BRPI0619475B8 - Composições farmacêuticas na forma de lipossomas compreendendo ciclosporina a, seu método de preparo e usos - Google Patents

Composições farmacêuticas na forma de lipossomas compreendendo ciclosporina a, seu método de preparo e usos

Info

Publication number
BRPI0619475B8
BRPI0619475B8 BRPI0619475A BRPI0619475A BRPI0619475B8 BR PI0619475 B8 BRPI0619475 B8 BR PI0619475B8 BR PI0619475 A BRPI0619475 A BR PI0619475A BR PI0619475 A BRPI0619475 A BR PI0619475A BR PI0619475 B8 BRPI0619475 B8 BR PI0619475B8
Authority
BR
Brazil
Prior art keywords
pharmaceutical compositions
cyclosporine
liposomes
preparation
cyclosporin
Prior art date
Application number
BRPI0619475A
Other languages
English (en)
Inventor
Aslihan Akkar
Manfred Keller
Ralf Mehrwald
Original Assignee
Breath Therapeutics Gmbh
Pari Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Breath Therapeutics Gmbh, Pari Pharma Gmbh filed Critical Breath Therapeutics Gmbh
Publication of BRPI0619475A2 publication Critical patent/BRPI0619475A2/pt
Publication of BRPI0619475B1 publication Critical patent/BRPI0619475B1/pt
Publication of BRPI0619475B8 publication Critical patent/BRPI0619475B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

composições farmacêuticas compreendendo ciclosporina. a presente invenção refere-se a composições farmacêuticas líquidas contendo: a) uma dose terapeuticamente eficaz de uma ciclosporina; b) um veículo líquido aquoso; c) uma primeira substância de aumento de solubilidade selecionada do grupo dos fosfolipídios; e d) uma segunda substância de aumento de solubilidade selecionada do grupo dos surfactantes não iônicos. de preferência, a ciclosporina é solubilizada em lipossomos. a composição da invenção é adequada para aplicação oral, parenteral, nasal, mucosa, tópica e particularmente pulmonar, na forma de um aerossol.
BRPI0619475A 2005-12-06 2006-11-29 Composições farmacêuticas na forma de lipossomas compreendendo ciclosporina a, seu método de preparo e usos BRPI0619475B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE102005058252 2005-12-06
DE102005058252.4 2005-12-06
DE102006051512.9 2006-10-31
DE102006051512A DE102006051512A1 (de) 2005-12-06 2006-10-31 Pharmazeutische Medikamentenzusammensetzungen mit Cyclosporin
PCT/EP2006/011459 WO2007065588A1 (de) 2005-12-06 2006-11-29 Pharmazeutische zusammensetzungen mit cyclosporin

Publications (3)

Publication Number Publication Date
BRPI0619475A2 BRPI0619475A2 (pt) 2011-10-04
BRPI0619475B1 BRPI0619475B1 (pt) 2022-01-11
BRPI0619475B8 true BRPI0619475B8 (pt) 2022-03-29

Family

ID=37682529

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0619475A BRPI0619475B8 (pt) 2005-12-06 2006-11-29 Composições farmacêuticas na forma de lipossomas compreendendo ciclosporina a, seu método de preparo e usos

Country Status (10)

Country Link
US (2) US9161963B2 (pt)
EP (1) EP1968538B1 (pt)
AT (1) ATE554746T1 (pt)
AU (1) AU2006322342B2 (pt)
BR (1) BRPI0619475B8 (pt)
CA (1) CA2639696C (pt)
DE (1) DE102006051512A1 (pt)
ES (1) ES2382884T3 (pt)
RU (1) RU2421209C2 (pt)
WO (1) WO2007065588A1 (pt)

