BRPI0608456A2 - 8-pirrolidinobenzimidazóis bicìclicos substituìdos, método para a sua produção e seu uso como medicamentos - Google Patents

8-pirrolidinobenzimidazóis bicìclicos substituìdos, método para a sua produção e seu uso como medicamentos Download PDF

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Publication number
BRPI0608456A2
BRPI0608456A2 BRPI0608456-7A BRPI0608456A BRPI0608456A2 BR PI0608456 A2 BRPI0608456 A2 BR PI0608456A2 BR PI0608456 A BRPI0608456 A BR PI0608456A BR PI0608456 A2 BRPI0608456 A2 BR PI0608456A2
Authority
BR
Brazil
Prior art keywords
alkyl
alkylene
aryl
heterocyclyl
cycloalkyl
Prior art date
Application number
BRPI0608456-7A
Other languages
English (en)
Portuguese (pt)
Inventor
Elisabeth Defossa
Karl Schoenafinger
Gerhard Jaehne
Christian Buning
Georg Tschank
Ulrich Werner
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of BRPI0608456A2 publication Critical patent/BRPI0608456A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BRPI0608456-7A 2005-03-19 2006-03-07 8-pirrolidinobenzimidazóis bicìclicos substituìdos, método para a sua produção e seu uso como medicamentos BRPI0608456A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005012872A DE102005012872A1 (de) 2005-03-19 2005-03-19 Substituierte, bizyklische 8-Pyrrolidino-benzimidazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PCT/EP2006/002055 WO2006099940A1 (de) 2005-03-19 2006-03-07 Substituierte, bizyklische 8-pyrrolidino-benzimidazole, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
BRPI0608456A2 true BRPI0608456A2 (pt) 2010-01-05

Family

ID=36579682

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0608456-7A BRPI0608456A2 (pt) 2005-03-19 2006-03-07 8-pirrolidinobenzimidazóis bicìclicos substituìdos, método para a sua produção e seu uso como medicamentos

Country Status (11)

Country Link
US (1) US7569700B2 (OSRAM)
EP (1) EP1863817B1 (OSRAM)
JP (1) JP2008533064A (OSRAM)
AT (1) ATE396997T1 (OSRAM)
AU (1) AU2006226637A1 (OSRAM)
BR (1) BRPI0608456A2 (OSRAM)
CA (1) CA2602229A1 (OSRAM)
DE (2) DE102005012872A1 (OSRAM)
IL (1) IL185805A0 (OSRAM)
MX (1) MX2007010841A (OSRAM)
WO (1) WO2006099940A1 (OSRAM)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102260265B (zh) 2010-05-24 2015-09-02 上海阳帆医药科技有限公司 六氢吡咯[3,4-b]吡咯衍生物、其制备方法及其用途
TWI757266B (zh) * 2016-01-29 2022-03-11 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
KR20210125471A (ko) 2018-10-05 2021-10-18 안나푸르나 바이오, 인코포레이티드 Apj 수용체 활성과 관련된 병태를 치료하기 위한 화합물 및 조성물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1122257B1 (en) * 2000-01-05 2005-10-12 Pfizer Inc. Benzimidazole compounds as ORL1-receptor agonists
JP4109111B2 (ja) * 2000-12-06 2008-07-02 エフ．ホフマン−ラ ロシュ アーゲー 縮合複素環式芳香族グルコキナーゼアクチベーター
US6855708B2 (en) * 2001-03-20 2005-02-15 Merck & Co., Inc. N-arylsulfonyl aza-bicyclic derivatives as potent cell adhesion inhibitors
US7541477B2 (en) * 2002-07-30 2009-06-02 Banyu Pharmaceutical Co., Ltd. Antagonists to melanin-concentrating hormone receptor comprising benzimidazole derivative as active ingredient
ATE450533T1 (de) * 2003-02-14 2009-12-15 Glaxo Group Ltd Carboxamidderivate
WO2005035526A1 (en) * 2003-10-09 2005-04-21 Argenta Discovery Ltd. Bicyclic compounds and their therapeutic use

Also Published As

Publication number Publication date
MX2007010841A (es) 2007-11-09
CA2602229A1 (en) 2006-09-28
US20080090890A1 (en) 2008-04-17
WO2006099940A1 (de) 2006-09-28
AU2006226637A1 (en) 2006-09-28
ATE396997T1 (de) 2008-06-15
IL185805A0 (en) 2008-01-06
EP1863817B1 (de) 2008-05-28
WO2006099940A8 (de) 2006-11-09
EP1863817A1 (de) 2007-12-12
US7569700B2 (en) 2009-08-04
JP2008533064A (ja) 2008-08-21
DE102005012872A1 (de) 2006-09-28
DE502006000850D1 (de) 2008-07-10

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]