BRPI0620291B8 - método e uso de 4,4'-diaminodifenil sulfona para produzir cepas rugosas de bactérias e composição de modulador imune - Google Patents

método e uso de 4,4'-diaminodifenil sulfona para produzir cepas rugosas de bactérias e composição de modulador imune

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Publication number
BRPI0620291B8
BRPI0620291B8 BRPI0620291A BRPI0620291A BRPI0620291B8 BR PI0620291 B8 BRPI0620291 B8 BR PI0620291B8 BR PI0620291 A BRPI0620291 A BR PI0620291A BR PI0620291 A BRPI0620291 A BR PI0620291A BR PI0620291 B8 BRPI0620291 B8 BR PI0620291B8
Authority
BR
Brazil
Prior art keywords
immune modulator
bacterial strains
modulator composition
diaminodiphenyl sulfone
roughened
Prior art date
Application number
BRPI0620291A
Other languages
English (en)
Inventor
Ann Stanford Cynthia
Mcintyre Graham
Lawson Stanford John
Adelmo Bottasso Oscar
Original Assignee
Bioeos Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioeos Ltd filed Critical Bioeos Ltd
Publication of BRPI0620291A2 publication Critical patent/BRPI0620291A2/pt
Publication of BRPI0620291B1 publication Critical patent/BRPI0620291B1/pt
Publication of BRPI0620291B8 publication Critical patent/BRPI0620291B8/pt

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Abstract

método de produzir cepas rugosas de bactérias e usos das mesmas a presente invenção refere-se a um método de produzir cepas rugosas de uma bactéria, como mycobacterium obuense, sendo que referido método compreende expor referida bactéria a uma sulfona e/ou sulfonamida (como 4,4'- diaminodifenil sulfona ou um análogo da mesma). uma cepa rugosa de mycobacterium obuense produzível por meio de referido método, e usos da mesma. em particular, usos de uma cepa rugosa de mycobacterium obuense depositada sob o tratado de budapeste na nctc com o número de acesso nctc 13365.
BRPI0620291A 2005-12-21 2006-12-19 método e uso de 4,4'-diaminodifenil sulfona para produzir cepas rugosas de bactérias e composição de modulador imune BRPI0620291B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0526033.6A GB0526033D0 (en) 2005-12-21 2005-12-21 Method
GB0526033.6 2005-12-21
PCT/GB2006/004780 WO2007071978A1 (en) 2005-12-21 2006-12-19 Method of producing rough strains of bacteria and uses thereof

Publications (3)

Publication Number Publication Date
BRPI0620291A2 BRPI0620291A2 (pt) 2011-11-08
BRPI0620291B1 BRPI0620291B1 (pt) 2020-12-15
BRPI0620291B8 true BRPI0620291B8 (pt) 2021-05-25

Family

ID=35840894

Family Applications (1)

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BRPI0620291A BRPI0620291B8 (pt) 2005-12-21 2006-12-19 método e uso de 4,4'-diaminodifenil sulfona para produzir cepas rugosas de bactérias e composição de modulador imune

Country Status (15)

Country Link
US (2) US8071354B2 (pt)
EP (2) EP2298860A3 (pt)
JP (1) JP5202330B2 (pt)
CN (1) CN101384699B (pt)
AT (1) ATE519838T1 (pt)
AU (1) AU2006328209B2 (pt)
BR (1) BRPI0620291B8 (pt)
CA (1) CA2633127C (pt)
DK (1) DK1963484T3 (pt)
ES (1) ES2369569T3 (pt)
GB (1) GB0526033D0 (pt)
NZ (1) NZ568810A (pt)
PL (1) PL1963484T3 (pt)
SI (1) SI1963484T1 (pt)
WO (1) WO2007071978A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0716778D0 (en) * 2007-08-29 2007-10-10 Bioeos Ltd Use
GB201120779D0 (en) * 2011-12-02 2012-01-11 Immodulon Therapeutics Ltd Cancer therapy
GB201216800D0 (en) * 2012-09-20 2012-11-07 Immodulon Therapeutics Ltd Novel use
GB201322725D0 (en) 2013-12-20 2014-02-05 Immodulon Therapeutics Ltd Cancer therapy
AU2016281765B2 (en) 2015-06-24 2022-06-16 Immodulon Therapeutics Limited A checkpoint inhibitor and a whole cell mycobacterium for use in cancer therapy
CA3015688A1 (en) * 2016-02-25 2017-08-31 Thomas Julius Borody Compositions and methods of treatment of chronic infectious diseases
BR112018076875A2 (pt) * 2016-06-24 2019-04-02 Aptimmune Biologics, Inc. método de pré-ativação de um sistema imune de sus.
US11077179B2 (en) * 2017-08-10 2021-08-03 Epicgenetics, Inc. Method for treating fibromyalgia and chronic fatigue syndrome
JP2022512813A (ja) * 2018-11-02 2022-02-07 フォーディー ファーマ リサーチ リミテッド 細菌株を含む組成物
MA54161A (fr) 2018-12-12 2022-03-23 4D Pharma Res Ltd Compositions comprenant des souches bactériennes parabacteroides pour le traitement du cancer
JP2023510232A (ja) * 2020-01-21 2023-03-13 ▲遼▼▲寧▼格瑞仕特生物制▲藥▼有限公司 ロドコッカス・ルーバーの細胞壁骨格の再生医学における用途