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BRPI0608152A2 (pt) 2005-02-09 2009-11-10 Macusight Inc formulações para tratamento ocular
US8663639B2 (en) 2005-02-09 2014-03-04 Santen Pharmaceutical Co., Ltd. Formulations for treating ocular diseases and conditions
EP3067046B1 (en) 2005-12-08 2020-03-25 Insmed Incorporated Lipid-based compositions of antiinfectives for treating pulmonary infections
WO2007092620A2 (en) * 2006-02-09 2007-08-16 Macusight, Inc. Stable formulations, and methods of their preparation and use
CA2645488C (en) 2006-03-23 2014-09-02 Macusight, Inc. Formulations comprising rapamycin and methods using same for vascular permeability-related diseases or conditions
JP2010522774A (ja) * 2007-03-30 2010-07-08 フォベア、ファルマスティカル、ソシエテ、アノニム 血管新生眼疾患を治療するための方法
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
AR066901A1 (es) * 2007-05-18 2009-09-23 Alcon Mfg Ltd Composiciones fodfolipidicas para elcuidado de lentes de contacto y conservacion de composiciones farmaceuticas
EP2195033A1 (en) * 2007-10-08 2010-06-16 Fovea Pharmaceuticals SA Aqueous ophthalmic formulations
TW201010727A (en) * 2008-09-03 2010-03-16 Alcon Res Ltd Pharmaceutical composition having relatively low ionic strength
US9351995B1 (en) * 2011-04-29 2016-05-31 Red Oax Holdings, LLC Compositions and methods of enhancing wound healing
DE102011108948A1 (de) * 2011-07-29 2013-01-31 Achim Göpferich Wässrige, kolloidale Lösungen von lipophilen Substanzen,insbesondere Arzneistofflösungen
CN104039308B (zh) * 2011-11-15 2018-06-05 阿勒根公司 环孢菌素a形式2的可热压性悬浮液
SI2852391T1 (sl) 2012-05-21 2022-04-29 Insmed Incorporated Sistemi za obravnavo pljučnih infekcij
US20140023696A1 (en) * 2012-07-20 2014-01-23 Frederick Timothy Guilford Treatment for idiopathic pulmonary fibrosis
CA2891487A1 (en) 2012-11-29 2014-06-05 Insmed Incorporated Stabilized vancomycin formulations
EP2968650B1 (en) 2013-03-14 2019-01-16 PanOptica, Inc. Ocular formulations for drug-delivery to the posterior segment of the eye
CA2920835A1 (en) 2013-08-20 2015-02-26 Anutra Medical, Inc. Syringe fill system and method
DK3466432T3 (da) 2014-05-15 2020-09-28 Insmed Inc Fremgangsmåder til behandling af pulmonale non-tuberkuløse mykobakterielle infektioner
USD763433S1 (en) 2014-06-06 2016-08-09 Anutra Medical, Inc. Delivery system cassette
USD750768S1 (en) 2014-06-06 2016-03-01 Anutra Medical, Inc. Fluid administration syringe
USD774182S1 (en) 2014-06-06 2016-12-13 Anutra Medical, Inc. Anesthetic delivery device
KR101587412B1 (ko) * 2014-10-17 2016-01-21 주식회사 휴온스 사이클로스포린 및 트레할로스를 포함하는 안과용 조성물
EP3069711A1 (en) * 2015-03-16 2016-09-21 PARI Pharma GmbH Cyclosporine formulations for use in the prevention or treatment of pulmonary chronic graft rejection
US11471445B2 (en) 2017-06-23 2022-10-18 Aki Therapeutics Aps Compositions for the prevention and treatment of acute renal injury
US20190083386A1 (en) 2017-09-15 2019-03-21 Ampersand Biopharmaceuticals, Inc. Methods and formulations for transdermal administration of buffering agents
WO2019191627A1 (en) 2018-03-30 2019-10-03 Insmed Incorporated Methods for continuous manufacture of liposomal drug products
BR112020020564A2 (pt) 2018-04-11 2021-01-12 Breath Therapeutics Gmbh Formulações de ciclosporina para uso no tratamento da síndrome de bronquiolite obliterante (bos)
BR112020026635A2 (pt) 2018-06-27 2021-04-20 Breath Therapeutics Gmbh composições inaláveis compreendendo imunosupressores macrocíclicos
BR112020026629A2 (pt) 2018-06-27 2021-03-23 Breath Therapeutics Gmbh Composições farmacêuticas na forma liofilizada
EA202092892A1 (ru) 2018-12-04 2021-05-27 Брес Терапьютикс Гмбх Ингаляционные композиции, содержащие макроциклические иммуносупрессанты
AU2020415302A1 (en) 2019-12-23 2022-06-16 Zambon S.P.A. Process for the preparation of dispersions comprising inhalable immunosuppressive active ingredients
WO2024028796A1 (en) * 2022-08-04 2024-02-08 Mimetech S.R.L. Udonitrectag for topical use in the treatment of dermatological diseases

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US6465016B2 (en) * 1996-08-22 2002-10-15 Research Triangle Pharmaceuticals Cyclosporiine particles
TW581681B (en) 1998-02-20 2004-04-01 Nektar Therapeutics Liquid crystal forms of cyclosporin
IL143604A0 (en) * 1998-12-30 2002-04-21 Dexcel Ltd Dispersable concentrate for the delivery of cyclosporin
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EP1506032A1 (en) * 2002-05-20 2005-02-16 Research Development Foundation Aerosol drug inhibition of lung metastases
DE10347994A1 (de) * 2003-10-15 2005-06-16 Pari GmbH Spezialisten für effektive Inhalation Wässrige Aerosol-Zubereitung
EP1712220A1 (en) * 2005-04-15 2006-10-18 PARI GmbH Spezialisten für effektive Inhalation Pharmaceutical aerosol composition

Also Published As

Publication number Publication date
US9724382B2 (en) 2017-08-08
AU2006322342A1 (en) 2007-06-14
WO2007065588A1 (de) 2007-06-14
CA2639696C (en) 2015-06-02
AU2006322342B2 (en) 2012-05-24
WO2007065588A8 (de) 2007-08-30
BRPI0619475B1 (pt) 2022-01-11
US20090169607A1 (en) 2009-07-02
BRPI0619475A2 (pt) 2011-10-04
DE102006051512A1 (de) 2007-06-14
EP1968538B1 (de) 2012-04-25
US9161963B2 (en) 2015-10-20
RU2008125986A (ru) 2010-01-20
US20130177626A1 (en) 2013-07-11
CA2639696A1 (en) 2007-06-14
ES2382884T3 (es) 2012-06-14
ATE554746T1 (de) 2012-05-15
EP1968538A1 (de) 2008-09-17
RU2421209C2 (ru) 2011-06-20

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B25A Requested transfer of rights approved

Owner name: BREATH THERAPEUTICS GMBH (DE)

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 29/11/2006, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: REF. RPI 2662 DE 11/01/2022 QUANTO AO INVENTOR E AO QUADRO REIVINDICATORIO.