BRPI0608658A2 - composto, composição farmacêutica, uso do composto, método para tratar um tumor maligno, inibidor de autofosforilação de c-met, e, agente para pesquisa de transdução de sinal de hgf/c-met - Google Patents
composto, composição farmacêutica, uso do composto, método para tratar um tumor maligno, inibidor de autofosforilação de c-met, e, agente para pesquisa de transdução de sinal de hgf/c-metInfo
- Publication number
- BRPI0608658A2 BRPI0608658A2 BRPI0608658A BRPI0608658A BRPI0608658A2 BR PI0608658 A2 BRPI0608658 A2 BR PI0608658A2 BR PI0608658 A BRPI0608658 A BR PI0608658A BR PI0608658 A BRPI0608658 A BR PI0608658A BR PI0608658 A2 BRPI0608658 A2 BR PI0608658A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- met
- hgf
- treating
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005092881 | 2005-03-28 | ||
| PCT/JP2006/306334 WO2006104161A1 (ja) | 2005-03-28 | 2006-03-28 | ｃ－Ｍｅｔ自己リン酸化阻害作用を有するチエノピリジン誘導体、キノリン誘導体、およびキナゾリン誘導体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0608658A2 true BRPI0608658A2 (pt) | 2016-08-23 |
Family
ID=37053417
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0608658A BRPI0608658A2 (pt) | 2005-03-28 | 2006-03-28 | composto, composição farmacêutica, uso do composto, método para tratar um tumor maligno, inibidor de autofosforilação de c-met, e, agente para pesquisa de transdução de sinal de hgf/c-met |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20090270391A1 (pt) |
| EP (1) | EP1870414A4 (pt) |
| JP (1) | JPWO2006104161A1 (pt) |
| KR (1) | KR20080007443A (pt) |
| CN (1) | CN101189241A (pt) |
| AU (1) | AU2006229343A1 (pt) |
| BR (1) | BRPI0608658A2 (pt) |
| CA (1) | CA2603125A1 (pt) |
| RU (1) | RU2007139785A (pt) |
| TW (1) | TW200716650A (pt) |
| WO (1) | WO2006104161A1 (pt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2007001216A (es) | 2004-07-30 | 2007-03-23 | Methylgene Inc | Inhibidores de la senalizacion del receptor del factor de crecimiento endotelial vascular y del receptor del factor de crecimiento del hepatocito. |
| CN101248080B (zh) * | 2005-05-20 | 2012-09-05 | 梅特希尔基因公司 | Vegf受体和hgf受体信号的抑制剂 |
| CA2611370C (en) | 2005-05-20 | 2014-11-25 | Oscar Mario Saavedra | Inhibitors of vegf receptor and hgf receptor signaling |
| CA2636242A1 (en) * | 2006-01-30 | 2008-05-29 | Array Biopharma, Inc. | Heterobicyclic thiophene compounds and methods of use |
| JP2009539878A (ja) * | 2006-06-08 | 2009-11-19 | アレイ バイオファーマ、インコーポレイテッド | キノリン化合物および使用方法 |
| RU2495044C2 (ru) * | 2007-08-29 | 2013-10-10 | Метилджен Инк. | Ингибиторы активности протеинтирозинкиназы |
| ES2593279T3 (es) | 2007-08-29 | 2016-12-07 | Methylgene Inc. | Procesos e intermedios para preparar inhibidores de cinasa heterocíclicos condensados |
| EP2332536A1 (en) * | 2008-03-05 | 2011-06-15 | MethylGene Inc. | Inhibitors of protein tyrosine kinase activity |
| CA2720552C (en) | 2008-04-10 | 2016-06-14 | Taiho Pharmaceutical Co., Ltd. | Acylthiourea compound or salt thereof, and use thereof |
| AR080875A1 (es) * | 2010-04-16 | 2012-05-16 | Methylgene Inc | Inhibidores de la actividad de la proteina tirosina quinasa |
| JP5789259B2 (ja) * | 2010-07-16 | 2015-10-07 | 協和発酵キリン株式会社 | 含窒素芳香族複素環誘導体 |
