 Immodulon Therapeutics Ltd Cancer therapy
MX2017016931A (es) 2015-06-24 2018-09-26 Immodulon Therapeutics Ltd Inhibidor del punto de regulacion y un mycobaterium de celula entera para uso en la terapia del cancer.
WO2017143386A1 (en) * 2016-02-25 2017-08-31 Borody Thomas J Compositions and methods of treatment of chronic infectious diseases
BR112018076875A2 (pt) * 2016-06-24 2019-04-02 Aptimmune Biologics, Inc. método de pré-ativação de um sistema imune de sus.
IL283973B (en) 2017-06-14 2022-08-01 4D Pharma Res Ltd Preparations containing bacterial strains
US11077179B2 (en) 2017-08-10 2021-08-03 Epicgenetics, Inc. Method for treating fibromyalgia and chronic fatigue syndrome
CN114025794A (zh) * 2018-11-02 2022-02-08 4D制药研究有限公司 包含细菌菌株的组合物
WO2020120717A1 (en) 2018-12-12 2020-06-18 4D Pharma Research Limited Compositions comprising parabacteroides bacterial strains for treating cancer
CN115087729B (zh) * 2020-01-21 2024-06-28 辽宁天安生物制药股份有限公司 赤红球菌细胞壁骨架在再生医学中的用途

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1054055A (en) 1975-05-27 1979-05-08 Raymond Turcotte Isolation and characterization of phenotypes of mycobacteria
EP0487633A4 (en) 1989-08-17 1993-10-20 Surgical Laser Products, Inc. Integral end structure for medical laser waveguide
GB8919321D0 (en) * 1989-08-25 1989-10-11 Univ London Treatment of chronic inflammatory conditions
EP0556284A1 (en) 1990-11-05 1993-08-25 Bsd Medical Corporation Urethral inserted applicator for prostate hyperthermia
ATE154759T1 (de) * 1990-11-08 1997-07-15 Univ London Mycobacterium als adjuvans für antigene
US5521300A (en) * 1991-08-13 1996-05-28 Norval B. Galloway Oligonucleotides complementary to mycobacterial nucleic acids
ES2158854T3 (es) * 1992-10-13 2001-09-16 Hoffmann La Roche Oligonucleotidos derivados de la familia de genes sod.
US6136529A (en) * 1993-09-03 2000-10-24 Gen-Probe Incorporated Nucleic acid probes to Mycobacterium avium complex
US5786326A (en) * 1995-02-03 1998-07-28 Horwitz; Lawrence D. Method for the treatment of atherosclerosis and vascular injury by prevention of vascular smooth muscle cell proliferation
US5994346A (en) * 1995-02-03 1999-11-30 Regents Of The University Of California Use of exochelins in the preservation of organs for transplant
US5721209A (en) * 1995-02-03 1998-02-24 The Regents Of The University Of California Iron chelator and inhibitor of iron-mediated oxidant injury
AU710996B2 (en) * 1996-05-22 1999-10-07 Gen-Probe Incorporated Compositions and methods for the detection of mycobacterium kansasii
US6126939A (en) 1996-09-03 2000-10-03 Yeda Research And Development Co. Ltd. Anti-inflammatory dipeptide and pharmaceutical composition thereof
GB9701897D0 (en) * 1997-01-30 1997-03-19 Aqua Health Europ Ltd Vaccine
US7067500B2 (en) * 1997-05-02 2006-06-27 Integrated Research Technology, Llc Betaines as adjuvants to susceptibility testing and antimicrobial therapy
US7329410B1 (en) * 1998-09-30 2008-02-12 Corixa Corporation Compositions and method for WT1 specific immunotherapy
DE19911208A1 (de) * 1999-03-13 2000-09-14 Walther Carl Kurt Gmbh Steckkupplung zur Verbindung von Rohrleitungen, Schläuchen oder dergleichen
GB0025694D0 (en) * 2000-10-19 2000-12-06 Univ London Vaccine
EP1511753A4 (en) * 2001-09-06 2005-10-12 Activbiotics Inc ANTIMICROBIAL MEDIUM AND ITS USE
WO2003045319A2 (en) * 2001-11-21 2003-06-05 Activbiotics, Inc. Targeted therapeutics and uses thereof
AU2002364562A1 (en) * 2001-12-13 2003-06-30 Activbiotics, Inc. Metal complexes and formulations of rifamycin analogues and uses therof
US7078399B2 (en) * 2001-12-13 2006-07-18 Activbiotics, Inc. Sulfhydryl rifamycins and uses thereof
AU2003209127A1 (en) * 2002-02-11 2003-09-04 Auburn University High-sensitivity real-time polymerase chain reaction for detection of nucleic acids
TW200403076A (en) * 2002-06-03 2004-03-01 Activbiotics Inc Intravenous rifalazil formulation and methods of use thereof
SI1534330T1 (sl) 2002-09-06 2014-08-29 Ucl Business Plc Cele bakterijske celice kot imunomodulatorji
US7413728B2 (en) 2003-11-14 2008-08-19 Ucl Biomedica Plc Immune modulator
US7442374B2 (en) 2004-07-19 2008-10-28 Ucl Biomedica Plc Composition for increasing the survival to slaughter rate of piglets
CA2594336A1 (en) * 2004-12-27 2006-07-06 Federal-Mogul Powertrain, Inc. Heat shield for engine mount

Also Published As

Publication number Publication date
EP1963484B1 (en) 2011-08-10
CN101384699B (zh) 2012-10-10
BRPI0620291A2 (pt) 2011-11-08
PL1963484T3 (pl) 2012-08-31
ES2369569T3 (es) 2011-12-02
EP2298860A2 (en) 2011-03-23
WO2007071978A1 (en) 2007-06-28
US8512694B2 (en) 2013-08-20
EP1963484A1 (en) 2008-09-03
EP2298860A3 (en) 2012-04-25
US20090304749A1 (en) 2009-12-10
JP2009520489A (ja) 2009-05-28
CN101384699A (zh) 2009-03-11
JP5202330B2 (ja) 2013-06-05
SI1963484T1 (sl) 2012-06-29
DK1963484T3 (da) 2011-09-19
GB0526033D0 (en) 2006-02-01
CA2633127C (en) 2015-08-04
US20120082699A1 (en) 2012-04-05
ES2369569T8 (es) 2012-06-26
US8071354B2 (en) 2011-12-06
AU2006328209A1 (en) 2007-06-28
BRPI0620291B1 (pt) 2020-12-15
CA2633127A1 (en) 2007-06-28
NZ568810A (en) 2011-09-30
ATE519838T1 (de) 2011-08-15
AU2006328209B2 (en) 2012-10-11

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B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

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B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2703 DE 25-10-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.