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1054055A (en) * 1975-05-27 1979-05-08 Raymond Turcotte Isolation and characterization of phenotypes of mycobacteria
EP0487633A4 (en) 1989-08-17 1993-10-20 Surgical Laser Products, Inc. Integral end structure for medical laser waveguide
GB8919321D0 (en) * 1989-08-25 1989-10-11 Univ London Treatment of chronic inflammatory conditions
CA2095516A1 (en) 1990-11-05 1992-05-06 Paul F. Turner Urethral inserted applicator for prostate hyperthermia
AU660430B2 (en) 1990-11-08 1995-06-29 Stanford Rook Limited Mycobacterium as adjuvant for antigens
US5521300A (en) 1991-08-13 1996-05-28 Norval B. Galloway Oligonucleotides complementary to mycobacterial nucleic acids
DE69330263T2 (de) 1992-10-13 2002-04-25 Hoffmann La Roche Von der SOD Familie abgeleitete Oligonukleotide
US6136529A (en) 1993-09-03 2000-10-24 Gen-Probe Incorporated Nucleic acid probes to Mycobacterium avium complex
US5786326A (en) 1995-02-03 1998-07-28 Horwitz; Lawrence D. Method for the treatment of atherosclerosis and vascular injury by prevention of vascular smooth muscle cell proliferation
US5994346A (en) 1995-02-03 1999-11-30 Regents Of The University Of California Use of exochelins in the preservation of organs for transplant
US5721209A (en) 1995-02-03 1998-02-24 The Regents Of The University Of California Iron chelator and inhibitor of iron-mediated oxidant injury
JP4241929B2 (ja) 1996-05-22 2009-03-18 ジェン―プローブ・インコーポレーテッド Mycobacterium Kansasiiを検出するための組成物および方法
US6126939A (en) 1996-09-03 2000-10-03 Yeda Research And Development Co. Ltd. Anti-inflammatory dipeptide and pharmaceutical composition thereof
GB9701897D0 (en) 1997-01-30 1997-03-19 Aqua Health Europ Ltd Vaccine
US7067500B2 (en) 1997-05-02 2006-06-27 Integrated Research Technology, Llc Betaines as adjuvants to susceptibility testing and antimicrobial therapy
US7329410B1 (en) * 1998-09-30 2008-02-12 Corixa Corporation Compositions and method for WT1 specific immunotherapy
DE19911208A1 (de) 1999-03-13 2000-09-14 Walther Carl Kurt Gmbh Steckkupplung zur Verbindung von Rohrleitungen, Schläuchen oder dergleichen
GB0025694D0 (en) 2000-10-19 2000-12-06 Univ London Vaccine
EP1511753A4 (en) 2001-09-06 2005-10-12 Activbiotics Inc ANTIMICROBIAL MEDIUM AND ITS USE
JP2005510534A (ja) 2001-11-21 2005-04-21 アクティブバイオティクス インコーポレイティッド 標的化治療薬およびその使用
US7078399B2 (en) 2001-12-13 2006-07-18 Activbiotics, Inc. Sulfhydryl rifamycins and uses thereof
WO2003051300A2 (en) 2001-12-13 2003-06-26 Activbiotics, Inc. Metal complexes and formulations of rifamycin analogues and uses therof
AU2003209127A1 (en) 2002-02-11 2003-09-04 Auburn University High-sensitivity real-time polymerase chain reaction for detection of nucleic acids
AU2003239919A1 (en) 2002-06-03 2003-12-19 Activbiotics, Inc. Intravenous rifalazil formulation and methods of use thereof
PT1534330E (pt) * 2002-09-06 2014-06-23 Ucl Business Plc Células bacterianas inteiras como moduladores imunitários
GB2422544B (en) 2003-11-14 2008-05-14 Ucl Biomedica Plc Immune modulator
US7442374B2 (en) 2004-07-19 2008-10-28 Ucl Biomedica Plc Composition for increasing the survival to slaughter rate of piglets
US7171940B2 (en) * 2004-12-27 2007-02-06 Federal-Mogul World Wide, Inc. Heat shield for engine mount

Also Published As

Publication number Publication date
EP1963484A1 (en) 2008-09-03
CA2633127C (en) 2015-08-04
US20120082699A1 (en) 2012-04-05
CA2633127A1 (en) 2007-06-28
US8512694B2 (en) 2013-08-20
CN101384699A (zh) 2009-03-11
ATE519838T1 (de) 2011-08-15
EP1963484B1 (en) 2011-08-10
EP2298860A3 (en) 2012-04-25
GB0526033D0 (en) 2006-02-01
JP5202330B2 (ja) 2013-06-05
SI1963484T1 (sl) 2012-06-29
WO2007071978A1 (en) 2007-06-28
CN101384699B (zh) 2012-10-10
BRPI0620291A2 (pt) 2011-11-08
PL1963484T3 (pl) 2012-08-31
US20090304749A1 (en) 2009-12-10
US8071354B2 (en) 2011-12-06
ES2369569T8 (es) 2012-06-26
AU2006328209B2 (en) 2012-10-11
JP2009520489A (ja) 2009-05-28
BRPI0620291B1 (pt) 2020-12-15
ES2369569T3 (es) 2011-12-02
AU2006328209A1 (en) 2007-06-28
EP2298860A2 (en) 2011-03-23
DK1963484T3 (da) 2011-09-19
NZ568810A (en) 2011-09-30

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