| EP2522341A1 (en) * | 2011-05-13 | 2012-11-14 | Tragex Pharma | Pharmaceutical compositions comprising Neuropilin inhibitors, and their use for the prevention and/or treatment of angiogenic disorders and cancers |
| CN110312511B (zh) | 2017-02-15 | 2023-10-27 | 大鹏药品工业株式会社 | 医药组合物 |
| EP3942045A1 (en) | 2019-03-21 | 2022-01-26 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| EP4054579A1 (en) | 2019-11-08 | 2022-09-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002345792A1 (en) * | 2001-06-21 | 2003-01-08 | Pfizer Inc. | Thienopyridine and thienopyrimidine anticancer agents |
| EP2088141A3 (en) * | 2001-06-22 | 2009-11-18 | Kirin Pharma Kabushiki Kaisha | Quinoline derivatives and quinazoline derivatives capable of inhibiting autophosphorylation of hepatocyte growth factor receptors, and pharmaceutical composition comprising the same |
| WO2005121125A1 (en) * | 2004-06-09 | 2005-12-22 | Pfizer Inc. | Ether-linked heteroaryl compounds |
| US7439246B2 (en) * | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
| US7173031B2 (en) * | 2004-06-28 | 2007-02-06 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| MX2007001216A (es) * | 2004-07-30 | 2007-03-23 | Methylgene Inc | Inhibidores de la senalizacion del receptor del factor de crecimiento endotelial vascular y del receptor del factor de crecimiento del hepatocito. |
| CN101248080B (zh) * | 2005-05-20 | 2012-09-05 | 梅特希尔基因公司 | Vegf受体和hgf受体信号的抑制剂 |
| CA2636242A1 (en) * | 2006-01-30 | 2008-05-29 | Array Biopharma, Inc. | Heterobicyclic thiophene compounds and methods of use |
-
2006
- 2006-03-27 AU AU2006229343A patent/AU2006229343A1/en not_active Abandoned
- 2006-03-28 CA CA002603125A patent/CA2603125A1/en not_active Abandoned
- 2006-03-28 TW TW095110760A patent/TW200716650A/zh unknown
- 2006-03-28 JP JP2007510537A patent/JPWO2006104161A1/ja not_active Withdrawn
- 2006-03-28 WO PCT/JP2006/306334 patent/WO2006104161A1/ja active Application Filing
- 2006-03-28 EP EP06730282A patent/EP1870414A4/en not_active Withdrawn
- 2006-03-28 CN CNA2006800099025A patent/CN101189241A/zh active Pending
- 2006-03-28 US US11/910,078 patent/US20090270391A1/en not_active Abandoned
- 2006-03-28 KR KR1020077024794A patent/KR20080007443A/ko not_active Application Discontinuation
- 2006-03-28 RU RU2007139785/04A patent/RU2007139785A/ru not_active Application Discontinuation
- 2006-03-28 BR BRPI0608658A patent/BRPI0608658A2/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| TW200716650A (en) | 2007-05-01 |
| RU2007139785A (ru) | 2009-05-10 |
| AU2006229343A1 (en) | 2006-10-05 |
| EP1870414A1 (en) | 2007-12-26 |
| US20090270391A1 (en) | 2009-10-29 |
| KR20080007443A (ko) | 2008-01-21 |
| CN101189241A (zh) | 2008-05-28 |
| WO2006104161A1 (ja) | 2006-10-05 |
| EP1870414A4 (en) | 2010-01-06 |
| JPWO2006104161A1 (ja) | 2008-09-11 |
| CA2603125A1 (en) | 2006-10-05 |
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| B06J | Correction of requirement [chapter 6.10 patent gazette] |
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| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
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| B350 | Update of information on the portal [chapter 15.35 patent gazette] |